Contains the active ingredient propranolol hydrochloride
Consumer Medicine Information
What is in this leaflet
Read this leaflet carefully before taking your medicine.
This leaflet answers some common questions about propranolol hydrochloride. It does not contain all the available information.
It does not take the place of talking to your doctor or pharmacist.
The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine
may be available.
Ask your doctor or pharmacist:
if there is anything you do not understand in this leaflet,
if you are worried about taking your medicine, or
to obtain the most up-to-date information.
You can also download the most up to date leaflet from www.apotex.com.au.
All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they
expect it will have for you.
Pharmaceutical companies cannot give you medical advice or an individual diagnosis.
Keep this leaflet with your medicine. You may want to read it again.
What this medicine is used for
The name of your medicine APO-Propranolol tablets. It contains the active ingredient propranolol hydrochloride.
It is used to treat or prevent a number of conditions, most of which are related to the heart:
to lower high blood pressure, also called hypertension
to prevent angina
to treat or prevent heart attacks, or reduce your risk of heart problems following a heart attack
to treat irregularities in heartbeat, including those caused by anxiety
essential tremor (shaking of head, chin, hands)
To prevent migraine headaches
Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed
this medicine for another reason.
This medicine is available only with a doctor's prescription.
How it works
Propranolol hydrochloride is a Beta-adrenoreceptor blocking agent which acts non selectively on Beta-receptors (Beta1 and
Beta 2). Propranolol hydrochloride reduces elevated blood pressure by an unknown mechanism.
There is no evidence that this medicine is addictive.
Use in children
This medicine should not be used in children under 7 years of age.
Before you take this medicine
When you must not take it
Do not take this medicine if:
You have or have had any of the following:
Congestive heart failure
Right ventricular failure secondary to pulmonary hypertension
Significant right ventricular hypertrophy
Sick sinus syndrome
Sinus bradycardia (less than 45 to 50 beats/minute)
Second and third degree A-V block
Severe peripheral arterial circulatory disturbances
Any other similar medicines such as beta blockers
You have asthma or severe breathing problems
Other heart problems for example heart failure, low blood pressure, problems with your circulation, or a slow heartbeat.
You have low blood sugar levels
You are pregnant.
Propranolol hydrochloride may affect your developing baby if you take it during pregnancy.
You are breastfeeding.
Propranolol hydrochloride may pass into human breast milk.
You are hypersensitive to, or have had an allergic reaction to, propranolol hydrochloride or any of the ingredients listed
at the end of this leaflet.
Symptoms of an allergic reaction may include: cough, shortness of breath, wheezing or difficulty breathing; swelling of the
face, lips, tongue, throat or other parts of the body; rash, itching or hives on the skin; fainting; or hay fever-like symptoms.
If you think you are having an allergic reaction, do not take any more of the medicine and contact your doctor immediately
or go to the Accident and Emergency department at the nearest hospital.
The expiry date (EXP) printed on the pack has passed.
The packaging is torn, shows signs of tampering or it does not look quite right.
Before you start to take it
Before you start taking this medicine, tell your doctor if:
1. You have allergies to:
any other medicines
any other substances, such as foods, preservatives or dyes.
2. You have or have had any medical conditions, especially the following:
asthma or serious breathing problems
low blood pressure
problems with your circulation
diabetes or low blood sugar
an overactive thyroid gland
3. You are currently pregnant or you plan to become pregnant. Do not take this medicine whilst pregnant until you and your doctor
have discussed the risks and benefits involved.
4. You are currently breastfeeding or you plan to breast-feed. Do not take this medicine whilst breastfeeding until you and your
doctor have discussed the risks and benefits involved.
5. You are planning to have surgery or an anaesthetic.
6. You are currently receiving or are planning to receive dental treatment.
7. You are taking or are planning to take any other medicines. This includes vitamins and supplements that are available from
your pharmacy, supermarket or health food shop.
