MMR by IHC can still be MSI-H

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	Gastroenterology‎
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MMR by IHC can still be MSI-H

Immunohistochemistry (IHC) detects the presence or absence of MMR proteins but won’t differentiate between functional and nonfunctional proteins. In contrast, MSI by PCR is a molecular test that determines if DNA mismatches are being repaired, making it a functional test for MMR protein activity.

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