Genetic marker links popular seizure drug to life-threatening reaction
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 New study reveals euchromatin forms dynamic condensed domains in cellsNew study reveals euchromatin forms dynamic condensed domains in cells
 
The human genome is about two meters long, yet it is folded inside a cell nucleus only about 10 micrometers in diameter.
 
 
 Genetic marker links popular seizure drug to life-threatening reactionGenetic marker links popular seizure drug to life-threatening reaction
 
A genetic marker already used to flag risk of a life-threatening reaction to the antibiotic vancomycin also identifies patients at risk of that reaction to lamotrigine - and it is missing from the gene panels clinicians order before prescribing the drug, Vanderbilt Health-led researchers report Sept. 2 in JAMA Network Open.
 
   New mechanism explains how red blood Cell breakdown drives inflammationNew mechanism explains how red blood Cell breakdown drives inflammation
 
When red blood cells break down, they release heme, a component of hemoglobin, that can contribute to inflammation and damage tissues and blood vessels.
 
   Computational chemistry breakthrough yields targeted molecule for acute myeloid leukemia treatmentComputational chemistry breakthrough yields targeted molecule for acute myeloid leukemia treatment
 
Pushing the accelerator and the brake at the same time is rarely a good idea. But researchers at the University of Gothenburg are using this approach to treat leukemia.
 
 FDA clears trial of dual-targeted CAR T-cell therapy for cancer
 
The U.S. Food and Drug Administration this week granted permission for investigators at the University of Colorado Anschutz to conduct a clinical trial testing genetically engineered immune cells in adults with advanced colorectal cancer and pediatric patients with solid cancers who have exhausted standard treatment options.
 
 
 Alcohol-linked cancer deaths doubled over three decades in America
 
Alcohol-attributable cancer deaths in the U.S. doubled between 1990 and 2023, a new study found. The study also revealed that alcohol-linked cancer deaths are not limited to older adults or liver cancer.
 
 
 Patients' responses to oncologists can help predict survival in chronic lymphocytic leukemia
 
Patients' responses to questions routinely raised by oncologists may provide important clues about their chances of survival from chronic lymphocytic leukemia (CLL), according to a new study published in the journal Therapeutic Advances in Hematology.
 
 
 New drug forces aggressive leukemia cells to die from stress
 
Pushing the accelerator and the brake at the same time is rarely a good idea. But researchers at the University of Gothenburg are using this approach to treat leukemia.
 
 
 High-dose folic acid appears safe from formaldehyde toxicity
 
Folic acid – an essential vitamin added to flour and cereals and prescribed at high doses for cancer patients and people with blood disorders – does not elevate toxic formaldehyde in the body, according to a new Cornell University study on mice and human cancer patients who consumed high doses.
 
 
 Cellular atlas offers clues to childhood Crohn’s treatment response
 
Researchers have created a detailed map of childhood Crohn's disease before and after treatment to help understand progression of the disease.
 
 
 Giving immunotherapy before surgery boosts brain tumor treatment success
 
A team from UNIGE and HUG has shown that administering cell immunotherapy before surgery to remove a brain tumor is significantly more effective than administering it afterwards.
 
 
 McMaster researchers discover molecular switch causing dangerous blood clots
 
A cross-campus team of McMaster University researchers has identified why some patients develop dangerous blood clots after exposure to a common blood thinner – and a potential way to prevent it.
 
 
 Newly diagnosed AML patients benefit from less-intensive combination treatment
 
Investigators from the Mass General Brigham Cancer Institute have found that adults with newly diagnosed acute myeloid leukemia (AML) receiving a less-intensive combination of azacitidine and venetoclax had more than twice as much time before treatment failed, the leukemia returned or worsened, or they died, compared with patients receiving intensive chemotherapy.
 
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