GLP-1 drugs may help curb addiction by targeting reward pathways
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 New therapies could help type 1 diabetes care move beyond insulin aloneNew therapies could help type 1 diabetes care move beyond insulin alone
 
Disease-modifying therapies for type 1 diabetes are beginning to move care beyond insulin replacement by targeting immune dysregulation, beta-cell stress, and preservation of endogenous beta-cell function. Teplizumab marks a major clinical milestone, but the review emphasizes that durable metabolic remission will likely require earlier screening, better patient selection, and sequential or combination therapies.
 
 
 GLP-1 drugs may help curb addiction by targeting reward pathwaysGLP-1 drugs may help curb addiction by targeting reward pathways
 
GLP-1 receptor agonists, already used for Type 2 diabetes and obesity, show promise in reducing alcohol and drug-seeking behaviors through central reward and dopamine-related pathways. Most evidence remains preclinical, with limited early human data, so larger clinical trials are needed before these drugs can be recommended for addiction treatment.
 
   Researchers use living human cells on a chip to study memory lossResearchers use living human cells on a chip to study memory loss
 
A University of Bath-led project has secured £500,000 to develop a first-of-its-kind 'organ-on-chip' device that replicates connections between the brain, gut and pancreas.
 
   HonorHealth Research Institute tests steam therapy for diabetes treatmentHonorHealth Research Institute tests steam therapy for diabetes treatment
 
HonorHealth Research Institute is looking to become the first research facility in the nation to begin a new clinical trial that aims to modify the lining of the digestive tract with the use of steam energy to control type II diabetes without the use of drugs.
 
   New AI framework maps systemic obesity damage at cellular resolutionNew AI framework maps systemic obesity damage at cellular resolution
 
Researchers at Helmholtz Munich, the Ludwig Maximilians University Munich (LMU) and collaborating institutions have developed an artificial intelligence (AI) framework that maps disease-related changes throughout the entire mouse body at cellular resolution.
 
 Oral AD109 improves sleep apnea severity but tolerability remains a challenge
 
Oral AD109 improves sleep apnea severity but tolerability remains a challengeAD109, an investigational once-daily oral combination of aroxybutynin and atomoxetine, significantly improved airway obstruction and oxygenation in adults with mild-to-severe obstructive sleep apnea who could not use PAP therapy. However, symptom improvements did not clearly differ from placebo, and about one in five AD109 recipients discontinued treatment due to adverse events.
 
 
 Innovative glucose-responsive platform targets diabetes care and food waste reduction
 
Innovative glucose-responsive platform targets diabetes care and food waste reductionKingston University London is celebrating a major milestone towards commercialization of its innovative diabetes and food management platform after a research team in the Department of Pharmacy was recommended by Innovate UK to work towards setting up a spin-out company.
 
 
 Higher marine microplastics may signal greater stroke and chronic disease burden in coastal communities
 
Higher marine microplastics may signal greater stroke and chronic disease burden in coastal communitiesA new U.S. coastal analysis links higher marine microplastic concentrations with increased chronic disease prevalence, raising new questions about how environmental pollution may intersect with cardiovascular and metabolic health. Study: Marine microplastic concentration and associations with stroke and chronic disease prevalence.
 
 
 Blood carotenoids offer the clearest signal of fruit and vegetable eating habits
 
Blood carotenoids offer the clearest signal of fruit and vegetable eating habitsThe review finds that several candidate biomarkers may help estimate fruit and vegetable intake more objectively than self-reported dietary tools, but most remain limited by specificity, sampling burden, supplement use, or incomplete validation.
 
 
 Research show worsening health trends for post-1946 generations
 
Research show worsening health trends for post-1946 generationsYounger generations appear to be experiencing poorer health earlier in life than previous generations, according to a review of studies comparing national birth cohort datasets involving tens of thousands of people across the UK born since 1946.
 
 
 Study supports routine childhood screening for type 1 diabetes
 
Study supports routine childhood screening for type 1 diabetesFor ten years, the Fr1da study, coordinated by Helmholtz Munich, has been investigating whether early stages of type 1 diabetes in children can be detected in routine pediatric care.
 
 
 Elevated blood glucose during pregnancy signals a significantly higher future diabetic risk
 
Elevated blood glucose during pregnancy signals a significantly higher future diabetic riskGestational diabetes is a strong risk factor for future type 2 diabetes, even in women with normal pre-pregnancy weight, according to a study at the University of Gothenburg. The researchers call for earlier testing and better follow-up.
 
 
 Diverse AI foundation models transform universal eye care imaging
 
Diverse AI foundation models transform universal eye care imagingArtificial intelligence (AI) has already changed many aspects of medical imaging, but traditional ophthalmic AI systems are often built for a single disease, dataset, or task.
 
 
 Pregnancy-related disorders may shape offspring heart health into adulthood
 
Pregnancy-related disorders may shape offspring heart health into adulthoodHypertensive disorders in pregnancy may lead to lasting cardiovascular issues in offspring, highlighting the need for improved maternal health strategies.
 
 
 Sleep disturbances during pregnancy may be a risk factor for gestational diabetes
 
Sleep disturbances during pregnancy may be a risk factor for gestational diabetesA recent study by Kuopio University Hospital and the University of Eastern Finland shows that sleep disturbances during pregnancy may be a significant risk factor for gestational diabetes mellitus (GDM).
 
 
 AI-created miniproteins show promise for targeting hard-to-treat diseases
 
G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our bodies - from the ability to see and smell, to sensing of adrenaline, insulin, nutrients and medicines.
 
 
 Researchers discover unexpected cellular triggers for precancerous pancreas lesions
 
In an unexpected finding, a new study flips on its head researchers' understanding of how precancerous pancreas lesions evolve into pancreatic cancer.
 
 
 Women may face greater cognitive impact from dementia risk factors
 
Researchers from the University of California San Diego School of Medicine found that women not only experience a higher burden of certain modifiable dementia risk factors, but also appear more vulnerable to their effects on cognitive function.
 
 
 Real-time narration, head safety, and biometrics with wearables
 
Wearables can bridge the communication gap between the body and a computer. They can serve various purposes, from displaying real-time narration from actual speech, to generating readable, measurable signals translated directly from the body and understood within the medical space.
 
 
 Researchers uncover new genetic links influencing blood lipid composition
 
DZNE researchers have generated new insights into how the human genome shapes the chemical composition and concentration of blood lipids.
 
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