Simple chair-rise test signals future health risks in seniors

	Arthritis
	The latest arthritis news from News Medical

	Simple chair-rise test signals future health risks in seniors How easily older adults can stand up from a chair may be a telling indicator of their overall quality of life.

	Obesity leaves lasting molecular tags on the immune system People who live with obesity are 'tagging' a memory of being overweight on a key part of the immune system - leaving people with ongoing risk of obesity-related conditions years after losing weight, according to a 10 year-long study published in EMBO Reports.

New study maps early molecular changes in jaw joint osteoarthritis

Temporomandibular joint disorders (TMDs) affect a large portion of the global population and are a common source of chronic jaw pain and difficulty in chewing or speaking.

	Scientists identify new inflammatory mechanism to treat chronic health conditions A protein long understood to drive inflammation by producing nitric oxide has a second, previously unknown role - it physically binds to another key protein inside cells to directly modulate the immune response.

	Natural compound obakulactone shows therapeutic potential for rheumatoid arthritis A new study published in Engineering reveals that obakulactone (OL), a natural tetracyclic triterpenoid isolated from Phellodendri cortex, exerts a therapeutic effect on rheumatoid arthritis (RA) by promoting the degradation of acyl coenzyme A thioesterase 1 (ACOT1) via the ubiquitin‒proteasome pathway and restoring the homeostasis of unsaturated fatty acids.

	Patient outcomes vary by drug class despite achieving clinical remission A study published in Rheumatology & Autoimmunity challenges the assumption that achieving clinical remission in rheumatoid arthritis is sufficient, showing that patient-reported outcomes vary significantly by drug class even when disease activity is comparable.

	Supportive relationships in childhood help buffer the long-term health effects of abuse A consistent, caring adult during childhood can make a profound difference for child survivors of physical or sexual abuse.

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