Contains the active ingredient metoprolol tartrate
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about this medicine. It does not contain
all the available information. It does not take the place of talking to your doctor
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
this medicine against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What this medicine is used for
The name of your medicine is APO-Metoprolol tablets. It contains the active ingredient
It is used:
to treat high blood pressure, also called hypertension
to prevent a type of chest pain, also called angina
after a heart attack
to prevent migraine headaches.
Metoprolol belongs to a group of medicines called beta-blockers. It works by affecting
the body's response to some nerve impulses, especially in the heart.
As a result, it decreases the heart's need for blood and oxygen and reduces the amount
of work that the heart must do. It also widens the blood vessels in the rest of the
Metoprolol can be used alone or in combination with other medicines to treat your
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed it for another reason.
Metoprolol is only available with a doctor's prescription.
There is no evidence that this medicine is addictive.
Use in children
Metoprolol is not recommended for use in children.
Before you take this medicine
When you must not take it
Do not take this medicine if you have or have had any of the following medical conditions:
sudden losses of consciousness
asthma, wheezing, difficulty breathing or other severe lung problems
a history of allergic problems, including hayfever
a very slow heartbeat (less than 45 to 50 beats per minute)
low blood pressure
a severe blood vessel disorder causing poor circulation in the arms and legs, severe
drops in blood pressure, dizziness, fast heartbeat, rapid and shallow breathing or
cold clammy skin
phaeochromocytoma (a rare tumour of the adrenal gland) which is not already being
treated with other medicines
sudden and oppressive chest pain, a sign of heart attack
irregular heart beat (without functioning pacemaker)
swollen ankles and/or tiredness due to heart disease or certain other heart conditions
poor blood circulation in your limbs (e.g. very cold, pale hands or feet, or pain
in your leg muscles when you walk)
If you are not sure whether any of the above medical conditions apply to you, check
with your doctor.
Do not take this medicine if you have an allergy to:
any medicine containing metoprolol
any other beta-blocker medicines
any of the ingredients listed at the end of this leaflet
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin
Do not take this medicine if you are pregnant.
Metoprolol should not be used throughout pregnancy, especially during the first 3
months of pregnancy, unless clearly necessary.
Metoprolol may affect your baby, especially if you take it in the last few days before
your baby is born.
Your doctor can discuss with you the risks and benefits involved.
Do not take this medicine after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, preservatives,
dyes or bee or wasp stings.
Your doctor will want to know if you are prone to allergies. Beta-blocker medicines
can make an allergic reaction worse.
Tell your doctor if you have or have had any of the following medical conditions:
an overactive thyroid gland
a heart attack
chest pain when you are at rest, or certain types of angina, such as Prinzmetal angina
or variant angina
oculomucocutaneous syndrome (signs include severe conjunctivitis and skin rash and
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding.
The active ingredient in metoprolol passes into breast milk and there is a possibility
that your baby could be affected.
Your doctor can discuss with you the risks and benefits involved.
If you have not told your doctor about any of the above, tell them before you start
taking this medicine.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you get without a prescription from your pharmacy, supermarket or health food
Some medicines may interact with metoprolol. These include:
other beta-blocker medicines, including beta-blocker eye drops
other medicines used to treat high blood pressure e.g. calcium channel blockers (such
as verapamil or diltiazem), clonidine and hydralazine
some medicines used to treat angina
adrenaline or similar substances, which are often found in eye or nose drops, or in
some cough and cold medicines
other medicines used to treat irregular heart beat (arrhythmias), e.g. amiodarone,
flecainide, disopyramide and quinidine
medicines for diabetes
quanethidine, used to treat certain heart conditions
some local and general anaesthetics used during surgery
warfarin or dipyridamole, used to prevent blood clots
non-steroidal anti-inflammatory drugs (NSAIDs), used to relieve pain or inflammation
e.g. ibuprofen or indomethacin
cimetidine, used for stomach ulcers
some antibiotics (e.g. rifampicin)
some antivirals (e.g. ritonavir)
some antihistamines (e.g. diphenhydramine)
some antidepressant medications (e.g. fluoxetine, paroxetine or bupropion)
monoamine-oxidase inhibitor (MAOI) medicines
some antifungals (e.g. terbinafine)
ergot alkaloids, used in the prevention and treatment of migraine headaches
These medicines may be affected by metoprolol or may affect how well it works. You
may need different amounts of your medicines, or you may need to take different medicines.
