TA Instruments' New Nano DSC

The TA Instruments Nano Series calorimeters represent the highest sensitivity and unmatched performance for the investigation of biological samples.

The Nano DSC differential scanning calorimeter is designed to measure the amount of heat absorbed or released by dilute in-solution bio-molecules as they are heated or cooled. Macromolecules such as proteins respond to heating or cooling by unfolding at a characteristic temperature. The more intrinsically stable the biopolymer, the higher the midpoint temperature of the unfolding transition. As these processes often exchange microjoule levels of heat, the sensitivity of the Nano DSC is critical for successful investigation of the reaction.

The Nano DSC obtains data with less sample than competitive designs and produces unmatched short term noise (±15 nanowatts) and baseline reproducibility (±28 nanowatts). Solid-state thermoelectric elements are used to precisely control temperature and a built-in precision linear actuator maintains constant or controlled
variable pressure in the cell. Increased sample throughput is realized by adding on the Nano DSC Autosampler. It provides true walk-away capability for up to 96 samples. With convenient USB connectivity, built-in pressure perturbation capability and capillary cell design, the Nano DSC provides maximum flexibility with a cell design that minimizes sample aggregation and precipitation, resulting in high quality data.

Applications

  • Characterization of Protein Stability
  • Investigation of Protein-Ligand Binding
  • Characterization of Protein Structure