Midlife exercise cuts dementia risk by up to 45 percent, new study shows
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 Arginine slows amyloid buildup and improves brain outcomes in Alzheimer’s disease modelsArginine slows amyloid buildup and improves brain outcomes in Alzheimer’s disease models
 
Arginine reduced amyloid beta aggregation in vitro and in both Drosophila and AppNL-G-F mouse models of Alzheimer’s disease, leading to fewer dense-core plaques and improved behavior. The study provides preclinical evidence that oral arginine may modulate amyloid pathology, although high dosing requirements and model limitations constrain human translation.
 
 
 Midlife exercise cuts dementia risk by up to 45 percent, new study showsMidlife exercise cuts dementia risk by up to 45 percent, new study shows
 
Higher physical activity in midlife and late life is linked to a substantially lower risk of all-cause and Alzheimer’s dementia. Midlife benefits are strongest for moderate or heavy activity, while late-life activity is protective across all intensity levels.
 
   Astrocyte-driven approach shows potential to reverse cognitive decline in Alzheimer’sAstrocyte-driven approach shows potential to reverse cognitive decline in Alzheimer’s
 
Researchers at Baylor College of Medicine have discovered a natural mechanism that clears existing amyloid plaques in the brains of mouse models of Alzheimer's disease and preserves cognitive function.
 
   Hearing loss emerges as a key early warning sign for Alzheimer diseaseHearing loss emerges as a key early warning sign for Alzheimer disease
 
Hearing loss also predicts a significantly higher risk of dementia, especially in APOE ε4 carriers, highlighting its value as an early risk marker.
 
   Does coffee truly boost memory and focus or is it all hype?Does coffee truly boost memory and focus or is it all hype?
 
Coffee’s bioactive compounds, especially caffeine, show potential cognitive, neuroprotective, and neuroplasticity benefits across animal and human studies. However, most findings are observational, mechanisms remain uncertain, and optimal intake is still unclear.
 
 New discovery could reshape how scientists think about Alzheimer’s treatment
 
New discovery could reshape how scientists think about Alzheimer’s treatmentRutgers neuroscientist Peng Jiang was visiting his hometown of Qianshan, a city in China's Anhui province, when a neighbor came to his parents' house with a story that would stay with him.
 
 
 Lecanemab doesn’t improve early brain waste-clearance in Alzheimer’s
 
Lecanemab doesn’t improve early brain waste-clearance in Alzheimer’sImaging findings reveal lecanemab's early impact on amyloid plaques does not extend to glymphatic activity, highlighting challenges in Alzheimer's treatment.
 
 
 Study clarifies how spermine can guard against Alzheimer’s and Parkinson’s
 
Study clarifies how spermine can guard against Alzheimer’s and Parkinson’sResearchers at the Paul Scherrer Institute PSI have clarified how spermine - a small molecule that regulates many processes in the body's cells - can guard against diseases such as Alzheimer's and Parkinson's: it renders certain proteins harmless by acting a bit like cheese on noodles, making them clump together.
 
 
 Clogged brain drains may signal early Alzheimer's risk
 
Clogged brain drains may signal early Alzheimer's risk"Drains" in the brain, responsible for clearing toxic waste in the organ, tend to get clogged up in people who show signs of developing Alzheimer's disease, a study by researchers from Nanyang Technological University, Singapore (NTU Singapore) has discovered.
 
 
 Evaluating whether LIT supplementation slows cognitive decline in Alzheimer’s patients
 
Evaluating whether LIT supplementation slows cognitive decline in Alzheimer’s patientsAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline such as memory loss and behavioral disturbances that severely impair quality of life. Despite decades of research, effective disease-modifying therapies remain elusive, underscoring the urgent need for novel neuroprotective strategies.
 
 
 Changes in brain fats play a key role in Alzheimer's development and progression
 
Changes in brain fats play a key role in Alzheimer's development and progressionMore than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as "lipoid granules," along with the buildup of amyloid-beta (amyloid) plaques and tau protein tangles.
 
 
 New signaling molecule drives development of tissue resident memory T cells
 
New signaling molecule drives development of tissue resident memory T cellsWe owe a lot to tissue resident memory T cells (TRM). These specialized immune cells are among the body's first responders to disease.
 
 
 Can diet calm early memory problems? Anti-inflammatory Mediterranean eating shows promise
 
Can diet calm early memory problems? Anti-inflammatory Mediterranean eating shows promiseOlder women who follow a strongly anti-inflammatory Mediterranean diet report far fewer subjective memory complaints than those who do not. The AnMED pattern outperforms both traditional Mediterranean and MIND diets, showing a clear advantage for protecting early cognitive symptoms.
 
 
 Scientists uncover how brain enzyme OTULIN controls tau expression
 
Scientists uncover how brain enzyme OTULIN controls tau expressionScientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease.
 
 
 Study elucidates how anti-amyloid antibody therapy lecanemab works in Alzheimer's disease
 
Study elucidates how anti-amyloid antibody therapy lecanemab works in Alzheimer's diseaseLecanemab, sold under the name Leqembi, is a monoclonal antibody therapy for Alzheimer's disease that clears toxic amyloid plaques and delays cognitive decline.
 
 
 Infection-related hospital stays linked to higher risk of developing dementia
 
Infection-related hospital stays linked to higher risk of developing dementiaA new research paper was published in Volume 17, Issue 10 of Aging-US on October 13, 2025, titled "Hospitalization with infections and risk of Dementia: a systematic review and meta-analysis."
 
 
 White matter alterations connect coronary artery disease to cognitive decline
 
White matter alterations connect coronary artery disease to cognitive declineIndividuals with coronary artery disease (CAD) - a constricting or blocking of blood vessels feeding the heart - face increased risks of strokes, cognitive impairment and dementia. However, the link between CAD and cognitive function is not fully understood.
 
 
 Early treatment after head injury lowers long-term risk of Alzheimer’s disease
 
Early treatment after head injury lowers long-term risk of Alzheimer’s diseaseGetting treatment within one week of a serious head injury can reduce the risk of developing Alzheimer's disease by up to 41%, according to new research from Case Western Reserve University.
 
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