Bowel Cancer - Dec 17, 2018 Edition

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	December 17, 2018
	Bowel Cancer
	The latest bowel cancer news from News Medical

Using PODXL as a Prognostic Biomarker for Colorectal and Urothelial Cancer

Usually, cancer is denoted as a singular disease; however, in reality, it is a multitude of diseases. Although this insight has been gained over the years, thus far, many patients have not been able to receive optimal treatment for their disease. If cancer patients have to receive a more individualized treatment, innovative and optimized ways to stratify patients are required.

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			Colorectal Cancer and Organ Preservation Colorectal cancer is the third most prevalent cancer worldwide – with 41,804 new cases being reported in 2012 in the UK alone, and a mortality rate of 43% from the disease. It was also shown that 54% of these cases were preventable. Treatment of colorectal cancer can vary, with chemotherapy being the most common choice of specialists.

			Immunotherapy achieves major pathological response in early-stage mismatch repair deficient colon cancer Pre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major pathological responses in 100% of early-stage colon cancers with mismatch repair deficiencies, according to results reported at ESMO 2018 from the first exploratory phase II trial to investigate this approach.

	Biological factors not responsible for racial differences in colorectal cancer incidence A systematic review and meta-analysis from the Regenstrief Institute and Indiana University School of Medicine has found that, in spite of the higher incidence and death rate of colorectal cancer in blacks, no difference exists in the overall prevalence of advanced, precancerous polyps between average-risk blacks and whites who underwent a screening colonoscopy.

	Colorectal cancer screening reduces need for intense treatments among male patients While screening for colorectal cancer did not, so far, reduce mortality, it did reduce the need for chemotherapy and emergency surgeries among male patients, shows a recent Finnish study.

	Treating pre-cancerous stem cells at early stage could be key to preventing bowel cancer Treating pre-cancerous stem cells at an early stage could be key to preventing bowel cancer in people born with a very high risk of the disease, according to a study in mice presented at the 2018 NCRI Cancer Conference.

	Exercise may reduce colorectal cancer risk after weight loss New research suggests that exercise is a key factor in reducing colorectal cancer risk after weight loss. According to the study, physical activity causes beneficial changes in the bone marrow. The study is published ahead of print in the American Journal of Physiology--Endocrinology and Metabolism.

	Study: Some bowel cancer patients in the UK have to wait more than a year to begin treatment It can take up to a year for some bowel cancer patients in the UK to start treatment, according to international research co-ordinated by Cancer Research UK and published in BMJ Open.

	Tailored lifestyle recommendations during colorectal cancer screening promote healthy behaviors A program that provided individually tailored lifestyle recommendations for patients undergoing screening for colorectal cancer helped encourage healthy behavior, according to results published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

	Regenstrief scientist calls for precision surveillance for colon cancer screening The interval at which an individual undergoes a repeat colonoscopy because of previous pre-cancerous polyps -- a practice known as "surveillance" -- should be tailored to the individual and not simply be determined by the results of prior colonoscopies, according to Regenstrief Institute research scientist Thomas F. Imperiale, M.D.

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