Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s

	Alzheimer's Disease
	The latest Alzheimer's disease news from News Medical

	Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s Researchers used single-nucleus RNA sequencing and chromatin accessibility profiling to map human hippocampal neurogenesis across adulthood, aging, and Alzheimer’s disease. They found that chromatin accessibility changes, more than gene expression alone, distinguish healthy aging, preclinical pathology, Alzheimer’s disease, and cognitive resilience in SuperAgers.

	New review explores whether berries can slow cognitive decline linked to obesity This systematic review in Nutrients evaluates human studies investigating whether polyphenol-rich berry consumption can modulate obesity-related metabolic dysfunction and support cognitive performance, particularly in individuals at risk of mild cognitive impairment. Evidence suggests modest memory benefits and possible metabolic improvements, although biomarker findings and long-term clinical relevance remain uncertain.

			Study finds widespread off-label use of antipsychotics among older people The use of antipsychotic medications for purposes other than those officially approved is common among older adults in Finland.

			Assessing long-term cognitive risks in ependymoma survivors A study led by St. Jude Children's Research Hospital assessed cognitive and communication abilities in children treated for the brain tumor ependymoma to understand the impact of treatment better. They found that radiation was a significant contributor to hearing loss, a risk directly linked to cognitive health.

			Lymphovenous anastomosis may be an effective treatment for Alzheimer's disease A small but growing body of evidence suggests that a minimally invasive surgical procedure called lymphovenous anastomosis (LVA) might be an effective treatment for Alzheimer's disease (AD), according to a special article in the March issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS).

			Imaging technique can objectively identify a recently recognized type of dementia, LATE A novel quantitative PET- and MRI-based imaging approach can objectively identify a recently recognized type of dementia--limbic-predominant age-related TDP-43 encephalopathy, or LATE--that is often mistaken as Alzheimer's disease.

			Could a rare gene variant help reduce smoking? New study suggests it might An exome-wide association study of nearly 38,000 smokers from the Mexico City Prospective Study identified rare coding variants in CHRNB3 that are associated with substantially fewer cigarettes smoked per day. Cross-ancestry analyses in European and East Asian datasets support a role for the β3 nicotinic receptor subunit in modulating smoking intensity.

	Natural compound from pomegranate leaves shows promise against TTR amyloidosis A research team in Kumamoto University has discovered that a natural compound found in pomegranate leaves and branches can directly break down harmful protein aggregates linked to transthyretin (TTR) amyloidosis, a progressive and potentially life-threatening disease affecting the nerves and heart.

	Viral RNA modifications trigger celiac inflammation An EHU study indicates that a drug already approved for use in humans could help to reduce the inflammation associated with celiac disease.

	Antibiotics alter gut bacteria to aid brain healing What if healing the brain after traumatic injury starts in the gut?

	Study finds brain changes related to worse memory in football players with repetitive head impacts In former college and professional football players, a new study has found higher levels of inflammation were associated with worse brain structure, which in turn was related to worse memory.

	Study connects vascular health to early Alzheimer’s brain changes Subtle changes in how blood flows through the brain and how brain tissue uses oxygen may be closely linked to Alzheimer's disease risk, according to new research from the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC.

	Muscles retain molecular memory of repeated inactivity Muscle loss, or atrophy, due to inactivity is common after illness, injury, hospitalization or falls, and becomes increasingly frequent with aging.

	New Mandarin cognitive tests improve dementia diagnosis for Chinese older adults Asian Americans are the fastest-growing group of older adults in the U.S., but they often face language and cultural barriers when seeking care for dementia-related symptoms.

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