Biochemistry - Overcoming Endosomal Escape in Oligonucleotide Drug Delivery
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   Overcoming Endosomal Escape in Oligonucleotide Drug DeliveryOvercoming Endosomal Escape in Oligonucleotide Drug Delivery
 
This study addresses endosomal escape in oligonucleotide therapies and how engineered peptides can enhance intracellular drug delivery efficiency.
 
   Brain-specific enzyme drives branching and extension of O-mannose glycansBrain-specific enzyme drives branching and extension of O-mannose glycans
 
Gifu University scientists have uncovered how a brain-specific enzyme reshapes protein-linked sugar chains to facilitate the formation of complex glycans essential for normal brain function.
 
 New nanomaterial kills cancer cells via oxidative stress
 
New nanomaterial kills cancer cells via oxidative stressScientists at Oregon State University have developed a new nanomaterial that triggers a pair of chemical reactions inside cancer cells, killing the cells via oxidative stress while leaving healthy tissues alone.
 
 
 Diabetic nephropathy shows severe biochemical abnormalities
 
Diabetic nephropathy shows severe biochemical abnormalitiesChronic diabetes mellitus is marked by hyperglycemia and metabolic dysfunction, increasing the risk of complications such as nephropathy.
 
 
 Role of food nutrients in reducing oxidative stress linked to micro- and nanoplastics
 
Role of food nutrients in reducing oxidative stress linked to micro- and nanoplasticsThis narrative review examines how micro- and nanoplastics may contribute to oxidative stress, inflammation, and metabolic dysfunction, including potential links with diabetes. It highlights plant-derived nutrients that activate the Nrf2 pathway as a possible strategy to enhance cellular stress resilience, although most evidence remains preclinical.
 
 
 New Research Reveals RFC's Dynamic Partnership in DNA Synthesis
 
New Research Reveals RFC's Dynamic Partnership in DNA SynthesisEvery time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its code and build new strands.
 
 
 Rapid Enzyme Screening Unlocks Efficient Routes to Complex Pharmaceuticals
 
Rapid Enzyme Screening Unlocks Efficient Routes to Complex PharmaceuticalsA team of biochemists at the University of California, Santa Cruz, has developed a faster way to identify molecules in the lab that could lead to more effective pharmaceuticals.
 
 
 Cells Use Protein Partnership to Manage Oxidative Stress
 
Cells Use Protein Partnership to Manage Oxidative StressCornell researchers have discovered a new way cells regulate how they respond to stress, identifying an interaction between two proteins that helps keep a critical cellular recycling system in balance.
 
 
 Powerful New Enzyme Efficiently Synthesizes RNA
 
Powerful New Enzyme Efficiently Synthesizes RNAFrom vaccines and diagnostics to emerging gene-based therapies, RNA molecules are now central to modern medicine.
 
 
 Uncoupling Nucleotide Synthesis: A Yeast-Derived Solution for Mitochondrial Disease
 
Uncoupling Nucleotide Synthesis: A Yeast-Derived Solution for Mitochondrial DiseaseNucleotide synthesis-the production of the basic components of DNA and RNA-is essential for cell growth and division.
 
 

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