How the microbiome shapes cancer immunity and therapy response
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 Metabolic rewiring could help CAR-T cells fight solid tumorsMetabolic rewiring could help CAR-T cells fight solid tumors
 
This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells inside solid tumors. It highlights metabolic reprogramming as a promising strategy to improve CAR-T cell persistence, adaptability, and anti-tumor function.
 
 
 How the microbiome shapes cancer immunity and therapy responseHow the microbiome shapes cancer immunity and therapy response
 
This review examines how the human microbiome regulates anti-tumor immunity through DNA damage, inflammation, immune-cell activity, microbial metabolites, and tumor microenvironment remodeling. It highlights emerging microbiome-based strategies, including FMT, probiotics, prebiotics, engineered bacteria, and live biotherapeutics, while stressing the need for rigorous validation and clinical trials.
 
   AI model detects pancreatic cancer years before clinical diagnosisAI model detects pancreatic cancer years before clinical diagnosis
 
An AI model (REDMOD) can pick up the very early subtle tissue changes of pancreatic ductal adenocarcinoma, the most common form of pancreatic cancer, which conventional imaging and the human eye find difficult to detect, finds research published online in the journal Gut.
 
   Repurposed cancer drugs offer potential breakthrough for Crohn’s disease treatmentRepurposed cancer drugs offer potential breakthrough for Crohn’s disease treatment
 
University of Houston biologists have contributed to a potential breakthrough in treating Crohn's disease by shifting the clinical focus from symptom management to addressing a primary underlying cause of the condition.
 
   Rising bowel and ovarian cancer rates in younger adults raise new concernsRising bowel and ovarian cancer rates in younger adults raise new concerns
 
Cases of several cancers are rising in England among both younger and older adults, but rates of bowel and ovarian cancer are rising only among younger adults (under 50s), finds research published in the open access journal BMJ Oncology.
 
 New immune mapping tool reveals how lung cancer reshapes immune cells
 
New immune mapping tool reveals how lung cancer reshapes immune cellsResearchers at VIB and VUB have developed a powerful new way to study how the immune system behaves inside lung tumors.
 
 
 Specific intestinal fungi play role in the pathogenesis of MASLD and cardiovascular disease
 
Specific intestinal fungi play role in the pathogenesis of MASLD and cardiovascular diseaseMetabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for cardiovascular disease (CVD). While gut bacteria have been linked to CVD, the role of intestinal fungi in subclinical coronary atherosclerosis (SCA) remains unclear.
 
 
 Newer mail-in stool tests increase colorectal cancer screening completion rates
 
Newer mail-in stool tests increase colorectal cancer screening completion ratesColorectal cancer (CRC) is the second most common cause of cancer death in the United States and disproportionally impacts people who receive care in under-resourced settings.
 
 
 Rectal cancer deaths in older millennials are rising rapidly
 
Rectal cancer deaths in older millennials are rising rapidlyRectal cancer deaths among older millennials are accelerating, with growth in mortality far outpacing colon cancer, suggesting primary care doctors should fully investigate early symptoms in patients under age 45, according to a study to be presented at Digestive Disease Week (DDW) 2026.
 
 
 Drinking coffee alters your microbiome, mood, and memory
 
Drinking coffee alters your microbiome, mood, and memoryCoffee consumption influences the microbiota-gut-brain axis, affecting cognitive performance and emotional regulation through complex biological pathways.
 
 
 Scientists identify new inflammatory mechanism to treat chronic health conditions
 
A protein long understood to drive inflammation by producing nitric oxide has a second, previously unknown role - it physically binds to another key protein inside cells to directly modulate the immune response.
 
 
 Restoring gut microbiome may prevent liver cancer in mice
 
Restoring the gut microbiome to its youthful state may hold the key to slowing aging and preventing liver cancer, one of the fastest-growing cancers worldwide, according to a study to be presented at Digestive Disease Week (DDW) 2026.
 
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