AHA calls for lifelong brain health strategy to prevent cognitive decline

	Cardiology
	The latest cardiology news from News Medical

	AHA calls for lifelong brain health strategy to prevent cognitive decline The AHA scientific statement calls for a life-course approach to brain health that integrates cognitive, emotional, behavioral, vascular, environmental, inflammatory, sleep, microbiome, and social factors. It highlights how early-life exposures, mental health, pollution, chronic inflammation, poor sleep, gut dysbiosis, and socioeconomic adversity may shape brain resilience and later-life cognitive decline.

	GLP-1 drugs promise wider health benefits, but experts urge caution on use GLP-1 receptor agonists are reshaping care for type 2 diabetes, obesity, chronic kidney disease, and obstructive sleep apnea, with evidence for glycemic, weight-loss, cardiovascular, and renal benefits. The review urges nurse practitioners to balance expanding clinical promise with careful prescribing, patient education, monitoring, access advocacy, and vigilance for gastrointestinal, endocrine, pregnancy-related, and rare serious risks.

			Twice-yearly blood pressure treatment could reshape hypertension care, but doctors warn against a “fire-and-forget” approach Long-acting RNA interference therapy for hypertension could shift blood pressure control from daily pill-taking to scheduled, system-led protection. But the authors warn that this “vaccine-like” model must preserve lifestyle support, monitoring, and follow-up to avoid clinical disengagement.

			Brief walking breaks help the body control sugar after carb-rich meals Brief brisk walking breaks during prolonged sitting improved post-meal interstitial glucose responses in healthy adults after carbohydrate-rich meals, with the strongest effects seen in women. Gluteal fat showed a more stable glucose pattern than abdominal fat, suggesting it may help buffer carbohydrate-related glucose rises through depot-specific uptake and lipid-synthesis pathways.

			New genetic risk report reveals hidden heart disease risk before symptoms appear Researchers developed and externally validated integrated polygenic risk scores for eight cardiovascular conditions using large U.S.-based biobank data. The clinically orderable report may help identify inherited cardiovascular risk that traditional clinical markers can miss, although broader prospective validation is still needed.

	Yoga to help manage obesity-related heart and metabolic risks The impact of yoga on heart health in obesity is modest, suggesting it as a complementary approach for improving metabolic outcomes in high BMI populations.

	AI eye screening shows promise for detecting six metabolic diseases Researchers developed Reti-Pioneer, an AI retinal imaging framework that screened for six endocrine and metabolic diseases using color fundus photographs and clinical metadata. The system showed moderate-to-strong performance across cohorts, improved specialist decision-making, and demonstrated promising, though still preliminary, potential for faster, scalable disease screening.

	Lipid pathways driving diabetes and heart disease risk in South Asians Identifying lipid-linked genetic pathways in Asian Indians offers insights into diabetes and heart disease, crucial for developing ancestry-specific therapies.

	M-TEER procedure effectively treats mitral regurgitation in patients with calcification Results from a new analysis show that patients with mitral annular calcification (MAC) who undergo minimally invasive mitral transcatheter edge-to-edge repair (M-TEER) experience similar reductions in mitral regurgitation (MR) and improvement in quality of life compared to those seen in patients without calcification.

	Preliminary model developed to improve cardiovascular risk prediction in Latin America and the Caribbean A preliminary model to improve the prediction of cardiovascular risk in Latin America and the Caribbean was presented today at ESC Preventive Cardiology 2026, the annual congress of the European Association of Preventive Cardiology (EAPC), a branch of the European Society of Cardiology (ESC).

	New genetic risk test estimates inherited risk for cardiovascular conditions Researchers at Mass General Brigham Heart and Vascular Institute and collaborators have developed and validated a new genetic risk test that can estimate a person's inherited risk for eight common cardiovascular conditions, offering a more comprehensive approach to prevention.

	Heatwaves and coldwaves linked to increase in major cardiovascular events Heatwaves and coldwaves are associated with increases in major cardiovascular events that are exacerbated by air pollution.

	Elite footballers show ancestry-related differences in cardiovascular evaluation Elite footballers of Black ethnicity show important ancestry-related differences in cardiac adaptation.

	Genetic research identifies rare DNA changes causing common heart valve defect New clues from genetic research may help explain what causes the most common heart defect present at birth.

	Email alerts boost valve replacement rates in older patients with aortic stenosis New data finds older patients with severe aortic stenosis (AS) were more likely to receive aortic valve replacement (AVR) and survive when clinicians received automated email notifications with abnormal heart ultrasound results detecting AS.

	Losing weight improves heart muscle contraction in people with obesity and heart failure In a new research report, a team of scientists led by Johns Hopkins Medicine say people with severe obesity and a common type of heart failure experience weakened heart muscles, and that losing weight may reverse some of these effects.

	Elevated Lp(a) levels associated with residual cardiovascular risk New data analyzing more than 20,000 patients from three major NIH studies show that elevated Lipoprotein(a) [Lp(a)] is associated with residual cardiovascular risk and warrants aggressive risk reduction.

	COVID-19 patients with STEMI show higher one-year mortality rates Findings from the North American COVID-19 Myocardial Infarction (NACMI) registry demonstrate significantly higher one-year mortality rates in patients with COVID-19 and ST-elevation myocardial infarction (STEMI) compared to patients with STEMI alone.

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