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The latest cardiology news from News Medical |
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 | | |  A common dietary nutrient feeds a gut pathway linked to atrial fibrillation Researchers linked higher plasma TMAO to prevalent atrial fibrillation in 5,090 people and found that TMAO or choline supplementation accelerated AF onset, progression, atrial remodeling, and electrical dysfunction in mice. Inhibiting gut microbial TMA production lowered circulating TMAO and delayed AF in mice, identifying a potential therapeutic pathway that now requires human testing. | | | | |  Review finds blueberry and grape polyphenols may improve vascular health A review of 37 publications found that grape- and blueberry-derived polyphenols were associated with modest improvements in cardiovascular risk markers, particularly endothelial function. However, most studies were small or short-term, frequently tested concentrated products, and measured biomarkers rather than cardiovascular events. | |
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| | | | |  The findings have direct implications for clinical practice and future research. For genetic screening, the study provides a clear priority: CHD7 for outflow‑tract defects, CHD4 for chamber‑patterning anomalies, and CHD8 for ventricular dysfunction. | | | | |  Researchers analyzing claims from more than 10.1 million commercial insurance and Medicare Advantage enrollees found that semaglutide use was associated with a 49% lower adjusted hazard of COVID-19-related death. The observational findings corroborate earlier SELECT trial results but do not establish causation, making further prospective research essential. | | | | |  Scientists have found that the 'sudden' cardiac death condition related to high profile deaths or major medical episodes of sports stars including Fabrice Muamba, Christian Erikson and Mark-Vivian Foe has numerous linked gene variations, or "spelling mistakes", which highlights a potentially treatable vulnerability. | | | | |  The American College of Cardiology (ACC) is introducing a new cardiogenic shock designation to improve outcomes for one of the most life-threatening complications of a heart attack. | | | | |  In animal models, the flexible implant captured local metabolic warning signs before selected systemic measurements and used them to guide earlier resuscitation. | | | | |  Congenital heart disease is the most common birth defect, affecting approximately 1 in 100 babies born each year. One of the many causes for this disorder is having only one functional copy of the gene TBX5, instead of two healthy copies, inherited from parents. | | | | |  Heart failure already affects more than 60 million people worldwide and is one of the leading causes of hospitalization among people over the age of 65. | | | | |  Researchers developed a microneedle electrochemiluminescence device that measured cardiac troponins in interstitial fluid at 30-minute intervals and detected cTnI down to 21.3 fg/mL in artificial interstitial fluid. In 15 rats and 1 pig, researchers recorded biomarker trends broadly consistent with serum ELISA results, although the wired, single-target prototype has not been tested in humans. | | | | |  Researchers developed an AI-assisted dual-mode paper assay that measures cTnI, CK-MB, and NT-proBNP from 50 µL of serum in 23 minutes. In single-site analytical validation, neural networks quantified the three biomarkers across distinct concentration ranges, supporting further development for multiplexed cardiac testing at the point of care. | |
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