Contains the active ingredient, ciprofloxacin hydrochloride
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about this medicine. It does not contain
all the available information. It does not take the place of talking to your doctor
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
this medicine against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What is this medicine used for
Ciprofloxacin is used to treat:
urinary tract infections
kidney and bladder infections
bone and joint infections
Ciprofloxacin belongs to a group of antibiotic medicines called quinolones.
It works by killing the bacteria which cause these infections.
It will not work against viral infections such as colds or flu.
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed this medicine for another reason.
This medicine is available only with a doctor's prescription.
There is no evidence that this medicine is addictive.
This medicine is not recommended for use in children or pre-pubertal teenagers.
Before you take this medicine
When you must not take it
Do not take this medicine if you have an allergy to:
any medicine containing ciprofloxacin
other quinolone antibiotics or nalidixic acid
any of the ingredients listed at the end of this leaflet
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin
Do not take this medicine if you are taking a medicine called tizanidine (used for
multiple sclerosis or spinal injuries).
Do not take this medicine after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, preservatives
Tell your doctor if you have or have had any of the following medical conditions:
brain disease or stroke
epilepsy (seizures or fits)
arrhythmias (fast or irregular heartbeats)
Ciprofloxacin may increase the risk of arrhythmias, especially in the elderly or patients
with low potassium levels.
myasthenia gravis (disease of the muscles causing drooping eyelids, double vision,
difficulty in speaking and swallowing and sometimes muscle weakness in the arms or
tendon disorders with the use of quinolones (e.g. moxifloxacin, norfloxacin, nalidixic
Tell your doctor if you are elderly or have previously taken corticosteroids such
as prednisolone or cortisone, or have had problems with your tendons before when taking
You may be at increased risk of swelling of or damage to the tendons. Symptoms include
pain, tenderness and sometimes restricted movement.
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding.
Do not take this medicine until you and your doctor have discussed the risks and benefits
Ciprofloxacin passes into human breast milk and may affect your baby, so your doctor
will discuss with you what to do.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you get without a prescription from your pharmacy, supermarket or health food
Some medicines must not be taken with ciprofloxacin.
Do not take ciprofloxacin if you are taking tizanidine, used for multiple sclerosis
or spinal injuries.
Some medicines and ciprofloxacin may interfere with each other. These include:
multivitamins, mineral supplements, antacids (used for indigestion) and other medicines
containing iron, magnesium, aluminium or calcium
certain anti-arrhythmics, antidepressants, antibiotics and antipsychotics
theophylline, and other methylxanthines, used to help breathing. Caffeine is also
duloxetine, used for depression, incontinence or diabetic neuropathy
cyclosporin, used in organ transplants, or for severe arthritis or psoriasis
methotrexate, used to treat certain cancers, or for severe arthritis or psoriasis
warfarin or other medicines called anticoagulants, used to prevent blood clots
phenytoin, used to treat epilepsy
certain non-steroidal anti-inflammatory medicines (NSAIDs), used to treat muscular
problems and arthritis. The combination of these medicines with ciprofloxacin may
clozapine, used to treat schizophrenia
ropinirole, used to treat restless legs syndrome
lidocaine, used in certain heart conditions and for local or spinal anaesthesia
sildenafil, used to treat erectile dysfunction
probenecid, used for gout or arthritis
omeprazole, used to treat stomach ulcers.
sucralfate, used to treat stomach ulcers
metoclopramide, used to treat nausea and vomiting
oral anti-diabetic agents such as glibenclamide and glimepiride
antiretroviral medicines such as didanosine, used to treat HIV infections
sevelamer, used to treat high blood levels of phosphate
oxpentifylline, used to treat circulation disorders
agomelatine, used to treat depression
zolpidem, used to treat sleep disorders
These medicines may be affected by ciprofloxacin or may affect how well it works.
You may need different amounts of your medicines, or you may need to take different
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while taking this medicine.
How to take this medicine
Follow carefully all directions given to you by your doctor.
