Genomics - RNA editing events influence gene expression and phenotypic manifestation
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   Phase 2 clinical trial is now open at Columbia to test gene therapy for dry macular degenerationPhase 2 clinical trial is now open at Columbia to test gene therapy for dry macular degeneration
 
A phase 2 clinical trial is underway at Columbia University and NewYork-Presbyterian to test an investigational gene therapy for dry age-related macular degeneration, a progressive, chronic eye disease with no cure and a leading cause of blindness in the United States.
 
   Study: Lowering the activity of KRAS gene can help fight pancreatic cancerStudy: Lowering the activity of KRAS gene can help fight pancreatic cancer
 
If clinicians could stop mutations of the KRAS gene in pancreatic cancer – which happens in more than 90 percent of pancreatic cancer cases and drastically reduces response to immunotherapy – the chances of improving treatment for this deadly form of cancer would be increased.
 
 Study identifies key gene associated with age-related brain deterioration
 
Study identifies key gene associated with age-related brain deteriorationA new study led by the University of Portsmouth has identified that one of the major factors of age-related brain deterioration is the loss of a substance called myelin.
 
 
 Optimizing The Genome Editing Workflow With Microfluidic Technology
 
Optimizing The Genome Editing Workflow With Microfluidic TechnologyA recent grant collaboration, funded by Innovate UK, between Sphere Fluidics, University of Edinburgh, Horizon Discovery, OXGENE, and Twist Bioscience has culminated in a prototype automated microfluidic genome editing platform.
 
 
 Genome-wide CRISPR screening used to identify factors essential for SARS-CoV-2 infection in humans
 
Genome-wide CRISPR screening used to identify factors essential for SARS-CoV-2 infection in humansIn a methodologically trailblazing paper published in the journal Nature Genetics, a team of Belgian scientists uncovered an assembly of coronavirus host factors that may be exploited to develop drugs against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also potentially forthcoming zoonotic coronaviruses.
 
 
 MGH researchers uncover new clues about X chromosome inactivation
 
MGH researchers uncover new clues about X chromosome inactivationResearchers at Massachusetts General Hospital have uncovered new clues that add to the growing understanding of how female mammals, including humans, "silence" one X chromosome.