Histoire de fentanyle

Le fentanyle a été préparé et développé la première fois par M. Paul Janssen en 1959 sous un brevet retenu par sa compagnie Janssen Pharmaceutica.

Comme analgésique efficace qui est presque une morphine plus intense de temps de hundrend puis, l'utilisation du fentanyle comme une antidouleur et un anesthésique ont été rapidement adoptés dans le cadre médical. Pendant les années 1960, l'agent a été introduit comme anesthésique intraveineux sous la marque Sublimaze.

Après la popularité de Sublimaze, des analogues du fentanyle ont été développés et Sufentanil, Alfentanil, Lofentanil et Remifentanil inclus.

D'ici mi-1990 s la correction de fentanyle a été développé, qui pourrait livrer le médicament à un patient transdermally. La correction de Duragesic a pu être usée sur la peau et était utile dans le management de la douleur chronique ressenti par des patients présentant le cancer, par exemple. La correction a été effectuée d'un gel inerte d'alcool infusé avec des doses prédéterminées de fentanyle. Le médicament est relâché par la correction dans les réserves lipidiques de l'organisme, où il entre lentement dans la circulation sanguine plus de deux ou trois jours, pour cette raison de fournir le soulagement de la douleur à long terme. Les corrections de Duragesic ont subi plusieurs tests cliniques, après quoi elles ont été introduites et popularisées dans la pratique clinique.

Ensuite, d'autres dispositifs de la distribution ont été développés avec des exemples comprenant les tablettes buccales de Fentora et la lucette d'Actiq. Ces préparations orales ont contenu le citrate de fentanyle mélangé aux remplissages. Actiq a fourni l'aide à action rapide de la douleur de découverte dans les souffrants à long terme de douleur. D'autres produits de fentanyle ont compris un losange effervescent et un pulvérisateur buccal. En dépit des différents modes d'accouchement variés qui ont été introduits, les timbres transdermiques transdermiques restent la forme la plus très utilisée de la distribution de fentanyle.

Plus récent, un autre produit de fentanyle qui a été reconnu par la nourriture et administration de médicaments des USA (FDA) pour la douleur de découverte est Onsolis. Ici, un film soluble de fentanyle sur un disque peut être mis dans la bouche et être absorbé, qui évite la possibilité d'inhalation ou d'écrasement.

Further Reading

Last Updated: Feb 26, 2019

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


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  1. Sherri Macdonald Sherri Macdonald Canada says:

    Congradulations on creating the drug that's now the most highly abused and killing thousands.   Was it worth it.

    • Chuck Winter Chuck Winter Belgium says:

      As of the 1960’s fentanyl has been essential in hospital settings in surgeries: it helped many patients survive, providing comfort. Even now, in the newer formulations, it helps terminal patients and chronic pain patients. It is a strong opioid, never meant to become available on the market, it has always been strongly regulated. However, criminals will be criminals... And China is infamous for illegally copying and producing anything for profit, without the least consideration for patents. The pirate economy and black market generates billions of dollars, untouched by Trump’s tariffs...

      • Russell Barton Russell Barton United States says:

        Into the hands of those that use unregulated opioids that are sold on the street in which our government can’t control, and never will,  and it’s our sister’s and brother’s, fathers and mother’s, innocent people who are dying by the hundreds of thousands every year, and are the real victims of the war on drugs, which our government has inflicted on its own people. It may not be known to most, but there has been a history of political agendas that deliberately let people who are physically dependent on opioids such as heroin, die, as if they were the real enemy of the war on drugs, As an example, and fact, the F.B.I. had tampered with illegal alcohol distribution lines during the alcohol prohibition during the 1920’s, by adding deadly chemical compounds to alcohol so people would get sick, go blind, and even die from drinking it. Just so that society would once and for all, demonize alcohol, and past political big shots think that by imprisoning street dealers and users alike will fix the problem! It’s the governments order for society to demonize something that they don’t like, but at the start, it wasn’t government that wanted narcotics outlawed, and there wasn’t any kind of social movements against narcotics. It was greed that started this prohibition movement, with the passing of the Harrison Narcotics Tax Act of 1914; one year after the federal government passed an income tax with the 16th amendment, which by all means was unconstitutional. Illegal or controlled narcotics are a big business for our government, as long as these highly addictive substances remain illegal. The government controls its own monopoly, and gets paid handsomely with corporate taxes paid by the pharmaceutical companies, and the more money these drug companies make, the more money the government pockets. So now you may know why drug prices are so outrageously high. These companies also receives hundreds of millions of dollars by the government for drug research and development. So there shouldn’t be any excuse for these drug companies to impose high drug prices. Did you know there is over 65 synthetic opioids? Drugs like heroin but are hundreds even thousands of times poor potent. Before there was narcotic prohibition, there was never a real social problem with drugs, and crimes that are usually associated with drug addiction today, like theft, robbery, burglary, was non-existent then. It was actually the law that created the crime in this instance. Most of Americans that are found dead from an apparent heroin over-doses, were actually deaths caused from fentanyl that was added to the heroin without the users knowledge.

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