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The latest Alzheimer's disease news from News Medical |
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 | | |  One cognitive ability stood out in a study of Western diets and Alzheimer’s risk genes A Western dietary pattern was associated with faster attention decline among older adults carrying the APOE ε4 allele, while no significant cognitive associations emerged for a Prudent dietary pattern. However, the Western diet association lost statistical significance after excluding participants with possible baseline cognitive impairment, making the finding exploratory. | | | | |  Simple biological age score flags higher cognitive decline risk in older adults A study of 4,818 middle-aged and older Chinese adults found that higher light BioAge was associated with greater risks of cognitive impairment, episodic memory decline, and reduced mental intactness. The simple measure, based on age, creatinine, glucose, and CRP, added modest predictive information but requires further validation before clinical use. | |
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|  | | | | |  Semaglutide slows blood protein signature linked to future dementia risk A post hoc analysis of 2,970 older SELECT participants found that semaglutide slowed worsening of a 25-protein blood signature that predicts future dementia risk. Over 104 weeks, semaglutide produced larger effects on modeled 5-year than 20-year dementia risk, but whether these biomarker changes translate into less cognitive decline or dementia remains unknown. | |  | | | | |  Early-life stress rewires brain epigenetics to heighten sensitivity to future stress . Early-life stress increased SETD7 and H3K4me1 in the ventral tegmental area of mice, creating an epigenetically primed state that heightened later transcriptional, neuronal, and behavioral responses to stress. Reducing Setd7 during development lowered H3K4me1 and weakened these stress-sensitizing effects, identifying a mechanism that may help explain how early adversity leaves lasting biological effects. | | | | | | |  Study links better midlife vascular health to nearly 13 more dementia-free years A long-term study of 12,409 adults found that a greater burden of diabetes, hypertension, and current smoking in midlife was associated with substantially fewer years lived free of dementia. Adults with none of these risk factors had about 30.1 dementia-free years from age 55, compared with 17.5 years among those with all three, a difference of nearly 13 years. | | | | | | |  Nocturnal micro-awakenings linked to genetic risk of Alzheimer's disease What if certain signs of the disease were to manifest themselves subtly during sleep, long before the first memory problems appear? This is the line of inquiry being explored by a team of researchers at ULiège, with the support of the Stop Alzheimer's Foundation. | |
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| | | |  Researchers have developed a computer model of the human cortex that links its microscopic chemistry to its brain-wide patterns of activity, providing new evidence that regional differences in receptor density help shape how activity and information move across the brain. | | | | |  For many who have struggled to learn a new language or instrument, it's a familiar pattern: they make rapid progress at first, then hit a plateau that no amount of diligent practice or concentration seems to break. | | | | |  A growing understanding of RNA biology is reshaping how scientists view the relationship between environmental toxicants, brain development, and neurodegenerative disease. | | | | |  A low-fat vegan diet lowers the energy density of the foods people eat by roughly 30%, allowing them to eat satisfying amounts of food while taking in fewer calories and losing weight-without deliberately restricting calories-according to new research published in JAMA Network Open. | | | | |  Accelerated biological age in midlife was associated with higher risks of cardiovascular disease and death in both men and women over nearly three decades of follow-up. Women with accelerated biological age also showed a higher risk of dementia, although adding biological age to standard risk factors provided only minimal additional predictive value. | | | | |  Researchers at University of California San Diego and their colleagues have identified a key cellular pathway that drives brain degeneration in both a rare childhood disorder and the far more common Alzheimer's disease. | | | | |  Women live longer than men in nearly every country in the world, yet they experience higher rates of disability, dementia and many other age-related conditions. | |
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