Protein Analysis - The Rise of Molecular Glues: A New Class of Smart Cancer Drugs
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Final Global ICH Drug Interaction Studies GuidelineFinal Global ICH Drug Interaction Studies Guideline

The new ICH M12 guideline has been adopted and missing requirements can lead to costly delays, additional studies and other setbacks. DDI expert, Dr. Brian Ogilvie, VP of Scientific Consulting at BioIVT, outlines important updates, strategic considerations, and takeaways so you can meet the new expectations.

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   The Rise of Molecular Glues: A New Class of Smart Cancer DrugsThe Rise of Molecular Glues: A New Class of Smart Cancer Drugs
 
Molecular glues are revolutionizing cancer therapy by targeting undruggable proteins for degradation, enhancing precision medicine and drug discovery.
 
   Gene Transcription Start Sites Identified as Hidden Mutational HotspotsGene Transcription Start Sites Identified as Hidden Mutational Hotspots
 
Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we study genetics and disease.
 
 Scientists Map How Transcription Factors Interpret DNA Sequences
 
Scientists Map How Transcription Factors Interpret DNA SequencesWith a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells.
 
 
 Real-Time Visualization Reveals the Transcriptional Gearbox
 
Real-Time Visualization Reveals the Transcriptional GearboxLife's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins.
 
 
 Transcription Factor SmMYB53 Drives Enhanced Tanshinone Synthesis in Salvia miltiorrhiza
 
Transcription Factor SmMYB53 Drives Enhanced Tanshinone Synthesis in Salvia miltiorrhizaSalvia miltiorrhiza has long been used in traditional medicine, with tanshinones being its main active compounds.
 
 
 DNA Rigidity Inside the Nucleosome Regulates INO80 Positioning
 
DNA Rigidity Inside the Nucleosome Regulates INO80 PositioningResearchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the physical structure and shape of DNA, not just genetic information, are key components of DNA transcription.
 
 
 Ambiguous Stop Codons Expand the Genetic Code in Archaea
 
Ambiguous Stop Codons Expand the Genetic Code in ArchaeaThe beauty of the DNA code is that organisms interpret it unambiguously. Each three-letter nucleotide sequence, or codon, in a gene codes for a unique amino acid that's added to a chain of amino acids to make a protein.
 
 
 Winter Leaves Traces in Our DNA
 
Winter Leaves Traces in Our DNASeasonal biology reveals how winter alters gene expression, hormones, and immune function, impacting health through circadian rhythms and environmental cues.
 
 

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