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while taking this medicine.
How to take this medicine
Follow carefully all directions given to you by your doctor. Their instructions may
be different to the information in this leaflet.
How much to take
Your doctor will tell you how much of this medicine you should take. This will depend
on your condition and whether you are taking any other medicines.
High blood pressure:
The usual dose is from 50 mg to 200 mg each day, either as a single dose or divided
into two doses.
The usual dose is from 100 mg to 300 mg each day, divided into two or three doses.
After a heart attack:
The usual dose is 200 mg each day, divided into two doses.
To prevent migraine:
The usual dose is from 100 mg to 150 mg each day, divided into two doses (morning
How to take it
Swallow the tablets whole with a full glass of water.
It does not matter if you take metoprolol before or after food.
How long to take it
Continue taking metoprolol for as long as your doctor tells you.
Metoprolol helps to control your symptoms, but it does not cure your condition. Your
doctor will check your progress to make sure the medicine is working and will decide
how long your treatment should continue.
Talk to your doctor if you are not sure how long you need to take your medicine for.
If you forget to take it
If it is almost time for your next dose, skip the missed dose and take your next dose
at the usual time.
Otherwise, take it as soon as you remember, and then go back to taking your medicine
as you would normally.
Do not take a double dose to make up for the one that you missed.
This may increase the chance of you getting an unwanted side effect.
If you have trouble remembering when to take your medicine, ask your pharmacist for
some hints to help you remember.
If you take too much
Immediately telephone your doctor or the Poisons Information Centre (telephone 13
11 26) for advice or go to Accident and Emergency at the nearest hospital, if you
think that you or anyone else may have taken too much of this medicine. Do this even
if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
Symptoms of an overdose may include feeling sick and vomiting, bluish skin and nails,
very low blood pressure, slow heartbeat, difficulty breathing, fainting, convulsions
(fits), coma or death.
While you are taking this medicine
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are taking this medicine.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking
If you are going to have surgery, tell the surgeon or anaesthetist that you are taking
It may affect other medicines used during surgery.
If you become pregnant or start to breastfeed while taking this medicine, tell your
If you have an allergic reaction to a food, another medicine or an insect sting while
you are taking this medicine, tell your doctor immediately.
There is a chance that metoprolol could make the allergic reaction worse or harder
If you feel light-headed, dizzy or faint when getting out of bed or standing up, get
You may feel light-headed or dizzy when you start to take metoprolol.
This is because your blood pressure is falling suddenly. If this problem doesn't go
away, talk to your doctor.
To avoid symptoms of low blood pressure, here are some hints that may help:
Stand up slowly to help your body get used to the change in position and blood pressure
If you feel dizzy, sit or lie down until you feel better
If you feel faint, breathe deeply and bend forward with your head between your knees
Take extra care when exercising, driving or standing for long periods, especially
in hot weather. Drink plenty of fluids, especially if you sweat a lot.
If you are being treated for diabetes, make sure you check your blood sugar regularly
and report any problems to your doctor.
Metoprolol may change how well your diabetes is controlled. It may also prevent some
of the warning signs of low blood sugar, such as fast heartbeat and may make low blood
sugar last longer. The dose of your diabetes medicines may need to be changed.
If you are about to have any blood tests, tell your doctor that you are taking this
It may interfere with the results of some tests.
Make sure you drink enough water during exercise and hot weather when you are taking
this medicine, especially if you sweat a lot.
If you do not drink enough water while taking metoprolol, you may feel faint or light
headed or sick. This is because your blood pressure is dropping too much. If you continue
to feel unwell, tell your doctor.
Keep all your doctor's appointments so that your progress can be checked.
Your doctor may do some tests from time to time to make sure the medicine is working
and to prevent unwanted side effects.
Things you must not do
Do not take this medicine to treat any other complaints unless your doctor tells you
Do not give your medicine to anyone else, even if they have the same condition as
Do not stop taking your medicine or lower the dosage without checking with your doctor.
Your doctor may want to gradually reduce the amount of metoprolol you are taking before
stopping it completely. This helps to reduce the chance of your condition becoming
worse or keep other unwanted heart problems from happening.
Things to be careful of
Be careful driving, operating machinery or doing jobs that require you to be alert
while you are taking this medicine until you know how it affects you.
