Research shows great potential of embryonic gene editing to prevent inherited diseases
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  August 9, 2017  
  Genetics  
  The latest Genetics news from News Medical  
 Research shows great potential of embryonic gene editing to prevent inherited diseasesResearch shows great potential of embryonic gene editing to prevent inherited diseases
 
Scientists have, for the first time, corrected a disease-causing mutation in early stage human embryos with gene editing.
 
 
 Gene-therapy administered through skin transplants could enable treatment of many diseasesGene-therapy administered through skin transplants could enable treatment of many diseases
 
A research team based at the University of Chicago has overcome challenges that have limited gene therapy and demonstrated how their novel approach with skin transplantation could enable a wide range of gene-based therapies to treat many human diseases.
 
   Expert outlines pros and cons of ordering various genetic testsExpert outlines pros and cons of ordering various genetic tests
 
The amount of information gathered via next-generation sequencing has made the diagnosis of genetic disorders quicker and more accessible to clinicians than ever before, but with expanded testing options come questions about ordering the correct type of testing.
 
   Study shows new method for repairing disease-causing mutation in human embryosStudy shows new method for repairing disease-causing mutation in human embryos
 
Scientists have demonstrated an effective way of using a gene-editing tool to correct a disease-causing gene mutation in human embryos and stop it from passing to future generations.
 
   Researchers explore genetic differences, hereditary factors involved in hemiplegic cerebral palsyResearchers explore genetic differences, hereditary factors involved in hemiplegic cerebral palsy
 
Hemiplegic cerebral palsy hampers movement in one side of a person's body. In the first genetic study of its kind to exclusively focus on those with hemiplegic cerebral palsy, a group of 26 Canadian researchers has investigated the genetic differences and hereditary factors involved in this neurodevelopmental condition.
 
 Gene Therapy as a Potential Cure for Cystic Fibrosis
 
Gene Therapy as a Potential Cure for Cystic FibrosisCystic fibrosis is a hereditary disease caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes an ion channel protein that is involved in the transport of salts across cell membranes. Any of dozens of different mutations of the gene can lead to the development of cystic fibrosis.
 
 
 High-throughput DNA Sequencing Techniques
 
High-throughput DNA Sequencing TechniquesFull genomes of several organisms have been sequenced in the past fifteen years, including the human genome in 2004. These studies were completed using Sanger DNA sequencing, which has a limited throughput and high cost meaning the human genome took fifteen years to sequence and cost nearly three billion dollars
 
 
 Genetics of Eyesight
 
Genetics of EyesightEyesight refers to the capability of an individual to view things. The eyes collect the light from an object that is processed by the brain. The retina is a light-responsive layer that acts as a screen located at the back of each eye.
 
 
 Genetic testing benefits youngest epilepsy patients, study finds
 
Genetic testing benefits youngest epilepsy patients, study findsBecause of genetic testing, Orion Maynard's parents knew the cause of his epilepsy weeks after he was born.
 
 
 PerkinElmer introduces affordable clinical genomics services
 
PerkinElmer introduces affordable clinical genomics servicesPerkinElmer, Inc. , a global leader committed to innovating for a healthier world, today announced the launch of PerkinElmer Genetics' clinical genomics services.
 
 
 Researchers identify new genetic mutation that prevents sperm production
 
Researchers identify new genetic mutation that prevents sperm productionResearchers at Ben-Gurion University of the Negev and Soroka University Medical Center in Beer-Sheva, Israel have discovered a new genetic mutation that prevents sperm production.
 
 
 Modifying gene expression may provide path to preventive treatments for heart failure, study suggests
 
Modifying gene expression may provide path to preventive treatments for heart failure, study suggestsHeart failure refers to a condition in which heart muscle becomes weakened over time, making it increasingly difficult for the heart to pump blood through the body like it should.
 
 
 Study reveals biological basis of severe neurological disorder in children
 
Study reveals biological basis of severe neurological disorder in childrenIn a new study published today in The American Journal of Human Genetics, a multinational team of researchers describes, for the first time, the biological basis of a severe neurological disorder in children.
 
 
 Cystic Fibrosis Evolution
 
Cystic Fibrosis EvolutionCystic fibrosis is the most common genetic disease among people of European descent. It is an autosomal recessive disorder caused by a mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. When a child inherits two copies of the mutated gene, the cystic fibrosis disease develops. People who have just one copy of the mutation are carriers, and are generally not affected by symptoms of cystic fibrosis.
 
 
 IDT introduces first Cas9 enzyme variant that greatly reduces off-target effects in CRISPR genome editing
 
IDT introduces first Cas9 enzyme variant that greatly reduces off-target effects in CRISPR genome editingIntegrated DNA Technologies today announced the launch of the first Cas9 enzyme variant that extensively reduces off-target effects in CRISPR genome editing without compromising on-target activity.
 
 
 Neuroscientists uncover genetic basis for formation of meningiomas in childhood cancer survivors
 
Neuroscientists uncover genetic basis for formation of meningiomas in childhood cancer survivorsNeuroscientists have uncovered the genetic basis for why many long-term survivors of childhood cancer develop meningiomas, the most common adult brain tumor, decades after their treatment with cranial radiation.
 
 
 Researchers rejuvenate plasticity of the mouse brain by manipulating one gene
 
Researchers rejuvenate plasticity of the mouse brain by manipulating one geneLike much of the rest of the body, the brain loses flexibility with age, impacting the ability to learn, remember, and adapt. Now, scientists at University of Utah Health report they can rejuvenate the plasticity of the mouse brain, specifically in the visual cortex, increasing its ability to change in response to experience.
 
 
 Researchers ferreting out patients most likely to become resistant to cancer treatment
 
Researchers ferreting out patients most likely to become resistant to cancer treatmentAccording to the National Cancer Institute, the number of people beating a cancer diagnosis reached nearly 14.5 million in 2014 and is expected to rise to almost 19 million by 2024. Now, that's good news, but it doesn't mean that cancer researchers - in the lab or clinic - are resting on any laurels.
 
 
 Biological bypass found safe for patients with coronary artery disease
 
Biological bypass found safe for patients with coronary artery diseaseA new gene therapy that targets the heart and requires only one treatment session has been found safe for patients with coronary artery disease, according to a successful trial carried out in Finland.
 
 
 Molecular tests that detect drug-resistant TB may become faster alternative to traditional testing
 
Molecular tests that detect drug-resistant TB may become faster alternative to traditional testingNovel molecular tests are gaining popularity as a rapid way to detect genetic mutations that render tuberculosis impervious to drugs. Yet, how well these new tests fare in gauging risk of actual drug failure and patient death has remained unclear.
 
 
 Accidental discovery opens up new way to find unknown viruses
 
Accidental discovery opens up new way to find unknown virusesA chance discovery has opened up a new method of finding unknown viruses. In research published in the journal Virus Evolution, scientists from Oxford University's Department of Zoology have revealed that Next-Generation Sequencing and its associated online DNA databases could be used in the field of viral discovery.
 
 
 Nanotechnology wonders: Organ healing with a single touch!
 
Nanotechnology wonders: Organ healing with a single touch!Scientists from the Ohio State University Wexner Medical Centre have come up with what sounds like a science fiction - a nanotechnology device that can switch the cell functions in such a way that the failing organs are revived using a single touch.