Researchers discover five new genetic changes that may increase pancreatic cancer risk
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  March 28, 2018  
  Endocrinology  
  The latest endocrinology news from News Medical  
 Researchers discover five new genetic changes that may increase pancreatic cancer riskResearchers discover five new genetic changes that may increase pancreatic cancer risk
 
In what is believed to be the largest pancreatic cancer genome-wide association study to date, researchers at the Johns Hopkins Kimmel Cancer Center and the National Cancer Institute, and collaborators from over 80 other institutions worldwide discovered changes to five new regions in the human genome that may increase the risk of pancreatic cancer.
 
 
 Dual thermal ablation can kill pancreatic cancer cells, research showsDual thermal ablation can kill pancreatic cancer cells, research shows
 
A heating and freezing process known as dual thermal ablation can kill pancreatic cancer cells, according to new research from Binghamton University, State University at New York.
 
   Unique progenitor cells in the pancreas have potential to develop glucose-responsive beta cellsUnique progenitor cells in the pancreas have potential to develop glucose-responsive beta cells
 
Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine have confirmed the existence of progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells.
 
   Modifying Oncolytic Adenoviruses to Target Pancreatic CancerModifying Oncolytic Adenoviruses to Target Pancreatic Cancer
 
Pancreatic cancer is one of the less common but deadliest cancers. Modified oncolytic adenoviruses represent an alternative to chemotherapy and targeted therapies, which have a high mortality rate.
 
   Researchers discover link between hypothyroidism and wound healing complicationsResearchers discover link between hypothyroidism and wound healing complications
 
Researchers at the University of Michigan have discovered a link between low thyroid hormone levels and wound healing complications.
 
 New optical point-of-care device could enhance screening for thyroid nodules
 
New optical point-of-care device could enhance screening for thyroid nodulesEarly diagnosis in thyroid cancer can improve a patient's likelihood of recovery, but current screening methods use instruments with poor sensitivity and can yield inaccurate results.
 
 
 Research shows link between chronic fatigue syndrome and lower thyroid hormone levels
 
Research shows link between chronic fatigue syndrome and lower thyroid hormone levelsNew research demonstrates a link between chronic fatigue syndrome (CFS) symptoms and lower thyroid hormone levels. Published in Frontiers in Endocrinology, the study indicates that CFS, a condition with unknown causes, can be explained by lower thyroid hormones -- but may be distinct from thyroidal disease.
 
 
 Patients on replacement therapy with thyroid hormone may have more comorbidities
 
Patients on replacement therapy with thyroid hormone may have more comorbiditiesPeople who take replacement thyroid hormone may have more comorbidities and lower quality of life than those who don't take the hormone, a large population-based study from the University of Groningen in the Netherlands reports.
 
 
 Gut microbiome may promote pancreatic cancer by inducing immune suppression
 
Gut microbiome may promote pancreatic cancer by inducing immune suppressionBacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain "bad" bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.
 
 
 African Americans with thyroid gene variation more likely to develop Alzheimer's
 
African Americans with thyroid gene variation more likely to develop Alzheimer'sAfrican Americans with a common genetic variation are at increased risk for developing Alzheimer's disease, while European Americans with the same variation are not, according to a study led by researchers at Rush University Medical Center.
 
 
 University Hospital of Santiago de Compostela participates in large pancreatic cancer study
 
University Hospital of Santiago de Compostela participates in large pancreatic cancer studyInternational validation through collaboration with leading cancer centers in Europe and US is a key part of Immunovia’s development and commercialization strategy for its portfolio of IMMray tests.
 
 
 Pancreatic progenitor cells could be used to treat diabetes, suggests study
 
Pancreatic progenitor cells could be used to treat diabetes, suggests studyResearchers have confirmed the existence of progenitor cells in the pancreas that can be stimulated to turn into glucose-responsive beta cells.
 
 
 Prediabetes linked to substantial risk for cardiovascular and chronic kidney diseases
 
Prediabetes linked to substantial risk for cardiovascular and chronic kidney diseasesResearchers at the Emory Rollins School of Public Health and U.S. Centers for Disease Control and Prevention have found that high proportions of patients with prediabetes are at substantial risk for cardiovascular disease and chronic kidney disease. Their findings are published in The Lancet Diabetes & Endocrinology.
 
 
 Menopausal hormone therapy reduces abdominal fat tissue in women
 
Menopausal hormone therapy reduces abdominal fat tissue in womenWomen who undergo hormone therapy to relieve menopausal symptoms tend to have less fat tissue, particularly in the abdomen, than other menopausal women, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.
 
 
 What are Antiandrogens?
 
What are Antiandrogens?Antiandrogens are a group of medications which bind to intracellular androgen receptors (AR) to prevent androgen effects on organs such as the testes, the hair follicles, the hypothalamus, pituitary, ovaries and the prostate gland, which are targets of endogenous androgens. They are used to treat a variety of clinical conditions which are characterized by hyperandrogenism, such as acne, hirsutism, and prostate cancer.
 
