Discover Spatial Multiomics for Deeper Genomic Insights

	Genomics
	The latest genomics news from News Medical

Discover how spatial transcriptomics and proteomics can be combined to generate richer biological insights at single-cell resolution. This on-demand webinar explores multimodal data integration, advanced computational strategies, and practical approaches for validating findings, offering valuable perspectives for researchers advancing spatial multiomics and translational genomics research.

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			Genome-mining tool reveals new antibiotic hidden in a silent gene cluster Researchers developed DiscERN, a genome-mining platform that combines four complementary algorithms to identify evolutionarily related biosynthetic gene clusters and prioritize candidates for experimental study. The approach revealed discomycin A, a previously unknown calcium-dependent lipopeptide antibiotic with potent activity against several Gram-positive bacteria.

			New model improves short- and long-term disease risk prediction Researchers developed ALADYNOULLI, a Bayesian generative model that combines longitudinal health records, age, and polygenic risk to identify reproducible disease signatures across more than 683,000 participants. In UK Biobank testing, the framework achieved stronger short- and long-term risk discrimination than established clinical scores while revealing disease subgroups and genetic associations.

	Why Rare E. coli Genes Rarely Create New Metabolic Functions A study reveals that rare E. coli genes mainly reshape existing metabolic reactions, highlighting genetic diversity without expanding biochemical pathways.

	Blood protein clocks flag higher risks of death and chronic disease Proteomic age clocks applied to two European cohorts linked faster biological aging with smoking, alcohol use, physical inactivity, all-cause mortality, cardiovascular disease, dementia, and several cancers. The Global proteomic clock predicted mortality as well as established lifestyle risk factors, while organ-specific clocks showed stronger links with related cancers of the kidney, lung, and stomach.

	Mitochondrial DNA mutations link to cardiometabolic parameters in metabolic syndrome Mitochondrial DNA (mtDNA) variability, especially heteroplasmy, is believed to affect cellular immunobiogenesis, particularly in monocytes in metabolic syndrome (MetS).

	New Study Reveals How Introns Jump Between Species Without Viral Help Jumping genes are parasites in the genetic material of bacteria, plants, animals and humans. They are released into the cell as small RNA molecules from ribonucleic acid (RNA) and possess complex mechanisms for inserting themselves into other parts of the genetic material within the cell, thereby often conferring new properties on the cell and thus accelerating evolution.

	New approach enhances radiotherapy by disabling cancer's DNA repair machinery Cancer treatments like radiation and chemotherapy work by doing one main thing: shredding the DNA of cancer cells so they can no longer multiply.

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