TNF-alpha from ACROBiosystems

TNF-alpha Molecule Information

Name:Tumor necrosis factor ?
Target Synonym:Intracellular domain 1?NTF?Cachectin?TNF-a?TNFSF2?ICD2?TNF?Intracellular domain 2?TNF-alpha?N-terminal fragment?Tumor necrosis factor ligand superfamily member 2?TNFA ?Tumor necrosis factor?Tumor necrosis factor, soluble form?Tumor necrosis factor, membra
Number of Launched Drugs:35
Number of Drugs in Clinical Trials:117
Lastest Research Phase:Approved

TNF-alpha Molecule Synonym Name

DIF, TNF-alpha, TNFA, TNFSF2, cachexin, cachectin, TNF¦Á

TNF-alpha Molecule Background

Tumor necrosis factor alpha (TNF¦Á) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNF¦Á is in the regulation of immune cells. TNF¦Á is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication.

Dysregulation of TNF¦Á production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNF¦Á is used as an immunostimulant under the INN tasonermin. TNF¦Á can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

TNF-alpha References