A comprehensive Lancet review synthesizes evidence from major clinical trials showing that GLP-1 receptor agonists and next-generation incretin therapies deliver substantial weight loss while reducing cardiovascular and kidney risks. Emerging dual, triple, and oral agents may further expand treatment options and improve outcomes across obesity, type 2 diabetes, and related metabolic diseases.
This article explores the intersection between drinking and nutrition to reveal how alcohol-induced malnutrition can perpetuate a cycle of craving and relapse.
Researchers analyzed gut microbiome profiles from 4,792 adults in the HELIUS cohort and tracked cardiometabolic outcomes over time to determine whether specific microbes predict disease risk. Certain microbes were linked to higher or lower cardiovascular risk, while plant-derived microbial metabolites suggested potential diet–microbiome interactions influencing heart health.
A global analysis of physical activity data from 68 countries shows large socioeconomic and gender inequalities in access to choice-based exercise, particularly active leisure. The study also synthesizes evidence linking physical activity to lower risks of severe infectious disease, depression, and cancer mortality, and proposes a new “physical activity for health and wellbeing” public health framework.
The link between childhood oral health and adult heart disease underscores the need for preventive dental care to enhance lifelong cardiovascular health.
The prevalence of congenital heart disease points to the need for a better understanding of how it influences neurodevelopment. New in JNeurosci, Jung-Hoon Kim and Catherine Limperopoulos, from Children's National Hospital, led a study examining brain network disruptions that may be linked to congenital heart disease.
Washington State University researchers have developed a 3D-printed model of the left side of the heart that contracts and beats, offering the chance for surgeons and medical students to rehearse important heart surgeries on a model that acts like the real thing.
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