Oral semaglutide fails to slow early Alzheimer’s decline in two phase 3 trials
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 Menopause may raise women’s Alzheimer risk earlier than doctors once thoughtMenopause may raise women’s Alzheimer risk earlier than doctors once thought
 
This review argues that women’s higher Alzheimer disease risk may be shaped in part by midlife neuroendocrine aging, especially the menopause transition, rather than by longevity alone. It highlights early menopause, bilateral oophorectomy, vasomotor symptoms, and midlife cognitive changes as underinvestigated but potentially important risk markers, while calling for sex-specific, biomarker-driven prevention strategies.
 
 
 Oral semaglutide fails to slow early Alzheimer’s decline in two phase 3 trialsOral semaglutide fails to slow early Alzheimer’s decline in two phase 3 trials
 
Two large phase 3 trials found that oral semaglutide 14 mg did not slow cognitive or functional decline over 104 weeks in people with early symptomatic, amyloid-positive Alzheimer’s disease. Semaglutide was generally consistent with its known safety profile and showed some biomarker changes, but these did not translate into clinical benefit.
 
   MIND diet may protect against structural brain deteriorationMIND diet may protect against structural brain deterioration
 
The combined Mediterranean and blood pressure lowering diet (MIND) may slow the structural changes related to brain aging, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.
 
   Higher meat intake may slow cognitive decline in older adults with APOE ε4Higher meat intake may slow cognitive decline in older adults with APOE ε4
 
In older Swedish adults, higher meat intake was associated with slower cognitive decline and lower dementia risk among people carrying APOE ε3/ε4 or ε4/ε4, but not among other genotype groups. A higher processed-to-total meat ratio was linked to worse dementia outcomes, while unprocessed red meat and poultry showed no substantial difference.
 
   Do artificial sweeteners increase appetite or food intake?Do artificial sweeteners increase appetite or food intake?
 
The study evaluates artificial sweeteners' role in appetite regulation, showing no significant effects on hunger or energy intake during weight management.
 
 New compound targets the neuronal epigenome to treat Alzheimer's disease
 
A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease.
 
 
 Brain age from sleep patterns may signal future dementia risk
 
A machine-learning analysis of brain waves recorded during sleep may help identify people at high risk of developing dementia, according to a study led by UC San Francisco and Beth Israel Deaconess Medical Center in Boston.
 
 
 ‘How low can you go?’ The shifting guidelines for blood pressure control
 
‘How low can you go?’ The shifting guidelines for blood pressure controlThe patient initially came to see Mark Supiano in 2017 because her family was concerned about her short-term memory loss.
 
 
 New nanoparticle therapy overcomes T cell exhaustion in solid tumors
 
Engineers at the University of Pennsylvania have developed a new type of lipid nanoparticle (LNP) that could one day serve as a universal immunotherapy for cancers that form solid tumors, including common variants such as cancers of the breast, liver and colon.
 
 
 Study highlights neurological and psychiatric impacts of long COVID
 
Nearly three years after the SARS-CoV-2 pandemic was declared over, conservative estimates suggest that between 80 million and 400 million people worldwide have long COVID.
 
 
 Genetic risk for Alzheimer's disease may be modified by higher meat intake
 
Genetic risk for Alzheimer's disease may be modified by higher meat intakeOlder people with a genetic risk of Alzheimer's disease did not experience the expected increase in cognitive decline and dementia risk if they consumed relatively large amounts of meat.
 
 
 Expanding blood-based Alzheimer's biomarker research
 
Expanding blood-based Alzheimer's biomarker researchAn overview on how reliable pTau 217 measurement is supporting population-level Alzheimer's research.
 
 
 Siemens Healthineers launches brain health research portfolio with first biomarker assays now available
 
Siemens Healthineers announced today its offerings for brain health research are expanding, with the brain-derived, fully automated Atellica IM Phosphorylated tau 217 (pTau217) and Atellica IM Brain Derived Tau (BDTau) assays now available for 1.
 
 
 People with type 1 diabetes face higher risk of developing dementia
 
Having type 1 diabetes is associated with a higher risk of developing dementia, according to a study published March 18, 2026, in Neurology®, the medical journal of the American Academy of Neurology.
 
 
 Anti-aging drug combination causes brain damage in mice
 
A two-drug combination frequently used in anti-aging research causes brain damage in mice, University of Connecticut researchers report in the March 16 issue of PNAS.
 
 
 Study identifies brain pathway crucial for proper functioning of working memory
 
Study identifies brain pathway crucial for proper functioning of working memoryWorking memory is a cognitive function that is essential for carrying out everyday activities and temporarily retaining information.
 
 
 New data platform transforms prediction and understanding of Alzheimer’s disease
 
A powerful new real-world data platform could transform how scientists predict and understand Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD), reports a new study at Columbia University Mailman School of Public Health and collaborators at the Vagelos College of Physicians and Surgeons, the School of Nursing as well as the University of Miami and University of Chicago.
 
 
 Targeting protein fragment may improve Huntington disease treatments
 
Targeting protein fragment may improve Huntington disease treatmentsTreatments that target a fragment of the mutant protein that causes Huntington's disease might be more effective than treatments, now in clinical trials, that target the whole protein but leave this fragment intact, a new study in mice suggests.
 
 
 Scientists identify new target to slow Huntington’s disease progression
 
Huntington's disease is a devastating brain disorder that slowly robs people of movement, memory and personality.
 
 
 Implantable device boosts immune cells to fight cancer effectively
 
Immunotherapy has transformed cancer treatment by harnessing the body's own immune system to fight disease.
 
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