Some medicines may interact with propranolol hydrochloride. These include:
calcium channel blockers - medicines used to treat high blood pressure
digoxin - a medicine used to treat heart failure
medicines for migraine
medicines for diabetes
warfarin - a medicine that stops blood clots
theophylline - a medicine used to treat asthma
rifampicin - a medicine used to treat tuberculosis
ibuprofen, indomethacin - medicines used to treat pain and inflammation
cimetidine - a medicine used to treat ulcers
chlorpromazine - a medicine used to treat psychotic illnesses
rizatriptan - a medicine used to treat migraine headaches
If you are taking any of these you may need a different dose or you may need to take different medicines.
Other medicines not listed above may also interact with this medicine.
How to take this medicine
Follow carefully all directions given to you by your doctor. Their instructions may be different to the information in this
How much to take
Your doctor will tell you how much of this medicine you should take. This will depend on your condition and whether you are
taking any other medicines.
For high blood pressure
The usual starting dose is one 40 mg tablet taken twice a day for one week.
The dose is then usually increased to between 120 mg to 320 mg daily.
If you are taking other medicines which lower blood pressure, your doctor may need to change the dose of them to obtain the
best results for you.
For angina and tremor
The usual dose is 80 mg taken twice a day, often starting with 40 mg taken four times a day for 2 or 3 days.
For migraine prevention
The usual dose is 40 mg taken twice a day. This may need to be increased up to 80 mg twice a day.
Children over 7 years
The starting dose is 10 mg taken once or twice daily. This can be increased if necessary.
Do not stop taking your medicine or change your dosage without first checking with your doctor.
How to take it
Take tablet with a glass of water.
When to take it
Take this medicine at the same time each day. Taking it at the same time each day will have the best effect and will also
help you remember when to take it.
It does not matter if you take it before, with or after food.
How long to take it for
Continue taking your medicine for as long as your doctor tells you.
Make sure you have enough to last over weekends and holidays.
If you forget to take it
If it is almost time to take your next dose, skip the missed dose and take your next dose at the usual time. Otherwise, take
it as soon as you remember and then go back to taking your medicine as you would normally.
Do not take a double dose to make up for missed doses.
This may increase the chance of you experiencing side effects.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints to help you remember.
If you take too much (overdose)
If you think that you or anyone else may have taken too much of this medicine, immediately telephone your doctor or the Poisons
Information Centre (Tel: 13 11 26 in Australia) for advice. Alternatively, go to the Accident and Emergency department at
your nearest hospital.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
While you are taking this medicine
Things you must do
Tell your doctor that you are taking this medicine if:
you are about to be started on any new medicine
you are pregnant or are planning to become pregnant
you are breastfeeding or are planning to breast-feed
you are about to have any blood tests
you are going to have surgery or an anaesthetic or are going into hospital. Your blood pressure may drop suddenly if propranolol
hydrochloride interacts with the anaesthetic
you are being treated for diabetes, make sure you check your blood sugar level regularly and report any changes to your doctor.
Propranolol hydrochloride may change how well your diabetes is controlled. It may also cover up some of the symptoms of low
blood sugar (hypoglycaemia) eg. Increased heart rate. It may also increase the time your body takes to recover from low blood
sugar. Your doses of diabetic medicines, including insulin, may need to change.
Propranolol hydrochloride may also occasionally cause low blood sugar (hypoglycaemia) in non-diabetic patients.
These may include the newly born, toddlers, children, elderly, patients suffering from overdose, patients suffering from chronic
liver disease, fasting patients or patients on haemodialysis.
Your doctor may occasionally do tests to make sure the medicine is working and to prevent side effects. Go to your doctor
regularly for a check-up.
Tell any other doctors, dentists and pharmacists who are treating you that you take this medicine.
Things you must not do
Give this medicine to anyone else, even if their symptoms seem similar to yours.
Take your medicine to treat any other condition unless your doctor tells you to.
Stop taking your medicine, or change the dosage, without first checking with your doctor.