They may differ from the information contained in this leaflet.
If you do not understand the directions, ask your doctor or pharmacist for help.
How much to take
Your doctor will tell you how many tablets you will need to take. This will depend
on your condition and whether or not you are taking any other medicines.
The usual adult dosage for most infections is one tablet twice daily for 7 to 14 days.
You may need to take your tablets for a longer period for some infections.
How to take it
Swallow the tablets whole with a full glass of water.
When to take it
Take your medicine at about the same time each day.
Taking it at the same time each day will have the best effect. It will also help you
remember when to take it.
It does not matter if you take this medicine before or after food.
If you need to take an antacid, take it at least 2 hours before or 2 hours after your
dose of ciprofloxacin.
How long to take it for
The length of treatment may vary from 1 to 28 days or longer depending on the type
Continue taking your medicine until you finish the pack or for as long as your doctor
Do not stop taking your tablets because you are feeling better.
If you do not complete the full course prescribed by your doctor, the infection may
not clear completely or your symptoms may return.
If you forget to take it
If it is almost time to take your next dose, skip the missed dose and take your next
dose at the usual time.
Otherwise, take it as soon as you remember, and then go back to taking your medicine
as you would normally.
Do not take a double dose to make up for the missed doses.
This may increase the chance of you experiencing side effects.
If you are not sure what to do, ask your doctor or pharmacist.
If you have trouble remembering to take your medicine, ask your pharmacist for some
If you take too much (overdose)
Immediately telephone your doctor or the Poisons Information Centre (telephone 13
11 26) for advice or go to Accident and Emergency at the nearest hospital, if you
think that you or anyone else may have taken too much of this medicine. Do this even
if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
While you are taking this medicine
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are taking this medicine.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking
If you are going to have surgery, tell the surgeon or anaesthetist that you are taking
It may affect other medicines used during surgery.
If you become pregnant or start to breastfeed while taking this medicine, tell your
If you are about to have any blood tests, tell your doctor that you are taking this
It may interfere with the results of some tests.
Keep all your doctor's appointments so that your progress can be checked.
Your doctor may do some tests from time to time to make sure the medicine is working
and to prevent unwanted side effects.
Drink plenty of water or fluids while taking this medicine.
This will help to prevent crystals forming in the urine which can cause kidney problems.
However, this is not a common problem.
Protect your skin when you are in the sun, especially between 10 am and 3 pm, or in
the presence of artificial ultraviolet (UV) light. Wear protective clothing and use
a 15+ sunscreen. If your skin does appear to be burning, stop taking this medicine
and tell your doctor.
Ciprofloxacin may cause your skin to be much more sensitive to sunlight and UV light
than it is normally. This may cause a skin rash, itching, redness, or a severe sunburn.
Things you must not do
Do not take this medicine to treat any other complaints unless your doctor tells you
Do not give your medicine to anyone else, even if they have the same condition as
Do not stop taking your medicine or lower the dosage without checking with your doctor.
If you do not complete the full course prescribed by your doctor, all the bacteria
causing your infection may not be killed. These bacteria may continue to grow and
multiply so that your infection may not clear completely or it may return and be more
difficult to treat.
Things to be careful of
Be careful while driving or operating machinery until you know how ciprofloxacin affects
This medicine may cause dizziness, light-headedness or drowsiness in some people,
or may change your reaction time. If you have any of these symptoms, do not drive
or operate machinery or do anything else that could be dangerous.
Be careful when drinking alcohol while you are taking this medicine.
If you drink alcohol, dizziness, light-headedness or drowsiness may be worse.
Be careful when drinking beverages containing caffeine (e.g. coffee, cola drinks)
while you are taking this medicine.
Ciprofloxacin tablets may increase the stimulatory effects of caffeine.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking this medicine.
All medicines can have side effects. Sometimes they are serious but most of the time
they are not.
