Alzheimer's Disease - Cognitive decline may signal heart trouble years before a cardiovascular event
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   Cognitive decline may signal heart trouble years before a cardiovascular eventCognitive decline may signal heart trouble years before a cardiovascular event
 
In a large ASPREE and ASPREE-XT nested case-control study of older adults without prior cardiovascular disease, people who later experienced a CVD event showed faster cognitive decline beginning roughly 3 to 8 years before the event. Processing speed declined earliest, suggesting that subtle cognitive changes may emerge well before overt cardiovascular disease.
 
   Alzheimer’s monoclonal antibodies fail to deliver meaningful resultsAlzheimer’s monoclonal antibodies fail to deliver meaningful results
 
Despite reducing amyloid plaques, antibody treatments for Alzheimer's fail to improve cognition, highlighting critical gaps in current therapeutic approaches.
 
 High immune cell ratios may predict future Alzheimer's disease risk
 
High immune cell ratios may predict future Alzheimer's disease riskCirculating white blood cells called neutrophils are some of the immune system's first responders. Their numbers shoot up during infection and inflammation, shifting the ratio of neutrophils to other types of immune cells in the blood.
 
 
 Brain organoids may guide Alzheimer’s diagnosis and treatment
 
Brain organoids may guide Alzheimer’s diagnosis and treatmentScientists from Johns Hopkins Medicine report new evidence that clusters of brain tissue derived from the cells of patients with Alzheimer's disease may be used to evaluate how certain patients with the neurodegenerative condition may respond to drugs commonly prescribed to treat psychiatric symptoms of the disorder.
 
 
 Cancer-linked mutations in the brain cells may drive Alzheimer’s disease
 
Cancer-linked mutations in the brain cells may drive Alzheimer’s diseaseAs the body ages, cells naturally accumulate dozens of genetic mutations each year. New research from Boston Children's Hospital, published in Cell, finds that the brain's resident immune cells, microglia, amass mutations in specific cancer-driving genes yet they don't manifest as cancer.
 
 

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