Apomorphine hydrochloride hemihydrate
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about APOMINE Intermittent. It does not
contain all the available information. It does not take the place of talking to your
doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you using
APOMINE Intermittent against the benefits they expect it will have for you.
If you have any concerns about using this medicine, ask your doctor or pharmacist.
Keep this leaflet in a safe place.
You may need to read it again.
For further information on APOMINE Intermitent please contact your health care professional.
What APOMINE Intermittent is used for
APOMINE Intermittent contains apomorphine, which belongs to a group of medicines called
Apomorphine is used in the treatment of Parkinson's disease to reduce the number and
severity of bouts of freezing and stiffness (or "off" periods).
This medicine works by acting on dopamine receptors. These receptors help control
movement by the body.
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed it for another reason.
This medicine is not addictive.
This medicine is available only with a doctor's prescription.
There is not enough information to recommend the use of this medicine in children
under 18 years.
Before you use APOMINE Intermittent
When you must not use it
Do not use APOMINE Intermittent if you have an allergy to:
sodium metabisulfite (E223)
certain types of pain killers such as morphine, or other opioid analgesics
Some of the symptoms of an allergic reaction may include shortness of breath, wheezing
or difficulty breathing; swelling of the face, lips, tongue or other parts of the
body; rash, itching or hives on the skin.
Do not use this medicine if you have or have had any of the following medical conditions:
certain forms of dementia eg. Alzheimer's Disease
severe kidney or liver disease
problems with circulation of blood in the brain (cerebrovascular disease)
breathing problems (respiratory depression)
Do not use this medicine after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start using this medicine, talk to your doctor.
Before you use it
Tell your doctor or pharmacist if you have allergies to any other medicines, foods,
preservatives or dyes.
Tell your doctor if you have or have had any of the following medical conditions:
a history of severe nausea or vomiting
any addictive behaviour (eg compulsive sex, shopping or eating)
If you have not told your doctor or pharmacist about any of the above, tell them before
you start using APOMINE Intermittent.
Taking other medicines
Tell your doctor or pharmacist if you are taking or using any other medicines, including
any that you get without a prescription from your pharmacy, supermarket or health
Some medicines may interfere with how APOMINE Intermittent works in your body. These
tetrabenazine, a medicine used to treat movement disorders
metoclopramide, a medicine used to treat nausea
medicines used to treat some psychiatric (mental) conditions (eg phenothiazines, haloperidol,
papaverine, a medicine which expands blood vessels
These medicines may be affected by APOMINE Intermittent, or may affect how well it
works. You may need different amounts of your medicine, or you may need to use different
Your doctor and pharmacist have more information on medicines to be careful of or
avoid while using this medicine.
How to use APOMINE Intermittent
How much is given
Your doctor will decide what dose you will receive. This depends on your initial response
to APOMINE Intermittent.
How it is given
You will usually be in hospital when you start using APOMINE Intermittent. It is recommended
that you are given an anti-nausea drug (domperidone) for a few days, and that you
temporarily stop all your other anti-Parkinsonian medication before you start using
APOMINE Intermittent, so that the correct dose of APOMINE Intermittent can be determined.
This medicine is given as an injection under the skin (subcutaneously), usually into
your lower abdomen or outer thigh. It is injected several times a day using a device
called D-Mine® Pen, and not with a conventional syringe and needle that you may be familiar with.
You and/or your carers will be trained by hospital staff to recognise when and how
to give the injections.
If you use too much (Overdose)
Immediately notify your doctor or nurse, or if you are not in the hospital, telephone
the Poisons Information Centre (13 11 26) or go to Accident and Emergency at your
nearest hospital, if you think that you or anyone else may have used too much APOMINE
Intermittent. Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
Symptoms of an overdose may include severe nausea and vomiting, slow or troubled breathing,
restlessness, hallucinations or unconsciousness.
While you are using APOMINE Intermittent
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are using APOMINE Intermittent.
Tell any other doctors, dentists, and pharmacists who are treating you that you are
using this medicine.
If you plan to have surgery, tell the surgeon or anaesthetist that you are using this
It may affect other medicines used during surgery.
If you become pregnant while you are using this medicine, tell your doctor immediately.
Keep all of your doctor's appointments so that your progress can be checked.
Things you must not do
Do not use APOMINE Intermittent to treat any other complaints unless your doctor tells
Do not give this medicine to anyone else, even if they have the same condition as
Things to be careful of
Be careful driving or operating machinery until you know how APOMINE Intermittent
This medicine may cause drowsiness, sudden onset of sleepiness, dizziness or light-headedness
in some people. If you have any of these symptoms, do not drive, operate machinery
or do anything else that could be dangerous.
Tell your doctor, nurse or pharmacist as soon as possible if you do not feel well
while you are using APOMINE Intermittent.
APOMINE Intermittent helps most people with Parkinson's disease but may have unwanted
side effects. All medicines can have side effects. Sometimes they are serious, most
of the time they are not. You may need medical treatment if you get some of the side
If you are over 65 years of age, you may have an increased chance of experiencing
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
Ask your doctor, nurse or pharmacist to answer any questions you may have.
Tell your doctor, nurse or pharmacist if you notice any of the following and they
nausea or vomiting
sudden onset of sleepiness
dizziness or light-headedness
pain and sores at the injection site
unpleasant metallic taste
spontaneous penile erection
lack of impulse control
decreased or increased sexual arousal
increased need to gamble
compulsive eating, shopping or medication use
aggression and agitation
swelling of your arms and hands, or legs and ankles (peripheral oedema).
The above list includes the more common side effects of your medicine. They are usually
mild and short-lived.
If any of the following happen tell your doctor immediately or go to Accident and
Emergency at your nearest hospital:
severe nausea and vomiting
The above list includes serious side effects which may require medical attention.
These side effects are rare.
Tell your doctor, nurse or pharmacist if you notice anything that is making you feel
Other side effects not listed above may also occur in some people.
After using APOMINE Intermittent
Store the APOMINE Intermittent below 25°C until it is time to use it. Do not refrigerate
Store the cartridges in their original packaging in order to protect from light.
Once opened, the contents of an APOMINE Intermittent cartridge should be used within
Any solution remaining after this time should be discarded.
Keep it where children cannot reach it.
Do not throw out the D-Mine Pen. You should keep it to use with the other cartridges.
If your doctor tells you to stop using this medicine or the expiry date has passed,
ask your pharmacist what to do with any medicine that is left over.
What it looks like
APOMINE Intermittent is a clear, colourless solution that comes in 3 mL glass cartridges,
in packs of 5.
Do not use APOMINE Intermittent if it looks cloudy or develops a green colour. Do
not use if there are particles in the liquid.
APOMINE Intermittent contains:
apomorphine hydrochloride hemihydrate
sodium metabisulfite (E223)
water for injections
APOMINE Intermittent does not contain lactose, sucrose, gluten, tartrazine or other
Pfizer Australia Pty Ltd
Sydney NSW 2000
Toll Free Number: 1800 675 229
This leaflet was prepared in March 2021.
APOMINE Intermittent 10 mg/mL AUST R 296520
® Registered trademark.