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The latest cholesterol news from News Medical |
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 | | |  What makes truffles more than a delicacy? They’re packed with bioactive compounds Italian researchers reviewed the chemical composition and biological potential of truffles, identifying them as rich sources of antioxidants, polysaccharides, sterols, and vitamins. The review highlights their promise as functional foods and natural therapeutics, while emphasizing the need for sustainable cultivation and clinical validation. | | | | |  Evolocumab shows clear benefit in preventing first-time heart attacks and strokes Adding the PCSK9 inhibitor evolocumab to standard lipid-lowering therapy significantly reduced first major cardiovascular events in adults with atherosclerosis or high-risk diabetes who had never had a heart attack or stroke. The 4.6-year study confirmed durable safety and benefit, supporting earlier, more intensive LDL cholesterol control. | |
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|  | | | | |  Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks. | |  | | | | |  One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial In a 15-patient, Phase 1 one, first-in-human trial, a one-time, CRISPR-Cas9 gene-editing therapy safely reduced LDL cholesterol and triglycerides in people with difficult-to-treat lipid disorders, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025. | | | | | | |  Major gaps found in cholesterol management for young adults Fewer than half of young adults with severely high low-density lipoprotein (LDL-C), or "bad" cholesterol, levels start taking a statin within five years of first high LDL-C measurement, according to a study published in JACC, the flagship journal of the American College of Cardiology, and presented at the American Heart Association's 2025 Scientific Sessions. | |
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| | | |  Whole genome sequencing in nearly 500,000 UK Biobank participants shows that observed rare and common variants now explain about 88% of family based heritability for many human traits. By partitioning heritability into rare versus common and coding versus non-coding components, the study narrows where missing heritability still hides and highlights traits that remain only partly understood. | | | | |  Adding the PCSK9 inhibitor evolocumab to a high-intensity, cholesterol-lowering regimen reduced the risk of a first major cardiovascular event among adults with atherosclerotic cardiovascular disease (ASCVD) or diabetes , according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025. | | | | |  In a small, short duration trial (12 weeks), a new medication called DR10624 reduced triglyceride levels in most patients with severe hypertriglyceridemia by more than 60%, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025. | | | | |  Among people with a previous heart attack or stroke, or who are at high risk for one, a daily oral medication may offer an effective alternative to injections of PCSK9 inhibitors to lower low-density lipoprotein (LDL or "bad" cholesterol), according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025. | | | | |  A quality improvement program helped reduce "bad cholesterol" (LDL or low-density lipoprotein) levels among military veterans who have heart and blood vessel disease, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025. | | | | |  People with lower incomes and people from racial and ethnic historically underrepresented groups in clinical studies are more likely to have modifiable risk factors for dementia, factors that could be changed to lower their risk, according to a study published November 12, 2025, in Neurology, the medical journal of the American Academy of Neurology. | | | | |  In the United States, one in every 250 people has inherited a genetic variant that leads to dangerously high cholesterol levels from birth. | | | | |  Cancer Center at Illinois (CCIL) Program Leader Erik Nelson's lab made an important discovery about the relationship between cholesterol and breast cancer progression with crucial implications for breast cancer therapeutics. | | | | |  The cholesterol medication alirocumab, a PCSK9 inhibitor, combined with a statin appeared to reduce LDL cholesterol levels by more than 50% among patients after a heart transplant, according to a late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025. | | | | |  This study analyzes how imaging is used to diagnose and manage Bell's palsy, a condition that causes sudden weakness in the muscles on one side of the face, usually temporarily. | | | | |  Advanced glycation end products arise from nonenzymatic reactions between sugars and proteins, contributing to oxidative stress, inflammation, and chronic disease. Dietary patterns, cooking methods, and clinical monitoring strategies can reduce AGE burden and help mitigate metabolic, cardiovascular, and neurodegenerative risks. | |
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