Genomics - Pathway Analysis After Genome-Wide Association Studies
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   Pathway Analysis After Genome-Wide Association StudiesPathway Analysis After Genome-Wide Association Studies
Genome-wide association studies are used to observe the genetics of multifactorial genetic diseases. Identifying the cause of such genetic diseases can be challenging, as the contribution of each genetic defect is often very small. Pathway analysis is used to further elucidate the impact of each genetic variant, thus increasing the physiological relevance and significance of the study.
   How Important is Intronic Variation?How Important is Intronic Variation?
The majority of human genomes have a variety of introns that must be removed one a gene has been transcribed from DNA to RNA, as they do not encode the information to translate RNA into proteins. As intronic mutations do not affect any protein-based sequences, they are ignored for the most part when attempting to pinpoint any normal or pathogenic genetic variations.


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