Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

	Ulcerative Colitis
	The latest ulcerative colitis news from News Medical

	Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth Researchers showed that chronic colitis leaves a long-lasting epigenetic memory in colonic stem cells, persisting for more than 100 days after recovery in mice. This memory is marked by durable AP-1-linked chromatin changes and later amplifies tumour outgrowth after oncogenic mutation.

	Guselkumab shows minor added benefit for specific Crohn's disease patients The human monoclonal antibody guselkumab has been approved for certain adults with moderately to severely active ulcerative colitis since April 2025.

			How siRNA technology targets disease-causing genes in inflammation and cancer Short interfering RNAs (siRNAs) enable targeted gene silencing, offering innovative solutions for immunotherapy and precision medicine in inflammatory diseases.

			How one antibiotic dose can reshape your gut microbiome for years Long-term registry-linked analysis of nearly 15,000 adults shows that antibiotic use is associated with persistent changes in gut microbiome diversity and composition for up to 4–8 years. These effects vary by antibiotic class, with clindamycin, fluoroquinolones, and flucloxacillin showing the strongest and most sustained associations.

	IGFBP1 identified as potential biomarker for IBD monitoring in elderly patients A recent study published in Current Molecular Pharmacology highlights the potential of insulin-like growth factor binding protein 1 (IGFBP1) as a monitoring biomarker for disease activity in elderly patients with inflammatory bowel disease (IBD).

	Vitamin D may help shape how the immune system responds to gut bacteria in IBD patients Vitamin D supplementation may help shape how the immune system responds to gut bacteria in people with inflammatory bowel disease (IBD), according to a Mayo Clinic–led study published in Cell Reports Medicine.

	Machine learning speeds up AMP discovery for treating ulcerative colitis Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent intestinal inflammation, abdominal pain and diarrhea.

	Whole wheat diets may reduce the risk of inflammatory bowel disease Enriching the diet with wheat fiber protects mice against intestinal inflammation, according to a study published by researchers in the Institute for Biomedical Sciences (IBMS) at Georgia State University.

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