Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about meropenem. It does not contain all
the available information. It does not take the place of talking to your doctor or
All medicines have risks and benefits. Your doctor has weighed the risks of you using
this medicine against the benefits they expect it will have for you.
If you have any concerns about receiving this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may want to read it again.
What this medicine is used for
Meropenem is used to treat many different types of infection, such as:
infections of the lungs
infections of the kidney or bladder (urinary tract infection)
infections around the stomach or bowel
infections of the vagina and womb
serious skin infections
infections in the lining of the brain (meningitis)
infections in the blood stream (septicaemia).
Meropenem is given by injection and is usually only used in hospitals.
How it works
Meropenem belongs to a group of medicines called carbapenem antibiotics. These medicines
work by killing the bacteria that are causing your infection.
Meropenem will not work against fungal or viral infections (such as colds or flu).
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed this medicine for another reason.
This medicine is available only with a doctor's prescription.
This medicine is not addictive.
This medicine is not recommended for use in children under the age of 3 months.
Before you are given this medicine
When you must not be given it
Do not use this medicine if you have an allergy to:
any other antibiotics such as other carbapenems, penicillins, cephalosporins or monobactams
any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips, tongue, throat or other parts of the body
rash, itching or hives on the skin
Do not use this medicine after the expiry date printed on the pack has passed or if
the packaging is torn or shows signs of tampering.
If you are not sure whether you should be given this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, preservatives
Tell your doctor if you have or have had any of the following medical conditions:
gastrointestinal or stomach problems, particularly colitis
liver or kidney problems, including dialysis
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding.
Do not take this medicine until you and your doctor have discussed the risks and benefits
If you have not told your doctor about any of the above, tell them before you are
given this medicine.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you may get without a prescription from your pharmacy, supermarket or health
Some medicines and meropenem. may interfere with each other. These include:
probenecid, used to treat gout
sodium valproate, used to treat epilepsy or mania
These medicines may be affected by meropenem or may affect how well it works. You
may need different amounts of your medicines, or you may need to take different medicines.
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while receiving this medicine.
Other medicines not listed above may also interact with meropenem.
How this medicine is given
Follow all directions given to you by your doctor or pharmacist carefully.
They may differ to the information contained in this leaflet.
How much will you be given
Your doctor will decide what dose of meropenem you will need, depending on certain
factors such as your type of infection and your age.
The usual dose is 500 mg to 1 g injected every 8 hours. If you have meningitis you
may require more, while a lower dose may be used for children or if you have kidney
How it is given
Meropenem is injected into your vein. It must always be given by a doctor or nurse.
Many people who get meropenem in hospital will have a drip (intravenous line). Meropenem
can be given directly into the vein or the drip without any need for an injection
through the skin. It is given either as a slow injection over approximately 5 minutes
or as a slow drip over 15 to 30 minutes. Your doctor will decide which method is best
How long will you be given
Your doctor will decide how many days you will receive meropenem.
If you take too much (overdose)
Immediately tell your doctor or nurse if you think that you or anyone else may have
been given too much of this medicine. Do this even if there are no signs of discomfort
You may need urgent medical attention.
While you are using this medicine
Things you must do
If you are about to be started on any new medicine, tell your doctor or pharmacist
that you are receiving this medicine.
Tell any other doctors, dentists and pharmacists who are treating you that you are
receiving this medicine.
If you find out that you are pregnant after being given this medicine, tell your doctor
Tell your doctor if you develop severe diarrhoea, even if it occurs several weeks
after you have been given meropenem.
It may mean that you have a serious bowel condition and you may need urgent medical
attention. Do not take any medicine for your diarrhoea without checking with your
Keep all of your doctor's appointments so that your progress can be checked.
Your doctor may do occasionally do tests to monitor your liver function if you have
pre-existing liver disorders.
Things to be careful of
Meropenem has been associated with headache, tingling or prickling skin and convulsions
(fits). If you have any of these symptoms, do not drive, operate machinery or do anything
else that could be dangerous.
Tell your doctor as soon as possible if you do not feel well while you are receiving
This medicine helps most people with infections, but it may have unwanted side effects
in a few people. All medicines can have side effects. Sometimes they are serious,
most of the time they are not. You may need medical attention if you get some of the
Do not be alarmed by the following lists of side effects. You may not experience any
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following:
pain, swelling or redness around the injection site
nausea and/or vomiting
skin rash, itchiness
tingling, 'pins and needles' sensation
The above list includes the more common side effects of your medicine.
Tell your doctor or nurse as soon as possible if you notice any of the following:
shortness of breath, wheezing or difficulty breathing; swelling of the face, lips,
tongue, throat or other parts of the body; rash, itching or hives on the skin (signs
of an allergic reaction)
severe diarrhoea, even if it occurs several weeks after you have been given meropenem
convulsions / seizures (fits)
unexpected breathlessness and/or red/brown urine - this may indicate damage to your
red blood cells
The above list includes serious side effects and you may need medical attention.
Occasionally, meropenem may be associated with changes in your blood that may require
your doctor to do certain blood tests.
Tell your doctor or pharmacist if you notice anything that is making you feel unwell.
Other side effects not listed above may occur in some patients.
Storage and disposal
The hospital staff will store meropenem in a safe place at a temperature below 25
degrees C. They will also check that the expiry date has not passed.
The hospital staff will dispose of any unused meropenem.
What it looks like
500mg: white to slightly yellow powder in a 20 mL glass vial
AUST R 218843.
1000mg: white to slightly yellow powder in a 30 mL glass vial
AUST R 218840
Meropenem vials come in a pack size of 10 vials.
* Not all strengths may be available.
Each vial contains 500 mg or 1000 mg of meropenem trihydrate as the active ingredient.
It also contains sodium carbonate as the inactive ingredient.
This medicine does not contain gluten, lactose, sucrose, tartrazine or any other azo
Apotex Pty Ltd
16 Giffnock Avenue
Macquarie Park NSW 2113
APO and APOTEX are registered trademarks of Apotex Inc.
This leaflet was prepared in October 2018.