AMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapy
AMSBIO announces new, best-in-class CAR-T cells, engineered CAR-T target cells, PBMC, cell media and activation beads in response to the rapid growth in research on the therapeutic uses of CAR-T cells.
All CAR-T cell products from AMSBIO are T cells produced from either a group of donors or from individual donor transduced with CAR (Chimeric antigen receptor) - lentivirus.
These CAR-T cells can target different tumor antigens such CD19, CD133, Her-2, EGFR, VEGFR-2 or mesothelin that are highly over-expressed in tumors. These CAR-T cells can express inducible caspase-9 or other suicide gene to induce CAR-T cell killing for increased safety in case this construct in future will be proposed to use in clinical trials. All CAR-T cell products from AMSBIO can be validated for transduction efficiency, cell killing activity and real time cytotoxicity activity. All CAR-T cells from AMSBIO have negative mock controls: lentivirus-transduced CAR-T cells, no ScFv-transduced CAR-T cells and non-transduced T cells.
In addition to these off-the-shelf CAR-T cell products, AMSBIO offers a growing list of engineered cell lines including CAR-T/NK cells and target cells (GFP-Raji cells) to support custom development in applications including animal studies.
PBMC (Peripheral Blood Mononuclear Cells) from AMSBIO are isolated from blood samples using standard Ficoll-Paque and density gradient centrifugation. These PMBC cells can be used for isolation of T cells (used to generate CAR-T cells) and other cell types.
AMSBIO's new CAR T-cell Expansion Medium is specifically optimized for expansion of CAR T-cells, providing 100-fold greater expansion than normal media. CD28 / CD3 cell activation/expansion beads have been introduced to enable researchers to activate and expand human T cells: CD4+, CD8+ T cells, antigen specific T cells or polyclonal T cells.
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AMS Biotechnology. (2019, July 10). AMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapy. News-Medical. Retrieved on August 08, 2020 from https://www.news-medical.net/news/20190710/AMSBIO-offers-new-best-in-class-CAR-T-cell-range-for-research-and-immunotherapy.aspx.
AMS Biotechnology. "AMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapy". News-Medical. 08 August 2020. <https://www.news-medical.net/news/20190710/AMSBIO-offers-new-best-in-class-CAR-T-cell-range-for-research-and-immunotherapy.aspx>.
AMS Biotechnology. "AMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapy". News-Medical. https://www.news-medical.net/news/20190710/AMSBIO-offers-new-best-in-class-CAR-T-cell-range-for-research-and-immunotherapy.aspx. (accessed August 08, 2020).
AMS Biotechnology. 2019. AMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapy. News-Medical, viewed 08 August 2020, https://www.news-medical.net/news/20190710/AMSBIO-offers-new-best-in-class-CAR-T-cell-range-for-research-and-immunotherapy.aspx.