Microneedle patches turn skin into a window for immune bioanalysis

	Dermatology
	The latest dermatology news from News Medical

	Microneedle patches turn skin into a window for immune bioanalysis Researchers combined local restimulation of skin-resident memory T cells with hydrogel-coated microneedle patches to recruit and sample rare immune cells. In mouse models, the approach recovered more antigen-specific T cells than a blood sample or punch biopsy, while studies in humans supported short-term tolerability and proof-of-concept cell sampling.

	Study of lung immune cells uncovers roots of autoimmune disease A massive analysis of immune cells in human tissue is yielding clues to the root cause of lung and autoimmune diseases.

			Newly-discovered protein acts as off switch for human immune cells Mayo Clinic researchers have identified a protein that cancer cells use to shut down the body's immune response, a discovery that could help scientists develop new treatments that make cancer immunotherapies more effective.

			Daily social connections may improve long-term health and cognition Calling a friend after a long day. Showing up to a neighbor's dinner when you'd rather stay home. Lingering a little longer in a conversation that didn't need to last.

			Common allergy medications offer no real relief for eczema patients It's typical for someone looking for relief from dry, itchy, red and irritated skin – also known as eczema or atopic dermatitis – to turn to common allergy medications called antihistamines.

	National scabies control program drastically reduces parasitic skin disease in Pacific nations A world-first scabies control program has drastically reduced cases of the highly contagious parasitic skin disease in Solomon Islands and Fiji, according to a new study.

	Multi-omics profiling of autoimmune diseases Machine learning and multi-omics integration help identify predictive biomarker signatures and reveal disease-specific molecular mechanisms.

	Study reveals steep financial burden of New Mexico measles outbreak A cost analysis of the 2025 measles outbreak in New Mexico found that the outbreak carried an estimated societal cost of $5.4 million, or more than $53,000 per case.

	Study questions antihistamine use for managing eczema symptoms Adding oral antihistamines to existing eczema treatments is unlikely to lead to clinically important reductions in eczema and itch severity, and may not reduce sleep disturbance or flare-ups, finds a review of the latest trial evidence published by The BMJ today.

	Wearable microneedle sensor enables in vivo bioanalysis of cardiac biomarkers Researchers developed a microneedle electrochemiluminescence device that measured cardiac troponins in interstitial fluid at 30-minute intervals and detected cTnI down to 21.3 fg/mL in artificial interstitial fluid. In 15 rats and 1 pig, researchers recorded biomarker trends broadly consistent with serum ELISA results, although the wired, single-target prototype has not been tested in humans.

	New stem cell vesicles accelerate diabetic wound healing Diabetic foot ulcers are among the most serious complications of diabetes because prolonged inflammation, poor circulation, and defective angiogenesis can leave wounds open for months and increase the risk of infection and amputation.

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