Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about perindopril. It does not contain
all the available information about this medicine. It does not take the place of talking
to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
this medicine against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may want to read it again.
What this medicine is used for
Perindopril is used to treat high blood pressure (also known as hypertension), heart
failure or coronary artery disease.
Perindopril belongs to a group of medicines called angiotensin converting enzyme (ACE)
High blood pressure
Perindopril helps to lower your blood pressure. Everyone has blood pressure, which
helps to circulate blood all around the body. Your blood pressure may be different
at different times of the day, depending on how busy or worried you are. You have
high blood pressure when your blood pressure stays higher than is needed, even when
you are relaxed. There are usually no symptoms of high blood pressure. The only way
of knowing that you have it is to have your blood pressure checked on a regular basis.
Untreated high blood pressure can lead to serious health problems, such as stroke,
heart disease and kidney failure.
Perindopril helps to treat heart failure. Heart failure means that the heart muscle
is not pumping blood strongly enough to circulate blood around the body properly.
Heart failure is not the same as a heart attack and does not mean that the heart stops
working. Heart failure may start off with no symptoms, but as the condition progresses,
you may feel short of breath or get tired easily after light physical activity such
as walking. Fluid may accumulate in the body, such as swollen ankles and feet. In
severe heart failure, symptoms like breathlessness may occur even at rest. If you
follow your doctor's advice, your ability to perform daily activities may improve.
You may breathe more easily, feel less tired and have less swelling.
Coronary artery disease
Coronary artery disease is the narrowing of the vessels carrying blood to the heart.
Perindopril has been shown to reduce some risks of coronary artery disease, including
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed this medicine for another reason.
This medicine is available only with a doctor's prescription.
This medicine is not addictive.
There is not enough information to recommend the use of this medicine should not be
used in children.
Before you take this medicine
When you must not take it
Do not take this medicine if you have an allergy to:
any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include:
shortness of breath, wheezing or difficulty breathing
swelling of the face, lips, tongue, throat or other parts of the body
rash, itching or hives on the skin.
Do not take this medicine if you have or have had any of the following medical conditions:
diabetes or kidney impairment and are taking aliskiren to treat high blood pressure
undergoing renal dialysis using polyacrylonitrile membranes
unilateral or bilateral renal artery stenosis (narrowing of the blood vessels to one
or both kidneys).
swelling of the face, tongue, lips or throat, either suddenly or in response to another
ACE inhibitor medicine (a rare allergic condition known as angioedema)
intolerance or allergy to lactose (this medicine contains lactose).
Do not take this medicine if you are taking a combined medicine called sacubitril/valsartan.
Do not take this medicine if you are pregnant or plan to become pregnant.
Perindopril may affect your developing baby if you take it during pregnancy.
Do not take this medicine if you are breastfeeding.
It is not known if perindopril passes into human breast milk.
Do not take this medicine after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, preservatives
Tell your doctor if you have or have had any of the following medical conditions:
narrowing of the main blood vessel leading from the heart
kidney or liver problems
high or low levels of potassium, sodium or other problems with salt balance
on a salt restricted diet or use salt substitutes containing potassium
you are undergoing, or have had an allergic reaction during, previous low-density
lipoprotein (LDL) apheresis, a technique where LDL is 'filtered' out of a patient's
blood, using dextran sulphate
recent diarrhoea or vomiting
you are undergoing de-sensitisation treatment or have had an allergic reaction during
previous desensitisation treatment (e.g. bee, wasp or ant venom).
Tell your doctor if you also take an angiotensin II receptor blocker (e.g. valsartan,
telmisartan, irbesartan), in particular if you have diabetes-related kidney problems.
Tell your doctor you are of African origin since you may have a higher risk of angioedema
and this medicine is less effective in lowering your blood pressure.
Tell your doctor if you are planning to have surgery, dental treatment or an anaesthetic.
If you have not told your doctor about any of the above, tell them before you start
taking this medicine.
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you get
without a prescription from your pharmacy, supermarket or health food shop.
Some medicines may interact with perindopril. These include:
some antibiotics to treat infection
some anti-inflammatory drugs for pain relief (e.g. ibuprofen)
medicines used to treat mood disorders (e.g. lithium, tricyclic antidepressants, antipsychotics)
potassium-sparing diuretics, potassium tablets, salt substitutes containing potassium
heparin, used to thin the blood
immunosuppressants, medicines which reduce the activity of the body's natural defences
some medications used to treat high blood pressure (e.g. diuretics), a fast or irregular
heartbeat and other heart conditions
vasodilators (e.g. nitrates)
medicines used to treat diabetes
gold injections, used for arthritis.
These medicines may be affected by this medicine or may affect how well it works.
You may need different amounts of your medicines, or you may need to take different
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while taking this medicine.
Other medicines not listed above may also interact with perindopril.
How to take this medicine
Follow all directions given to you by your doctor carefully.
They may differ to the information contained in this leaflet.
If you do not understand the instructions on the box, ask your doctor or pharmacist
How much to take
Your doctor will tell you how much of this medicine you should take. This will depend
on your condition, such as elderly people or severe kidney failure, and whether you
are taking any other medicines.
High blood pressure, coronary artery disease
The usual starting dose is 4 mg once daily. This may be increased by your doctor up
to 8 mg once daily.
The usual starting dose is 2 mg once daily. This may be increased by your doctor up
to 4 mg once daily.
How to take it
Swallow your tablet whole with a glass of water.
When to take it
Take it at about the same time each day, preferably in the morning before a meal.
Taking your medicine at the same time each day will have the best effect. It will
also help you remember when to take it.