 
 What is Oxytocin?
 
What is Oxytocin?Oxytocin is a small but potent nine-amino acid hormone secreted within the brain, from the hypothalamus. It is secreted into the posterior pituitary via the pituitary stalk which contains axons projecting from the hypothalamic neuroendocrine cells, and is finally released from the nerve terminals in response to appropriate and varied stimuli.
 
 
 Pregnancy and Oxytocin
 
Pregnancy and OxytocinPregnancy is a physiological state which subjects the female body to a range of extreme change in form and function. One of these is in the level of oxytocin.
 
 
 Types of Psychosurgery
 
Types of PsychosurgeryPsychosurgery is a field of surgery which consists of stereotactic operations on the brain aimed at altering abnormal physiology by severing certain connections between the frontal lobe and the rest of the brain, including the cortex, the nuclei or other brain pathways, which may appear to function normally or abnormally, in order to reduce mental and/or physical suffering in otherwise untreatable patients.
 
 
 Glucagon Signaling Pathway
 
Glucagon Signaling PathwayThis article describes the glucagon signaling pathway, an important process used to maintain blood glucose homeostasis.
 
 
 What is Acute Fatty Liver of Pregnancy?
 
What is Acute Fatty Liver of Pregnancy?Acute fatty liver of pregnancy (AFLP) is a relatively rare but very serious complication of pregnancy that typically occurs in the third trimester.
 
 
 Turner Syndrome Causes
 
Turner Syndrome CausesTurner syndrome (TS) is a genetic disorder caused by the partial or complete absence of one X chromosome. This is called monosomy and is typically caused by chromosomal nondisjunction. It is a very common abnormality among the sex chromosome disorders, with an incidence of 1 in 2000 liveborn females.
 
 
 UC researcher granted patent for potential pulmonary infection treatment
 
UC researcher granted patent for potential pulmonary infection treatmentA researcher in the University of Cincinnati (UC) College of Medicine has been granted a U.S. patent for a potential treatment for a pulmonary infection in patients with cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD).
 
 
 Graphic: Opioid painkiller is top prescription in 11 states
 
Graphic: Opioid painkiller is top prescription in 11 statesAmericans fill about 4.5 billion prescriptions each year, at a cost of more than $323 billion. But what are we actually buying? In 11 states, the top prescriptions are opioid pain pills that are mixtures of acetaminophen and hydrocodone (brand names Vicodin and Norco), according to new data from GoodRx, an online prescription cost service.
 
 
 New analysis describes how childhood obesity 'pandemic' promotes cancer
 
New analysis describes how childhood obesity 'pandemic' promotes cancerA Case Western Reserve University School of Medicine researcher has compiled evidence from more than 100 publications to show how obesity increases risk of 13 different cancers in young adults.
 
 
 Common genetic variation shown to increase Alzheimer’s risk
 
Common genetic variation shown to increase Alzheimer’s riskA recent study has found that African Americans with a common genetic variation are at an increased risk for developing Alzheimer’s disease.
 
 
 Normalizing estrogen levels can benefit female athletes with irregular menstrual periods
 
Normalizing estrogen levels can benefit female athletes with irregular menstrual periodsGiving one year of estrogen replacement to female athletes with exercise-induced menstrual irregularities improves drive for thinness, body dissatisfaction and uncontrolled eating, a new study finds.
 
 
 Telediabetes program improves blood sugar control for veterans
 
Telediabetes program improves blood sugar control for veteransA telehealth program for diabetes self-management not only shortens the wait to talk to a physician specialist versus an in-person visit but also results in patients with type 2 diabetes having comparable improvements in blood glucose (sugar) control to patients receiving traditional care, a study conducted in veterans finds.
 
 
 Wearable medical patch shows promise for early detection of hypoglycemia in type 1 diabetes
 
Wearable medical patch shows promise for early detection of hypoglycemia in type 1 diabetesA wearable medical patch measuring the beat-to-beat variation in heart rate is a promising device for the early detection of hypoglycemia, or low blood sugar, in type 1 diabetes, according to the researchers who tested the new monitor.
 
 
 Newer treatment for type 2 diabetes reduces liver fat in patients with NAFLD
 
Newer treatment for type 2 diabetes reduces liver fat in patients with NAFLDIn people with type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) is common and can progress to a severe liver disease known as nonalcoholic steatohepatitis (NASH).
 
 
 Oral micronized progesterone may reduce hot flashes, night sweats in perimenopausal women
 
Oral micronized progesterone may reduce hot flashes, night sweats in perimenopausal womenOral micronized progesterone may diminish hot flashes and night sweats in perimenopausal women, new research from Canada reports.
 
 
 Poor dental health may be related to increased diabetes risk
 
Poor dental health may be related to increased diabetes riskPoor dental health may be linked with increased risk for diabetes, a new study suggests. The results will be presented in a poster Monday, March 19, at ENDO 2018, the 100th annual meeting of the Endocrine Society in Chicago, Ill.
 
