A wife’s account reveals the hidden burden of young-onset Alzheimer’s caregiving

	Alzheimer's Disease
	The latest Alzheimer's disease news from News Medical

	A wife’s account reveals the hidden burden of young-onset Alzheimer’s caregiving Karina Acton Reid recounts caring for her husband with young-onset Alzheimer’s disease presenting as posterior cortical atrophy while raising two young children. Her perspective shows how visual disorientation, diagnostic delays, changing family roles, and inadequate age-appropriate support affect the entire household.

	Blood p-tau217 levels signal cognitive impairment risk years before symptoms emerge Higher baseline plasma p-tau217 was associated with greater 5- and 10-year risks of cognitive impairment and faster cognitive decline among 2,684 cognitively unimpaired adults. Very high levels corresponded to an estimated 38% risk at five years, but selected cohorts and limited long-term data mean routine screening and individualized prediction remain premature.

			Medical THC and CBD formulation significantly reduces late-life dementia agitation In a first-of-its-kind clinical trial, U.S. researchers have found that people with agitation and dementia in late life who took a special medical formulation of two active ingredients found in marijuana – THC and CBD – had significantly less agitation compared to people who received a placebo.

			Study shows how stress forces brain to prioritize memories The brain is the machine that perceives, analyses, sorts, stores and prioritizes our memories. However, not all experiences and perceptions are stored in the same way, and not everything is remembered equally, especially when under pressure or emotional stress.

			Study reveals how adolescent brain remodeling reshapes memory retrieval Scientists have long known that the human brain continues developing well beyond the teenage years, with important changes involving decision-making and emotional regulation extending into the mid-to-late 20s.

	Researchers identify immune cell receptor that drives organ aging process We may age at different rates, but none of us escapes aging. A study in mice and in human cells by Stanford Medicine researchers pins much of the blame on a particular type of immune cell's increased inability, with advancing age, to gobble up another immune cell type.

	Tau buildup in progressive supranuclear palsy alters brain networks linked to thinking and behavior Researchers at Japan's National Institutes for Quantum Science and Technology (QST) have found that tau buildup in progressive supranuclear palsy (PSP) may affect brain networks involved in thinking and behavior.

	Study identifies immune response causing severe COVID-19 susceptibility Although the COVID-19 pandemic has largely subsided, scientists continue to investigate why the virus proved so deadly, causing at least three million deaths worldwide, according to the latest estimates by the World Health Organization (WHO).

	Brain’s immune cells play key role in maintaining stability of neuronal networks in Alzheimer's disease Researchers at Trinity College Dublin have discovered that microglia – the main immune cells of the brain – play a critical role in maintaining the stability of neuronal networks in Alzheimer's disease.

	Sleeping longer may signal early Alzheimer's-related brain changes Regularly sleeping long hours each night is associated with higher levels of an Alzheimer's-related protein in the blood, even accounting for other health factors, suggests a new study from UT Health San Antonio, the academic health center of The University of Texas at San Antonio.

	Poor sleep alters brain communication networks differently across adult lifespan Have trouble sleeping? The reason may depend in part on your age. A recent study including psychology researchers from Binghamton University, State University of New York investigates how poor sleep alters brain communication across the adult lifespan, specifically examining how these changes vary by age and biological sex.

	Face recognition declines with age may lie in how your eyes move Aging-related declines in face recognition are linked to reduced eye movement consistency, emphasizing the role of cognitive processes in visual routines.

	Researchers identify new genetic pathway driving epilepsy and seizures Researchers have uncovered a novel biological pathway that can lead to seizures when disrupted. The findings also provide a new approach to improve the diagnosis of epilepsy, for which a genetic cause cannot be found in about 50 % of individuals with the condition

	High-risk emergency surgery reduces healthy days at home for seniors Older adults who undergo high-risk emergency general surgery spend significantly fewer days living independently at home after surgery than those undergoing lower-risk procedures, according to a study published in the Journal of the American College of Surgeons (JACS).

	WHO updates guidelines to reduce risk of dementia worldwide The World Health Organization (WHO) today released updated guidelines on reducing the risk of cognitive decline and dementia, providing countries with evidence-based recommendations to help prevent or delay the onset of dementia across the life course.

	Experimental KRAS vaccine safely generates durable immune response against pancreatic cancer Researchers at the Johns Hopkins Kimmel Cancer Center and its Skip Viragh Center for Pancreatic Cancer report that an experimental vaccine targeting mutant KRAS, one of the most common genetic drivers of pancreatic cancer, was safe and generated durable immune responses aimed at preventing the cancer in people at high risk.

	Study sheds light on the prognostic value of blood test for predicting cognitive impairment risk A blood test for the biomarker phosphorylated tau 217 (p-tau217) recently received federal clearance, but questions have emerged around the extent to which such tests can accurately predict whether a cognitively healthy individual will go on to develop cognitive impairment-a key symptom of Alzheimer's disease.

	New diagnostic blood test improves food allergy detection accuracy Allergies can be minor or life-threatening, and current diagnostic blood tests are not always adequate at determining which substances patients need to avoid to prevent a reaction.

	Lockdown-born children show lower executive function at school age Children born during the first COVID-19 lockdown in England had lower reported levels of executive function - crucial skills involved in making plans, solving problems and adapting to new situations - suggest the findings of a study published online in the Archives of Disease in Childhood.

	New report highlights top ten brain health breakthroughs for clinicians "Understanding Breakthroughs in Brain Health: Top 10 Articles of 2025" - the latest "Top 10" report in the Gerontological Society of America's Insights & Implications in Gerontology series - presents a curated collection of the year's most impactful research on cognitive decline, dementia detection, and brain health across the lifespan, with a focus on actionable insights for primary care providers.

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