How long to take it for
Continue taking your medicine for as long as your doctor tells you.
Perindopril can help control your condition, but cannot cure it. It is important to
keep taking your medicine even if you feel well.
Make sure you have enough to last over weekends and holidays.
If you forget to take it
If it is almost time to take your next dose, skip the dose you missed and take your
next dose when you are meant to.
Otherwise, take it as soon as you remember and then go back to taking your medicine
as you would normally.
Do not take a double dose to make up for missed doses.
This may increase the chance of you experiencing side effects.
If you have trouble remembering to take your medicine, ask your pharmacist for some
If you take too much (overdose)
Immediately telephone your doctor or the Poisons Information Centre (telephone 13
11 26) for advice, or go to Accident and Emergency at your nearest hospital, if you
think that you or anyone else may have taken too much of this medicine. Do this even
if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
If you take too much perindopril, your blood pressure may fall (also known as hypotension),
which can make you feel dizzy or faint.
While you are taking this medicine
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are taking this medicine.
Tell any other doctors, dentists and pharmacists who are treating you that you take
If you become pregnant while taking this medicine, tell your doctor immediately.
Tell your doctor if you are about to have any blood tests.
Tell your doctor if you are going to have surgery or an anaesthetic or are going into
Keep all of your doctor's appointments so that your progress can be checked.
Your doctor may occasionally do tests to make sure the medicine is working and to
prevent side effects.
Things you must not do
Do not give this medicine to anyone else, even if they have the same condition as
Do not take your medicine to treat any other complaint unless your doctor tells you
Do not stop taking your medicine or change the dosage without first checking with
Things to be careful of
Be careful while driving or operating machinery until you know how perindopril affects
Dizziness or weakness due to low blood pressure may occur in certain patients. If
you have any of these symptoms do not drive or operate machinery or do anything else
that could be dangerous.
Tell your doctor and pharmacist as soon as possible if you do not feel well while
you are taking perindopril.
This medicine helps most people, but it may have unwanted side effects in a few people.
All medicines can have side effects. Sometimes they are serious, most of the time
they are not. You may need medical attention if you get some of the side effects.
Do not be alarmed by the following lists of side effects. You may not experience any
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor or pharmacist if you notice any of the following:
dry irritating cough, shortness of breath, discomfort on exertion
headache, dizziness, vertigo, pins and needles
feeling tired or lethargic
tinnitus (persistent noise in the ears), vision disturbances
nausea, vomiting, taste disturbances, indigestion, diarrhoea, constipation or abdominal
rash, pruritus (itching)
decreased blood sugar levels.
The above list includes the more common side effects of your medicine.
Tell your doctor as soon as possible if you notice any of the following:
hypotension, flushing, impaired peripheral circulation, nose bleeds, fainting
problems urinating, blood in urine, tiredness (signs of kidney problems)
yellowing of the skin and/or eyes (signs of liver problems)
bleeding or bruising more easily than normal (may be caused by a low blood platelet
These may be serious side effects and you may need medical attention.
If you experience any of the following, stop taking your medicine and contact your
doctor immediately or go to Accident and Emergency at your nearest hospital:
shortness of breath, wheezing or difficulty breathing; swelling of the face, lips,
tongue, throat or other parts of the body; rash, itching or hives on the skin, severe
blisters (signs of an allergic reaction)
purple spots with occasional blisters on the front of your arms, legs, around your
neck and ears (Stevens-Johnson Syndrome)
changes in the rhythm or rate of the heartbeat
fast or irregular heartbeat
fever, chest pain, shortness of breath, feeling unwell (signs of eosinophilic pneumonia)
feeling of tightness, pressure or heaviness in the chest (signs of myocardial infarction,
frequent infections, fever, severe chills, sore throat or mouth ulcers (may be caused
by a lack of white blood cells)
These are very serious side effects and you may need urgent medical attention or hospitalisation.
Tell your doctor or pharmacist if you notice anything that is making you feel unwell.
Other side effects not listed above may occur in some patients.
Storage and disposal
Keep your medicine in the pack until it is time to take it.
If you take your medicine out of the pack it may not keep well.
Keep your medicine in a cool, dry place where the temperature stays below 25°C. Do
not store your medicine, or any other medicine, in the bathroom or near a sink. Do
not leave it on a window sill or in the car.
Heat and dampness can destroy some medicines.
Keep this medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
If your doctor tells you to stop taking this medicine or the expiry date has passed,
ask your pharmacist what to do with any medicine left over.
What it looks like
2 mg tablets: light pink to pink-coloured capsule-shaped tablets debossed with ‘P’
and ‘9’ on either side of the score line on one side and deep break-line on other
Blister packs of 30 tablets AUST R 304693.
4 mg tablets: white to off-white capsule-shaped tablets debossed with ‘P’ and ‘9’
on either side of the score line on one side and deep break-line on other side.
Blister packs of 30 tablets. AUST R 304694.
8 mg tablets: white to off-white capsule-shaped tablets debossed with ‘P’ and ‘6’
on either side of the break-line on one side and break-line on other side.
Blister packs of 30 tablets AUST R 304695.
* Not all strengths may be available.
Each tablet contains 2 mg, 4 mg or 8 mg perindopril erbumine as the active ingredient.
It also contains the following:
colloidal anhydrous silica
Additionally, the 2mg tablet contains iron oxide red as colourant.
This medicine does not contain gluten, sucrose, tartrazine or any other azo dyes.
Apotex Pty Ltd
16 Giffnock Avenue
Macquarie Park NSW 2113
This leaflet was last revised in: