TNF-alpha Molecule Information
Name：Tumor necrosis factor ?
Target Synonym：Intracellular domain 1?NTF?Cachectin?TNF-a?TNFSF2?ICD2?TNF?Intracellular domain 2?TNF-alpha?N-terminal fragment?Tumor necrosis factor ligand superfamily member 2?TNFA ?Tumor necrosis factor?Tumor necrosis factor, soluble form?Tumor necrosis factor, membra
Number of Launched Drugs：35
Number of Drugs in Clinical Trials：117
Lastest Research Phase：Approved
TNF-alpha Molecule Synonym Name
DIF, TNF-alpha, TNFA, TNFSF2, cachexin, cachectin, TNF¦Á
TNF-alpha Molecule Background
Tumor necrosis factor alpha (TNF¦Á) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNF¦Á is in the regulation of immune cells. TNF¦Á is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication.
Dysregulation of TNF¦Á production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNF¦Á is used as an immunostimulant under the INN tasonermin. TNF¦Á can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
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