Things to be careful of
Be careful when driving or operating machinery until you know how this medicine affects you.
Propranolol hydrochloride may cause dizziness, light-headedness, tiredness, or drowsiness in some people. Make sure you know
how you react to this medicine before you drive a car, operate machinery, or do anything else that could be dangerous if you
are dizzy or light-headed.
Be careful drinking alcohol while you are taking propranolol hydrochloride.
Dizziness or light-headedness may be worse. Alcohol can also increase the effects of propranolol hydrochloride.
Dress warmly during cold weather, especially if you will be outside for a long time (for example when playing winter sports).
Propranolol hydrochloride, like other beta-blocker medicines, may make you more sensitive to cold temperatures, especially
if you have circulation problems.
Possible side effects
Tell your doctor as soon as possible if you do not feel well while you are taking propranolol hydrochloride or if you have
any questions or concerns.
Do not be alarmed by the following lists of side effects. You may not experience any of them. All medicines can have side
effects. Sometimes they are serious but most of the time they are not.
Tell your doctor if you notice any of the following:
Nausea (feeling sick), vomiting
Loss of appetite
Diarrhoea, stomach pain, flatulence
Cold hands or feet
Feeling tired, lethargic, lack of energy
Tell your doctor as soon as possible if you notice any of the following.
These may be serious side effects and you may need medical attention:
Disturbed sleep, vivid dreams or nightmares
Conjunctivitis, dry eyes
Trouble passing urine
Mood changes, confusion
Loss of hearing
Slow heart beats
If you experience any of the following, stop taking your medicine and contact your doctor immediately or go to the Accident
and Emergency department at your nearest hospital.
These are very serious side effects and you may need urgent medical attention or hospitalisation:
Extreme tiredness or breathlessness on mild exercise
Wheezing, difficulty breathing or an asthma attack
Fast heart beats (palpitations)
Other side effects not listed above may occur in some patients.
If you think you are having an allergic reaction to propranolol hydrochloride, do not take any more of this medicine and tell
your doctor immediately or go to the Accident and Emergency department at your nearest hospital.
Symptoms of an allergic reaction may include some or all of the following:
cough, shortness of breath, wheezing or difficulty breathing
swelling of the face, lips, tongue, throat or other parts of the body
rash, itching or hives on the skin
hay fever-like symptoms.
Storage and disposal
Keep your medicine in its original packaging until it is time to take it.
If you take your medicine out of its original packaging it may not keep well.
Keep your medicine away from direct sunlight and in a cool dry place, where the temperature will stay below 25°C.
Do not store your medicine, or any other medicine, in the bathroom or near a sink. Do not leave it on a window sill or in
the car. Heat and dampness can destroy some medicines.
Keep this medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor tells you to stop taking this medicine or it has passed its expiry date, your pharmacist can dispose of the
remaining medicine safely.
What APO-Propranolol tablets looks like
10 mg tablet
Orange coloured, round, biconvex tablets, embossed with "P" and "10" on either side of the breakline on one side and plain
on the other side.
40 mg tablet
Green coloured, round, biconvex tablets, embossed with "P" and "40" on either side of the breakline on one side and plain
on the other side.
Bottles of 100 tablets
* Not all strengths may be available.
Each tablet contains 10 mg or 40 mg propranolol hydrochloride as the active ingredient.
It also contains the following inactive ingredients:
sunset yellow FCF aluminium lake
sodium starch glycollate
brilliant blue FCF aluminium lake (40 mg only)
This medicine is gluten-free, sucrose-free, tartrazine-free and free of other azo dyes.
Australian Registration Numbers
APO-Propranolol 10 mg tablets (bottle): AUST R 222958.
APO-Propranolol 40 mg tablets (bottle): AUST R 222969.
Apotex Pty Ltd
16 Giffnock Avenue
Macquarie Park NSW 2113
APO and APOTEX are registered trade marks of Apotex Inc.
This leaflet was last updated in: February 2015.