AI tool offers early warning system for dementia

	Alzheimer's Disease
	The latest Alzheimer's disease news from News Medical

	AI tool offers early warning system for dementia—years before symptoms begin With cutting-edge AI, Prodromic transforms dementia detection, providing clinicians with accurate forecasts to improve patient care and intervention timing.

	New diagnostic approach identifies dementia stages based on neurovascular and metabolic changes Researchers from the Indiana University School of Medicine have developed a highly sensitive diagnostic that predicts a person's stage of dementia based on neurovascular and metabolic changes.

			Midlife blood test may reveal Alzheimer’s disease risk in advance A simple blood test for platelet activity at middle age could one day help identify people at risk for Alzheimer's disease decades ahead of time, allowing for possible preventive therapy.

			Targeting RNA splicing errors protects against tau-induced neurodegeneration Alzheimer's Disease (AD), the leading cause of dementia, affects nearly 40 million individuals globally, resulting in a gradual loss of memory and independence. Despite extensive research over the past decades, no treatments have been found that can halt or reverse the progression of this devastating disease.

			Amyloid-clearing drug fails to change waste clearance function in the brains of Alzheimer's patients A group from Osaka Metropolitan University in Japan, led by graduate student Tatsushi Oura and Dr. Hiroyuki Tatekawa, found that treatment using the drug lecanemab to remove amyloid plaques in the brain does not change the waste clearance function in the brains of Alzheimer's disease (AD) patients in the short term.

	Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

	Scientists pinpoint a reason Alzheimer’s patients forget loved ones One of the most devastating moments for family members of a patient with Alzheimer's is when their loved one forgets who they are. New University of Virginia School of Medicine research may explain why that happens and could lead to a way to prevent it.

	Empowering early detection of dementia with a dual approach involving AI and patient input Few primary care practices are designed for the timely detection of Alzheimer's disease and related dementias. The limited time that primary care clinicians are able to spend with patients, the need to focus on the health problems which brought the patient to the clinic, as well as the stigma of Alzheimer's disease and dementia are major reasons for lack of recognition of the condition.

	Income and social disparities found to influence dementia risk factors People with lower incomes and people from racial and ethnic historically underrepresented groups in clinical studies are more likely to have modifiable risk factors for dementia, factors that could be changed to lower their risk, according to a study published November 12, 2025, in Neurology, the medical journal of the American Academy of Neurology.

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