Do GLP-1 drugs reduce cancer risk or increase it?

	Bowel Cancer
	The latest bowel cancer news from News Medical

	Do GLP-1 drugs reduce cancer risk or increase it? Emerging evidence links popular weight-loss drugs to lower cancer rates, but are these effects real, or simply a reflection of better metabolic health?

	Chronic inflammation leaves epigenetic scars that increase future cancer risk Chronic inflammation can raise a person's risk of cancer, and a new study reveals key details about how that might happen in the gut and points to better ways to identify and reduce risk.

			Immunotherapy plus chemotherapy improves outcomes in stage III dMMR colon cancer A new study from researchers at the Alliance for Clinical Trials in Oncology (Alliance) shows that patients with stage III colon cancer with deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR) had significantly better outcomes when the immunotherapy drug atezolizumab (Tecentriq®) was added to standard chemotherapy after surgery.

			Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth Researchers showed that chronic colitis leaves a long-lasting epigenetic memory in colonic stem cells, persisting for more than 100 days after recovery in mice. This memory is marked by durable AP-1-linked chromatin changes and later amplifies tumour outgrowth after oncogenic mutation.

			Primerdesign partners with Origin Sciences to create novel rectal mucosal extraction workflow Primerdesign (part of the Novacyt Group), a company focused on the design, manufacture, validation and supply of nucleic acid extraction and real-time PCR kits, and Origin Sciences (Origin), a company pioneering the detection and diagnosis of gastrointestinal (GI) disease through an unprecedented focus on a unique biospecimen: rectal mucus; today announced a strategic partnership to create a new protocol that optimizes DNA extraction from novel...

	Experts propose trial to evaluate obesity medications for cancer prevention In new research to be presented at this year's European Congress on Obesity (ECO2026) in Istanbul, Turkey (12-15 May), a global panel of 21 obesity and cancer experts suggest that to test the potential efficacy of the new generation of obesity drugs such as semaglutide and tirzepatide in preventing obesity-related cancer (ORC), a trial of the drugs for some 5,000 participants at high risk of cancer due to their having a cancer pre-cursor...

	piRNA: Epigenetic regulators of genome stability, development and disease piRNAs silence transposons through DNA methylation and histone modification, shaping genome stability, epigenetic inheritance, and disease risk.

	Reversing memory loss in aging mice by targeting gut bacteria The study uncovers how gut bacteria like Parabacteroides goldsteinii contribute to memory decline, offering insights for potential cognitive interventions.

	Vitamin D may help shape how the immune system responds to gut bacteria in IBD patients Vitamin D supplementation may help shape how the immune system responds to gut bacteria in people with inflammatory bowel disease (IBD), according to a Mayo Clinic–led study published in Cell Reports Medicine.

	Whole wheat diets may reduce the risk of inflammatory bowel disease Enriching the diet with wheat fiber protects mice against intestinal inflammation, according to a study published by researchers in the Institute for Biomedical Sciences (IBMS) at Georgia State University.

	Advanced endoscopic technique successfully treats early-stage colorectal cancer In the months before his wedding, Queens resident Roberto Pineda Sanchez noticed persistent rectal bleeding, a dangerous symptom he almost ignored.

	Guselkumab shows minor added benefit for specific Crohn's disease patients The human monoclonal antibody guselkumab has been approved for certain adults with moderately to severely active ulcerative colitis since April 2025.

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