Biochemistry - Researchers discover hydrogen-producing enzyme group that resists oxygen attack
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#ALT# mRNA Therapeutics – Analytical and Bioanalytical Characterization

RNA-based therapeutics can be used to modulate disease-associated proteins. Protein overproduction can be druggable by small interfering RNA (siRNA) and antisense oligonucleotides (ASO). In this case, the RNA therapeutics inhibit the translation of the mRNA to the disease-causing protein. In this interview, News-Medical Life Sciences talks to Annette Bak, Head of Advanced Drug Delivery in Pharmaceutical Sciences, R&D at AstraZeneca, about mRNA therapeutics and their analytical challenges in pharmaceutical development that she will present at Pittcon.

Find Out More at Pittcon
 
   Researchers discover hydrogen-producing enzyme group that resists oxygen attackResearchers discover hydrogen-producing enzyme group that resists oxygen attack
 
Hydrogen-producing enzymes are beacons of hope in biohydrogen research. However, they are so vulnerable to oxygen in the air that it has not been possible to exploit their potential on a larger scale.
 
   Research may help better understand the biochemistry underlying catalysis in cellsResearch may help better understand the biochemistry underlying catalysis in cells
 
Investigators from the Institute of Scientific and Industrial Research at Osaka University, together with the Hiroshima Institute of Technology, have announced the discovery of a new protein that allows an organism to conduct an initial and essential step in converting amino acid residues on a crosslinked polypeptide into an enzyme cofactor.
 
 New technique reveals natural structure of large enzyme complex
 
New technique reveals natural structure of large enzyme complexA new technique has revealed the natural structure of specifically massive and complex enzymes.
 
 
 Pancreatic β cells secrete miR-29 in response to high levels of free fatty acids
 
Pancreatic β cells secrete miR-29 in response to high levels of free fatty acidsIn a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output.
 
 
 Researchers discover previously-unknown function in enzyme critical for cancer growth
 
Researchers discover previously-unknown function in enzyme critical for cancer growthConsidered the most lethal form of DNA damage, double-strand breaks must be repaired to prevent cell death. In developing therapies for hard-to-treat breast and ovarian cancers in patients with BRCA gene mutations, scientists aim to identify ways to keep cancer cells from using DNA break repair pathways.