A novel approach to improving survival in treatment-resistant cancers
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  The latest bowel cancer news from News Medical  
 Trial aims to improve family communication about inherited colorectal cancer riskTrial aims to improve family communication about inherited colorectal cancer risk
 
In time for Colorectal Cancer Awareness Month in March, the Alliance for Clinical Trials in Oncology has launched a new clinical study aimed at helping improve how patients with colorectal cancer share information about the genetic risks to their family members.
 
 
 A novel approach to improving survival in treatment-resistant cancersA novel approach to improving survival in treatment-resistant cancers
 
Researchers at the National University of Singapore (NUS) have identified a protein called tyrosine phosphatase 1B (PTP1B) as a potential "switch" that can modulate a type of cancer cell death known as immunogenic cell death (ICD).
 
   Specific gut bacteria may signal long-term risk of heart and metabolic diseaseSpecific gut bacteria may signal long-term risk of heart and metabolic disease
 
Researchers analyzed gut microbiome profiles from 4,792 adults in the HELIUS cohort and tracked cardiometabolic outcomes over time to determine whether specific microbes predict disease risk. Certain microbes were linked to higher or lower cardiovascular risk, while plant-derived microbial metabolites suggested potential diet–microbiome interactions influencing heart health.
 
   Alcohol abstinence can lead to regression of existing liver-related complicationsAlcohol abstinence can lead to regression of existing liver-related complications
 
Consistent and permanent abstinence from alcohol can lead to the regression of existing liver-related complications, even in cases of advanced alcohol-related cirrhosis.
 
 Targeting IGF2BP2 improves anti-angiogenic therapy effectiveness in colorectal cancer
 
Targeting IGF2BP2 improves anti-angiogenic therapy effectiveness in colorectal cancerA recent study published in Engineering has shed light on a novel therapeutic target for improving anti-angiogenic treatment in colorectal cancer (CRC).
 
 
 What are predictive markers for drug response and why do they matter?
 
What are predictive markers for drug response and why do they matter?Learn what predictive markers for drug response are and why they matter in modern drug development.
 
 
 Using engineered bacteria to breach tumor defenses
 
Baylor University researchers have published a novel approach to fight colorectal cancer, using modified bacteria as a courier to deliver potent cancer-killing proteins into tumor cells. Michael S. VanNieuwenhze, Ph.D.
 
 
 Hormonal imbalance and gut microbes linked to cognitive deficits in patients with PitNETs
 
Pituitary neuroendocrine tumors (PitNETs) are commonly associated with visual disturbances and endocrine abnormalities; however, many patients also experience cognitive deficits, particularly in memory, attention, and executive function, which significantly affect quality of life.
 
 
 Yale study identifies parent stress as an obesity risk factor
 
In recent years, rates of childhood obesity have been rising, with the U.S. Centers for Disease Control estimating in 2024 that approximately one in five children and adolescents met the clinical definition of obese.
 
 
 Tufts researchers identify new vulnerabilities to combat persistent C. diff infections
 
Affecting roughly half a million Americans each year, bacterial infections caused by Clostridioides difficile—commonly known as C. diff—are a serious and persistent problem for patients and hospitals alike.
 
 
 Microbial ecosystems influence success of cancer checkpoint immunotherapy
 
Immune checkpoint inhibitors targeting PD-1 and PD-L1 have revolutionized cancer therapy, delivering long-term survival benefits in several malignancies.
 
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