Event guide: The Non-Opioid Pain Therapeutics Summit

	Pharmacy & Pharmacology
	The latest pharmacy / pharmacology news from News Medical

Non-opioid pain drug development is finally turning a corner. With Vertex’s recent approval paving the way, the field is entering a new era–one defined by safer, more effective treatments for neuropathic, musculoskeletal, chemotherapy-induced, and other chronic pain conditions.

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			The Rise of Molecular Glues: A New Class of Smart Cancer Drugs Molecular glues are revolutionizing cancer therapy by targeting undruggable proteins for degradation, enhancing precision medicine and drug discovery.

			Arginine slows amyloid buildup and improves brain outcomes in Alzheimer’s disease models Arginine reduced amyloid beta aggregation in vitro and in both Drosophila and AppNL-G-F mouse models of Alzheimer’s disease, leading to fewer dense-core plaques and improved behavior. The study provides preclinical evidence that oral arginine may modulate amyloid pathology, although high dosing requirements and model limitations constrain human translation.

	CAR T cell therapy could be a highly effective tool against atherosclerosis A pioneering preclinical study has shown that CAR T cell therapy-a personalized form of immunotherapy used in cancer treatment-could be a highly effective tool against atherosclerosis, the condition where a build-up of plaque in the arteries reduces blood flow, leading to heart attacks and strokes.

	Study uncovers how a specific immune cell may contribute to HIV persistence Researchers from the Institute of Human Virology (IHV) at the University of Maryland School of Medicine have discovered how a specific type of immune cell may contribute to the persistence of HIV infections.

	Gut bacteria threatened by pesticides and other common chemical pollutants A large-scale laboratory screening of human-made chemicals has identified 168 chemicals that are toxic to bacteria found in the healthy human gut.

	Higher teen blood pressure predicts who develops heart disease A study reveals that adolescent blood pressure levels are strong predictors of coronary atherosclerosis, emphasizing the importance of monitoring in youth.

	Study finds major setbacks in blood pressure prevention and management in England A comprehensive new analysis by researchers at Queen Mary University of London warns that England has lost the substantial gains made in high blood pressure prevention, diagnosis and management during the 2000s.

	Generative AI aids discovery of ISM3830's novel scaffold Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, playing a central role in modulating T-cell activation and immune tolerance, and its inhibition enhances T cells and NK cells function, also provides a strategy for the function restoration of exhausted T cells.

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