Subtle changes in deep sleep before Alzheimer's symptoms appear

	Alzheimer's Disease
	The latest Alzheimer's disease news from News Medical

	Subtle changes in deep sleep before Alzheimer's symptoms appear The study identifies slow-wave sleep alterations as potential biomarkers for Alzheimer's, emphasizing their role in cognitive health and disease progression.

	Could eating more mushrooms help protect your brain as you age? A review of existing research suggests that ergothioneine, a natural antioxidant found primarily in mushrooms, may protect brain cells against oxidative stress, inflammation, and damage associated with Alzheimer's and Parkinson's diseases.

			Exercise, diet or stress? One lifestyle habit stood out in a heart disease study A hospital-based case-control study involving 495 adults in Iran found that higher healthy lifestyle scores were associated with lower odds of cardiovascular disease, even after adjustment for demographic and socioeconomic factors. Physical activity and recreation showed the strongest numerical association per questionnaire point, although the observational design could not establish whether healthier habits prevented cardiovascular disease.

			Study shows opposite synaptic mechanisms cause identical cognitive deficits A research team led by Dr. SHENG Nengyin of the Kunming Institute of Zoology (KIZ) of the Chinese Academy of Sciences has reframed ZC4H2-associated rare disorder (ZARD)-a disorder marked by intellectual disability, developmental delays, muscle weakness, and other neurological or physical abnormalities-as a "disease spectrum" rather than a condition driven by a single mechanism.

	Obesity drugs may help protect memory and cognitive abilities Drugs used to treat obesity may also help protect the brain. In a review published in Science, researchers outline how a better understanding of these drugs' effects could lead to new treatments that protect memory and other important cognitive abilities.

	Single-pill therapy achieves better long-term blood pressure control Antihypertensive medications combined into a single pill lowered blood pressure more effectively than typical treatment with multiple pills for patients in Jamaica and Colombia, a study co-led by UT Southwestern Medical Center researchers shows.

	Targeting brain cleaning gene could help treat or prevent Alzheimer's A gene responsible for compacting trash inside the brain appears to be a key player in Alzheimer's disease, and doctors may be able to target it to better treat or help prevent the devastating condition, new UVA Health research suggests.

	UT MD Anderson announces major expansion to transform cancer care The University of Texas MD Anderson Cancer Center today announced the historic expansion of its Texas Medical Center (TMC) campus through two new facilities: Inspiration Tower and Prism.

	Graded physical activity prescriptions improve functional outcomes in psychiatry Most of us have heard the advice so often that it has worn smooth, like a stone in a river: get some exercise. A new peer-reviewed Viewpoint in Brain Health, drawing on randomized trials, meta-analyses, and cohort studies, argues that this familiar sentence has been doing the wrong job.

	A simple salt swap could prevent nearly 3 million deaths a year, researchers estimate A global modelling study covering 193 countries and territories estimated that replacing regular salt with a potassium-enriched substitute containing 25% potassium chloride could prevent 2.96 million deaths, 10.17 million new cardiovascular and chronic kidney disease cases, and 69.43 million disability-adjusted life years annually.

	Modified zinc finger protein reduces brain plaques in Alzheimer's mice A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer's disease.

	Struggling with constipation? Two green kiwifruits a day may help A narrative review of 33 publications found that consuming two fresh green kiwifruits daily for approximately four weeks can improve bowel movement frequency and gastrointestinal comfort in adults with functional constipation or constipation-predominant irritable bowel syndrome (IBS-C).

	Hidden genetic differences in gut bacteria may hold clues to aging Researchers analyzed approximately 12.8 million gut microbial genetic variants in 10,781 individuals across six cohorts, identifying 940 independent associations with 69 human health characteristics and environmental exposures.

	Scientists scanned people's brains before and after 45 days of yoga. Here's what changed In a randomized controlled trial involving 139 healthy adults, 45 days of a standardized yoga program improved mood, self-reported sleep quality, and selected short-term memory measures compared with a waitlist control group. Brain scans from 43 participants also revealed changes in functional connectivity across networks involved in movement, attention, language, and cognitive processing, although the long-term significance remains uncertain

	Coffee, vegetables and exercise share a surprising connection in your gut In a study of 6,803 Japanese adults, researchers identified two opposing gut microbiome patterns linking diet, physical activity, smoking, and alcohol consumption with general health and 15 chronic diseases.

	Brain scans reveal clues to Alzheimer's risk years before memory loss begins Inside the brains of some cognitively normal adults, firing patterns were able to foretell Alzheimer's disease years before the onset of memory loss or the accumulation of plaques and tangles, according to new Stanford Medicine-led research.

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