Aspirin lowers diabetes risk during COVID-19, but not without side effects
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 UNIGE scientists uncover two key proteins that regulate chromatin remodellingUNIGE scientists uncover two key proteins that regulate chromatin remodelling
 
Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, determines which genetic instructions are activated.
 
 
 Aspirin lowers diabetes risk during COVID-19, but not without side effectsAspirin lowers diabetes risk during COVID-19, but not without side effects
 
A large real-world Italian cohort study found that daily low-dose aspirin use significantly lowered the risk of developing type 2 diabetes, especially during the COVID-19 pandemic. The protective effect appears linked to aspirin’s anti-inflammatory properties, though bleeding risks require caution.
 
   Herpes virus reshapes the human genome's architecture to aid its replicationHerpes virus reshapes the human genome's architecture to aid its replication
 
Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the host's cellular machinery to make new copies of themselves.
 
   Breakthrough study reveals killing power of CD4 T cells against cancerBreakthrough study reveals killing power of CD4 T cells against cancer
 
In the fight against cancer, immunotherapy - which aims to boost the body's natural defences against cancer - is experiencing remarkable growth. Most of these treatments are based on CD8 T lymphocytes, ''killer cells'' able to eliminate diseased cells.
 
   Methylene blue emerges as an adjunct in septic shockMethylene blue emerges as an adjunct in septic shock
 
Recent evidence suggests methylene blue may help reduce vasopressor needs and ICU stays in septic shock, but current data do not support replacing standard therapies. Further research is needed to clarify its optimal dosing, timing, and patient selection for best outcomes.
 
 BMJ investigation raises new concerns over ticagrelor approval trials
 
BMJ investigation raises new concerns over ticagrelor approval trialsIn a follow up investigation into the multibillion dollar drug ticagrelor, The BMJ has uncovered fresh concerns, this time in key platelet studies used in its FDA approval.
 
 
 Endometriosis linked to higher odds of autoimmune conditions
 
Endometriosis linked to higher odds of autoimmune conditionsNew research links endometriosis to autoimmune diseases, revealing shared mechanisms that may lead to earlier diagnosis and targeted treatments for patients.
 
 
 Discovery of a genetic dimmer switch controlling embryonic development
 
Discovery of a genetic dimmer switch controlling embryonic developmentA team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development.
 
 
 Embryos from women with PCOS carry distinctive epigenetic memory
 
Embryos from women with PCOS carry distinctive epigenetic memoryNovel research presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) has found that embryos from women with polycystic ovary syndrome (PCOS) carry a distinctive 'epigenetic memory' that could explain why the condition often runs in families.
 
 
 Appendix Cancer on the Rise: Implications for Diagnosis and Patient Care
 
Appendix Cancer on the Rise: Implications for Diagnosis and Patient CareAppendix cancer is a rare but increasingly recognized malignancy, often discovered incidentally during surgery for presumed appendicitis. Advances in imaging, molecular profiling, and classification have improved diagnosis, management, and spurred ongoing research into targeted therapies.
 
 
 Next generation CAR-T cells push the boundaries of lymphoma treatment
 
CAR-T cells, which are genetically programmed to specifically recognize and kill target cells, have altered the therapeutic landscape of lymphoma.
 
 
 Researchers turn a deadly fungus into potent cancer-fighting compound
 
Researchers turn a deadly fungus into potent cancer-fighting compoundPenn-led researchers have turned a deadly fungus into a potent cancer-fighting compound. After isolating a new class of molecules from Aspergillus flavus, a toxic crop fungus linked to deaths in the excavations of ancient tombs, the researchers modified the chemicals and tested them against leukemia cells.
 
 
 Blood test can reveal early signs of leukemia without bone marrow sampling
 
Blood test can reveal early signs of leukemia without bone marrow samplingWhat if a blood test could reveal the pace of our aging – and the diseases that may lie ahead? The labs of Profs. Liran Shlush and Amos Tanay at the Weizmann Institute of Science have been conducting in-depth studies into the biology of blood to better understand the aging process and why some people become more susceptible to disease over the years.
 
 
 Single-cell transcriptomes of immune cells offer insight into juvenile idiopathic arthritis
 
Single-cell transcriptomes of immune cells offer insight into juvenile idiopathic arthritisJuvenile idiopathic arthritis (JIA), a type of arthritis commonly occurring in children, is a chronic, inflammatory condition that affects the joints, causing pain, swelling, stiffness, and limiting the range of motion.
 
 
 Targeted nanoparticles enable in vivo production of CAR T cells for cancer therapy
 
Targeted nanoparticles enable in vivo production of CAR T cells for cancer therapyResearchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells.
 
 
 Fusion genes found to be pivotal players in cancer development
 
Fusion genes found to be pivotal players in cancer developmentFusion genes, arising from abnormal chromosomal rearrangements, are gaining recognition as pivotal players in cancer development. These genetic alterations result in the creation of hybrid genes with altered functions, often driving tumor progression.
 
 
 Excess trace metal levels may trigger gestational diabetes
 
Excess trace metal levels may trigger gestational diabetesExcess micronutrients in early pregnancy may raise gestational diabetes risks. Study links essential metal levels to GDM onset, urging a rethink on supplements.
 
 
 New technology tracks solid tumor treatment response through blood samples
 
New technology tracks solid tumor treatment response through blood samplesAltum Sequencing, a start-up supported by the C3N-IA Science Park at Universidad Carlos III de Madrid (UC3M) and specialized in oncology, has developed a tool to monitor treatment response in patients with solid tumors from a simple blood sample.
 
 
 Scientists identify novel combination therapy approach to treat pediatric acute myeloid leukemia
 
Scientists identify novel combination therapy approach to treat pediatric acute myeloid leukemiaScientists at St. Jude Children's Research Hospital and Dana-Farber Cancer Institute today report the identification of a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML).
 
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