sustained release capsules
dipyridamole and aspirin
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Asasantin SR. It does not contain
all the available information. It does not take the place of talking to your doctor
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
Asasantin SR against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
This leaflet was last updated on the date at the end of this leaflet. More recent
information may be available. The latest Consumer Medicine Information is available
from your pharmacist, doctor, or from www.medicines.org.au and may contain important
information about the medicine and its use of which you should be aware.
Keep this leaflet with the medicine.
You may need to read it again.
What Asasantin SR is used for
Asasantin SR contains dipyridamole and aspirin. It is used to help prevent the recurrence
of stroke in people who have had a previous stroke or transient ischaemic attack (TIA).
This type of medication is called an antithrombotic agent. An antithrombotic agent
is a drug that reduces the formation of blood clots (thrombi).
Dipyridamole and aspirin work by preventing blood clots from forming. These drugs
work on the blood cells which help blood to clot (platelets) and help prevent them
from clumping and sticking together. This reduces the risk of forming blood clots
that can lead to a stroke. The effects of these drugs are additive.
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed it for another reason.
Before you take Asasantin SR
When you must not take it
Do not take Asasantin SR if you have an allergy to:
any medicines containing dipyridamole or aspirin
any of the ingredients listed at the end of this leaflet
any other NSAIDs (non-steroidal anti-inflammatory drugs).
Some of the symptoms of an allergic reaction may include:
shortness of breath, wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin.
Do not take Asasantin SR if you:
have severe kidney disease
are taking the medicine ketorolac
have an ulcer of the stomach or intestine
have any conditions that increases your risk of bleeding.
Do not take this medicine if you are intolerant to fructose or galactose.
Each capsule contains 53 mg lactose monohydrate and 11.3 mg sucrose resulting in 106
mg lactose monohydrate and 22.6 mg sucrose per maximum recommended daily dose.
Do not take this medicine if you are more than 6 months pregnant.
It may affect your developing baby if you take it during late pregnancy.
Do not give this medicine to a child.
Safety and effectiveness in children have not been established.
Do not give Asasantin SR to children or adolescents with a fever or a viral infection
(with or without a fever) except on doctor's advice.
The aspirin component of Asasantin SR can cause a very rare disease called 'Reye's
Syndrome' if given to children or adolescents who have a fever or a viral infection
(with or without a fever).
Do not take this medicine after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, preservatives
Tell your doctor if you have, or have had, any of the following conditions:
any heart condition (e.g. angina, heart attack or failure, heart valve problems)
any bleeding disorder (a condition that affects the way your blood normally clots)
severe muscle disease (myasthenia gravis)
asthma or hay fever
any unusual growth or tumour inside the nose (e.g. nasal polyps)
long-term stomach or intestinal problems
kidney or liver disease
deficiency of the enzyme glucose-6-phosphate dehydrogenase, which may lead to a condition
known as haemolytic anaemia (reduced red blood cells and iron stores).
Tell your doctor if you are pregnant or plan to become pregnant or are breast-feeding.
This medicine should not be used during late pregnancy. Your doctor can discuss with
you the risks and benefits involved.
The active ingredients in Asasantin SR pass into breast milk. There is a possibility
that your baby may be affected.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you get without a prescription from your pharmacy, supermarket or health food
Some medicines and Asasantin SR may interfere with each other. These include:
medicines used to thin your blood (e.g. warfarin, dabigatran, apixaban, rivaroxaban)
or prevent blood cells from clotting (e.g. eptifibatide, ticlopidine, clopidogrel,
other NSAIDs (e.g. diclofenac, ibuprofen)
metamizole, a medicine used to treat pain
any medicines used to treat high blood pressure (e.g. diltiazem and verapamil)
medicines used to treat rapid heart rhythm or assess heart function (e.g. quinidine,
adenosine and regadenoson)
medicines used to treat myasthenia gravis (e.g. neostigmine, distigmine and related
medicines used to control blood sugar levels
alendronate, a medicine used to treat and prevent osteoporosis
methotrexate, a medicine used to treat certain types of cancer, autoimmune diseases
such as psoriasis and rheumatoid arthritis
medicines used to treat epilepsy (e.g. phenytoin and sodium valproate)
medicines used in the treatment of depression known as selective serotonin reuptake
inhibitors (SSRIs) (e.g. fluoxetine)
spironolactone, a diuretic (water pill)
corticosteroids and substances that control the actions of corticosteroids (e.g. corticotropin)
zafirlukast, a medicine used to prevent asthma symptoms
medicines that promote the excretion of uric acid in the urine (e.g. probenecid)
anagrelide, a medicine used to treat the overproduction of blood platelets.
These medicines may be affected by Asasantin SR or may affect how well it works. You
may need different amounts of your medicines, or you may need to take different medicines.
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while taking this medicine.
How to take Asasantin SR
Follow all directions given to you by your doctor or pharmacist carefully.
They may differ from the information contained in this leaflet.
If you do not understand the instructions on the box, ask your doctor or pharmacist
How much to take
The recommended dose for adults is one capsule twice a day.
Tell your doctor if you experience headaches when you first start Asasantin SR at
the recommended dose.
Your doctor may change your dose for one week. The changed dose will be one Asasantin
SR capsule at bedtime and low dose aspirin (e.g. 75 mg, 100 mg or 150 mg) in the morning.
After this time, your doctor will put you back onto your normal dose.
How to take it
Swallow the capsules whole with a full glass of water.
When to take it
Take your medicine at about the same time each day, usually one in the morning and
one in the evening, preferably with meals.
