Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Xalacom. It does not contain all
the available information. It does not take the place of talking to your doctor or
All medicines have risks and benefits. Your doctor has weighed the risks of you using
Xalacom against the benefits it is expected to have for you.
If you have any concerns about using this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What Xalacom is used for
Xalacom is used to lower raised pressure in the eye and to treat glaucoma. Glaucoma
is a condition in which the pressure of fluid in the eye may be high. However, some
people with glaucoma may have normal eye pressure.
Glaucoma is usually caused by a build up of the fluid which flows through the eye.
This build up occurs because the fluid drains out of your eye more slowly than it
is being pumped in. Since new fluid continues to enter the eye, joining the fluid
already there, the pressure continues to rise. This raised pressure may damage the
back of the eye resulting in gradual loss of sight. Damage can progress so slowly
that the person is not aware of this gradual loss of sight. Sometimes even normal
eye pressure is associated with damage to the back of the eye.
There are usually no symptoms of glaucoma. If glaucoma is not treated it can lead
to serious problems, including total blindness. In fact, untreated glaucoma is one
of the most common causes of blindness.
Xalacom is made up of 2 active ingredients, latanoprost and timolol maleate. Latanoprost
works by allowing more fluid to flow out from within your eye(s). Timolol maleate
lowers the pressure in the eye by reducing the production of fluid.
Latanoprost belongs to a family of medicines called prostaglandin agonists. Timolol
maleate belongs to a family of medicines called beta-blockers.
Although Xalacom helps control your glaucoma it does not cure it. So you must keep
using it until your doctor tells you to stop.
Ask your doctor if you have any questions about why Xalacom has been prescribed for
Your doctor may have prescribed it for another reason.
Xalacom is not recommended for use in children. The safety and effectiveness of Xalacom
in children have not been established.
Before you use Xalacom
When you must not use it
Do not use Xalacom if:
you have an allergy to Xalacom or any of the ingredients listed at the end of this
Symptoms of an allergic reaction may include:
asthma, wheezing or shortness of breath
swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing
hives, itching or skin rash
you have asthma, or a history of asthma, chronic obstructive lung disease (emphysema)
or other breathing problems
you have certain heart conditions, such as a very slow heart rate, an irregular heartbeat,
or heart failure
the bottle/packaging shows signs of tampering
the expiry date on the pack has passed.
If you use this medicine after the expiry date has passed, it may not work.
If you are not sure whether you should start using Xalacom, talk to your doctor.
Before you start to use it
Tell your doctor if:
1. you have had an allergy to any other medicines or any other substances, such as foods,
preservatives or dyes
2. you are pregnant or intend to become pregnant
There is no adequate experience with Xalacom in pregnant women, therefore, it should
not be used during pregnancy.
3. you are breast-feeding or intend to breast-feed
One of the active ingredients in Xalacom has been detected in breast milk. Because
of the potential harm to the infant, nursing women should either stop using Xalacom
or stop breast-feeding while using it.
4. you have or have had any medical conditions, especially the following:
any other types of glaucoma or eye conditions
Tell your doctor if you plan to have surgery.
If you have not told your doctor about any of the above, tell him or her before you
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you buy without a prescription from your pharmacy, supermarket or health food
Some medicines and Xalacom may interfere with each other. These include:
certain medicines used to treat high blood pressure or heart conditions such as beta-blockers,
calcium channel blockers or digoxin
certain medicines used to treat irregular heartbeats such as amiodarone and quinidine
some medicines used to treat depression, such as phenelzine, fluoxetine or paroxetine
some medicines used to treat Parkinson's disease, such as selegiline
adrenaline, a hormone used in the treatment of asthma, slow or irregular heartbeat,
acute allergic disorders and glaucoma
some medicines that may have been prescribed to help you pass urine or restore normal
narcotics such as morphine used to treat moderate to severe pain
eye drops which contain an ingredient called thiomersal. If using such eye drops
as well as Xalacom, you should wait at least 5 minutes between using these eye drops
medicines used to treat diabetes or high blood sugar
some other eye drops that contain a beta-blocker or a prostaglandin. The use of two
or more beta-blocker eye drops and/or two or more prostaglandin eye drops at the same
time is not recommended.
Your doctor or pharmacist has more information on medicines to be careful with or
avoid while using Xalacom.
How to use Xalacom
Use Xalacom only when prescribed by your doctor.
Follow all directions given to you by your doctor carefully.
They may differ from the information contained in this leaflet.
If you are being changed from one eye drop to another, follow your doctor's instructions
carefully as to when to stop the old drops and when to start the new drops.
