Johns Hopkins scientist calls for more integration of epigenetics and genetics research
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  April 10, 2018  
  Genetics  
  The latest Genetics news from News Medical  
 Johns Hopkins scientist calls for more integration of epigenetics and genetics researchJohns Hopkins scientist calls for more integration of epigenetics and genetics research
 
In a review article published April 5 in the New England Journal of Medicine, scientist Andrew Feinberg, M.D., calls for more integration between two fields of DNA-based research: genetics and epigenetics.
 
 
 Physical fitness helps reduce genetic risk of heart disease, study findsPhysical fitness helps reduce genetic risk of heart disease, study finds
 
Keeping fit, even if you're born with a high genetic risk for heart disease, still works to keep your heart healthy, according to a study led by researchers at the Stanford University School of Medicine.
 
 
 Oxford Gene Technology announces leadership changesOxford Gene Technology announces leadership changes
 
Oxford Gene Technology, The Molecular Genetics Company, has announced that on 1st April 2018 Dr John Anson who has been with the company since 2006 as EVP of R&D took over as CEO from Dr Mike Evans, who has become a non-executive director of OGT’s board.
 
   Exercise may be best defense for people with genetic predisposition to heart diseaseExercise may be best defense for people with genetic predisposition to heart disease
 
Exercise may be the best way to keep hearts healthy - and it works even for people with a genetic pre-disposition for heart disease, according to new findings in the American Heart Association's journal, Circulation.
 
   Micronic develops 0.30ml tube with external thread for genomic applicationsMicronic develops 0.30ml tube with external thread for genomic applications
 
To address the ever-increasing need for low volume genomics, Micronic developed the 0.30ml tube with external thread that enables miniaturization of reaction volume required in genomic applications.
 
   New method simplifies genetic modification of T-cells in miceNew method simplifies genetic modification of T-cells in mice
 
A new method enables genes in living T-cells in mice to be modified quickly and efficiently. It makes use of plasmids, a tried-and-tested method of genetic engineering.
 
   Scientists identify key genetic events responsible for initiating childhood leukemiaScientists identify key genetic events responsible for initiating childhood leukemia
 
The key genetic events responsible for initiating the early stages of a type of childhood leukemia have been identified by scientists at The Institute of Cancer Research, London. Insights into the ‘founder’ genetic mutation for this type of leukemia, present in all the cancer cells, could be used in the development of new targeted drugs.
 
 Searching for most appropriate genetic factors that contribute to alcohol sensitivity
 
Searching for most appropriate genetic factors that contribute to alcohol sensitivityAlcohol use disorder is a complex trait, both in its causes and characteristics. Individuals' sensitivity to alcohol can predict their risk of adverse alcohol outcomes like AUD. Further, AUD runs in families, reflecting in part a genetic component.
 
 
 ALS and frontotemporal dementia share genetic connections
 
ALS and frontotemporal dementia share genetic connectionsNearly half of all patients with amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disorder, develop cognitive problems that affect memory and thinking.
 
 
 Researchers find link between common genetic variant and AFib risk in Latinos
 
Researchers find link between common genetic variant and AFib risk in Latinos"There is a paradox at play when it comes to atrial fibrillation in the Latino population," said Dr. Dawood Darbar.
 
 
 What is Cleidocranial Dysplasia?
 
What is Cleidocranial Dysplasia?Cleidocranial Dysplasia is a genetically inherited medical condition. It is also known as Cleidocranial Dysostosis and Marie- Sainton Disease. Another name for the condition is Osteodental Dysplasia. It is a rare disorder which affects the skeletal system. The development of the bones and the teeth are affected, although the degree to which they are affected is markedly different in each patie
 
 
 UCLA researchers tweak CRISPR to accelerate genomic editing
 
UCLA researchers tweak CRISPR to accelerate genomic editingThe powerful gene-editing tool, CRISPR, has revolutionized research by allowing scientists to snip and patch DNA with remarkable precision. But tracking the impact of these changes on gene function can be time-consuming. Researchers currently analyze each edit one at a time, a process that can take weeks.
 
 
 Study reveals how apoE4 gene confers risk for Alzheimer's disease in brain cells
 
Study reveals how apoE4 gene confers risk for Alzheimer's disease in brain cellsUsing human brain cells, scientists at the Gladstone Institutes discovered the cause of--and a potential solution for--the primary genetic risk factor for Alzheimer's disease, a gene called apoE4.
 
