New review shows why antidepressants often fail in Alzheimer’s and Parkinson’s depression
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 Blood circRNAs may predict Alzheimer’s before symptoms emergeBlood circRNAs may predict Alzheimer’s before symptoms emerge
 
Blood-based circular RNAs showed strong potential for identifying biomarker-confirmed Alzheimer’s disease and predicting progression to symptomatic disease. When combined with pTau217, the circRNA model produced the strongest predictive performance, but larger prospective validation is still needed.
 
 
 New review shows why antidepressants often fail in Alzheimer’s and Parkinson’s depressionNew review shows why antidepressants often fail in Alzheimer’s and Parkinson’s depression
 
A Molecular Psychiatry review shows that depression in Alzheimer’s and Parkinson’s disease may reflect disease-specific molecular, neurotransmitter, inflammatory, and circuit-level disruptions rather than standard depression biology alone. It argues that broad antidepressants often show limited efficacy in these patients and that future trials should use biomarkers, neuroimaging, and symptom profiling to guide targeted treatments.
 
   Short sleep and poor sleep quality track with Parkinson’s riskShort sleep and poor sleep quality track with Parkinson’s risk
 
Using CHARLS data from 2011 to 2020, researchers found that sleep duration and self-reported sleep quality were associated with Parkinson’s disease risk in middle-aged and older Chinese adults. Short sleep was linked to higher PD risk, while age-specific patterns suggested a linear association in adults aged ≤60 years and a U-shaped relationship in those aged >60 years.
 
   Study offers insight into how long-term inflammation may contribute to cognitive declineStudy offers insight into how long-term inflammation may contribute to cognitive decline
 
The King's College London study, published in Nature Communications, offers insight into how long-term inflammation may contribute to cognitive decline in disorders such as Alzheimer's disease, aging, depression, and the lingering neurological effects of viral infections.
 
   Prenatal high fructose exposure impairs brain development and memoryPrenatal high fructose exposure impairs brain development and memory
 
Nutritional imbalance during pregnancy can have long-lasting effects on the health status and disease susceptibility of the offspring.
 
 BCG vaccine may remodel the human brain's immune environment
 
BCG vaccine may remodel the human brain's immune environmentNew research led by Mass General Brigham investigators suggests that the Bacillus Calmette-Guérin (BCG) vaccine - which is delivered through the skin to prevent tuberculosis - may remodel the human brain's immune environment, offering a potential biological explanation for previously observed associations between BCG vaccination and lower Alzheimer's disease risk.
 
 
 Study tracks long-term recovery patterns of COVID-19 patients
 
Study tracks long-term recovery patterns of COVID-19 patientsSix years after the world first learned of COVID-19, the pandemic has faded into an unpleasant memory for many. For others, however, it never fully ended.
 
 
 Investigational drug ameliorates neuronal DNA damage and inflammation in Alzheimer's model
 
Investigational drug ameliorates neuronal DNA damage and inflammation in Alzheimer's modelAccumulation of DNA damage in the brain's neurons may contribute to the development of Alzheimer's disease.
 
 
 Experimental drug shields nerve cells from damage caused by ALS
 
Experimental drug shields nerve cells from damage caused by ALSAmyotrophic Lateral Sclerosis, or ALS, received widespread awareness in the summer of 2014 thanks to an Ice Bucket Challenge. Millions of people participated in the challenge, drenching themselves in ice cold water to bring visibility to this devastating neurodegenerative disease and generate charitable donations for research.
 
 
 Study explores the relationship between heart issues and cognitive function
 
Study explores the relationship between heart issues and cognitive functionNew in JNeurosci, Xia Zhang, from the Max Planck Institute for Human Cognitive and Brain Sciences, led a study exploring the relationship between heart issues and cognitive function.
 
 
 Study provides new insights into biological processes linked to Huntington’s disease
 
Study provides new insights into biological processes linked to Huntington’s diseaseA study conducted by the Sant Pau Research Institute (IR Sant Pau) and Hospital de Sant Pau has identified for the first time in living individuals a brain pattern related to the tau protein that changes according to the stage of Huntington's disease.
 
 
 Study identifies promising drug target to prevent neurodegenerative conditions
 
Study identifies promising drug target to prevent neurodegenerative conditionsParkinson's disease (PD) is the second most common form of neurodegenerative disease and afflicts more than ten million people worldwide. While current therapies address disease symptoms, they do not prevent the underlying neurodegeneration that drives the disease.
 
 
 Nursing home shortages threaten care for rapidly aging Americans
 
Nursing home shortages threaten care for rapidly aging AmericansAs the oldest Baby Boomers turn 80, the country's nursing homes are bracing for an anticipated surge. The number of people who need help with dementia, disabilities and the activities of daily living is growing at a time when the number of nursing home beds is shrinking.
 
 
 Early menopause remains common among women in low and middle income countries
 
Early menopause remains common among women in low and middle income countriesEarly menopause affects 1 in 14 women aged 30 to 49 living in low and middle income countries, finds a pooled data analysis of its prevalence in 44 nations published in the open access journal BMJ Global Health.
 
 
 Scent-enhanced virtual reality eased negative emotions after use
 
Scent-enhanced virtual reality eased negative emotions after useIntegrating scents into virtual reality may reduce negative emotions in isolated environments, but more research is needed for sustained psychological benefits.
 
 
 Beckman Coulter Diagnostics expands Alzheimer’s portfolio with CE-marked p-Tau217 blood test and new high-specificity research assay
 
Beckman Coulter Diagnostics expands Alzheimer’s portfolio with CE-marked p-Tau217 blood test and new high-specificity research assayBeckman Coulter Diagnostics, a global leader in clinical diagnostics and a Danaher company, today announced it received CE Mark under IVDR for its Access p-Tau217 assay, a blood test designed to support clinical evaluation of amyloid pathology in patients with signs and symptoms of cognitive decline.
 
 
 Advancing Motor Neuron Disease Diagnosis with Non-Invasive Ultrasound and AI
 
Advancing Motor Neuron Disease Diagnosis with Non-Invasive Ultrasound and AIResearch led by Professor Hodson-Tole combines ultrasound and AI to improve motor neuron disease diagnosis, reducing reliance on invasive procedures.
 
 
 USC scientists target brain inflammation to prevent Alzheimer's disease
 
USC scientists target brain inflammation to prevent Alzheimer's diseaseAn interdisciplinary team at the USC Center for Personalized Brain Health (CPBH) is targeting a family of enzymes that can increase the risk of inflammation in the brains of people with the APOE4 gene variation-the most significant genetic risk factor for late-onset Alzheimer's-as a way to prevent the disease.
 
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