Genetics - dTag for Target Validation in Cancer
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  September 18, 2019  
  Genetics  
  The latest Genetics news from News Medical  
 Genetic variants associated with adult obesity start playing a role during early childhoodGenetic variants associated with adult obesity start playing a role during early childhood
 
Body mass index (BMI) in infants, children and adults is influenced by different genetic factors that change as we age, according to a major new study. An international consortium of researchers, led by scientists at Imperial College London, the University of Surrey, and the University of Oulu, Finland, discovered that BMI in babies is influenced by a distinct set of genetic variants that play little role in determining weight in later life.
 
 
    KeysightdTag for Target Validation in Cancer
 
dTAG (degradation TAG) is an innovative approach to target validation, using heterobifunctional small molecule Degraders to harness a cell’s protein degradation system and eliminate a protein of interest. dTAG-13 has been used to identify and validate novel targets in cancer.
 
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    KeysightAutomation of Plasmid DNA Isolation from Bacterial Cells
 
Plasmid DNA isolation from bacteria is a vital molecular biology method used to create template DNA for preferred downstream reactions. Plasmid isolation approaches are basic; however, high-throughput plasmid DNA extraction has been challenging, with problems such as low yield and genomic DNA (gDNA) contamination.
 
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 Researchers map uncharted area of genome using advanced imaging
 
Researchers map uncharted area of genome using advanced imagingUsing advanced imaging techniques, researchers at the University of Colorado Anschutz Medical Campus have mapped a previously uncharted region of the human genome that gives rise to a variety of disease, setting the stage to potentially test for the conditions in the future.
 
 
 Unhealthy lifestyle raises heart disease risk more than genetics
 
Unhealthy lifestyle raises heart disease risk more than geneticsA new study has found that an unhealthy lifestyle increases a person’s risk of heart disease significantly more than a person’s genetic make-up.
 
 
 Genetic testing may help patients with metastatic breast cancer
 
Genetic testing may help patients with metastatic breast cancerBreast cancer is a condition wherein the cells in the breast grow uncontrollably. Breast cancer can spread to the other parts of the body, termed as metastatic breast cancer. It is one of the most aggressive and potentially deadly types of cancer.
 
 
 New gene therapy helps stroke patients develop new neurons
 
New gene therapy helps stroke patients develop new neuronsIschemic stroke is a condition in which parts of the brain lose their blood supply, causing nerve damage. Once brain tissue suffers irreparable harm, the patient will experience irreversible disability or death, depending on the extent of neuronal loss.
 
 
 Strongest genetic risk factor for Alzheimer’s disease impairs function of human microglia
 
Strongest genetic risk factor for Alzheimer’s disease impairs function of human microgliaA study carried out with a new human stem cell-derived model reveals that the most prevalent genetic risk factor of Alzheimer’s disease (AD), apolipoprotein E4 (APOE4), impairs the function of human brain immune cells, microglia. These findings pave the way for new, effective treatment approaches for AD. The results were published in Stem Cell Reports.
 
 
 Researchers identify an unexpected genetic plasticity in bat-borne influenza viruses
 
Researchers identify an unexpected genetic plasticity in bat-borne influenza virusesInfluenza viruses have an inherent high mutation rate. We therefore first tested the bat flu virus' genetic stability to assess its natural mutational potential in cell culture.