Heavy drinking fuels Alzheimer’s disease by igniting brain inflammation and protein damage

	Alzheimer's Disease
	The latest Alzheimer's disease news from News Medical

	Heavy drinking fuels Alzheimer’s disease by igniting brain inflammation and protein damage Chronic alcohol use accelerates Alzheimer’s disease (AD) progression by intensifying oxidative stress, neuroinflammation, and amyloid-tau pathology through shared molecular pathways. The review highlights emerging therapies, targeting TLR4, GSK-3β, and metabolic dysfunction, that may mitigate alcohol-induced neurodegeneration.

	Social and environmental inequality linked to risk of Alzheimer’s The study uncovers links between neighborhood disadvantage and Alzheimer's biomarkers, stressing the importance of addressing social inequalities in healthcare.

			Study reveals how a microglial mutation increases risk for Alzheimer's disease Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer's Disease by Impairing Microglial Function."

			Living environment may influence dementia markers in the brain The conditions where you live may influence your brain health and risk for dementia, according to a new study from Wake Forest University School of Medicine

			Advanced MRI technique reveals early markers of hereditary frontotemporal dementia An international study led by researchers at Karolinska Institutet in Sweden demonstrates that it is possible to detect subtle changes in the brain and identify early signs of hereditary frontotemporal dementia using advanced brain imaging techniques.

	New NIA grant advances tools for dementia caregiving More than 7 million Americans live with Alzheimer's disease and related dementias (ADRD), supported by 12 million unpaid family caregivers whose contributions are valued at $413 billion annually.

	The role of SignalChem’s Tau proteins in fast-tracking neurodegenerative research Explore how SignalChem’s Tau proteins are accelerating breakthroughs in neurodegenerative research.

	New research helps explain how the brain implements visual working memory Imagine you are a security guard in one of those casino heist movies where your ability to recognize an emerging crime will depend on whether you notice a subtle change on one of the many security monitors arrayed on your desk.

	Discovery explains why women face higher risk of Alzheimer’s and multiple sclerosis New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain, offering insight into why women are disproportionately affected by conditions such as Alzheimer's disease and multiple sclerosis as well as offering a potential target for intervention.

	Nanopore sensing of protein and peptide conformation for healthcare Nanopore sensors enable precise protein and peptide analysis, crucial for early disease diagnosis and advancing personalized healthcare solutions.

	Cellular switches direct supplies during memory formation When we form a memory, brain cells need to deliver supplies to strengthen specific neural connections.

	The biological tagging of astrocytes enhances memory recall Why are we able to recall only some of our past experiences? A new study led by Jun Nagai at the RIKEN Center for Brain Science in Japan has an answer.

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