New skin-permeable polymer delivers insulin without needles

	Diabetes
	The latest diabetes news from News Medical

	New skin-permeable polymer delivers insulin without needles Innovative zwitterionic polymer facilitates insulin absorption through the skin, offering a painless alternative to injections for diabetes management.

	Metformin fails to improve insulin resistance in type 1 diabetes Metformin treatment in type 1 diabetes lowers insulin dosage but does not improve insulin resistance, highlighting its complex role in diabetes management.

	Study compares GLP-1 drug benefits and finds substantial variation in clinical effects GLP-1 receptor agonists improve glycaemic control and provide renal, metabolic, and selective cardiovascular benefits in people with type 2 diabetes, based on an umbrella review of 17 meta-analyses. However, these agents consistently increase gastrointestinal adverse effects and show important distinctions between class-level outcomes and individual drug effects, particularly for semaglutide.

			Oral GLP-1 pill shows strong weight loss and blood sugar benefits in adults with diabetes A new oral GLP-1 medication can help adults with obesity and Type 2 diabetes lose more weight and improve their blood sugar levels compared to a placebo, according to findings from the ATTAIN-2 trial led by a UTHealth Houston researcher.

			Study compares the kidney, cardiovascular and mortality risks of three different GLP-1 RAs Public interest in drugs known as glucagon-like peptide-1 receptor agonists, also called GLP-1 RAs, has surged in recent years, with popular types like semaglutide (sold under brand names like Ozempic and Wegovy) becoming known for their weight-loss effects.

			New platform enables unbiased evaluation of AI algorithms for diabetic eye screening Researchers have developed the world's first real-world head-to-head testing platform to determine whether commercial artificial intelligence (AI) algorithms are fit for NHS use to detect disease in a fair, equitable, transparent and trustworthy way, using diabetic eye disease as the first example.

			Study finds people with type 1 diabetes have higher bladder cancer risk People with type 1 diabetes (previously called juvenile diabetes) are 4.29 times more likely to develop bladder cancer, according to a systematic review and meta-analysis by researchers at the Keck School of Medicine of USC.

	Ultra-processed foods linked to rise in prediabetes risk The study reveals that ultra-processed foods heighten prediabetes risk in young adults with obesity history, stressing the importance of healthy eating habits.

	New clues in pancreas lymph nodes, spleen could help detect and prevent type 1 diabetes Type 1 diabetes (T1D) impacts nearly two million Americans, and by the time most people learn they have it, most of the body's insulin-producing cells are destroyed.

	Reduced ketone body metabolism may be key to impaired energy production in type 2 diabetes The liver plays a central role in storing and supplying energy to the body. In type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD, commonly referred to as fatty liver disease), mitochondria-the cell's power plants-cannot switch efficiently between fuel sources.

	Scientists uncover molecular mechanism behind chemotherapy-induced peripheral neuropathy Chemotherapy activates a stress sensor in immune cells, triggering inflammation and nerve damage, which may help explain why many cancer patients experience debilitating pain as a side effect, according to a new study by Weill Cornell Medicine and Wake Forest University School of Medicine researchers

	Aged blood vessel cells play key role in the development of metabolic disorders Investigators from the Center for Advanced Gerotherapeutics at Cedars-Sinai found that aged blood vessel cells play a key role in the development of metabolic disorders, including diabetes.

	GLP-1 discontinuation associated with more weight gain and pregnancy complications In a study led by researchers at Mass General Brigham, pregnant individuals who stopped taking popular weight loss GLP-1 medications before or early in their pregnancy tended to gain more weight and have higher risks of diabetes and hypertensive disorders during pregnancy, and experienced preterm delivery more so than people who had never taken GLP-1 drugs.

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