Weekend lie-ins may boost insulin sensitivity, but too much may backfire
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 Most weight lost on GLP-1 drugs returns within a year after stoppingMost weight lost on GLP-1 drugs returns within a year after stopping
 
The cessation of GLP-1RAs is linked to a 60% weight regain within a year, emphasizing the importance of tailored strategies for effective long-term weight loss.
 
 
 Weekend lie-ins may boost insulin sensitivity, but too much may backfireWeekend lie-ins may boost insulin sensitivity, but too much may backfire
 
This study explores the relationship between sleep patterns and insulin sensitivity, emphasizing the impact of weekday sleep and weekend catch-up on metabolism.
 
   Could GLP-1 drugs help curb addiction? Large veteran study points to potential benefitCould GLP-1 drugs help curb addiction? Large veteran study points to potential benefit
 
A large cohort study of more than 600,000 US veterans with type 2 diabetes found that initiating GLP-1 receptor agonists was associated with lower risks of developing substance use disorders compared with SGLT-2 inhibitors. Among veterans with existing substance use disorders, GLP-1 receptor agonist use was also linked to fewer overdose events, hospitalizations, and suicide-related outcomes.
 
   How the placenta predicts lifelong health and disease riskHow the placenta predicts lifelong health and disease risk
 
Scientists are uncovering how the placenta, long viewed as a temporary pregnancy organ, acts as a powerful biological predictor of lifelong health, linking prenatal environments to future risks of cardiovascular and metabolic disease.
 
   Alcohol intake linked to lower micronutrient intake in men with type 2 diabetesAlcohol intake linked to lower micronutrient intake in men with type 2 diabetes
 
Researchers analyzed 1,565 Japanese outpatients with type 2 diabetes and found that higher alcohol consumption was associated with lower intake of several micronutrients, particularly potassium, calcium, and vitamins A and C, in younger men. The study also linked alcohol intake to a savory dietary pattern rich in rice, meat, fish, and seasonings, highlighting age- and sex-specific nutritional risks.
 
 Berries, apples, and citrus linked to greater happiness and optimism
 
Berries, apples, and citrus linked to greater happiness and optimismA study links flavonoid-rich diets to sustained happiness and optimism, highlighting the bidirectional relationship between diet and psychological well-being.
 
 
 GLP-1 drugs may be effective at treating and preventing substance use disorders
 
GLP-1 drugs may be effective at treating and preventing substance use disordersResearchers at Washington University School of Medicine in St. Louis show in a new study that GLP-1 medications may be effective at treating and preventing substance use disorders across all major addictive substances studied, suggesting these drugs target a common biological pathway underlying addiction.
 
 
 Why we keep craving food even when we are full
 
Why we keep craving food even when we are fullResearch shows food cues activate brain reward signals, leading to eating without hunger, shedding light on obesity and appetite regulation mechanisms.
 
 
 Mapping the year-one weight trajectory after stopping GLP-1s
 
Mapping the year-one weight trajectory after stopping GLP-1sA year after stopping taking weight loss drugs such as Ozempic and Wegovy, people regain, on average, 60% of their lost weight – but beyond this, their weight regain plateaus, with individuals managing to keep off 25% of the weight lost to treatment, say researchers at the University of Cambridge.
 
 
 Specific gut bacteria may signal long-term risk of heart and metabolic disease
 
Specific gut bacteria may signal long-term risk of heart and metabolic diseaseResearchers analyzed gut microbiome profiles from 4,792 adults in the HELIUS cohort and tracked cardiometabolic outcomes over time to determine whether specific microbes predict disease risk. Certain microbes were linked to higher or lower cardiovascular risk, while plant-derived microbial metabolites suggested potential diet–microbiome interactions influencing heart health.
 
 
 How diet influences gene expression through epigenetic mechanisms
 
How diet influences gene expression through epigenetic mechanismsThis article explains how diet creates sustained epigenetic changes that affect long-term health, disease risk, aging, and future environmental responses.
 
 
 Women face higher liver fibrosis risk from cardiometabolic factors than men
 
Women face higher liver fibrosis risk from cardiometabolic factors than menWomen with certain cardiometabolic risk factors, including type 2 diabetes and high waist circumference, face a greater increase in risk for liver fibrosis than men with the same risk factors.
 
 
 Postbiotics may help treat PCOS by restoring microbiome balance
 
Postbiotics may help treat PCOS by restoring microbiome balanceEmerging studies suggest postbiotics could aid PCOS management by restoring gut microbiome balance and enhancing insulin sensitivity and hormonal regulation.
 
 
 Study identifies the hidden challenges of women with gestational diabetes
 
Study identifies the hidden challenges of women with gestational diabetesA study from University of Limerick in Ireland has identified the hidden challenges of women living with and managing Gestational Diabetes Mellitus (GDM).
 
 
 Engineered lettuce may turn injectable GLP-1 therapies into oral pills
 
Few drugs have entered mainstream awareness as quickly or as dramatically as glucagon-like peptide-1, or GLP-1 receptor agonists. Initially approved by the FDA for the treatment of type 2 diabetes, they have since also transformed the therapeutic landscape of obesity and weight management.
 
 
 BCAT2 enzyme identified as a target for diabetic foot recovery
 
Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification is one of the key pathological mechanisms. Calcification in atherosclerotic plaque can cause stiffness and decreased compliance of the vascular wall, and induce atherosclerotic plaque rupture, which increases the risk of acute cardiovascular events.
 
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