SLAMF7 Molecule Information
Name：SLAM family member 7
Target Synonym：Novel Ly9?CS1?CD_antigen=CD319?Membrane protein FOAP-12?CRACC?SLAMF7?Protein 19A?SLAM family member 7?CD2 subset 1?CD2-like receptor-activating cytotoxic cells
Number of Launched Drugs：1
Number of Drugs in Clinical Trials：3
Lastest Research Phase：Approved
SLAMF7 Molecule Synonym Name
SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12
SLAMF7 Molecule Background
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors.
SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.