How common spices may improve gut, brain, and metabolic health

	Cholesterol
	The latest cholesterol news from News Medical

	How common spices may improve gut, brain, and metabolic health The health effects of spices are explored, revealing their potential to influence blood sugar, inflammation, and brain function through various mechanisms.

	Research challenges long standing beliefs about cannabis and male hormones The effects of cannabis on the hormonal system and male fertility remain controversial within the scientific community. A study conducted by the University of Geneva (UNIGE), in collaboration with the Swiss Center for Applied Human Toxicology (SCAHT), provides a new answer by showing that cannabis use does not reduce testosterone levels in young men and may even increase its testicular synthesis.

			One-time gene editing cuts LDL cholesterol in early hypercholesterolemia trial A phase 1 NEJM interim analysis found that a single infusion of the investigational base-editing therapy VERVE-102 produced dose-dependent reductions in circulating PCSK9 protein and LDL cholesterol in adults with heterozygous familial hypercholesterolemia or premature coronary artery disease.

			Ensitrelvir cuts household COVID-19 risk when given after exposure Ensitrelvir, an oral SARS-CoV-2 3C-like protease inhibitor, reduced symptomatic RT-PCR-confirmed COVID-19 among household contacts when given within 72 hours after symptom onset in the infected index patient. In the phase 3 SCORPIO-PEP trial, COVID-19 occurred in 2.9% of ensitrelvir recipients versus 9.0% of placebo recipients, with similar overall adverse-event rates.

			Healthy plant-based foods may improve pregnancy cardiometabolic markers Higher-quality plant-based diets were associated with more favorable cardiometabolic biomarkers in pregnant U.S. women, especially higher HDL-C and lower TG/HDL-C ratio. Indices that emphasized healthy plant foods, rather than simply penalizing animal foods, showed the strongest links with insulin resistance and lipid markers.

	Early lung damage patterns uncovered in children with cystic fibrosis Researchers have mapped how lung damage begins early in life for children with cystic fibrosis, providing new insights that will help reshape future care.

	Healthy hearts prior to pandemic reduced severe COVID-19 risk Better heart health before the pandemic was linked to a lower risk of severe COVID-19 events, according to research published today in the Journal of the American Heart Association, an open-access, peer-reviewed journal of the American Heart Association.

	Heart health before pandemic influenced severity of COVID-19 infections Better heart health before the pandemic was linked to a lower risk of severe COVID-19 events, according to research published today in the Journal of the American Heart Association, an open-access, peer-reviewed journal of the American Heart Association.

	Poor lipid metabolism may reduce cognitive performance in teens A new Finnish study shows that blood markers of dysfunctional lipid metabolism are associated with poorer cognitive function in 15-17-year-olds.

	Tezepelumab reduces steroid dependence in severe asthma patients New results from the Phase 3 SUNRISE clinical trial show that tezepelumab significantly reduced the need for long-term oral corticosteroid use in adults with severe oral corticosteroid-dependent asthma while maintaining asthma control and improving key clinical outcomes.

	Extreme trait values often have simpler genetic explanations than thought Researchers at the Icahn School of Medicine at Mount Sinai have found evidence that people who fall at the extreme high or low ends of certain traits, such as cholesterol, blood glucose, height, and age at menopause, are more likely to have a simple genetic explanation than previously thought.

	New guidelines urge earlier cholesterol treatment to prevent heart disease Doctors should consider treating high cholesterol much earlier and more aggressively than they have in the past, according to a new perspective by Weill Cornell Medicine, NewYork-Presbyterian and Yale School of Medicine investigators.

	Researchers uncover new genetic links influencing blood lipid composition DZNE researchers have generated new insights into how the human genome shapes the chemical composition and concentration of blood lipids.

	Targeting lipid enzymes triggers starvation states in aggressive tumor cells While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite.

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