The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo).
In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.
VEGF R2 References
- Holmes K,et al., 2007, Cell Signal. 19 (10): 2003¨C2012.
- Stuttfeld E, et al., 2009, IUBMB Life 61 (9): 915¨C22.
- Fujita, N, et al., 2008, Biochem Biophys Res Commun, 372(2):367-72.
VEGF R2 Related Molecule