How much to use
The usual dose of Xalacom is one drop into the affected eye, or eyes, once daily.
Use Xalacom every day, at about the same time each day, unless your doctor tells you
Using your eye drops at the same time each day will have the best effect on your eye
pressure. It will also help you remember when to use the eye drops.
How to use it
If you are wearing soft contact lenses, remove them before putting the drops in your
The preservative in Xalacom (benzalkonium chloride) may be deposited in soft contact
lenses. You can put your soft contact lenses back into your eyes 15 minutes after
you have used Xalacom.
If using other eye drops in addition to Xalacom, wait at least 5 minutes before putting
any other drops in your eye(s).
Be careful not to touch the dropper tip against your eye, eyelid or anything else.
Touching the dropper tip against something may contaminate the eye drops and give
you an eye infection.
You may find it easier to put drops in your eye while you are sitting or lying down.
1. Wash your hands well with soap and water.
2. Twist off the protective overcap from the bottle.
3. Unscrew the inner cap.
4. Use your finger to gently pull down the lower eyelid of your affected eye.
5. Tilt your head back and look up.
6. Place the tip of the bottle close to but not touching your eye. Squeeze the bottle
gently so that only one drop goes into your eye, then release the lower eyelid. Close
your eye. Do not blink or rub your eye.
7. While your eye is closed, place your index finger against the inside corner of your
eye and press against your nose for about two minutes. This will help to stop the
medicine from draining through the tear duct to the nose and throat, from where it
can be absorbed into other parts of your body. Ask your doctor for more specific
instructions on this technique.
8. Screw the inner cap back on the bottle.
9. Wash your hands again with soap and water to remove any residue.
You may feel a slight burning sensation in the eye shortly after using the eye drops.
If this persists, or is very uncomfortable, contact your doctor or pharmacist.
How long to use it
Continue using Xalacom every day for as long as your doctor prescribes.
Xalacom helps control your condition but does not cure it.
If you forget to use it
If you miss a dose, skip the dose you missed and use your next dose when you are meant
If you are not sure whether to skip the dose, talk to your doctor or pharmacist.
Do not use double the amount to make up for the dose that you missed.
If you use too much (overdose)
If you accidentally put several drops in your eye(s), immediately rinse your eye(s)
with warm water.
If you think that you or anyone else may have swallowed Xalacom, immediately telephone
your doctor or the Australian Poisons Information Centre (telephone 131 126) or the
New Zealand National Poisons Information Centre (telephone 0800 POISON or 0800 764
766) for advice, or go to Accident and Emergency at your nearest hospital. Do this
even if there are no signs of discomfort or poisoning.
If Xalacom is accidentally swallowed, or if you use too many drops, you may feel light-headed
or dizzy, you may faint, have a very slow pulse rate, or have wheezing or difficulty
breathing. Other effects include headache, nausea, abdominal pain, fatigue, hot flushes
While you are using Xalacom
Things you must do
To make sure Xalacom is working properly, have your eye pressure checked regularly.
Have your eyes checked regularly for any other changes, including a change in eye
A slow change in eye colour, which may be permanent, has been reported to occur in
some patients who use Xalacom. Your doctor will decide whether you should continue
If you develop an eye infection, receive an eye injury, or have eye surgery tell your
Your doctor may tell you to use a new container of Xalacom because of possible contamination
of the old one, or may advise you to stop your treatment with Xalacom.
If you become pregnant while using Xalacom tell your doctor immediately.
If you are about to be started on any new medicine tell your doctor and pharmacist
that you are using Xalacom.
Tell all doctors and pharmacists who are treating you that you are using Xalacom.
Things you must not do
Do not give Xalacom to anyone else, even if they have the same condition as you.
Do not use this medicine to treat any other complaints unless your doctor tells you
Do not stop using Xalacom without first talking to your doctor.
If you stop using your eye drops, your eye pressures may rise again and damage to
your eye may occur.
Things to be careful of
Be careful driving or operating machinery until you know how Xalacom affects you.
Xalacom generally does not cause any problems with your ability to drive a car or
operate machinery. However, it may cause blurred vision in some people. Make sure
you know how you react to Xalacom or that your vision is clear before driving a car
or operating machinery.
Check with your doctor as soon as possible if you have any problems while using Xalacom,
even if you do not think the problems are connected with the medicine or are not listed
in this leaflet.
