Researchers show how smartwatches can help identify insulin resistance
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 Study finds GLP-1 medicines cut fat while preserving muscle functionStudy finds GLP-1 medicines cut fat while preserving muscle function
 
Researchers found that GLP-1 medicines caused weight loss mainly through fat reduction, with only modest decreases in absolute muscle mass and no disproportionate loss of muscle function. In mice, physical performance improved, while in a small 12-week human pilot trial, strength was preserved despite reduced thigh muscle size.
 
 
 Researchers show how smartwatches can help identify insulin resistanceResearchers show how smartwatches can help identify insulin resistance
 
Researchers developed a scalable framework that predicts insulin resistance using wearable-device signals, routine blood biomarkers, and demographic data, with stronger performance when these data streams were combined. The study also introduced an AI agent to explain insulin resistance risk, interpret results, and support earlier metabolic risk screening.
 
   How long should you take GLP-1 drugs? Study links longer use to lower heart riskHow long should you take GLP-1 drugs? Study links longer use to lower heart risk
 
Continuous use of GLP-1 receptor agonists in adults with type 2 diabetes was associated with a lower risk of major cardiovascular events compared with sulfonylureas, with benefits increasing over time. Discontinuation or interruption was associated with a progressive loss of this protective effect, with risks approaching those of comparator therapy.
 
   GLP-1 drugs cut heart and kidney risks in type 1 diabetes studyGLP-1 drugs cut heart and kidney risks in type 1 diabetes study
 
In a large target trial emulation of 174,678 people with type 1 diabetes, GLP-1 receptor agonist initiation was associated with lower risks of major cardiovascular events and end-stage kidney disease over five years. The study also found no increased risk of hospitalization for diabetic ketoacidosis or severe hypoglycemia, supporting further randomized trials of GLP-1RAs as adjunctive therapy in type 1 diabetes.
 
   Oral semaglutide fails to slow early Alzheimer’s decline in two phase 3 trialsOral semaglutide fails to slow early Alzheimer’s decline in two phase 3 trials
 
Two large phase 3 trials found that oral semaglutide 14 mg did not slow cognitive or functional decline over 104 weeks in people with early symptomatic, amyloid-positive Alzheimer’s disease. Semaglutide was generally consistent with its known safety profile and showed some biomarker changes, but these did not translate into clinical benefit.
 
 Early morning workouts may improve cardiometabolic health
 
Early morning workouts may improve cardiometabolic healthPeople who regularly exercised early in the morning were significantly less likely to have coronary artery disease, high blood pressure, Type 2 diabetes or obesity compared with people who exercised later in the day, according to a study being presented at the American College of Cardiology's Annual Scientific Session (ACC.26).
 
 
 AI diet plans underestimate teen nutrition and miss key nutrients
 
AI diet plans underestimate teen nutrition and miss key nutrientsAI tools for adolescent diet planning may fall short, consistently underestimating nutrient intake and energy needs compared to individualized dietitian plans.
 
 
 GLP-1 medications linked to reduced psychiatric hospital visits
 
GLP-1 medications linked to reduced psychiatric hospital visitsGLP-1 medications used to treat diabetes and obesity were associated with a reduced need for hospital care and sickness absence due to psychiatric reasons, a new study shows.
 
 
 Anti-aging drug combination causes brain damage in mice
 
Anti-aging drug combination causes brain damage in miceA two-drug combination frequently used in anti-aging research causes brain damage in mice, University of Connecticut researchers report in the March 16 issue of PNAS.
 
 
 Tailored prediabetes treatment may better prevent Type 2 diabetes
 
Tailored prediabetes treatment may better prevent Type 2 diabetesA one-size-fits-all approach to prediabetes treatment may miss the opportunity to implement an early, more intensive, tailored prevention approach for those with the highest risk of developing Type 2 diabetes, according to preliminary research presented at the American Heart Association's EPI|Lifestyle Scientific Sessions 2026.
 
 
 More US adolescents are obese but fewer are trying to lose weight
 
More US adolescents are obese but fewer are trying to lose weightThe rising obesity rates in American adolescents, coupled with declining weight-loss efforts, signal urgent needs for targeted public health interventions.
 
 
 Scientists turn red blood cells into long-lasting drug and imaging carriers in mice
 
Scientists turn red blood cells into long-lasting drug and imaging carriers in miceA new preclinical study shows that red blood cells can be tagged in vivo and used as long-lasting carriers for imaging agents and therapies, opening a new route for safer drug delivery and vascular imaging.
 
 
 How one antibiotic dose can reshape your gut microbiome for years
 
How one antibiotic dose can reshape your gut microbiome for yearsLong-term registry-linked analysis of nearly 15,000 adults shows that antibiotic use is associated with persistent changes in gut microbiome diversity and composition for up to 4–8 years. These effects vary by antibiotic class, with clindamycin, fluoroquinolones, and flucloxacillin showing the strongest and most sustained associations.
 
 
 Stopping GLP-1 treatment linked to increase in risk of major cardiovascular events
 
Following a rapid increase in popularity of GLP-1 drugs for diabetes and weight loss, such as semaglutide and tirzepatide, approximately one in eight U.S. adults now take these medications, which also provide cardiovascular benefits.
 
 
 Researchers explore "block and lock" strategy for functional HIV cure
 
For millions of people living with HIV, a daily regimen of medications is a lifelong necessity. If they stop taking the drugs-commonly referred to as antiretroviral therapy-the virus usually rushes back within weeks.
 
 
 Mandated caps reduce insulin out-of-pocket costs among US Medicare beneficiaries
 
A new analysis led by researchers at the Johns Hopkins Bloomberg School of Public Health finds that out-of-pockets caps on insulin for Medicare Part D beneficiaries have reined in insulin prices.
 
 
 Study links gut microbiome imbalance to worsening kidney disease
 
Researchers at UC Davis School of Medicine have uncovered how an imbalanced gut microbiome escalates the production of metabolic byproducts by certain gut bacteria.
 
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