Why do some people respond better to GLP-1 drugs? Gut microbiome may hold clues

	Diabetes
	The latest diabetes news from News Medical

	Why do some people respond better to GLP-1 drugs? Gut microbiome may hold clues A review in the Canadian Journal of Physiology and Pharmacology examines emerging evidence linking glucagon-like peptide-1 receptor agonists (GLP-1 RAs), the gut microbiome, and obesity treatment outcomes. The authors conclude that microbiome changes seen during therapy are most likely driven by diet, behavior, and weight loss, although microbial profiling may eventually help predict patient responses.

	Eating earlier in the day is linked to lower nighttime glucose in gestational diabetes A secondary analysis of a randomized trial examined whether the timing of the first daily meal affects 24-hour glucose patterns in pregnancies with gestational diabetes. Earlier first meals were associated with lower nocturnal glucose levels and an earlier daily glucose rhythm, although overall glycaemic control metrics were similar between groups.

			Patients who stop GLP-1 drugs often restart or try alternatives The study highlights that after stopping GLP-1 medications, many patients resume treatment or try alternatives, influencing weight management strategies.

			Skipping breakfast may raise metabolic syndrome risk The link between skipping breakfast and metabolic syndrome highlights the need for dietary strategies to improve cardiometabolic health in at-risk populations.

			Some antibiotics alter gut microbiome composition for up to eight years Antibiotic treatments can affect the composition of the community of bacteria living in the gut, known as the gut microbiome, for a long time.

	Can eating almonds reduce inflammation in obesity? Adding almonds to the diet of adults with obesity enhances inflammatory cytokine profiles and diet quality, highlighting a simple anti-inflammatory strategy.

	Wegovy linked to higher risk of eye stroke and vision loss Wegovy, a GLP-1 agonist for weight loss, may carry the highest risk of 'eye stroke' (ischemic optic neuropathy) and sudden sight loss of the semaglutide drugs, finds an analysis of unintended side effect reports published in the British Journal of Ophthalmology.

	Higher intake of ultra processed foods linked to weaker bones From flavored yogurts to frozen pizzas, breakfast cereals and instant oats, ultra-processed foods are convenient, often cheaper items designed for a quick bite.

	New polygenic risk scores improve prediction of metabolic disease outcomes Type 2 diabetes (T2D) and obesity are metabolic conditions with many causes, including overlapping and distinct genetic features.

	Kyoto University unveils noninvasive assessment for diabetes In type 1 diabetes, the immune system starts to destroy insulin-producing beta cells in the pancreas. Progressive loss of these cells destabilizes the body's glucose levels and drives the course of the disease, so preserving or restoring beta cell mass is a central treatment goal.

	FDA-approved drug fedratinib enhances communication between cellular organelles Cells behave like cities and organelles carry out infrastructural roles: Mitochondria are powerhouses, the endoplasmic reticulum serves as a transport hub and lysosomes help with waste disposal.

	Families scramble to pay five-figure bills as clock ticks on promised preauthorization reforms Sheldon Ekirch is used to being disappointed by her health insurance company.

	Experimental therapy eliminates pancreatic precancerous cells in mice study A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors.

	Global indicators identified to monitor health before pregnancy worldwide The key health and social indicators needed for a new global system to monitor people's health before pregnancy have been identified for the first time by researchers at University College London and the University of Southampton.

	Updated guideline emphasizes earlier treatment for high cholesterol The American College of Cardiology (ACC), the American Heart Association and nine other leading medical associations, today issued an updated guideline for the management of dyslipidemia-abnormal levels of one or more types of lipids or lipoproteins in the blood, including cholesterol and triglycerides.

	Routine care gap leaves metabolic acidosis undetected in chronic kidney disease A Japanese registry has identified a blind spot in the routine care of patients with chronic kidney disease (CKD). Serum bicarbonate levels are rarely measured, leaving metabolic acidosis largely undetected and hence, undertreated.

	Study reveals limitations of large language models in medical diagnostics Artificial intelligence (AI) is rapidly transforming healthcare. AI systems can now detect diabetic eye disease from retinal photos and analyze CT images for signs of early-stage lung cancers and stroke.

	Real-world study shows modest weight regain after GLP-1 discontinuation As the use of injectable GLP-1 drugs continues to rise, questions persist about what happens after patients stop taking them in real-world settings.

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