Regular aerobic exercise slows a key marker of brain aging in midlife
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 Evidence links gut microbiome changes to Alzheimer’s progressionEvidence links gut microbiome changes to Alzheimer’s progression
 
Human studies consistently report gut microbiome differences in mild cognitive impairment and Alzheimer’s disease, but findings vary widely by cohort, methods, and taxa. Heterogeneity and limited longitudinal data prevent causal inference, highlighting the need for functional profiling and well-designed intervention trials.
 
 
 Regular aerobic exercise slows a key marker of brain aging in midlifeRegular aerobic exercise slows a key marker of brain aging in midlife
 
Regular aerobic activity significantly reduces brain-PAD, indicating that exercise is crucial for maintaining brain health and reducing dementia risk.
 
   Ageing slows brain protein clearance and shifts synaptic waste to microgliaAgeing slows brain protein clearance and shifts synaptic waste to microglia
 
Ageing slows neuronal protein degradation in mice, leading to widespread accumulation and aggregation of long-lived proteins, particularly at synapses. As neuronal clearance declines, microglia selectively accumulate synaptic proteins, suggesting a compensatory but potentially strained proteostasis pathway in the ageing brain.
 
   Brain complexity declines in Alzheimer's diseaseBrain complexity declines in Alzheimer's disease
 
As individuals with Alzheimer's disease (AD) move from the mild cognitive impairment stage to moderate and severe dementia, complex awareness deteriorates although lower-level sensory awareness is relatively maintained.
 
   Genetic study establishes causal link between obesity and cognitive declineGenetic study establishes causal link between obesity and cognitive decline
 
People with obesity and high blood pressure may face a higher risk of dementia, according to a new study published in The Journal of Clinical Endocrinology & Metabolism.
 
 High BMI linked to vascular dementia risk
 
High BMI linked to vascular dementia riskHigh body mass index (BMI) could cause a higher risk of vascular-related dementia (a combination of vascular + unspecified dementia), according to new research from the University of Bristol and University Hospital of Copenhagen (Rigshospitalet and Herlev-Gentofte hospital).
 
 
 The neuroscience of motivation-driven memory retention
 
The neuroscience of motivation-driven memory retentionResearchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and Duke University have proposed a neuroscience framework explaining how different types of motivation fundamentally reshape what and how the brain remembers.
 
 
 Exercise-triggered mitochondrial transfer offers hope for stroke and dementia
 
Exercise-triggered mitochondrial transfer offers hope for stroke and dementiaPhysical rehabilitation and symptom management still remain the mainstay of treatment for stroke, as clot removal or dissolution is effective only within a narrow time frame after the stroke.
 
 
 Selective inhibition of cPLA2 shows promise against Alzheimer's-related brain inflammation
 
Selective inhibition of cPLA2 shows promise against Alzheimer's-related brain inflammationA multidisciplinary USC research team has identified new compounds that may target a key driver of brain inflammation linked to Alzheimer's disease. Their research just published in the Nature publication npj Drug Discovery.
 
 
 CTE should be recognized as new cause of dementia, study suggests
 
CTE should be recognized as new cause of dementia, study suggestsThe largest study of its kind from the Boston University CTE Center reveals that chronic traumatic encephalopathy (CTE) should be recognized as a new cause of dementia.
 
 
 Suppressing brain immune cells enhances memory recall in young mice
 
Suppressing brain immune cells enhances memory recall in young miceBabies of every species from mouse to human rapidly forget things that happen to them-an effect called infantile amnesia.
 
 
 Minimally invasive biopsy enables real-time tracking of amyloid disease progression
 
Minimally invasive biopsy enables real-time tracking of amyloid disease progressionTransthyretin amyloidosis (ATTR) is a rare, progressive and highly aggressive degenerative disease. It is caused by the misfolding of a specific protein, leading to its toxic accumulation in the form of filamentous deposits in various organs.
 
 
 New research initiative aims to develop retinal screening tool for Alzheimer's
 
New research initiative aims to develop retinal screening tool for Alzheimer'sThe human eye may literally become a window revealing the earliest signals of Alzheimer's disease, thanks to a new federally funded research initiative at Oregon Health & Science University.
 
 
 KAIST proposes novel strategy for multifactorial Alzheimer's treatment
 
KAIST proposes novel strategy for multifactorial Alzheimer's treatmentConventional treatments of Alzheimer's disease, one of the most common forms of dementia, have been largely focused on targeting individual pathological features.
 
 
 Experimental study reveals advanced episodic memory replay in rats
 
Experimental study reveals advanced episodic memory replay in ratsIn a new study Indiana University researchers observed episodic memory in rats to a degree never documented before, suggesting that rats can serve as a model for complex cognitive processes often considered exclusively human.
 
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