Synthesizing Peptides with the Liberty Blue


The most sold peptide synthesizer in the world is the Liberty Blue™ Automated Microwave Peptide Synthesizer. It has a 4-minute cycle time and a 90% solvent reduction based on High Efficiency Solid Phase Peptide synthesis (HE-SPPS) developed in 2013. The Liberty Blue is used in hundreds of laboratories in the world and yields unparalleled peptide quality due to its unique methodology and use of microwaves. It has latest features in engineering for fluidic deliveries, true internal temperature feedback control, and software control with 21 CFR Part 11 compliance.

Unique Chemistry

  • CarboMAX™ coupling chemistry (patented)
  • Microwave deprotection and coupling (patented)


  • 4 min cycle time
  • 90% waste reduction (HE-SPPS)
  • Flex-Add™ critical reagent delivery system (patented)
  • True Internal fiber-optic temperature control
  • 0.005 - 5 mmol scale range
  • 27 amino acid positions
  • Integrated Camera (optional)
  • High-throughput upgrade options

An Incredibly Fast Peptide Synthesizer

  • 4 min cycle times (HE-SPPS)
  • Access to peptides in less than a day
  • Optional automated synthesis of up to 24 peptides

The Best Coupling Method for Peptide Synthesis

  • The fastest and most complete coupling
  • Unmatched low level of epimerization for all 20 amino acids
  • Highest purities with patented microwave deprotection and coupling (US7393920, US7582728, US8058393, CA2471687)
  • Simplify synthesis by eliminating the need for time consuming method screening

The Best Way to Deliver Critical Reagents

  • Infinitely variable – deliver whatever volume you want (unlike sample loops)
  • No priming ever
  • No washing and less complex than syringe pumps

Unprecedented 90% Solvent Reduction

  • Judicious use of solvents and reagents from optimized washing and synthetic protocols
  • Superior system design minimizes calibration, cleaning, and maintenance needs

The Most Advanced Software for Simple and Flexible Control

  • Automated programming of standard and complex peptides (branched, cyclized, disulfide bonding)
  • 21 CFR Part 11 compliance including full run history and method reports
  • Integrated real-time camera into microwave cavity

We’ve Raised the Standard for Peptide Purity

The peptide quality and synthesis success provided by Liberty Blue is unrivaled. Our systems use controlled microwave energy to heat the reaction and not the vessel. In addition to the innovative design of hardware, software and speciality chemicals we focus on efficient systems for loading, delivery, monitoring and removal. This lets us deliver the optimal chemistry for the highest purity and yields.

Synthesize Standard and Complex Peptides

  • Branched Peptides
  • Cyclized Peptides
  • Disulfide Bonding
  • Glycopeptides (N/O-linked)
  • High Throughput Synthesis
  • N-Methyl Peptides
  • Peptide Thioesters
  • Peptoids
  • Phospho-peptides
  • PNA