Cannabinoid 感受器官

Cannabinoids 通過配合產生他們的作用與當前 cannabinoid 的感受器官對細胞表面用這個中央神經系統的不同的部分。

迄今,仅 cannabinoid 感受器官的二種類型被識別,在 1990年被克隆的 CB1 感受器官和在 1993年被克隆的 CB2 感受器官。 這兩種感受器官只共享 48% 氨基酸順序身分,被分配用不同的組織並且有不同的發信號的結構。 他們在他們的區分也有所不同给收縮筋和反對者。 研究向顯示 cannabinoid 感受器官的啟動導致腺苷酸環化酶的禁止,終止 ATP 轉換嚮循環 AMP (陣營)。

在腦子內的一種自然發生的物質叫對 CB1 的困境在 1992年被檢測的 anandamide。 以後發現的此像 cannabinoid 的化學製品和其他,指 endocannabinoids。

感受器官的地點

CB1 感受器官

CB1 感受器官主要神經細胞位於腦子,脊髓,但是他們在某個外圍機構和組織也被找到例如生殖,食道和尿道的脾臟、白細胞、內分泌腺和部分。

在腦子, CB1 感受器官在後腦、基底神經節、海怪和背部主要輸入脊髓地區,上是豐富的為什麼是 cannabinoids 影響函數例如處理的內存,痛苦管理規定和電動機控制。 在腦乾, cannabinoids 的濃度是低的,可能與大麻使用為什麼有關沒有與猝死相關由於沮喪的呼吸作用,例如。

CB2 感受器官

CB2 感受器官主要被找到在白細胞,在扁桃腺和在這個脾臟。 免疫細胞也表示 CB1,雖然比 CB2 有少量他們。 在免疫系統, cannabinoid 感受器官的一個重要功能是細胞因子版本的管理規定。 CB1 感受器官的刺激導致對靈魂和循環的像大麻的作用,而這樣作用沒有被看到,當激活時 CB2 感受器官。 所以,有選擇性的 CB2 感受器官收縮筋有研究成為的日益普遍的主題他們潛在的抗發炎和抗癌作用的。

來源

  1. http://www.rollersports.org/public/pagein/File/FACT%20SHEET%20-%20Cannabinoids.pdf
  2. http://adai.uw.edu/marijuana/factsheets/cannabinoids.pdf
  3. http://www.currentpsychiatry.com/pdf/1009/1009CP_Pierre.pdf
  4. http://www.i-gap.info/app/dokumente/Pharmacology%20of%20Cannabinoids.pdf
  5. http://www.aerzteblatt.de/pdf/DI/109/29/m495.pdf

[深層讀取:Cannabinoid]

Last Updated: Aug 23, 2018

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Comments

  1. NotJames Cunningham NotJames Cunningham United States says:

    What psychological behaviors and effects are these cannabinoid receptors responsible for? And what natural functions and behaviors we may experience everyday effected by them?

    • Little Cutting Little Cutting Sweden says:

      It feels like my brain speeding up in activity in the beginning of the high.

      My thinking is flying and gives me lot of ideas in a high tempo.
      After some time I just get calm.

      Most of the times is the thoughts that is flying great feeling thoughts.

      So I think the cannabinoid receptors somehow regulates the frequency of some parts of the brain.

      • Miriam English Miriam English Australia says:

        Because the brain is the organ trying to measure itself, subjective impressions of the speed of thinking can be very wrong. For example if the sense of time is conveyed by the length of time something is kept in short-term memory then impairing short-term memory can make it feel like your thoughts are moving faster when they are really having more difficulty keeping track of previous items in the time stream.

        Time sense is notoriously unreliable. Time yourself counting, trying judge ten seconds when you're excited, and again when you're bored, and again a couple of minutes after you've woken up from sleep. You'll be surprised at how differently time moves, yet in each of those it subjectively feels like it moves the same.

        Watch a wheel spinning, and turn the light illuminating the scene down -- the wheel will seem to speed up.

        Listen to a song while it plays loudly, then turn the volume way down -- the song will seem to speed up.

        Time sense in the brain is very unreliable, and often doesn't mean what you think it does.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
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