Genetics - CRISPR and the Ethics of Human Germline Intervention
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   CRISPR and the Ethics of Human Germline InterventionCRISPR and the Ethics of Human Germline Intervention
 
The use of CRISPR-Cas9 in germline editing presents opportunities for genetic disease correction, alongside risks of off-target effects and ethical issues.
 
   Polygenic scores show promise for early obesity preventionPolygenic scores show promise for early obesity prevention
 
New genetic research reveals polygenic scores can predict obesity risk, offering early prevention insights while raising ethical healthcare access concerns.
 
 HIV trial points to semaglutide as a new anti-aging contender
 
HIV trial points to semaglutide as a new anti-aging contenderOnce-weekly semaglutide significantly slowed epigenetic aging in adults with HIV-associated lipohypertrophy, as measured by multiple DNA methylation clocks in a randomized controlled trial. These exploratory findings suggest GLP-1 receptor agonists could impact biological aging but require further validation in broader populations.
 
 
 Researchers trace metabolic superpowers of hibernators to shared DNA
 
Researchers trace metabolic superpowers of hibernators to shared DNAAnimals that hibernate are incredibly resilient. They can spend months without food or water, muscles refusing to atrophy, body temperature dropping to near freezing as their metabolism and brain activity slow to a crawl.
 
 
 Scientists open new atlas of genetic diversity with advanced sequencing
 
Scientists open new atlas of genetic diversity with advanced sequencingA global team mapped over 100,000 structural variants in human genomes by applying Oxford Nanopore long-read sequencing and a novel graph-based analytical approach to samples from 26 populations. The study reveals the extraordinary complexity and diversity of human DNA, providing an open-access atlas that will accelerate discoveries in genetic disease and human evolution.
 
 
 AI identifies novel gene variants linked to Alzheimer’s risk
 
AI identifies novel gene variants linked to Alzheimer’s riskThis study reveals how machine learning models uncover new genetic variants linked to Alzheimer’s, advancing predictive accuracy in genetic epidemiology.
 
 
 CPADS enables comprehensive analysis of drug resistance across 44 cancer types
 
CPADS enables comprehensive analysis of drug resistance across 44 cancer typesCPADS integrates data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and the Genomics of Drug Sensitivity in Cancer (GDSC) databases, encompassing over 29,000 samples across 44 cancer types and involving 288 drugs. It provides five main analysis modules: differential expression analysis, correlation analysis, pathway analysis, drug analysis, and gene perturbation analysis.
 
 
 Every Newborn Sequenced Within a Decade: What Does This Mean for Healthcare?
 
Every Newborn Sequenced Within a Decade: What Does This Mean for Healthcare?We spoke with Neil Ward from PacBio about England’s plan to introduce whole genome sequencing for every newborn, and how long-read technology is shaping the future of early diagnosis around the world.
 
 
 Understanding how long non-coding RNAs control gene expression in cancer
 
Understanding how long non-coding RNAs control gene expression in cancerLong non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed.
 
 
 New Genetic Research Reveals Hibernation Secrets Hidden in Human DNA
 
New Genetic Research Reveals Hibernation Secrets Hidden in Human DNAAnimals that hibernate are incredibly resilient. They can spend months without food or water, muscles refusing to atrophy, body temperature dropping to near freezing as their metabolism and brain activity slow to a crawl.
 
 

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