Do not be alarmed by the following lists of side effects. You may not experience any
Tell your doctor if you notice any of the following:
nausea, vomiting, mild diarrhoea
loss of appetite
mild stomach pain or wind
agitation, anxiety or restlessness
dizziness or light-headedness
tremor, twitching or weakness
purple or red spots on the skin
strange taste, smell or touch sensations.
Tell your doctor as soon as possible if you notice any of the following:
vaginal itching or discharge
a sore white mouth or tongue
altered vision (specialist consult needed)
difficulty walking, uncoordinated, shaking
getting sunburnt very easily
joint or muscle pain, muscle cramps, or inflamed, painful or ruptured tendons such
as the Achilles tendon
tinnitus (ringing in the ears), problems with hearing
symptoms of hypoglycaemia (low blood sugar) e.g. sweating, weakness, dizziness, trembling,
headache, and having a fast, pounding heartbeat
symptoms of hyperglycaemia (high blood sugar) e.g. feeling hungry, thirsty and/or
frequent or excessive urination
a worsening of the symptoms of myasthenia gravis, e.g. weaker muscles which tire more
easily, drooping eyelids, double vision, difficulty in speaking and swallowing
confusion, hallucinations, depression
The above list includes serious side effects and you may need medical attention.
If any of the following happen, tell your doctor immediately or go to Accident and
Emergency at your nearest hospital:
severe watery or bloody diarrhoea, even if it occurs several weeks after you have
stopped taking this medicine
severe stomach pains
severe skin rashes or blistering
numbness, pain, burning, tingling or pins and needles in outer limbs
palpitations, or fast or irregular heart beats
dark, bloody or cloudy urine
yellowing of the skin or eyes (jaundice)
fits (convulsions or seizures)
confusion, nightmares, hallucinations, depression and psychotic reaction (even progressing
to self-endangering behaviour)
ringing in the ear, loss of hearing
symptoms of an allergic reaction including cough, shortness of breath, wheezing or
difficulty breathing; swelling of the face, lips, tongue, throat or other parts of
the body; rash, itching or hives on the skin
The above list includes very serious side effects. You may need urgent medical attention
Other side effects not listed above may occur in some patients.
After finishing it
Tell your doctor immediately if you notice any of the following side effects, particularly
if they occur several weeks after stopping treatment with ciprofloxacin:
severe abdominal cramps or stomach cramps
watery and severe diarrhoea, which may also be bloody
fever, in combination with one or both of the above
Do not take any anti-diarrhoea medicine without first checking with your doctor.
You may have a serious condition affecting your bowel, and may therefore need urgent
medical attention. However, this side effect is rare.
Storage and disposal
Keep your medicine in its original packaging until it is time to take it.
If you take your medicine out of its original packaging they may not keep well.
Keep your medicine in a cool dry place where the temperature will stay below 25°C.
Do not store your medicine, or any other medicine, in the bathroom or near a sink.
Do not leave it on a window sill or in the car on hot days.
Heat and dampness can destroy some medicines.
Keep it where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
If your doctor tells you to stop taking this medicine or the expiry date has passed,
ask your pharmacist what to do with any medicine that is left over.
What APO-Ciprofloxacin looks like
White to off-white, round, film-coated tablets marked with "250" on one side and plain
on the other. AUST R 135650.
White to off-white, caplet (oval) shaped, film-coated tablets marked with "500" on
one side and plain on the other. AUST R 135651.
White to off-white, caplet (oval) shaped, film-coated tablets marked with "750" on
one side and plain on the other. AUST R 135652.
Available in blister packs of 14 tablets
* Not all strengths, pack types and/or pack sizes may be available.
Each tablet contains 250 mg, 500 mg or 750 mg of ciprofloxacin.
It also contains the following inactive ingredients:
colloidal anhydrous silica
sodium starch glycollate type A
This medicine is gluten-free, lactose-free, sucrose-free, tartrazine-free and free
of other azo dyes.
Apotex Pty Ltd
16 Giffnock Avenue
Macquarie Park NSW 2113
APO and APOTEX are registered trademarks of Apotex Inc.
This leaflet was updated in September 2019.