Protein Analysis - Providing a New Generation of cDNA Sequencing
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  September 18, 2019  
  Protein Analysis  
  The latest Protein Analysis news from across the AZoNetwork  
 

#ALT# New Arrival - QPrEST Protein Standards for Mass Spectrometry

As of this week, QPrEST standards targeting the majority of human proteins are available for you through Atlas Antibodies. QPrESTs are Stable Isotope-Labeled protein standards for absolute quantification using Mass Spectrometry. Discover the QPrEST offering and how the QPrESTs will improve the accuracy of your quantification.

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    KeysightProviding a New Generation of cDNA Sequencing
 
Transcriptomics enables researchers to study how the stable DNA ‘code’ of an organism is interpreted at a given moment in time. A powerful technique for this is nanopore technology, which allows researchers to sequence millions of whole transcripts end-to-end in single reads. This gives them a powerful base to tackle challenges in the areas of full-length transcript identification, isoform characterization and quantification.
 
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   Proteomics of Single Mouse Brain SlicesProteomics of Single Mouse Brain Slices
 
Mouse brain slices are widely used in neurological research. Scientists have long been interested in using these samples to understand proteome changes in response to neuroactive compounds. However, the protein extraction yield from brain slices is usually too low for protein analysis.
 
 

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 Scientists discover how resistance to the chemotherapy drug 5-fluorouracil arises
 
Scientists discover how resistance to the chemotherapy drug 5-fluorouracil arisesAustralian researchers have unlocked the mystery as to why the chemotherapy drug 5-Fluorouracil (5-FU) is not effective at treating certain cancers and have claimed a breakthrough in boosting its efficacy. The research could potentially lead to a laboratory test that could flag up resistance to the drug and thereby reduce unnecessary chemotherapy treatments.
 
 
 KIT researchers develop new method to predict protein structure
 
KIT researchers develop new method to predict protein structureProteins are biological high-performance machines. They can be found in every cell and play an important role in human blood coagulation or as main constituents of hairs or muscles. The function of these molecular tools is obvious from their structure. Researchers of Karlsruhe Institute of Technology (KIT) have now developed a new method to predict this protein structure with the help of artificial intelligence.
 
 
 Spin Labels in Electron Spin Resonance (ESR) Spectroscopy
 
Spin Labels in Electron Spin Resonance (ESR) SpectroscopyIn ESR, a spin label is added to the target site using cysteine substitution. This is followed by modifying the sulfhydryl group with a paramagnetic nitroxide reagent. The ESR then provides information about the mobility of nitroxide side chain, accessibility of the solvent, distance between nitroxide and other paramagnetic centers.
 
 
 Identifying Protein Biomarkers for COPD from Exhaled Air Condensate
 
Identifying Protein Biomarkers for COPD from Exhaled Air CondensateChronic obstructive pulmonary disease (COPD) is a medical condition where damage to the airway leads to a chronic inflammatory response. In this case study, scientists from Peking and Shanghai identified novel protein biomarkers from exhaled air condensate provided by patients with COPD. These samples were analyzed by liquid chromatography coupled to mass spectrometry (LC-MS).
 
 
 'Protein mapping' approach reveals why metastatic melanoma patients do not respond to immunotherapy
 
'Protein mapping' approach reveals why metastatic melanoma patients do not respond to immunotherapyTel Aviv University and Sheba Medical Center researchers say they have discovered why more than half of patients with metastatic melanoma do not respond to immunotherapy cancer treatments.