Neuroscience relevant ion channels NaV1.8 and NaV1.9, are TTX resistant sodium channels expressed in the dorsal root ganglion neurons involved in pain sensation. These have proved a tricky target to approach because they do not express well in heterologous systems. In this interview, Nanion representatives discuss how their high throughput patch clamp technology instrumentation has shown recordings of these ion channels.
New research reveals RNAs, which are crucial for cells to produce proteins, are also involved in protein aggregation, where proteins do not fold properly and 'clump' together into aggregates. If cells cannot clear these away, they become toxic and prevent cells working properly.
Lifetime adversity and increased neural processing during a traumatic event combine to increase the frequency of intrusive traumatic memories and the distress they cause, according to a new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
Cholinergic neurons use the neurotransmitter acetylcholine to communicate with one another. During the progression of neurodegenerative diseases, which result in a loss of brain function, a reduction in the number of cholinergic neurons has been observed.
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