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The latest diabetes news from News Medical |
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 | | |  Genetic analysis of 1 million people points to FNIP1 as a promising metabolic target Mega-scale exome sequencing of 1,032,116 people identified 59 independent genes linked to the TG:HDL ratio, including 44 rare-coding associations not detected in the previous largest analysis. Ultra-rare FNIP1 loss-of-function variants were associated with favorable fat distribution, lower liver fat and glycemia, and around 60% lower odds of a composite cardiometabolic disease outcome. | | | | |  Semaglutide slows blood protein signature linked to future dementia risk A post hoc analysis of 2,970 older SELECT participants found that semaglutide slowed worsening of a 25-protein blood signature that predicts future dementia risk. Over 104 weeks, semaglutide produced larger effects on modeled 5-year than 20-year dementia risk, but whether these biomarker changes translate into less cognitive decline or dementia remains unknown. | |
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| | | | |  A long-term study of 12,409 adults found that a greater burden of diabetes, hypertension, and current smoking in midlife was associated with substantially fewer years lived free of dementia. Adults with none of these risk factors had about 30.1 dementia-free years from age 55, compared with 17.5 years among those with all three, a difference of nearly 13 years. | | | | |  A secondary analysis of 7,067 nulliparous participants found that first-trimester protein intake of 0.8 to less than 1.1 g/kg/day was associated with 22% lower adjusted odds of delivering an SGA infant than intake of at least 1.1 g/kg/day. The association was exploratory, with no dose-response pattern and no confirmation in sensitivity analyses. | | | | |  The size of a person's midsection is a better indicator of cardiovascular disease risk when compared to their body mass index (BMI) alone, according to a study published in JACC, the flagship journal of the American College of Cardiology. | | | | |  Having normal blood pressure, no diabetes, and not smoking from age 48 to 68, are associated with nearly 13 additional years on average of dementia-free life, a new study shows. | | | | |  Accelerated biological age in midlife was associated with higher risks of cardiovascular disease and death in both men and women over nearly three decades of follow-up. Women with accelerated biological age also showed a higher risk of dementia, although adding biological age to standard risk factors provided only minimal additional predictive value. | | | | |  Adding the GLP-1 receptor agonist drug tirzepatide (marketed as Mounjaro) to standard care for patients with type 2 diabetes and heart disease is associated with a lower risk of a major cardiovascular event, such as a heart attack or stroke, finds a study published by The BMJ today. | | | | |  A study of 4,818 middle-aged and older Chinese adults found that higher light BioAge was associated with greater risks of cognitive impairment, episodic memory decline, and reduced mental intactness. The simple measure, based on age, creatinine, glucose, and CRP, added modest predictive information but requires further validation before clinical use. | | | | |  A new UC San Francisco study helps explain why people with HIV remain at elevated risk for type 2 diabetes despite effective suppression of the virus with modern medications. | | | | |  A population-based study of 26,582 live singleton births in Madrid found that associations between NO₂ exposure and adverse birth outcomes varied by pregnancy stage, with key patterns emerging in the first and third trimesters. | | | | |  Higher residential nighttime light exposure was associated with contrasting biological aging patterns in nearly 300,000 UK Biobank participants, depending on the aging algorithm used. PhenoAge and homeostatic dysregulation suggested a potentially adverse aging pattern, while KDM-BA showed the opposite association, underscoring uncertainty about how nighttime light relates to biological aging. | | | | |  Mechanosensitive Piezo ion channels, particularly Piezo1 and Piezo2, are gaining recognition as central regulators of digestive system physiology and disease. | | | | |  A growing body of evidence suggests that a rare epithelial cell type known as the tuft cell may play a far more significant role in cancer than previously recognized. | |
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