Historia del fentanilo

El fentanilo primero fue preparado y desarrollado por el Dr. Paul Janssen en 1959 bajo patente llevada a cabo por su compañía Janssen Pharmaceutica.

Como analgesia potente que casi es una morfina más fuerte de los tiempos del hundrend entonces, el uso del fentanilo como un analgésico y un anestésico fueron adoptados rápidamente en la fijación médica. En los años 60, el agente fue introducido como anestésico intravenoso bajo marca Sublimaze.

Después del renombre de Sublimaze, los análogos del fentanilo fueron desarrollados y Sufentanil, Alfentanil, Lofentanil y Remifentanil incluidos.

A mediados de 1990 s el remiendo del fentanilo fue desarrollado, que podría entregar la droga a un paciente transdermally. El remiendo de Duragesic se podía desgastar en la piel y era útil en la administración del dolor crónico aserrada al hilo por los pacientes con el cáncer, por ejemplo. El remiendo fue hecho de un gel inerte del alcohol infundido con las dosis predeterminadas del fentanilo. La droga es liberada por el remiendo en las grasas de cuerpo, donde se traslada despacio a la circulación sanguínea durante dos o tres días, por lo tanto de ofrecer alivio del dolor a largo plazo. Los remiendos de Duragesic experimentaron varias juicios clínicas, después de lo cual fueron introducidos y popularizados en práctica clínica.

Después, otros dispositivos del lanzamiento fueron desarrollados con ejemplos incluyendo las tablillas bucales de Fentora y la piruleta de Actiq. Estas preparaciones orales contuvieron el citrato del fentanilo mezclado con los rellenadores. Actiq ofreció el relevo de acción rápida del dolor de la ruptura en víctimas a largo plazo del dolor. Productos más futuros del fentanilo incluyeron un rombo efervescente y un aerosol bucal. A pesar de las diversas diversas maneras del lanzamiento que fueron introducidas, los remiendos transdérmicos de la piel siguen siendo la forma más ampliamente utilizada del lanzamiento del fentanilo.

Más recientemente, otro producto del fentanilo que ha sido aprobado por la Agencia de Medicamentos y Alimentos de los E.E.U.U. (FDA) para el dolor de la ruptura es Onsolis. Aquí, una película soluble del fentanilo en un disco puede ser colocada en la boca y ser absorbida, que evita la posibilidad de la inhalación o del machacamiento.


  1. http://rcp.nshealth.ca/sites/default/files/clinical-practice-guidelines/fentanyl.pdf
  2. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM162427.pdf
  3. http://www.nps.org.au/publications/health-professional/nps-radar/2006/august-2006/fentanyl-patches
  4. http://www.medsafe.govt.nz/profs/datasheet/f/Fentanylinj.pdf

Further Reading

Last Updated: Feb 26, 2019

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


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  1. Sherri Macdonald Sherri Macdonald Canada says:

    Congradulations on creating the drug that's now the most highly abused and killing thousands.   Was it worth it.

    • Chuck Winter Chuck Winter Belgium says:

      As of the 1960’s fentanyl has been essential in hospital settings in surgeries: it helped many patients survive, providing comfort. Even now, in the newer formulations, it helps terminal patients and chronic pain patients. It is a strong opioid, never meant to become available on the market, it has always been strongly regulated. However, criminals will be criminals... And China is infamous for illegally copying and producing anything for profit, without the least consideration for patents. The pirate economy and black market generates billions of dollars, untouched by Trump’s tariffs...

      • Russell Barton Russell Barton United States says:

        Into the hands of those that use unregulated opioids that are sold on the street in which our government can’t control, and never will,  and it’s our sister’s and brother’s, fathers and mother’s, innocent people who are dying by the hundreds of thousands every year, and are the real victims of the war on drugs, which our government has inflicted on its own people. It may not be known to most, but there has been a history of political agendas that deliberately let people who are physically dependent on opioids such as heroin, die, as if they were the real enemy of the war on drugs, As an example, and fact, the F.B.I. had tampered with illegal alcohol distribution lines during the alcohol prohibition during the 1920’s, by adding deadly chemical compounds to alcohol so people would get sick, go blind, and even die from drinking it. Just so that society would once and for all, demonize alcohol, and past political big shots think that by imprisoning street dealers and users alike will fix the problem! It’s the governments order for society to demonize something that they don’t like, but at the start, it wasn’t government that wanted narcotics outlawed, and there wasn’t any kind of social movements against narcotics. It was greed that started this prohibition movement, with the passing of the Harrison Narcotics Tax Act of 1914; one year after the federal government passed an income tax with the 16th amendment, which by all means was unconstitutional. Illegal or controlled narcotics are a big business for our government, as long as these highly addictive substances remain illegal. The government controls its own monopoly, and gets paid handsomely with corporate taxes paid by the pharmaceutical companies, and the more money these drug companies make, the more money the government pockets. So now you may know why drug prices are so outrageously high. These companies also receives hundreds of millions of dollars by the government for drug research and development. So there shouldn’t be any excuse for these drug companies to impose high drug prices. Did you know there is over 65 synthetic opioids? Drugs like heroin but are hundreds even thousands of times poor potent. Before there was narcotic prohibition, there was never a real social problem with drugs, and crimes that are usually associated with drug addiction today, like theft, robbery, burglary, was non-existent then. It was actually the law that created the crime in this instance. Most of Americans that are found dead from an apparent heroin over-doses, were actually deaths caused from fentanyl that was added to the heroin without the users knowledge.

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