[Free Webinar] Squeeze all viscosity from just microliters with Honeybun

	Protein Analysis
	The latest Protein Analysis news from News Medical

A crucial element of formulation development is knowing about viscosity and rheology, especially when high-concentration biologics for subcutaneous application, their syringeability and manufacturability are relevant. Classic viscometers need large sample volumes and read one sample at a time, and even chip-based instrumentation just automates sample loading and requires extensive washing between samples.

Honeybun addresses all these bottlenecks. Join this webinar for an intro to quick viscosity experiments with Honeybun, looking at a monoclonal antibody in different formulations.

			Newly Identified Protein Prevents T Cells From Destroying Cancer Cells Researchers at Mayo Clinic have identified a protein that cancer cells use to suppress the body's immune response, a finding that could support the development of new treatments to improve the effectiveness of cancer immunotherapies.

			AI redesign helps enzymes evolve beyond natural limits Researchers showed that AI-redesigned botulinum neurotoxin proteases provided more stable starting points for directed evolution, allowing enzymes to access beneficial mutations that were poorly tolerated in wild-type backgrounds. In BoNT/E models, the approach improved activity, evolvability, and specificity, including an ataxin-2-targeting variant with markedly reduced cleavage of the native SNAP25 substrate.

	Study uses alternative splicing data to predict protein function A single human gene can produce multiple protein isoforms through alternative splicing, greatly expanding the functional diversity of the proteome.

	Researchers Engineer AI Framework to Solve Longstanding Protein Isoform Mystery A single human gene can produce multiple protein isoforms through alternative splicing, greatly expanding the functional diversity of the proteome.

	Research Maps Structural Mechanism Linking Amino Acid Availability to Cancer Growth Cells carry their own growth switches. When enough nutrients-amino acids in particular-are available, cells flip this switch on and begin to grow. Researchers at KAIST and Yonsei University have now uncovered the molecular mechanism by which amino acid signals activate this cellular growth switch.

	Molecular Insights Into Fungal Effectors Disabling Host Immune Transcription Factors Plants defend themselves through a layered innate immune system: pathogen-associated molecular pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), mediated by pattern recognition receptors (PRRs) and nucleotide-binding leucine-rich repeat (NLR) receptors, respectively.

	Study reveals evolutionary shift in gene crucial for the human nervous system Certain variants in the PSPH gene, which encodes an enzyme called phosphoserine phosphatase, prevent the body from making sufficient amounts of amino acid L-serine, leading to a range of nervous system problems.

	Single-cell analysis identifies key regulators of cancer metastasis By analyzing individual cancer cells, researchers from the Université Libre de Bruxelles (ULB) discovered the transcriptional regulators governing EMT in tumors and identified key master regulators that control metastasis, unraveling novel therapeutic vulnerabilities to block metastatic dissemination.

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