Researchers map how menstrual cycle phases affect athletic performance
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 Large US study finds never-married adults face higher risk for most major cancersLarge US study finds never-married adults face higher risk for most major cancers
 
A large US population-based study found that never-married adults had higher cancer incidence than ever-married adults across most cancer types, with the largest disparities seen in older adults and in Black men. The pattern was especially strong for HPV-related, tobacco-related, and several reproductive cancers, suggesting marital status may act as an important social marker of cancer risk.
 
 
 Researchers map how menstrual cycle phases affect athletic performanceResearchers map how menstrual cycle phases affect athletic performance
 
In a repeated-measures study of 18 eumenorrheic female athletes, half-squat strength was highest in the late follicular phase and around ovulation, while handgrip strength peaked in the late luteal phase. Psychological measures also shifted across the cycle, with lower vigor and higher fatigue and depression scores in the late luteal phase, supporting more individualized training monitoring.
 
   Genetic variants may help explain who loses more weight and who gets side effects on GLP-1 drugsGenetic variants may help explain who loses more weight and who gets side effects on GLP-1 drugs
 
A large 23andMe-based GWAS found that common variants in GLP1R and GIPR help explain why some people lose more weight or experience more nausea and vomiting on GLP-1 drugs. The findings suggest genetics may eventually help predict who responds best to semaglutide or tirzepatide and who is more likely to develop side effects.
 
   Higher optimism may lower dementia risk in older adultsHigher optimism may lower dementia risk in older adults
 
Higher optimism in adults aged 70 and older was associated with a lower risk of developing dementia over up to 14 years of follow-up in the Health and Retirement Study. The association remained after adjustment for demographic factors, depression, health conditions, smoking, and physical activity, although the study was observational and cannot prove causation.
 
 ChatGPT delivers clearer PCOS answers than standard resources
 
ChatGPT delivers clearer PCOS answers than standard resourcesChatGPT outperforms traditional resources in clarity for PCOS information, highlighting its role as a supportive tool in evidence-based healthcare education.
 
 
 Lab study shows cigarette smoke damaged lung cells more than e-cigarette vapor
 
Lab study shows cigarette smoke damaged lung cells more than e-cigarette vaporResearchers found that cigarette smoke extract disrupted the lung cell barrier, increased IL-6 inflammation, and caused DNA damage in Calu-3 cells, while e-cigarette vapor extract showed no significant adverse effects on these measures under the study conditions. The authors caution that these were in vitro findings using liquid extracts and unflavored e-liquid, so they do not directly predict long-term human health outcomes.
 
 
 Why early-onset cancers are rising and how researchers plan to stop them
 
Why early-onset cancers are rising and how researchers plan to stop themEarly-onset cancers are rising worldwide, and this Cell Perspective argues that cancer prevention must move beyond static risk-factor snapshots toward life-course exposure mapping, tissue-level biology, and dynamic estimates of preventability. The authors propose three linked frameworks to speed discovery of cancer causes and translate those findings into more precise prevention and interception strategies.
 
 
 Clusterin inhibition offers new hope for treating cervical gastric-type adenocarcinoma
 
Clusterin inhibition offers new hope for treating cervical gastric-type adenocarcinomaGastric-type adenocarcinoma (GAS) is one of the most aggressive non-human papillomavirus (HPV)-associated cervical adenocarcinomas and remains especially difficult to diagnose and treat.
 
 
 Insilico Medicine nominates AI-driven drug candidate for cancer, Cushing's syndrome and obesity
 
Insilico Medicine nominates AI-driven drug candidate for cancer, Cushing's syndrome and obesityThe NR3C1 (nuclear receptor subfamily 3 group C member 1) gene encodes the glucocorticoid receptor (GR), a nuclear receptor vital for maintaining physiological homeostasis, and inhibition of NR3C1 could increase the sensitivity of cancer cells to standard chemotherapy, particularly in ovarian cancer.
 
 
 Cola may quickly lower pH inside orthodontic clear aligners and shift oral bacteria within hours
 
Cola may quickly lower pH inside orthodontic clear aligners and shift oral bacteria within hoursResearchers found that cola exposure quickly lowered pH and altered the microbiome on the inner surface of clear aligners, with the greatest disruption observed when aligners were removed before drinking and then reinserted. In this small 24-hour study, wearing aligners during exposure appeared less disruptive than removing them, though the authors said the mechanism still needs further study.
 
 
 Smoking during pregnancy raises children’s mental health risk
 
Smoking during pregnancy raises children’s mental health riskSmoking during pregnancy may increase children's mental health issues, with implications for internalizing and externalizing symptoms throughout development.
 
 
 New cell atlas reveals biological links to pregnancy complications
 
New cell atlas reveals biological links to pregnancy complicationsThe biological connection between a pregnant woman and her developing baby has been mapped in unprecedented detail by UC San Francisco scientists, revealing new cell types and insights into conditions such as preeclampsia, preterm birth, and miscarriage.
 
 
 Crisis-driven maternal psychological stress can affect fetal development and birth outcomes
 
Crisis-driven maternal psychological stress can affect fetal development and birth outcomesFetal development is a critical stage with effects that can last throughout life. Yet, identifying the effects of maternal psychological stress on the fetus has been difficult, mainly because stressful events often produce psychological and physical consequences that directly affect mothers and their children.
 
 
 Extracellular vesicles from menstrual blood cells show potential to stimulate cartilage repair
 
New research by an interdisciplinary team in Lithuania has revealed a promising and unconventional approach to cartilage regeneration.
 
 
 Study shows long-term weight benefits for breastfeeding mothers
 
Breastfeeding does not only affect your weight while you are breastfeeding. Women gain up to 6.5 kilos less on average later in life if they breastfeed for at least three months, according to a new study.
 
 
 AI analyzes Reddit posts to find underreported GLP-1 side effects
 
By using AI to analyze more than 400,000 Reddit posts, Penn researchers have identified patient-reported symptoms associated with GLP-1s, the popular weight-loss and diabetes drugs semaglutide and tirzepatide, that may not be fully captured in clinical trials or regulatory documents.
 
 
 Breastfeeding patterns in India differ between slum and non-slum neighborhoods
 
A new study from the University of Toronto shows that where a mother lives in an Indian city – in a slum or a non‑slum neighborhood – is linked to how she breastfeeds her baby.
 
 
 Weight gain timing affects long-term health outcomes
 
When in life we gain weight can have a significant impact on our health many years later. In a study involving over 600,000 people, researchers at Lund University in Sweden have investigated how changes in weight between the ages of 17 and 60 are linked to the risk of dying from various diseases
 
 
 Letrozole monotherapy falls short in ovarian cancer clinical trial
 
Late breaking results from the phase III NRG GY019 trial indicate that letrozole monotherapy (L) did not demonstrate non inferiority to paclitaxel/carboplatin followed by letrozole (PC/L) for progression free survival (PFS) in patients with newly diagnosed stage II-IV low grade serous carcinoma of the ovary or peritoneum.
 
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