Taking it at the same time each day will have the best effect. It will also help you
remember when to take it.
How long to take it
Continue taking your medicine for as long as your doctor tells you.
This medicine helps to control your condition, but does not cure it. It is important
to keep taking your medicine even if you feel well.
If you forget to take it
If you miss a dose, take it as soon as you remember.
If you remember when it is almost time for your next dose, skip the dose you missed
and take your next dose when you are meant to.
Do not take a double dose to make up for the dose that you missed.
This may increase the chance of you getting an unwanted side effect.
If you are not sure what to do, ask your doctor or pharmacist.
If you have trouble remembering to take your medicine, ask your pharmacist for some
If you take too much (overdose)
Immediately telephone your doctor or the Poisons Information Centre (telephone 13
11 26) for advice, or go to Emergency at the nearest hospital, if you think that you
or anyone else may have taken too much Asasantin SR. Do this even if there are no
signs of discomfort or poisoning.
You may need urgent medical attention.
Symptoms of an overdose may include feeling warm, flushing, sweating, restlessness,
dizziness, weakness, rapid breathing, ringing in the ears, nausea, vomiting, vision
and hearing disturbances and confusion. There may be effects on the heart and circulation
causing chest pain, an increase in heart rate and a drop in blood pressure. In severe
overdose, symptoms may include severe mental confusion, shaking, difficulty in breathing,
sweating, bleeding, dehydration, reduced body temperature and coma.
While you are taking Asasantin SR
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are taking Asasantin SR.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking
If you are going to have surgery, tell the surgeon or anaesthetist that you are taking
Asasantin SR can slow down blood clotting.
If you become pregnant while taking this medicine, tell your doctor immediately.
Tell your doctor or pharmacist if you experience headache or migraine-like headache,
so that it can be properly treated.
Do not treat the headache or migraine-like headache with aspirin.
Tell your doctor or dentist that you are taking Asasantin SR if you plan to have 'pharmacological
stress testing' or other treatments (even at the dentist).
Keep all of your doctor's appointments so that your progress can be checked.
Things you must not do
Do not take Asasantin SR to treat any other complaints unless your doctor tells you
Do not give your medicine to anyone else, even if they have the same condition as
Do not stop taking your medicine or lower the dosage without checking with your doctor.
Things to be careful of
Be careful driving or operating machinery until you know how Asasantin SR affects
This medicine may cause dizziness and confusion in some people. If you have any of
these symptoms, do not drive, operate machinery or do anything else that could be
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking Asasantin SR.
This medicine helps most people, but it may have unwanted side effects in a few people.
All medicines can have side effects. Sometimes they are serious, most of the time
they are not. You may need medical attention if you get some of the side effects.
Do not be alarmed by the following list of side effects. You may not experience any
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor or pharmacist if you notice any of the following and they worry you:
headache or migraine-like headache, especially when you start taking Asasantin SR
indigestion, vomiting, nausea, stomach pain, diarrhoea.
The above list includes the more common side effects of your medicine. They are usually
mild and short-lived.
Tell your doctor as soon as possible if you notice any of the following:
muscle aches and pains
symptoms of low blood pressure (e.g. lightheadedness)
signs of anaemia (e.g. tiredness, being short of breath, dizziness, looking pale)
symptoms of a reduced blood platelet count (e.g. bruising or bleeding more easily
than normal, reddish or purplish blotches under the skin).
The above list includes serious side effects that may require medical attention.
If any of the following happen, tell your doctor immediately or go to Emergency at
your nearest hospital:
vomiting blood or material that looks like coffee grounds or bleeding from the back
passage (rectum), black sticky bowel motions (stools) or bloody diarrhoea
bleeding (including nose bleeds, bleeding within the head, bleeding in the eyes or
increased bleeding during or after surgery)
worsening of symptoms of heart disease (e.g. chest pain, fast heart beat)
skin rash, hives or itching, swelling of the face, lips or tongue, difficulty in breathing.
The above list includes very serious side effects. You may need urgent medical attention
Tell your doctor or pharmacist if you notice anything that is making you feel unwell.
Other side effects not listed above may also occur in some people.
After using Asasantin SR
Keep your capsules in the bottle until it is time to take them.
If you take the capsules out of the bottle they may not keep well.
Keep your capsules in a cool, dry place where the temperature stays below 30°C.
Do not store Asasantin SR or any other medicine in the bathroom or near a sink. Do
not leave it on a window sill or in the car.
Heat and dampness can destroy some medicines.
Keep it where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
If your doctor tells you to stop taking this medicine or the expiry date has passed,
ask your pharmacist what to do with any medicine that is left over.
What it looks like
Asasantin SR is the brand name of your medicine. One half of the capsule is red and
the other half is ivory.
Asasantin SR capsules are available in bottles of 20*, 30*, 50*, 60 or 100* capsules.
* Not distributed in Australia.
Asasantin SR capsules contain:
200 mg of dipyridamole in a sustained-release form
25 mg of aspirin in a standard (immediate) release form.
methacrylic acid copolymer
colloidal anhydrous silica
titanium dioxide (as colouring agent)
iron oxide red (as colouring agent)
iron oxide yellow (as colouring agent).
Asasantin SR is supplied in Australia by:
Boehringer Ingelheim Pty Limited
ABN 52 000 452 308
This Consumer Medicine Information was updated in November 2019.
® Asasantin is a registered trademark of Boehringer Ingelheim.
© Boehringer Ingelheim Pty Limited 2019.
Australian Registration Number
AUST R 68051