Metformin fails to improve insulin resistance in type 1 diabetes
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 New 10-minute scan shows hidden cause of high blood pressureNew 10-minute scan shows hidden cause of high blood pressure
 
A speedy new scan could improve how millions of people with high blood pressure are treated, suggests a new study led by UCL (University College London) researchers.
 
 
 Metformin fails to improve insulin resistance in type 1 diabetesMetformin fails to improve insulin resistance in type 1 diabetes
 
Metformin treatment in type 1 diabetes lowers insulin dosage but does not improve insulin resistance, highlighting its complex role in diabetes management.
 
   Regenerative medicine offers a pathway toward curing type 1 diabetesRegenerative medicine offers a pathway toward curing type 1 diabetes
 
Type 1 diabetes (T1D) is an autoimmune disorder characterized by the specific destruction of insulin-producing pancreatic β-cells.
 
   How the gut microbiome links obesity to colorectal cancerHow the gut microbiome links obesity to colorectal cancer
 
The gut microbiome serves as both a biomarker and therapeutic target in diseases like obesity, metabolic syndrome, and colorectal cancer.
 
   Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancerNovel antibody suppresses primary tumor growth and spread of triple-negative breast cancer
 
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows quickly, spreads early and lacks the hormone receptors that make other breast cancers treatable with targeted therapies.
 
 Routine blood test may flag hidden osteoporosis risk, study finds
 
Routine blood test may flag hidden osteoporosis risk, study findsA large hospital-based cross-sectional study examined whether routinely measured serum alkaline phosphatase can indicate osteoporosis risk in adults undergoing health checks. Higher ALP levels, even within the normal range, were associated with greater osteoporosis likelihood, particularly in younger, female, and metabolically healthy individuals.
 
 
 Researchers discover a surprising ally in the fight against insulin resistance and type 2 diabetes
 
Researchers discover a surprising ally in the fight against insulin resistance and type 2 diabetesAn international research team led by Professor Marc-Emmanuel Dumas at Imperial College London & CNRS together with Prof. Patrice Cani (Imperial & University of Louvain, UCLouvain), Dr. Dominique Gauguier (Imperial & INSERM, Paris) and Prof. Peter Liu (University of Ottawa Heart Institute) has uncovered a surprising ally in the fight against insulin resistance and type 2 diabetes: a microbial metabolite called trimethylamine (TMA).
 
 
 New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer
 
New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancerA new targeted alpha therapy is showing promise for patients whose thyroid cancer no longer responds to radioactive iodine, the standard beta-emitting treatment. In a first-in-human study, investigators found that a single dose of the alpha-emitting radionuclide 211At (astatine) was both well-tolerated and effective, achieving disease control without molecularly targeted drugs.
 
 
 Early exposure to fat-related food smells increases lifelong obesity risk
 
Early exposure to fat-related food smells increases lifelong obesity riskEarly exposure to fat-related food odors during development alters central sensory processing and metabolic regulation, independently of maternal obesity or nutrient intake. These sensory cues program long-term susceptibility to obesity, impaired thermogenesis, and altered brain responses to dietary fat in adulthood.
 
 
 Study links endocrine-disrupting chemicals to hidradenitis suppurativa
 
Study links endocrine-disrupting chemicals to hidradenitis suppurativaA Johns Hopkins Medicine study involving a dozen people with the inflammatory skin disease hidradenitis suppurativa (HS), which mostly affects skin folds, is believed to be the first to provide evidence that hormone-disrupting chemicals commonly found in ultra-processed food and single-use water bottles may contribute to the development of or worsen the condition in some people.
 
 
 Supportive marriages may shape appetite control through oxytocin and the brain–gut axis
 
Supportive marriages may shape appetite control through oxytocin and the brain–gut axisSupportive marital relationships are associated with lower BMI, fewer food addiction symptoms, higher oxytocin, stronger frontal brain responses to food cues, and favorable gut tryptophan metabolites. These coordinated social, neural, hormonal, and gut pathways suggest a plausible biological link between emotional support and healthier eating regulation.
 
 
 A personalized approach to treating pancreatic cancer
 
A personalized approach to treating pancreatic cancerIt's not surprising that pancreatic cancer is often referred to as a silent killer. With few early symptoms and an aggressive nature, it has one of the lowest survival rates of all cancers.
 
 
 Everyday PFAS exposure alters placental function in early pregnancy
 
Everyday PFAS exposure alters placental function in early pregnancyThis study measured real-life PFAS concentrations in first-trimester human placentas and used these data to create a pregnancy-relevant PFAS mixture. In 3D trophoblast spheroid models, the mixture altered invasion, hormone secretion, and gene expression without broadly reducing viability at environmentally relevant doses.
 
 
 Higher PFAS levels reduce blood sugar improvements after teen bariatric surgery
 
Higher PFAS levels reduce blood sugar improvements after teen bariatric surgeryA new USC study shows teens with higher blood levels of per- and polyfluoroalkyl substances (PFAS) measured before bariatric surgery had smaller improvements in blood sugar over five years, including fasting glucose and hemoglobin A1c (HbA1c), which measures average blood sugar levels over the past 60-90 days.
 
 
 Winter leaves traces in our DNA
 
Winter leaves traces in our DNASeasonal biology reveals how winter alters gene expression, hormones, and immune function, impacting health through circadian rhythms and environmental cues.
 
 
 Overweight boys hit puberty earlier than peers
 
Overweight boys hit puberty earlier than peersChildhood obesity accelerates puberty in boys, with heavier children showing earlier testicular enlargement and pubic hair development, study finds.
 
 
 Most Americans still back early hepatitis B vaccination despite policy debate
 
Most Americans still back early hepatitis B vaccination despite policy debateOn December 5, 2025, the Trump administration's Advisory Committee on Immunization Practices (ACIP), whose members were handpicked by Health and Human Services (HHS) Secretary and vaccination critic Robert F. Kennedy Jr., is scheduled to determine whether it should recommend that the Centers for Disease Control and Prevention (CDC) change the recommendation in place since 1991 that newborns be vaccinated against hepatitis B.
 
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