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The latest Alzheimer's disease news from News Medical |
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 | | |  A study links a blood protein to memory and brain changes in Down syndrome Researchers studying 88 adults with Down syndrome and 43 controls estimated that serum β-synuclein increased approximately two decades before expected Alzheimer’s symptoms, preceding changes in other blood biomarkers. | | | | |  People who walk more each day tend to score better on several brain tests Researchers analyzed 14 years of physical activity and blood pressure records from 3,093 US adults and found that higher daily step counts were associated with better performance on tests of attention, cognitive control, and reward-related decision-making. Higher systolic blood pressure was associated with poorer delay-discounting performance, but accounted for only 4. | |
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| | | | |  Cinzia Vicidomini, PhD, and Amar Sahay, PhD, of the Mass General Brigham Department of Psychiatry, the Harvard Stem Cell Institute and the Broad Institute of Harvard and MIT, are the lead and senior authors of a paper published in Nature Neuroscience, "An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience." | | | | |  For nearly 20 years, the Friends of BrainHealth donor circle has helped turn promising ideas into innovative brain health research. | | | | |  In a phase 3 randomized clinical trial involving 410 people with early Parkinson disease, 52 weeks of nicotinamide riboside supplementation increased blood NAD levels but failed to improve clinical outcomes compared with placebo. Participants receiving the supplement had modestly worse overall disease scores, although the difference was below the threshold generally considered clinically meaningful. | | | | |  People who develop Alzheimer's disease before the age of 65 experience a growing range of health problems and increasing use of healthcare services years before diagnosis. | | | | |  A pilot study suggests that low doses of LSD may have different effects on sustained attention in women and men. The findings, presented at the ECNP annual congress in Munich, are preliminary, but they add to growing evidence that people may not all respond to psychedelic microdosing in the same way. | | | | |  In a phase 1 study of 10 adults with advanced retinitis pigmentosa, researchers found that optogenetic gene therapy combined with light-stimulating goggles was generally well tolerated, although one participant experienced a severe but transient ocular adverse event. | | | | |  Researchers developed EpiScreen, an AI system that distinguished epilepsy from psychogenic non-epileptic seizures using clinical notes from 13,633 patient records across two institutions. AI assistance improved neurologists’ classification accuracy in a retrospective assessment of 300 cases, but prospective studies must establish its performance and benefits in routine clinical care. | |
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