Researchers identify immune cell receptor that drives organ aging process

	Bowel Cancer
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	Researchers identify immune cell receptor that drives organ aging process We may age at different rates, but none of us escapes aging. A study in mice and in human cells by Stanford Medicine researchers pins much of the blame on a particular type of immune cell's increased inability, with advancing age, to gobble up another immune cell type.

	New biological feedback loop helps the immune system attack colorectal cancers A subset of cancers, known as microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) cancers, are more visible to the immune system than others.

			Ketogenic diet may increase small intestine cancer risk in mice A high-fat, low-carbohydrate diet, also called a ketogenic diet, can help some people lose weight by forcing their bodies to burn fat for fuel instead of sugar.

			Experimental KRAS vaccine safely generates durable immune response against pancreatic cancer Researchers at the Johns Hopkins Kimmel Cancer Center and its Skip Viragh Center for Pancreatic Cancer report that an experimental vaccine targeting mutant KRAS, one of the most common genetic drivers of pancreatic cancer, was safe and generated durable immune responses aimed at preventing the cancer in people at high risk.

			Gut microbial metabolites may shape vulnerability to stress-related mental disorders Gut microbiome-derived metabolites may influence stress-related mental disorders through neural, immune, endocrine, and epigenetic pathways. Evidence is strongest for depression and preclinical models, while larger longitudinal human studies are needed to establish causality and clinical value.

	Global childhood IBD trends reveal unequal progress in diagnosis and survival An analysis of GBD 2021 estimates across 204 countries and territories found that global deaths from early-onset IBD fell by approximately 71% among children younger than 10 between 1990 and 2021. However, estimated incident and prevalent case numbers rose while the age-standardized incidence rate remained broadly stable, with persistent socioeconomic and regional inequalities.

	Study reveals sex-based protein differences across lung cancer types Biological sex factors into cancer in ways you might not expect. In lung cancer, a form called squamous cell carcinoma disproportionately affects males while adenocarcinoma occurs more frequently in females.

	Study Identifies Immune Cell Failures as Aging Drivers We may age at different rates, but none of us escapes aging.

	Early PFAS exposure linked to childhood intestinal inflammation Researchers at the Icahn School of Medicine at Mount Sinai have found that exposure to per- and polyfluoroalkyl substances (PFAS), commonly known as "forever chemicals," during pregnancy and early life is associated with increased intestinal inflammation during childhood.

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