As with other beta-blocker medicines, metoprolol may cause dizziness, light-headedness
or decreased alertness in some people.
If you have any of these symptoms, do not drive or do anything else that could be
Be careful drinking alcohol while you are taking this medicine.
If you drink alcohol, dizziness or light-headedness may be worse.
Be careful to dress warmly during cold weather, especially if you will be outside
for a long time.
Like other beta-blocker medicines, metoprolol may make you more sensitive to cold
temperatures, especially if you have problems with your blood circulation. These medicines
tend to decrease blood circulation in the skin, fingers and toes.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking this medicine.
All medicines can have side effects. Sometimes they are serious but most of the time
they are not.
Do not be alarmed by the following lists of side effects. You may not experience any
Ask your doctor or pharmacist to answer any questions you may have.
If you are over 65 years of age, you may have an increased chance of getting side
Tell your doctor if you notice any of the following and they worry you:
tiredness, drowsiness or decreased alertness
dizziness, spinning sensation (vertigo) or light-headedness
headache or other aches and pains
sleepiness during the day, difficulty sleeping or nightmares
stomach ache or upset, nausea (feeling sick) or vomiting
diarrhoea or constipation
dry or irritated eyes; blurred vision
runny or blocked nose
abnormal triglycerides, cholesterol values or liver function tests during treatment
Tell your doctor as soon as possible if you notice any of the following:
depression or other changes in mood
confusion or loss of memory
buzzing or ringing in the ears, or other difficulty hearing
problems with sexual function
worsening of psoriasis
muscle cramps or painful joints
a tingling sensation
The above list includes serious side effects that may require medical attention.
Tell your doctor immediately or go to Accident and Emergency at your nearest hospital
if you notice any of the following:
shortness of breath, sometimes with tiredness, weakness or reduced ability to exercise
swelling of the feet or legs due to fluid build-up
coldness, burning, numbness or pain in arms and legs
pain behind the breastbone (different from angina)
changes in heart rate (fast, slow or irregular)
yellowing of the skin or eyes (jaundice), sometimes with pain in the abdomen
constant "flu-like" symptoms (chills, fever, sore throat, aching joints, swollen glands,
tiredness or lack of energy)
unusual bleeding or bruising
skin reactions (rash, itching or worsening of psoriasis)
symptoms of sunburn (redness, itching, swelling or blistering) that happen much more
quickly than normal
abnormal thinking or hallucinations (seeing or hearing things that are not there)
symptoms of an allergic reaction including cough, shortness of breath, wheezing or
difficulty breathing; swelling of the face, lips, tongue, throat or other parts of
the body; rash, itching or hives on the skin
Other side effects not listed above may occur in some patients.
Storage and Disposal
Keep your tablets in the original pack, away from direct light, until it is time to
If you take your medicine out of its original packaging it may not keep well.
Keep your medicine in a cool dry place where the temperature will stay below 30°C.
Do not store your medicine, or any other medicine, in the bathroom or near a sink.
Do not leave it in the car or on window sills.
Heat and dampness can destroy some medicines.
Keep this medicine where children cannot reach it.
A locked cupboard at least one and-a-half metres above the ground is a good place
to store medicines.
If your doctor tells you to stop taking this medicine or the expiry date has passed,
ask your pharmacist what to do with any medicine that is left over.
What APO-metoprolol looks like
Metoprolol 50 mg tablets:
Pink, round, biconvex film-coated tablets with notch break line on one side and '50'
debossed on the other side. AUST R 192766.
A blister pack contains 10 tablets or 100 tablets.
Metoprolol 100 mg tablets:
White to off white, round, biconvex film-coated tablets with notch break line on one
side and '100' debossed on the other side. AUST R 192772.
A blister pack contains 10 tablets or 60 tablets.
* Not all strengths and/or pack sizes may be available.
Metoprolol contains 50 mg or 100 mg of metoprolol tartrate as the active ingredient.
The tablets also contain the following in-active ingredients:
Sodium starch glycollate
Colloidal anhydrous silica
Pregelatinised maize starch
Iron oxide red (50 mg only)
Apotex Pty Ltd
16 Giffnock Avenue
Macquarie Park NSW 2113
APO and APOTEX are registered trademarks of Apotex Inc.
This leaflet was last updated in August 2019.