One-time gene editing cuts LDL cholesterol in early hypercholesterolemia trial
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 How do everyday spices help protect the heart?How do everyday spices help protect the heart?
 
A Nutrition Reviews supplement article reviewed controlled studies showing that culinary spice and herb blends may improve selected cardiometabolic risk markers, including post-meal triglycerides, insulin responses, inflammation, endothelial function, and 24-hour blood pressure.
 
 
 One-time gene editing cuts LDL cholesterol in early hypercholesterolemia trialOne-time gene editing cuts LDL cholesterol in early hypercholesterolemia trial
 
A phase 1 NEJM interim analysis found that a single infusion of the investigational base-editing therapy VERVE-102 produced dose-dependent reductions in circulating PCSK9 protein and LDL cholesterol in adults with heterozygous familial hypercholesterolemia or premature coronary artery disease.
 
   Indian adapted Mediterranean diet targets inflammation in heart disease trialIndian adapted Mediterranean diet targets inflammation in heart disease trial
 
The paper describes a single-center randomized controlled trial testing whether an Indian Adapted Mediterranean Diet can reduce dietary inflammation in adults with stable coronary artery disease or moderate-to-high cardiovascular risk. The protocol will assess changes in the Dietary Inflammatory Index, inflammatory biomarkers, cardiometabolic risk factors, body measurements, and metabolic hormones over six months.
 
   Scientists rethink GLP-1 delivery to improve dosing, tolerability, and adherenceScientists rethink GLP-1 delivery to improve dosing, tolerability, and adherence
 
The review highlights nanocarriers, microspheres, hydrogels, microneedles, long-acting formulations, and co-formulations as promising but mostly early-stage strategies that still require stronger long-term clinical evidence.
 
   Why blood pressure rises faster in women after midlifeWhy blood pressure rises faster in women after midlife
 
This review examines how sex-specific blood pressure trajectories are shaped by genetics, hormones, metabolic risk factors, lifestyle exposures, environmental stressors, and medical treatments. It highlights that women generally have lower blood pressure earlier in life but may experience steeper increases with aging, especially around and after menopause, with exogenous stressors appearing to have a greater impact in women than in men.
 
 RNA therapy targets genetic cause of heart failure in the Netherlands
 
RNA therapy targets genetic cause of heart failure in the NetherlandsUsing patient-derived cardiac tissue and stem cell-based models, the team of translational researchers demonstrated that targeting the genetic cause of disease improved cellular abnormalities and identified the biological pathways involved.
 
 
 Experts urge specialized heart centers for women across European healthcare
 
Experts urge specialized heart centers for women across European healthcareWomen are more likely to face delays in diagnosis of cardiovascular disease and, as a result, they are more likely to die or develop more serious illness. To address this in inequality, Europe needs dedicated women's heart centers, according to a report published in the European Heart Journal today (Tuesday).
 
 
 AI model tracks child maturity patterns through routine ECG data
 
AI model tracks child maturity patterns through routine ECG dataA new study from Wake Forest University School of Medicine suggests a routine heart test – an electrocardiogram (ECG) – may offer researchers a new way to measure biological development in children and adolescents.
 
 
 Study reveals right ventricle better tolerates oxygen loss during cardiac arrest
 
Study reveals right ventricle better tolerates oxygen loss during cardiac arrestA study led by scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) provides new insights into ventricular fibrillation (VF), the most dangerous type of cardiac arrhythmia.
 
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