Mature intestinal cells regain stem cell behavior to trigger tumor growth

	Bowel Cancer
	The latest bowel cancer news from News Medical

	Mature intestinal cells regain stem cell behavior to trigger tumor growth In a groundbreaking study, Stevens researchers show how colorectal cancers can evolve from mature intestinal cells that revert to stem cells.

	Genetically-modified hookworms successfully deliver medicine to animal hosts Hookworms, intestinal parasites that infect hundreds of millions of people in under-resourced tropical regions around the globe, have evolved to survive inside the human gut for years, secreting molecules that enable co-existence with their hosts.

			Three-drug strategy forces pancreatic tumors into lasting regression A triple-targeted preclinical therapy combining daraxonrasib, afatinib, and SD36 drove durable pancreatic cancer regression by blocking KRAS/RAS, EGFR/HER2, and STAT3 signaling. The approach prevented treatment resistance across mouse and human tumor-derived models, but remains preclinical and requires more clinically suitable drug combinations before human testing.

			Modified injectable vaccine shows promise for complete polio eradication In the United States, children routinely receive an injectable form of the polio vaccine. This vaccine is very effective at preventing illness, but it doesn't block transmission of the polio virus as well as the oral polio vaccine does.

			New manufacturing platform produces targeted mixtures of beneficial gut bacteria Researchers at the Icahn School of Medicine at Mount Sinai have developed a new manufacturing platform for producing targeted mixtures of beneficial gut bacteria, an approach that could help expand access to microbiome-based therapies for patients with recurrent Clostridioides difficile (C. difficile) infection.

	Microenvironmental CTHRC1 protein promotes colorectal cancer tumor growth A new research paper was published in Volume 17 of Oncotarget on May 20, 2026, titled "Microenvironmental CTHRC1 has a pro-tumorigenic role in colorectal cancer."

	Scientists map how genetic variation drives inflammatory bowel disease Scientists have created the most detailed cell map to date showing how genetic variation influences inflammatory bowel disease (IBD), revealing the specific cells and genes that drive the disease.

	Streamline adherent and suspension cell culture workflows with CellXpress.ai Discover how the CellXpress.ai automated cell culture system streamlines 2D adherent and suspension workflows.

	Intact Gut Microbes Accelerate Selenium Excretion to Protect Against Toxic Overload Selenium is an essential micronutrient that supports antioxidant and immune functions, yet how its metabolism is regulated by interactions between host and gut microbiota remains unclear. In a recent study, researchers from Japan used rats to investigate how gut microbiota and the host jointly manage selenium metabolism.

	Bispecific Antibodies Target Tumors While Sparing Healthy Tissue A new generation of bispecific antibodies effectively targets cancer cells, minimizing toxicity and enhancing treatment precision in preclinical studies.

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