Measuring Tau Tangle Pathology in Blood

	Alzheimer's Disease
	The latest Alzheimer's disease news from News Medical

Blood-based Alzheimer’s biomarkers are expanding beyond early amyloid-associated changes. eMTBR-Tau is an emerging biomarker associated with neurofibrillary tau tangle pathology and advancing disease.
Learn how ultra-sensitive plasma measurement of eMTBR-Tau could provide researchers with a more accessible way to investigate tau pathology across Alzheimer’s disease progression.

			Blood-brain barrier-crossing blood pressure drugs linked to lower dementia risk In a large Australian cohort of adults with hypertension, use of blood-brain barrier-crossing antihypertensive medications was associated with a lower risk of dementia and mortality than use of non-crossing drugs. The association was strongest for beta-blockers and angiotensin II receptor blockers, although the observational design means the findings cannot establish causality.

			HRT linked to lower dementia risk, but timing and menopause type matter In a UK Biobank study of 183,450 postmenopausal women followed for an average of 13.3 years, hormone replacement therapy use was associated with a modestly lower risk of dementia, with stronger associations in women who had surgical menopause or shorter natural estrogen exposure. The relationship also varied by age at HRT initiation, while the observational design means the findings cannot establish that HRT prevents dementia.

	Coffee’s link to Parkinson’s risk may depend on how your body handles caffeine In 435,551 UK Biobank participants followed for a median of 15.7 years, overall coffee consumption was not associated with Parkinson’s disease risk, but the relationship differed significantly according to CYP1A2 genotype.

	Nanoparticles regenerate neurons and improve cognition in Alzheimer’s mice The adult human brain has limited capacity to repair or regenerate neurons lost to Alzheimer's disease, the most common type of dementia.

	Brain shrinkage biomarker may predict early-onset Alzheimer’s progression In people diagnosed with early-onset Alzheimer's disease, a biomarker tool that detects shrinkage of the brain's gray matter may predict how quickly someone may progress from mild cognitive impairment (MCI) to dementia, according to a new study published August 26, 2026, in Neurology, an official journal of the American Academy of Neurology.

	Egg yolk peptides protect brain cells from oxidative stress As the human lifespan increases, so too does the risk of developing neurological disorders such as Parkinson's disease, Alzheimer's disease, anxiety and depression.

	Memory declines begin earlier in life than previously thought Memory loss is usually thought of as something to address as a person ages. Slip-ups like forgetting someone's name or recognizing a familiar face but not remembering where you know them from are often viewed as issues that arise later in life.

	Adolescent binge drinking causes lasting changes in brain function New research from the Marshall University Joan C. Edwards School of Medicine provides insight into how binge alcohol exposure during adolescence may cause lasting changes in brain function that persist into adulthood, potentially identifying a new target for future treatment approaches.

	Blood pressure intervention lowers dementia risk in community-based trial In a community-based trial in rural China, an intensive blood-pressure lowering intervention reduced the incidence of dementia compared with usual care, according to results from the China Rural Hypertension Control Program presented in a Hot Line session today at ESC Congress 2026.

	Hormone replacement therapy may reduce dementia risk for some women Hormone replacement therapy (HRT) may reduce the risk of dementia, particularly for certain groups of women - according to a study from the University of East Anglia and the University of Exeter.

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