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    Event guide: The 5th ALS Drug Development SummitEvent guide: The 5th ALS Drug Development Summit
 
After a period of clinical recalibration, the ALS and FTD field is regaining momentum, driven by a deeper biological understanding, more refined translational strategies, and continued industry commitment.
 
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   Nearly 70 weeks after infection, long COVID patients show no detectable inflammation in blood testsNearly 70 weeks after infection, long COVID patients show no detectable inflammation in blood tests
 
A controlled Norwegian case-control study examined circulating biomarkers of inflammation and neuronal injury in people with long COVID about 69 weeks after infection. The researchers found no significant differences in systemic inflammatory or neuroinjury markers compared with recovered controls after statistical correction.
 
 Researchers propose that Parkinson’s disease may start in the gut, not the brain
 
Researchers propose that Parkinson’s disease may start in the gut, not the brainA perspective in The Journal of Clinical Investigation argues that environmental exposures may interact with the gut microbiome and intestinal barrier to trigger biological processes linked to Parkinson’s disease. The authors propose that cumulative environmental stressors can erode host resilience, promoting α-synuclein pathology, immune activation, and neurodegeneration.
 
 
 Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s
 
Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80sResearchers used single-nucleus RNA sequencing and chromatin accessibility profiling to map human hippocampal neurogenesis across adulthood, aging, and Alzheimer’s disease. They found that chromatin accessibility changes, more than gene expression alone, distinguish healthy aging, preclinical pathology, Alzheimer’s disease, and cognitive resilience in SuperAgers.
 
 
 Nature reduces stress by shifting brain activity
 
Nature reduces stress by shifting brain activityThis review examines how nature exposure impacts brain function, stress reduction, and emotional well-being, highlighting gaps and future research directions.
 
 
 Machine learning predicts who will decline faster in Alzheimer’s disease using routine clinic data
 
Machine learning predicts who will decline faster in Alzheimer’s disease using routine clinic dataResearchers developed and validated ElasticNet machine learning models that predict 12-month MMSE and BADL outcomes in Alzheimer’s disease and mild cognitive impairment using routinely collected clinical data. The cognitive model demonstrated external validation in ADNI, showing that individualized progression forecasting is feasible without biomarkers or neuroimaging.
 
 
 Why we keep craving food even when we are full
 
Why we keep craving food even when we are fullResearch shows food cues activate brain reward signals, leading to eating without hunger, shedding light on obesity and appetite regulation mechanisms.
 
 
 The surprising neurological benefits of GLP-1s
 
The surprising neurological benefits of GLP-1sFor people with chronic migraine, taking glucagon-like peptide-1 receptor agonists, or GLP-1 drugs, for other conditions such as diabetes and weight loss, was associated with fewer emergency department visits and hospitalizations overall, and with less need for medications used to stop and prevent migraine attacks, according to a preliminary study released March 1, 2026, that will be presented at the American Academy of Neurology's 78th Annual...
 
 
 Detecting major neurological disorders via saliva
 
Detecting major neurological disorders via salivaA team of Korean researchers has, for the first time in the world, developed a technology capable of enabling early diagnosis of major neurological disorders, including epilepsy, Parkinson's disease, and schizophrenia, using only a small amount of saliva.
 
 

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