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The latest pharmacy / pharmacology news from News Medical |
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 Tracking Biologics with Radiolabeled Study Approaches
This webinar explores how radiolabeled studies reveal the biodistribution and behavior of biologics in vivo. Through case studies on peptides and recombinant proteins, scientists will gain practical insights into isotope selection, PK/PD interpretation, and overcoming challenges linked to tissue complexity, target engagement, and molecular size in pharmacological research.
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|  | | | | |  EV Engineering Boosts Drug Delivery and Improves Sepsis Survival The engineered scaffold protein EN144 significantly improves extracellular vesicle therapies, showing potential in sepsis treatment and targeted drug delivery. | |  | | | | |  Palmatine improved fatty liver markers in a preclinical type 2 diabetes study Researchers used a bioinformatics-plus-rat-model approach to investigate how palmatine may help treat T2DM-associated MASLD, identifying five core targets: ADRB2, BCL3, EGR1, FOS, and MAP3K8. In rats, palmatine improved liver injury, inflammation, oxidative stress, glycolipid metabolism, steatosis, and fibrosis, while reducing apoptosis-related signaling, providing a preclinical foundation for further therapeutic study. | | | | | | |  Why do some people respond better to GLP-1 drugs? Gut microbiome may hold clues A review in the Canadian Journal of Physiology and Pharmacology examines emerging evidence linking glucagon-like peptide-1 receptor agonists (GLP-1 RAs), the gut microbiome, and obesity treatment outcomes. The authors conclude that microbiome changes seen during therapy are most likely driven by diet, behavior, and weight loss, although microbial profiling may eventually help predict patient responses. | | | | | | |  New nanomaterial enhances bioimaging and targeted cancer drug delivery The Nanomedicine and Nanotoxicology Group (GNano) at the University of São Paulo's São Carlos Institute of Physics (IFSC-USP) in Brazil has discovered a way to transform hydroxyapatite, a bioceramic material, into a nanoparticle with enhanced intrinsic luminescence. | |
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