Like other medicines, Xalacom can cause some side effects. If they occur, most are
likely to be minor and temporary. However, some may be serious and need medical attention.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you:
a slow change in eye colour over a period of time. The iris may become browner in
colour and appear darker. This change may be permanent and more noticeable if you
are only being treated in one eye
blurred vision, double vision or other visual problems
allergic reactions including redness, swelling and/or itching of the eye
burning, grittiness or stinging of the eyes
redness or watering of the eye/s
irritation or feeling of having something in the eye, dry eyes
discharge, itching of the eye/s, crusty eyelashes
drooping of eyelid/s
darkening, thickening, lengthening or an increase in the number of eye lashes and
fine hair on the eyelids
misdirected eye lashes sometimes causing eye irritation
darkening of the skin of the eyelids
crusting, redness, thickening, itching or burning of the eyelids
sensitivity to light
ringing or buzzing in the ears
difficulty sleeping, nightmares
change in mood such as depression, anxiety or nervousness
confusion, disorientation or memory loss
feeling sick (nausea) or vomiting, upset or painful stomach
change to your sense of taste
cold hands or feet
numbness, tingling and colour change (white, blue then red) in fingers when exposed
to the cold (Raynaud's Phenomenon)
numbness or tingling in the fingers or toes
hair loss or thinning
less desire for sex
impotence or sexual dysfunction
Tell your doctor immediately if you notice any of the following:
fast or irregular heartbeat, also called palpitations
dizziness and light-headedness, which may be due to low blood pressure
skin rash, itching
swelling of hands, feet, ankles or legs.
These may be serious side effects. You may need urgent medical attention. Serious
side effects are rare.
If any of the following happen, stop using Xalacom and tell your doctor immediately
or go to Accident and Emergency at your nearest hospital:
wheezing, difficulty in breathing (asthma or worsening of asthma)
shortness of breath
very slow pulse, chest pain
swelling of the face, lips, mouth, tongue or throat which may cause difficulty in
swallowing or breathing
severe and sudden onset of pinkish, itchy swellings on the skin, also called hives
or nettle rash
white deposits or plaque in the cornea causing the transparent front part of your
eye to look white or cloudy.
These are very serious side effects. You may need urgent medical attention. These
side effects are rare.
Tell your doctor if you notice any other effects.
Other side effects not listed above may also occur in some patients.
Do not be alarmed by this list of possible side effects. You may not experience any
After using Xalacom
Keep your eye drops in a safe place away from the sight and reach of children.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
Before opening Xalacom, keep the bottle in its box in a refrigerator (2°C - 8°C) protected
After opening Xalacom, keep the bottle in its box in a cool place where the temperature
stays below 25°C. You do not need to keep it refrigerated. Keep the box properly
closed and protected from light.
Do not store Xalacom or any other medicine in the bathroom or near a sink. Do not
leave it in the car or on window sills. Do not carry the eye drops in pockets of
Heat and dampness can destroy some medicines.
Put the top back on the bottle right away after use to avoid contaminating the eye
Write the date on the bottle when you open the eye drops and throw out any remaining
solution after four weeks.
Open a new bottle every 4 weeks.
Eye drops contain a preservative which helps prevent germs growing in the solution
for the first four weeks after opening the bottle. After this time there is a greater
risk that the drops may become contaminated and cause an eye infection.
If your doctor tells you to stop using the eye drops or they have passed their expiry
date, ask your pharmacist what to do with any remaining solution.
What it looks like
Xalacom eye drops come in a plastic bottle with a dropper and screw cap inside a protective
overcap. Remove this overcap before use.
When you first receive your Xalacom bottle, it will appear half full. This corresponds
to 2.5 mL of eye drop solution, giving a minimum of 80 drops. This volume is enough
to last 4 weeks if used in both eyes.
The active ingredients in Xalacom eye drops are latanoprost and timolol maleate.
Each 1 mL of Xalacom contains 50 micrograms of latanoprost and 5 mg of timolol (equivalent
to 6.83 mg timolol maleate). Each drop contains about 1.5 micrograms of latanoprost
and 150 micrograms of timolol.
Xalacom eye drops also contain:
monobasic sodium phosphate monohydrate
dibasic sodium phosphate
water for injections
benzalkonium chloride (as a preservative).
Xalacom can be identified by the Australian Register Number AUST R 80311, which is
found on the box.
Xalacom is supplied in Australia by:
Pfizer Australia Pty Ltd
Toll Free number: 1800 675 229
Xalacom is supplied in New Zealand by:
Pfizer New Zealand Ltd
PO Box 3998
Auckland, New Zealand
Toll Free number: 0800 736 363.
For more information about glaucoma, contact Glaucoma Australia Inc. (telephone 1800
500 880), or Glaucoma New Zealand (telephone 09 373 8779).
This leaflet was revised in May 2020.
© Pfizer Australia Pty Ltd 2014.