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The latest neurology news from News Medical |
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 Advancing Parkinson’s disease and synucleinopathy research
Misfolding and aggregation of α-synuclein drive pathology in Parkinson’s disease and related synucleinopathies. Phosphorylation at Ser129 is strongly enriched in disease-linked inclusions, making total and pS129 α-synuclein valuable biomarkers.
Using ratio-based analysis can further improve disease differentiation, with ultra-sensitive methods enabling 100% quantifiability of even very low levels in healthy samples. Read the full paper to understand the data behind these findings.
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|  | | | | |  AHA calls for lifelong brain health strategy to prevent cognitive decline The AHA scientific statement calls for a life-course approach to brain health that integrates cognitive, emotional, behavioral, vascular, environmental, inflammatory, sleep, microbiome, and social factors. It highlights how early-life exposures, mental health, pollution, chronic inflammation, poor sleep, gut dysbiosis, and socioeconomic adversity may shape brain resilience and later-life cognitive decline. | |  | | | | |  Scientists uncover why brain damage continues after stroke Every stroke begins with a sudden interruption of blood flow in the brain. But what happens afterward—why neurons continue to lose function and die over the following days—has remained one of the most important unanswered questions in neuroscience. | |
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| | | |  Brain health isn't determined only by genetics or what happens later in life. A growing body of research shows that a range of factors-from mental health and sleep to environment, lifestyle and social conditions-play a powerful role in shaping how the brain functions and ages. | | | | |  Glioblastoma remains a highly challenging malignancy with a pronounced tendency for recurrence. The hypoxic microenvironment is a key contributor to its therapy resistance. | | | | |  Electrical stimulation of vagus nerve via implantable stimulators can effectively suppress inflammatory responses, offering a novel strategy for treating autoimmune diseases. | | | | |  In neurological intensive care, it is quickly learned that the brain cannot wait. As the most sensitive organ in the human body, it can sustain irreversible damage after just a few minutes of severe hypoxia. | |
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