Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease

	Gastroenterology
	The latest gastroenterology‎ news from News Medical

	Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease Study reveals that group B [FeFe]-hydrogenase is the primary enzyme driving fermentative hydrogen production in the healthy human gut, mainly through Bacteroides species. These genes are significantly depleted in Crohn’s disease, indicating a metabolic shift and altered hydrogen cycling dominated by respiratory bacteria

	Scientists uncover new obesity genes that reshape understanding of weight and disease risk Researchers identified five previously unknown genes linked to obesity by analyzing rare protein-truncating variants across six ancestries. The study reveals how rare and common genetic factors combine to influence BMI and related diseases like diabetes and heart failure.

			Study highlights high prevalence of non-coeliac gluten sensitivity lacking clear markers Around one in ten people worldwide report gastrointestinal and other symptoms such as fatigue and headache after eating foods containing gluten or wheat despite not having a diagnosis of either coeliac disease or wheat allergy, finds a large systematic review and meta-analysis published online in Gut.

			Baby formula can harbor heat-resistant bacteria even after safe preparation Research shows that powdered infant formula may contain microbial contaminants despite following 70°C preparation guidelines, highlighting potential risks.

			How nerve cells in the gut adapt to microbial and immune challenges Ramnik Xavier, MD, PhD, of the Department of Molecular Biology at Massachusetts General Hospital, is the senior author of a paper published in Science, "Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation."

	Advances in diagnosis and management of systemic light chain amyloidosis Systemic light chain (AL) amyloidosis is a rare and life-threatening disorder characterized by the deposition of misfolded immunoglobulin light chains as insoluble amyloid fibrils in various tissues and organs, leading to progressive structural and functional impairment.

	New research reveals how human astroviruses enter the body Human astroviruses are a leading viral cause of the stomach bug-think vomiting, diarrhea, and fever. It often impacts young children and older adults, leading to vicious cycles of sickness and malnutrition, particularly for those in low and middle income countries.

	So your insurance dropped your doctor. Now what? Last winter, Amber Wingler started getting a series of increasingly urgent messages from the local hospital in Columbia, Missouri, letting her know her family's health care might soon be upended.

	Therapeutic potential of Scleromitrion diffusum in gastric cancer treatment Gastric cancer remains a major global health challenge, characterized by high mortality and limited therapeutic efficacy, especially in advanced stages.

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