The common gamma-chain cytokines communicate with the common cytokine receptor chain (γc/CD132/IL2RG) via cytokine receptors. At least six short-chain cytokines belong to this family: IL2, IL4, IL7, IL9, IL15 and IL21.
IL2RB (CD122), IL4R (CD124), IL7R (CD127), IL9R (CD129) and IL21R, along with IL2RG, are all members of the γc family of cytokine receptors. The γc subunit forms distinct heterodimeric receptors for IL4, IL7, IL9 and IL21, as well as heterotrimeric receptors for IL2 and IL15, by binding with these separate cytokine-specific receptor subunits.
This cytokine family regulates the formation, longevity, proliferation, specialization and function of cells both in innate and adaptive immune systems by activating three key signaling pathways (PI3K-Akt, RAS-MAPK and JAK-STAT).
Designer cytokines that target this family have now shown promise in the treatment of allergies, autoimmunity, immunodeficiency and cancer. To aid in the research of the cytokine family, Sino Biological has created a panel of high-quality recombinant γc family cytokines, receptor proteins and antibodies.
Recombinant γc family cytokine & receptor proteins
Featured IL-21 protein
Human IL-21 Protein: 10584-HNAE
> 95 % as determined by SEC-HPLC. Image Credit: Sino Biological Inc.
Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.
Batch-to-batch Consistency. Image Credit: Sino Biological Inc.
Featured IL-2 protein
Human IL-2 (11848-H08H)
Cell proliferation assay using CTLL2 cells. The ED50 is typically 1-5 ng/mL. Image Credit: Sino Biological Inc.
Rat IL-2 (80075-RNAE)
Cell proliferation assay using CTLL2 cells. The ED50 is typically 0.5-3 ng/mL. Image Credit: Sino Biological Inc.
Antibodies for γc family cytokines and receptors
Sino Biological has created a complete array of antibodies that may be utilized in ELISA, WB, FCM, Neutralization, IP and IHC to target γc family cytokines and receptors. ELISA antibody pairs that are matched are also accessible.
Learn more about γc family cytokine and receptor proteins and antibodies.
Image Credit: Sino Biological Inc.