| Biochemistry - Researchers discover hydrogen-producing enzyme group that resists oxygen attack |
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The latest biochemistry news from AZoNetwork |
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 | | |  mRNA Therapeutics – Analytical and Bioanalytical Characterization
RNA-based therapeutics can be used to modulate disease-associated proteins. Protein overproduction can be druggable by small interfering RNA (siRNA) and antisense oligonucleotides (ASO). In this case, the RNA therapeutics inhibit the translation of the mRNA to the disease-causing protein. In this interview, News-Medical Life Sciences talks to Annette Bak, Head of Advanced Drug Delivery in Pharmaceutical Sciences, R&D at AstraZeneca, about mRNA therapeutics and their analytical challenges in pharmaceutical development that she will present at Pittcon.
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| | | | |  A new technique has revealed the natural structure of specifically massive and complex enzymes. | | | | |  In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output. | | | | |  Considered the most lethal form of DNA damage, double-strand breaks must be repaired to prevent cell death. In developing therapies for hard-to-treat breast and ovarian cancers in patients with BRCA gene mutations, scientists aim to identify ways to keep cancer cells from using DNA break repair pathways. | |
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