The latest biochemistry news from AZoNetwork
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  Biochemistry  
  The latest biochemistry news from AZoNetwork  
 

#ALT# The Use of IMC-MS for Protein Characterization

In the pharmaceutical industry, accurate characterization of protein structure is crucial to understanding protein function and in facilitating the design of effective therapeutics. IMS separates ions based on their differential mobility through a drift-tube containing buffer gas. The differing mobility depends on an ion’s characteristic collision cross-section (CSS), which is greater in the case of larger ions that experience more collisions and take longer to cross the drift tube than smaller ions. Learn More at Pittcon 2020 in Chicago.

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    KeysightA double-edged sword: reactive oxygen species and how they are detected
 
Reactive oxygen species are unstable molecules containing oxygen as a by-product of the natural metabolism of oxygen. They are very reactive and can take many different forms. The build-up of reactive oxygen species to a high level inside cells is known as oxidative stress. This causes damage to proteins, DNA and RNA and can even result in cell death.
 
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   Forensic Nucleic Acid Analysis of Uncultivatable Microbes: New Method Expand the Microbial ToolkitForensic Nucleic Acid Analysis of Uncultivatable Microbes: New Method Expand the Microbial Toolkit
 
The molecular characterization of microorganisms is achieved by microbial culturing techniques. The primary bottleneck in this procedure is the inability to culture forensically relevant pathogens under laboratory conditions; moreover, nucleic acids may be low quality or damaged, rendering them incapable of analysis.
 
 Molecular Imaging in Drug Development
 
Molecular Imaging in Drug DevelopmentWhile healthcare has made significant advancements over the last century, and medical professionals are more equipped than ever with the tools to treat a whole range of illnesses, the landscape of healthcare continues to evolve, and with this ever-changing environment comes the continued need for new drug candidates.
 
 
 Supercoiled Minicircle DNA Analysis: A Quality Assessment Based on Chromatographic Analysis
 
Supercoiled Minicircle DNA Analysis: A Quality Assessment Based on Chromatographic AnalysisA team from the Universidade da Beira, Portugal have developed a rapid and non-expensive analytical method for characterising minicircle DNA (mcDNA). This methodology represents the first analytical chromatographic method for the quantification of mcDNA. This work builds on existing research from which a purification strategy for the isolation of supercoiled (sc) mcDNA is achieved using a cadaverine-modified monolith.
 
 
 What is Polyethylene Glycol (PEG)?
 
What is Polyethylene Glycol (PEG)?Polyethylene glycol (PEG) is a biocompatible, synthetic, hydrophilic polyether compound that has many applications, mostly in the medical industry, but also in the chemical and industrial sectors. The structure of the compound is known as H−(O−CH2−CH2)n−OH.