Gut infection leaves long-lasting immune ‘memories’ at the brain’s borders in mice
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 Menopause may start changing the gut years before periods stopMenopause may start changing the gut years before periods stop
 
A longitudinal study of 964 women found that blood markers of gut epithelial barrier dysfunction and microbial product translocation began to rise around 2 to 2.5 years before the final menstrual period and remained elevated after menopause. The findings suggest that changes in gut barrier integrity may form part of the biological transition through menopause and could help explain links between menopause, inflammation, and later health outcomes.
 
 
 Gut infection leaves long-lasting immune ‘memories’ at the brain’s borders in miceGut infection leaves long-lasting immune ‘memories’ at the brain’s borders in mice
 
In mice, intestinal infections reshaped dural CD4+ T-cell populations and seeded the brain’s outer meningeal border with antigen-specific memory cells that persisted for months and mounted rapid recall responses to bloodborne antigens.
 
   Like your tea or coffee very hot? A study of nearly 1 million adults found a striking cancer linkLike your tea or coffee very hot? A study of nearly 1 million adults found a striking cancer link
 
In pooled prospective data from 977,282 UK adults, preferring tea or coffee “very hot” was associated with more than threefold higher risk of esophageal squamous cell carcinoma compared with preferring drinks “warm,” while drink temperature showed no material association with adenocarcinoma risk.
 
   People with ADHD face higher odds of gastrointestinal problemsPeople with ADHD face higher odds of gastrointestinal problems
 
University of Warwick researchers have analyzed data from over 1.9 million people across 23 studies and found that ADHD is linked to an almost 50% increase in overall gastrointestinal symptoms compared with people without ADHD The association was even stronger for specific problems: nearly double the odds of constipation, a 58% increase in irritable bowel syndrome, and more than four times the odds of encopresis (loss of bowel control).
 
   New funding supports LMU research on pediatric inflammatory bowel diseaseNew funding supports LMU research on pediatric inflammatory bowel disease
 
The non-profit Boehringer Ingelheim Stiftung supports LMU clinician-scientist Daniel Kotlarz through its Rise up! program.
 
 Gut bacterial metabolite linked to inflammation in liver disease
 
Researchers have identified a link between specific activities in gut bacteria and the liver disease PSC.
 
 
 Helicobacter pylori exposure linked to one in five cases of bowel cancer
 
Exposure to the stomach microbe Helicobacter pylori may be associated with more than 1 in 5 cases of bowel cancer worldwide, suggests an exploratory risk attribution study, published in the open access journal eGastroenterology.
 
 
 Bariatric surgery restores menstrual cycles and reduces polycystic ovaries in obese women
 
Metabolic bariatric surgery improves menstrual cycle frequency and symptoms of polycystic ovaries in women living with obesity, a new study from the University of Surrey reports.
 
 
 Antifungal medication may reduce inflammatory bowel disease symptoms
 
A commonly used systemic antifungal medication may help reduce symptoms in a subset of patients with inflammatory bowel disease (IBD) by restoring a healthier gut microbiome, according to a preliminary study by Weill Cornell Medicine investigators.
 
 
 Cancer treatments alter the landscape of genetic mutations in healthy body tissues
 
Cancer treatments, including chemotherapy and radiotherapy, give a growth advantage to cells with particular genetic changes in healthy tissue, new research finds.
 
 
 New treatment approach preserves organs, improves survival in head and neck cancer patients
 
Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) whose tumors responded to neoadjuvant immunochemotherapy (ICT) and who underwent less extensive surgery had high disease-free survival and organ preservation rates.
 
 
 New AI tool automates colonoscopy quality assessment at scale
 
Colonoscopies are one of the most effective ways to prevent colorectal cancer, which is surging among young adults in the U.S. Yet, the quality of each procedure can vary substantially from one physician to another.
 
 
 Cellular atlas offers clues to childhood Crohn’s treatment response
 
Researchers have created a detailed map of childhood Crohn's disease before and after treatment to help understand progression of the disease.
 
 
 C. diff uses dual-threat sensing system to survive gut stress
 
The pathogen Clostridioides difficile (C. diff) - a leading cause of hospital-acquired infections - must contend with a variety of threats inside the harsh environment of the gut to survive and grow.
 
 
 PCORI funding awarded to study symptom management for rare cholestatic liver diseases
 
The Patient-Centered Outcomes Research Institute (PCORI) has announced a $13 million funding award to the University of North Carolina at Chapel Hill over five years to study innovative symptom management interventions for patients with rare cholestatic liver diseases.
 
 
 Biolife granted U.S. patent for novel effervescent oral peptide delivery technology
 
BioLife today announced that the United States Patent and Trademark Office has granted U.S. Patent 12,667,605 B2 for its novel effervescent oral peptide delivery technology, designed to support current and future peptide therapeutics for obesity, diabetes and metabolic disease.
 
 
 IBD patients with family cancer history more likely to develop colorectal cancer
 
People with inflammatory bowel disease (IBD) who have several close relatives with colorectal cancer are significantly more likely to develop the disease themselves.
 
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