Genomics - Pathway Analysis After Genome-Wide Association Studies
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  July 15, 2019  
  Genomics  
  The latest genomics news from News-Medical  
 

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   Pathway Analysis After Genome-Wide Association StudiesPathway Analysis After Genome-Wide Association Studies
 
Genome-wide association studies are used to observe the genetics of multifactorial genetic diseases. Identifying the cause of such genetic diseases can be challenging, as the contribution of each genetic defect is often very small. Pathway analysis is used to further elucidate the impact of each genetic variant, thus increasing the physiological relevance and significance of the study.
 
   How Important is Intronic Variation?How Important is Intronic Variation?
 
The majority of human genomes have a variety of introns that must be removed one a gene has been transcribed from DNA to RNA, as they do not encode the information to translate RNA into proteins. As intronic mutations do not affect any protein-based sequences, they are ignored for the most part when attempting to pinpoint any normal or pathogenic genetic variations.
 
 

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 Uses of CRISPR/Cas Biosensing Systems
 
Uses of CRISPR/Cas Biosensing SystemsThe CRISPR/Cas 9 system is being widely employed for editing genes in mammalian systems. However, recently, the Cas9 enzyme has demonstrated potential as a biosensor, and various Cas effectors are now being applied to molecular diagnostics.
 
 
 Regulatory Mechanisms Involved in Gene Expression
 
Regulatory Mechanisms Involved in Gene ExpressionGene expression can be regulated by various cellular processes with the aim to control the amount and nature of the expressed genes. This article aims to describe the regulatory mechanisms that control gene expression in both eukaryotes and prokaryotes.
 
 
 Researchers completely eliminate all traces of HIV from infected mice
 
Researchers completely eliminate all traces of HIV from infected miceFor the first time, researchers have successfully removed HIV-1 DNA from the genomes of living animals, a critical step towards a potential cure for the disease. The team initially used drugs to suppress viral replication in mice. They then used the gene-editing tool CRISPR-Cas9 to eliminate viral DNA that had hidden itself in immune cells.
 
 
 Study reveals time taken for DNA repair after chemotherapy
 
Study reveals time taken for DNA repair after chemotherapyIn the time it takes for an Amazon Prime delivery to arrive, cells damaged by chemotherapy can almost completely fix their most important DNA. That is the case in the livers of mice at least, according to a new study. A team of researchers led by Nobel laureate Aziz Sancar found that DNA damaged by the widely used chemotherapy drug cisplatin is mostly good as new in noncancerous tissue within two circadian cycles, or two days.
 
 
 A Guide to Understanding Gene Expression
 
A Guide to Understanding Gene ExpressionBeing able to analyze gene expression patterns is essential for understanding protein function, biological pathways and cellular responses to external and internal stimuli. This article aims to provide a brief overview of the processes that underpin gene expression and the techniques that can be used to quantify the expression of specific genes.