(Atropine sulfate monohydrate )
CONSUMER MEDICINE INFORMATION
What is in this leaflet
This leaflet answers some common questions about Atropine Injection. It does not contain
all the available information. It does not take the place of talking to your doctor
All medicines have benefits and risks. Your doctor has weighed the risks of you taking
Atropine Injection against the benefits this medicine is expected to have for you.
This medicine is likely to be used while you are at the clinic or in hospital. If
possible, please read this leaflet carefully before this medicine is given to you.
In some cases this leaflet may be given to you after the medicine has been used.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet.
You may need to read it again.
What Atropine Injection is used for
Atropine sulfate monohydrate belongs to a group of medicines called antimuscarinic
agents. Atropine Injection is given before anaesthesia to decrease mucus secretions,
such as saliva. During anaesthesia and surgery, atropine is used to help keep the
heart beat normal. Atropine sulfate monohydrate is also used to block or reverse the
adverse effects caused by some medicines and certain type of pesticides.
Atropine Injection may be used for the management of other conditions that are not
mentioned above. Your doctor will be able to tell you about the specific condition
for which you have been prescribed Atropine Injection.
This medicine is available only with a doctor's prescription.
Before you are given Atropine Injection
When you must not be given it
Do not use Atropine Injection if you have an allergy or have had an unusual reaction
to atropine or any of the anticholinergic medicines such as hyoscyamine and belladonna.
Do not use Atropine Injection if you have or have had any medical conditions, especially
severe and chronic inflammation of the large intestine and rectum
gastrointestinal blockage and/or diseases
urinary tract blockage and/or bladder problems
fever, or if you are exposed to very high temperatures
glaucoma and/or family history of glaucoma
myasthenia gravis (severe muscle weakness)
acute bleeding, especially if you have heart problems
high blood pressure due to pregnancy
If you are not sure whether any of these apply to you, check with your doctor.
Before you are given it
Tell your doctor if you have allergies to any other medicines, foods, preservatives
Tell your doctor if you have or have had any medical conditions, especially the following:
brain damage and/or mental confusion
liver and/or kidney diseases
high blood pressure
fast heart beat
stomach and intestinal problems
gastric ulcer, diarrhoea or gastrointestinal infection.
Tell your doctor if you are pregnant or plan to become pregnant or are breast-feeding.
Your doctor can discuss with you the risks and benefits involved.
Taking other medicines
Tell your doctor if you are taking any other medicines, including:
all prescription medicines
all medicines, vitamins, herbal supplements or natural therapies you buy without a
prescription from a pharmacy, supermarket, naturopath or health food shop.
Some medicines and atropine sulfate monohydrate may interfere with each other. These
medicines to treat irregular heart beat e.g. disopyramide and quinidine
blood "thinning" medicines e.g. heparin, warfarin
medicines to treat Parkinson's disease
metoclopramide, a medicine to treat nausea and vomiting
cisapride, a medicine used in certain stomach problems
anticholinergic medicines to prevent travel sickness, relieve stomach cramps or spasms
bethanechol, a medicine used in bladder function disorders
medicines to treat depression such as tricyclic antidepressants
medicines used to treat certain mental and emotional conditions
ketaconazole, a medicine to treat fungal infections
narcotic analgesics to treat severe pain
medicines used for glaucoma e.g. pilocarpine, carbachol
medicines to treat Alzheimer's disease e.g. rivastigmine and donepezil
muscle relaxants used during an operation.
If you are to receive Atropine Injection as a premedication, your doctor will advise
if you should continue to take your regular medicines.
How Atropine Injection is given
Atropine sulfate monohydrate will be injected by your doctor or nurse under the skin,
into the muscle or directly into the blood stream.
Your doctor will decide what dose and how often you will receive Atropine Injection.
The dosage you will be given will depend on your condition, what it is being used
for and other factors, such as your age, and whether or not other medicines are being
given at the same time.
If you are given too much (overdose)
This rarely happens as Atropine Injection is administered under the care of a highly
However, if you are given too much atropine sulfate monohydrate, you may experience
some of the effects listed under "Side effects" below. The signs of overdose are dilation
of the pupils, difficulty in swallowing, hot dry skin, thirst, dizziness, flushing
and inability to pass urine. Rapid breathing, increased heart rate, tremor, fatigue,
loss of muscle control, confusion, hallucinations, paranoid, hyperactivity and occasionally
seizures or convulsions may also occur.
Your doctor has information on how to recognise and treat an overdose. Ask your doctor
if you have any concerns.
Tell your doctor, nurse or pharmacist as soon as possible if you do not feel well
after you have being given atropine sulfate monohydrate.
Like other medicines, atropine sulfate monohydrate can cause some side effects. If
they occur, most are likely to be minor or temporary. However, some may be serious
and need medical attention.
Ask your doctor or pharmacist to answer any questions that you may have.
Do not be alarmed by this list of possible side effects. You may not experience any
Tell your doctor if you notice any of the following:
blurred vision and/or discomfort in the eyes especially if your eyes are more sensitive
to light than normal, dilation of pupils
difficulty in urinating
flushing, dryness of skin
skin rash, hives
headache, dizziness, drowsiness and/or weakness
nervousness, restlessness, confusion, unusual excitement shaking and/or tremor
fast and/or irregular heart beat
loss of taste
dryness of the mouth, nose and throat, thirst.
Other side effects not listed above may also occur in some patients. If you notice
any other effects, check with your doctor or nurse.
Atropine Injection will be stored in the pharmacy or on the ward. The injection is
kept in a cool dry place, where the temperature stays below 25°C.
What it looks like
Atropine Injection is a clear, colourless solution in a plastic ampoule.
It is available in packs of 10 (600 microgram only) and packs of 50.
Atropine Injection contains the active ingredient atropine sulfate monohydrate 600
microgram per mL or 1.2 mg per mL. It also contains sodium chloride and Water for
It does not contain preservatives.
Pfizer Australia Pty Ltd
Toll Free Number: 1800 675 229
Australian registration numbers
Atropine Injection BP 600 microgram in 1mL (sterile) Steriluer® ampoules: AUST R 11302
Atropine Injection BP 1.2 mg in 1mL (sterile) Steriluer® ampoules: AUST R 11303
Date of preparation
This leaflet was prepared in October 2021
® = Registered Trademark
© Pfizer Australia Pty Ltd