 
 Diabetes mellitus reclassified into 5 subtypes
 
Diabetes mellitus reclassified into 5 subtypesDiabetes classification has been typically restricted to three types until now – types 1 and 2 and gestational diabetes. Type 1 was a result of autoimmune conditions wherein insulin hormones would be necessary to correct its deficiency while type 2 diabetes was associated with an imbalance of insulin need and supply and utilization within the body.
 
 
 Gastric bypass can provide better outcomes for patients with obesity and diabetes than lifestyle intervention
 
Gastric bypass can provide better outcomes for patients with obesity and diabetes than lifestyle interventionPeople with worrisome levels of obesity and poor control of their type 2 diabetes face two dramatically different options to substantially improve their health: bariatric (weight loss) surgery or intensive lifestyle management.
 
 
 New technique provides pairs of genetically matched cells to study disease
 
New technique provides pairs of genetically matched cells to study diseaseResearchers led by Dr. Knut Woltjen report a new gene editing method that can modify a single DNA base in the human genome with absolute precision.
 
 
 Hypoglycemia poses unaddressed threat to type 2 diabetes patients
 
Hypoglycemia poses unaddressed threat to type 2 diabetes patientsNew research from the Endocrine Society and Avalere Health finds that clinicians lack the resources to identify, assess and manage patients who are at a high risk of developing hypoglycemia, or episodes of dangerously low blood sugar.
 
 
 New study identifies the body's 'glucostat'
 
New study identifies the body's 'glucostat'It is the pancreatic islets that have the overall responsibility for maintaining normal blood glucose levels in our bodies, according to a new study by researchers at Karolinska Institutet in Sweden and the University of Miami Miller School of Medicine, USA.
 
 
 UIC researchers examine how arsenic affects development of diabetes
 
UIC researchers examine how arsenic affects development of diabetesA five-year, $2.7 million grant from the National Institute of Environmental Health Sciences will help researchers at the University of Illinois at Chicago answer basic questions about the role of arsenic in the development of diabetes and examine the mechanisms by which selenoproteins - found in the human body in 25 different forms - counter the effects of arsenic.
 
 
 Study: Soy-fed infants have differences in reproductive system tissues
 
Study: Soy-fed infants have differences in reproductive system tissuesInfants who consumed soy-based formula as newborns had differences in some reproductive-system cells and tissues, compared to those who used cow-milk formula or were breastfed, according to a new study.
 
 
 ACEA Biosciences develops novel assay for rapid identification of endocrine-disrupting chemicals
 
ACEA Biosciences develops novel assay for rapid identification of endocrine-disrupting chemicalsEndocrine-disrupting chemicals are substances that interfere with the ability of endogenous hormones to regulate homeostasis via their cognate nuclear receptors.
 
 
 Researchers develop method to make adult cardiomyocytes divide and repair damaged hearts
 
Researchers develop method to make adult cardiomyocytes divide and repair damaged heartsSome organisms have a remarkable capacity for regenerating tissue. If a fish or salamander suffers heart damage, for instance, their cells are able to divide and successfully repair the injured organ. Imagine if you could do the same.
 
 
 Study suggests novel approach for protecting diabetes patients from vascular disease
 
Study suggests novel approach for protecting diabetes patients from vascular diseaseRecent findings suggest a novel approach for protecting people with diabetes from their higher risk of advanced blood vessel disease, which sets the stage for early heart attacks and strokes.
 
 
 Study: Diagnosis of celiac disease takes 3.5 years for patients who do not report GI symptoms
 
Study: Diagnosis of celiac disease takes 3.5 years for patients who do not report GI symptomsIt takes an average of 3.5 years to diagnose celiac disease in patients who do not report gastrointestinal symptoms, a Loyola Medicine study has found.
 
 
 Scientists identify four viruses that can produce insulin-like hormones
 
Scientists identify four viruses that can produce insulin-like hormonesEvery cell in your body responds to the hormone insulin, and if that process starts to fail, you get diabetes. In an unexpected finding, scientists at Joslin Diabetes Center have identified four viruses that can produce insulin-like hormones that are active on human cells.
 
 
 Brain's quality control process holds clues to obesity's roots
 
Brain's quality control process holds clues to obesity's rootsDeep in the middle of our heads lies a tiny nub of nerve cells that play a key role in how hungry we feel, how much we eat, and how much weight we gain. Around the clock, they produce a "grandfather" form of several hormones that help us regulate these crucial functions.
 
 
 Women with Type 1 diabetes come across unique challenges
 
Women with Type 1 diabetes come across unique challengesWhen diagnosed at a young age with Type 1 diabetes, the disease affects girls and boys equally. However, that changes when girls enter puberty and women face unique challenges throughout their life in maintaining sugar levels.
 
 
 Cancer initiation found to be similar across organs
 
Cancer initiation found to be similar across organsRecent research at Washington University School of Medicine in St. Louis demonstrated that mature cells in the stomach sometimes revert back to behaving like rapidly dividing stem cells.