 
 Largest-ever study to examine anatomical alterations in the brains of epilepsy patients
 
Largest-ever study to examine anatomical alterations in the brains of epilepsy patientsAn international research consortium used neuroimaging techniques to analyze the brains of more than 3,800 volunteers in different countries. The largest study of its kind ever conducted set out to investigate anatomical similarities and differences in the brains of individuals with different types of epilepsy and to seek markers that could help with prognosis and treatment.
 
 
 Study provides systematic view of gene enhancer activity in diverse tumors
 
Study provides systematic view of gene enhancer activity in diverse tumorsAt the heart of any cancer diagnosis or treatment are cells. If one thinks of the cell components controlling gene activation as a Russian nesting-doll of gene regulatory layers, within those increasingly smaller tiers are short pieces of non-coding DNA called enhancers.
 
 
 Largest genomic analysis supports additional classification of tumors
 
Largest genomic analysis supports additional classification of tumorsUniversity of North Carolina Lineberger Comprehensive Cancer Center researchers are reporting the concluding findings from a major analysis of nearly 10,000 different tumor samples that focused on identifying similarities between cancers based on changes in their genes, and the way their genes are expressed.
 
 
 Positive lifestyle changes could reduce risk of developing cancer
 
Positive lifestyle changes could reduce risk of developing cancerThere are many factors that determine your likelihood of developing cancer, including age, genetic predisposition and lifestyle.
 
 
 Families support groundbreaking research on Charcot-Marie-Tooth disease
 
Families support groundbreaking research on Charcot-Marie-Tooth diseaseLorena Martin's twin daughters kick butt on the soccer field. Martin is proud of how they hold their own, despite having a rare genetic disease called Charcot-Marie-Tooth (CMT), which has damaged their peripheral nervous system. The girls lack proper control of their hands and feet because their nerves can't send signals properly, so they play using power wheelchairs.
 
 
 New comprehensive analysis of breast and gynecological cancers
 
New comprehensive analysis of breast and gynecological cancersA large amount of information has been gathered by researchers from University of Texas MD Anderson Cancer Center who were studying the molecular features of tumors and their subtypes. They were working on breast and four types of gynaecological cancers.
 
 
 Scientists develop indices that provide information about prognosis of cancers
 
Scientists develop indices that provide information about prognosis of cancersResearchers from the School of Medicine in Ribeirão Preto, at the University of São Paulo, in collaboration with international groups, have developed indices that provide information about the prognosis of cancers, aid in the choice of the most appropriate therapy to be used and identify potential targets for the development of new drugs.
 
 
 Researchers discover a new molecular cause for aggressive leukemia in children
 
Researchers discover a new molecular cause for aggressive leukemia in childrenAround 600 children under the age of 15 are diagnosed with leukemia each year in Germany. The effects are especially dramatic if this severe illness develops at birth or shortly afterwards.
 
 
 New discovery may offer insight into treating sickle cell anemia and other blood disorders
 
New discovery may offer insight into treating sickle cell anemia and other blood disordersDiscovery by Scripps Research scientists may offer insight into treating blood disorders such as sickle cell anemia.
 
 
 DNA-mimicking synthetic molecule could lead to new HIV treatment
 
DNA-mimicking synthetic molecule could lead to new HIV treatmentResearchers have developed a synthetic compound that mimics the surface of DNA and is able to inhibit several DNA-processing enzymes.
 
 
 Insilico to present recent advances in AI for aging biomarkers and age management research
 
Insilico to present recent advances in AI for aging biomarkers and age management researchInsilico Medicine, a Baltimore-based next-generation artificial intelligence company specializing in the application of deep learning for drug discovery, biomarker development and aging research, is pleased to announce the presentation of its Director of Drug Discovery, Dr. Ivan Ozerov, at the 24th Clinical Applications for Age Management Medicine Conference, April 27, 2018, organized by Age Management Medicine Group.
 
 
 Scientists create organoids that could help guide bladder cancer treatment
 
Scientists create organoids that could help guide bladder cancer treatmentResearchers have created patient-specific bladder cancer organoids that imitate many of the features of real tumors and may therefore be used to study how cancer evolves.
 
 
 Research links DNA variants to increased risk of IBS in women
 
Research links DNA variants to increased risk of IBS in womenNew research coordinated by Karolinska Institutet in Sweden links certain DNA variants to increased risk of irritable bowel syndrome in women. The findings, published in the scientific journal Gastroenterology, might help explain why IBS is more common in women than in men.
 
 
 What is DNA Loop Extrusion?
 
What is DNA Loop Extrusion?DNA loop extrusion is a method used to analyze how DNA is compacted into the nucleus whilst bringing regulatory elements close to protein coding genes.