Forecasting disease intensity through genomic risk
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 High-dose curcumin fails to produce lasting gut microbiome changes in IBD patientsHigh-dose curcumin fails to produce lasting gut microbiome changes in IBD patients
 
In an open-label study of 29 men, including patients with ulcerative colitis and Crohn’s disease in remission, 6 g per day of curcumin for eight weeks led to modest, transient shifts in gut microbiota composition without sustained restructuring. Despite achieving high fecal concentrations and minimal systemic bioavailability, curcumin did not produce durable microbiome changes, and disease activity scores remained stable.
 
 
 Forecasting disease intensity through genomic riskForecasting disease intensity through genomic risk
 
Approximately 60,000 Danes live with chronic inflammatory bowel disease. Some experience limited discomfort, while others go through a debilitating disease course involving surgery and a stoma. Add to this the fear of leaving home due to urgent toilet needs.
 
   New research initiative aims to predict and prevent diseases before they startNew research initiative aims to predict and prevent diseases before they start
 
What if doctors could tell you a disease was coming years before you felt a single symptom-and stop it in its tracks? That is the goal of a sweeping new research initiative launched by the Icahn School of Medicine at Mount Sinai in collaboration with the Uniformed Services University of the Health Sciences (USU) and the Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF).
 
 Tick-derived protein discovery can advance treatment for inflammatory diseases
 
Tick-derived protein discovery can advance treatment for inflammatory diseasesWhen the immune system detects a harmful or foreign agent it triggers an inflammatory response small proteins called chemokines direct immune cells to the site of the injury or infection, resulting in the invader being inactivated.
 
 
 New collaboration explores familial inflammatory bowel disease in Saudi Arabia
 
Mount Sinai and King Saud University Medical City in Riyadh, Saudi Arabia, today announced a three-year collaboration aimed at better understanding why inflammatory bowel disease (IBD) runs in some Saudi families, and how that knowledge can lead to risk ascertainment, earlier diagnosis and more personalized treatment options.
 
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