Study focuses on improving pharmacokinetic properties of therapeutic aptamers
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  December 6, 2017  
  Pharmacy / Pharmacology  
  The latest pharmacy / pharmacology news from News Medical  
 Study focuses on improving pharmacokinetic properties of therapeutic aptamersStudy focuses on improving pharmacokinetic properties of therapeutic aptamers
 
Designing new therapeutic DNA aptamers with diverse side chains can improve their ability to interact with targets, and a new study describes characteristics of these side chains that may determine how long the aptamers remain in the bloodstream.
 
 
 Chemicals in cigarette smoke, industrial processes may cause hazardous effectsChemicals in cigarette smoke, industrial processes may cause hazardous effects
 
It's no surprise that chemicals in smoke cause cancer, but a new study published in the Archives of Toxicology shows that some chemicals in cigarette smoke and industrial processes may be more dangerous than previously thought.
 
   Less than one-third of glaucoma patients talk to their doctor about medication costs, study findsLess than one-third of glaucoma patients talk to their doctor about medication costs, study finds
 
Less than one-third of patients with glaucoma talk to their doctor about the costs of medications needed to control their disease, reports a study in the December issue of Optometry and Vision Science, the official journal of the American Academy of Optometry.
 
   UT Southwestern researchers identify potential approach to suppress lethal parasitic infectionsUT Southwestern researchers identify potential approach to suppress lethal parasitic infections
 
UT Southwestern Medical Center researchers have identified a chemical that suppresses the lethal form of a parasitic infection caused by roundworms that affects up to 100 million people and usually causes only mild symptoms.
 
   Older adults do not get enough help to make sure multiple drugs mix safely, new poll findsOlder adults do not get enough help to make sure multiple drugs mix safely, new poll finds
 
Most older Americans take multiple medicines every day. But a new poll suggests they don't get – or seek – enough help to make sure those medicines actually mix safely.
 
 Research suggests general mechanism by which dietary fats affect cellular physiology
 
Research suggests general mechanism by which dietary fats affect cellular physiologyYou are what you eat when it comes to fat, report scientists from McGovern Medical School at The University of Texas Health Science Center at Houston in the journal Science Advances.
 
 
 Researchers unravel novel mechanism of estrogen action on heart physiology
 
Researchers unravel novel mechanism of estrogen action on heart physiologyEstrogens are powerful hormones important for the formation and function of the nervous, reproductive and cardiovascular systems.
 
 
 Researchers receive DoD grant to identify alternatives to opioids for pain management
 
Researchers receive DoD grant to identify alternatives to opioids for pain managementWhat does a marine snail's ability to kill prey with two shots of venom have to do with the opioid epidemic ravaging the United States?
 
 
 AIDA project optimizes use of old antibiotics for better patient care
 
AIDA project optimizes use of old antibiotics for better patient careA European consortium of researchers studied five off-patent community and hospital antibiotics with modern methods. They integrated the results of three randomised controlled clinical trials with extensive non-clinical studies.
 
 
 Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis
 
Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell AnalysisThere's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets.
 
 
 New small-molecule drug restores brain function, memory in mouse model of Alzheimer's disease
 
New small-molecule drug restores brain function, memory in mouse model of Alzheimer's diseaseAn international team of researchers has shown that a new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease.
 
 
 FDA grants approval to first biosimilar for treatment of patients with breast, stomach cancers
 
FDA grants approval to first biosimilar for treatment of patients with breast, stomach cancersThe U.S. Food and Drug Administration today approved Ogivri (trastuzumab-dkst) as a biosimilar to Herceptin (trastuzumab) for the treatment of patients with breast or metastatic stomach cancer (gastric or gastroesophageal junction adenocarcinoma) whose tumors overexpress the HER2 gene (HER2+).
 
 
 Agoraphobia Overview
 
Agoraphobia OverviewThe fear or anxiety must occur in two of five situations to meet criteria for agoraphobia. According to the DSM-V, if the individual fears only one situation, the specific phobia is the diagnosis. Agoraphobia also differs from a specific phobia in terms of feared consequences. If the situation is feared for anxiety or panic responses alone, it falls into the category of agoraphobia.
 
 
 Agoraphobia Treatments
 
Agoraphobia TreatmentsAgoraphobia is generally known as a fear of open spaces, but is a complex condition that may involve fear of visiting certain public areas like shopping centers, fear of specific situations like public transit, or a fear of leaving home altogether. Exposure to the feared stimulus usually results in anxiety or a panic attack. Symptoms of a panic attack include rapid heartbeat, hyperventilation, sweating, and nausea.
 
 
 Treating Claustrophobia
 
Treating ClaustrophobiaClaustrophobia is a condition characterized by the development of unbearable anxiety in enclosed spaces or with physical restriction. Common triggers for claustrophobia include small rooms, elevators, crowded places, and MRI scanners. The symptoms of claustrophobia are typical anxiety symptoms. They can be mild, such as trembling and sweating. Symptoms can also be severe, such as rapid heartbeat, fainting, or panic attack.
 
 
 The ratcheting cost of the pneumococcal vaccine: What gives?
 
Every November, like clockwork, she gets the same letter, said Dr. Lindsay Irvin, a pediatrician in San Antonio.
 
 
 INRS researchers evaluate how chemotherapy among men affects health of future generations
 
INRS researchers evaluate how chemotherapy among men affects health of future generationsHow do cancer and cancer treatments affect the reproductive function of men? Can this affect the health of their direct descendants and subsequent generations? To get a clear picture, INRS researchers evaluate the current state of knowledge on this public health issue in a review article appearing in the journal Gynécologie Obstétrique & Fertilité.
 
 
 Patients with rare diseases and congress square off over orphan drug tax credits
 
Patients with rare diseases and congress square off over orphan drug tax creditsAs President Donald Trump talked tax reform on Capitol Hill Tuesday, Arkansas patient advocate Andrea Taylor was also meeting with lawmakers and asking them to save a corporate tax credit for rare disease drug companies.