Genomics - Understanding the Tumor Immune Microenvironment of Liver Cancer
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Bring Next-Generation Sequencing to a New Level Bring Next-Generation Sequencing to a New Level

DNA library preparation is an essential step in Next-Generation Sequencing (NGS). It is crucial to select a library preparation kit with a convenient protocol and high-quality output to simplify the sequencing step. Developed by Vazyme Biotech, VAHTS Universal Plus DNA Library Prep Kit for Illumina is the latest product that provides a state-of-the-art library preparation experience, bringing your NGS research to a new level.

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    Understanding the Tumor Immune Microenvironment of Liver CancerUnderstanding the Tumor Immune Microenvironment of Liver Cancer
 
Liver cancer has the third most lethality in the world, and hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancer. Cancer immunotherapy has achieved remarkable results in clinical trials, while the therapeutic effects are uneven and the response rates in liver cancer and liver metastasized CRC are low.
 
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   Research progress on the three-dimensional interaction between virus and host genomeResearch progress on the three-dimensional interaction between virus and host genome
 
A recent study reviewed the current progress on 3D interactions between host and viral genomes.
 
 A genome-wide catalog of rare copy-number variant associations for 54 disease phenotypes
 
A genome-wide catalog of rare copy-number variant associations for 54 disease phenotypesA recent study published in Cell illustrated a human genome map with dosage sensitivity across disorders.
 
 
 IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response
 
IRB scientists identify critical spots on the genome where gene editing could cause an unwanted responseScientists at IRB Barcelona, led by ICREA researcher Dr. Fran Supek, have reported that, depending on the targeted spot of the human genome, CRISPR gene editing can give rise to cell toxicity and genomic instability.
 
 
 Researchers discover a genome that provides an understanding of diterpenoids
 
Researchers discover a genome that provides an understanding of diterpenoidsA recent high-quality genome of sage was produced by an international group of scientists from China and the UK, which also disclosed the evolutionary characteristics of Salvia’s diterpenoids biosynthesis. Cell Reports has released the study.
 
 
 Study provides guidelines on how to design safer CRISPR reagents
 
Study provides guidelines on how to design safer CRISPR reagentsAccording to new research, CRISPR gene editing can result in cell toxicity and genomic instability depending on the region of the human genome that is being edited. The research was conducted at IRB Barcelona under the direction of ICREA researcher Dr Fran Supek.
 
 
 Next-generation sequencing system yields results comparable to traditional diagnostics
 
Next-generation sequencing system yields results comparable to traditional diagnosticsIn a paper first posted online June 13, 2022, in the American Society for Microbiology's Journal of Clinical Microbiology, the researchers compared the pathogen detecting ability of an NGS system — the Respiratory Pathogen Infectious Diseases/Antimicrobial Resistance Panel (RPIP) — with a previously studied NGS system and standard of care (SOC)...