Genetics - Genomics study reveals five genes linked to treatment resistance in prostate cancer
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  May 16, 2019  
  Genetics  
  The latest Genetics news from News Medical  
 

#ALT# Sodium Bisulfite Conversion of DNA

When DNA is treated with sodium bisulfite, cytosine residues in the DNA are deaminated to uracil leaving 5-mC residues intact. This alteration in the DNA sequence gives more information about the degree of methylation within a region of DNA to a resolution of a single nucleotide when the bisulfite conversion is followed by sequencing analysis.

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Age-related macular degeneration (AMD) is one of the most common causes of vision loss in people over age 65. The exact cause is unknown, but the fact that a family history of AMD increases a person's risk for the condition suggests genetics play an important role. Using stem cells derived from six people, University of California San Diego School of Medicine researchers recapitulated retinal cells in the lab. This "eye-in-a-dish" model allowed them to look for genetic variants that might contribute to AMD.
 
   Genomics study reveals five genes linked to treatment resistance in prostate cancerGenomics study reveals five genes linked to treatment resistance in prostate cancer
 
A new genomics study has found that men are three times more likely to die from prostate cancer if they possess mutations the retinoblastoma 1 (RB1) gene. The researchers also found that men with the mutation were seven times more likely to relapse than men without the mutation.
 
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 DNA Repair and Transcription: A Balancing Act
 
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 Researchers reveal ebb and flow of gene expression that may awaken neural stem cells
 
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