PerkinElmer, Inc., a global leader focused on the health and safety of people and the environment, is highlighting its latest scientific solutions for pharmaceutical laboratories at PITTCON 2010, Feb. 28-March 5, Booth 2769.
“The true value of this hyphenated technique is in its ability to classify and characterize polymorphs”
PerkinElmer will be showcasing several innovative hyphenated techniques and molecular spectroscopy instruments designed to help scientists gain greater sample insight for quality control testing; from the receipt of raw materials, through product development, to the characterization required for filing new patents.
The Differential Scanning Calorimetry (DSC)-Raman spectroscopy hyphenated system is making its PITTCON booth debut and will also be featured in presentations focused on utilizing this simultaneous technique in the study of pharmaceutical materials, including carbamazepine and acetaminophen.
“The true value of this hyphenated technique is in its ability to classify and characterize polymorphs,” explained Martin Long, vice president, Spectroscopy, Analytical Sciences and Laboratory Services, PerkinElmer. “This is especially important in the pharmaceutical industry, because if a polymorph is not classified accurately when filing a patent, the pharmaceutical company could risk the integrity of their product, costing their company millions in revenue.”
When the DSC and Raman techniques are combined, snapshots of Raman spectra are captured as the sample material is heated with a thermal analyzer. As events occur in the sample, the Raman spectrometer collects the various spectral signatures. These can be accurately matched to a library, leaving the scientist with a clear fingerprint of the pharmaceuticals structure.
PerkinElmer technologies also on display at PITTCON Booth 2769 include:
- TG-GC/MS Hyphenated System – In this system, the Pyris® 1 thermogravimetric analyzer (TGA) has been combined with the Clarus® 680 gas chromatography mass spectrometer (GC/MS) for the study of Evolved Gas Analysis (EGA). As samples are heated on the thermal analyzer, the materials separate and volatiles are released. These gases are then transferred to the GC/MS where low levels of impurities can be detected.
- IdentiCheck™ – This portable Raman spectrometer combines the high performance of a laboratory-based instrument with the convenience of a portable, light-weight unit that can be easily taken to the point of analysis.
- Spotlight™ 150 – The FT-IR microscope system offers simplicity of operation with high performance to allow for easier and faster measurements of even the most challenging samples, at an exceptional value.