A portable molecular test, MiniDock MTB, detected pulmonary tuberculosis rapidly and accurately across seven high-burden countries, using sputum or tongue swab samples. The study suggests the low-cost, battery-operated platform could expand near-point-of-care TB diagnosis in low-resource settings, although real-world implementation and drug-resistance integration still need evaluation.
Scientists have long known that the immune system plays a key role in aging. As people age, they have weaker responses to vaccination, greater risks of infection and higher levels of inflammation.
Superspreading became a familiar concept to many during the COVID-19 pandemic. Prior studies examining infectious disease epidemics, including those on COVID-19, have found that some individuals are much more likely to transmit infections to other people. Superspreading, when one person with an infection passes it to an unusually large number of other people, is a key feature of tuberculosis (TB) epidemiology.
Household contacts of people with tuberculosis (TB) have a high risk of getting TB themselves, at around 2 percent. It is currently difficult to detect TB in its early stages, or predict who will go on to have TB, and therefore preventive treatment is not widely used.
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