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The latest Alzheimer's disease news from News Medical |
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 | | |  Why new Alzheimer’s drugs are dividing regulators worldwide The Lancet World Report examines why regulators in the US, UK, and Europe have reached different decisions on new amyloid-targeting Alzheimer’s drugs despite evidence that they can modestly slow clinical decline. It highlights the unresolved balance among benefits, safety risks, costs, access, and the need for broader, earlier, and more patient-centered treatment strategies. | | | | |  Lower Alzheimer’s amyloid levels in Black and Latinx adults Findings show lower amyloid PET positivity in Black and Latinx adults with cognitive impairment, highlighting disparities in dementia diagnosis and treatment. | |
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|  | | | | |  Is any level of alcohol safe? Major review reveals where drinking risks rise This Burden of Proof review found that alcohol consumption is associated with higher risks for several cancers, liver disease, pancreatitis, lower respiratory infections, tuberculosis, and atrial fibrillation. Although low-to-moderate drinking showed modest observational links with lower risks of type 2 diabetes, dementia, and some cardiovascular outcomes, the evidence was weaker and potentially biased. | |  | | | | |  Researchers uncover new clues about the origin of Alzheimer's tau tangles Researchers at Columbia University have uncovered new clues about the earliest molecular events that may trigger Alzheimer's disease, shedding light on how toxic tau filaments begin to form in the brain. | | | | | | |  How common spices may improve gut, brain, and metabolic health The health effects of spices are explored, revealing their potential to influence blood sugar, inflammation, and brain function through various mechanisms. | |
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| | | |  Experiencing a traumatic event sometimes produces long-lasting biological changes that can lead to an exaggerated fear response to future stressful events, such as what occurs in individuals with post-traumatic stress disorder (PTSD). | | | | |  A first-in-class PET imaging approach can accurately detect a biomarker for chronic traumatic encephalopathy (CTE), a devastating neurodegenerative disease associated with repeated head impact. | | | | |  When a person has a new experience, their brain faces a subtle but critical decision: should this experience be categorized with other stored memories, or should it be filed away as its own new memory? Getting it right allows the brain to help people navigate the world. | | | | |  Investigating brain foods, this review highlights dietary influences on cognition and neurodevelopment, while addressing significant gaps in current research. | | | | |  For the first time, researchers found blood biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults who did not have dementia. | | | | |  Researchers mapped more than 11,000 transcriptomes across mice, rats, macaques, and humans, revealing conserved molecular signatures of aging and mortality across tissues, species, and cell types. The study developed interpretable transcriptomic clocks that track age, mortality-related molecular change, chronic disease signals and responses to lifespan-altering interventions. | | | | |  Cell function is determined by how DNA is expressed into proteins. That process includes two main steps - transcription, when messenger RNA (mRNA) makes copies of active genes, and translation, when mRNA guides protein assembly. | | | | |  BD-pTau 217 is a refined biomarker which enhances Alzheimer’s specificity while retaining the strengths of plasma pTau 217. | | | | |  The brain may reuse some cells to store many different memories without mixing them up with or erasing older memories, a new study in mice suggests. | | | | |  A new brain imaging test can detect a key hallmark of Alzheimer's disease before symptoms appear and earlier than the method currently used in clinical practice in the United States and Europe, report University of Pittsburgh School of Medicine researchers today in The Lancet. | | | | | A new breakthrough technology, co-developed by UCL scientists, that simultaneously records and manipulates neuron activity deep within the brain could transform our understanding of neural circuits and neurological conditions, such as Alzheimer's disease and schizophrenia. | | | | | Think of the brain as if it were a house. Insulated from its environment, a house relies on complex networks-pipes, drains, and disposal systems-that interface with the outside world to keep the home functional on the inside. | | | | | Researchers from the University of Cambridge highlight new ways that neurons and many cell types use to sense nutrients - opening potential novel therapeutic avenues for disorders such as Alzheimer's and Parkinson's disease. | | | | | Current therapies for rheumatoid arthritis rely on sustained immunosuppression rather than restoration of immune tolerance, with off-drug remission remaining rare. | | | | | A team led by researcher José Vicente Sánchez Mut at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University of Elche (UMH), together with researcher Johannes Gräff at the École Polytechnique Fédérale de Lausanne (EPFL), has identified an experimental molecule capable of "reprogramming" the brain's immune cells to restore part of their protective function against... | |
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