Genomics - Scientists successfully create age-resistant mice with hyper-long telomeres
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   Scientists successfully create age-resistant mice with hyper-long telomeresScientists successfully create age-resistant mice with hyper-long telomeres
 
Researchers at the Spanish National Cancer Research Centre (CNIO) have shown that it is possible to extend the life of mice, without using any gene modifying technologies. The finding is the result of a study launched some years ago that aimed to investigate mice with hyper-long telomeres.
 
   New method prevents the release of synthetic DNA from genetically modified cellsNew method prevents the release of synthetic DNA from genetically modified cells
 
Scientists at Columbia University in New York have created a method that resolves two major problems commonly encountered in synthetic protein engineering. The method prevents a gene that encodes a synthetic protein from spreading into the wild and also stabilizes it so that it cannot mutate and lose its function over time.
 
 Scientists use ultrasound to detect active genes in live cells
 
Scientists use ultrasound to detect active genes in live cellsA startling new study published in the journal Science shows that ultrasound can help scientists to understand whether specific genes are in the active or inactive state in live cells. This incredible feat promises to transform the way scientists examine a host of living cell activities, ranging from the growth of tumors to neuron function.
 
 
 Novel viral vector improves gene therapy for sickle cell disease
 
Novel viral vector improves gene therapy for sickle cell diseaseResearchers at the National Institutes of Health (NIH) have developed a unique, improved viral vector to use in gene therapy for sickle cell disease. Using animal models, the new vector was shown to support the transfer of corrective genes into bone marrow stem cells up to ten times more efficiently than current vectors. It also had a carrying capacity that was ten times greater than conventional vectors.
 
 
 Machine learning reveals links between genetic factors and behavior
 
Machine learning reveals links between genetic factors and behaviorResearchers at the University of Utah Health have used machine learning to start making links between seemingly instinctive, random behaviors and the genetic factors that shape such behaviors. Using machine learning to study mice with differences in their genetics and age, the team found that these differences influenced the behavioral sequences the animals expressed while they foraged for food.
 
 
 Improved Cas9 enzyme reduces chance of off-target CRISPR mutations
 
Improved Cas9 enzyme reduces chance of off-target CRISPR mutationsGenomics experts are finding new ways to improve the use of the enzyme Cas9 for CRISPR gene-editing to reduce the likelihood of off-target mutations. The research, which addresses concerns about off-target mutagenesis and identifies new ways to improve precision, was recently presented at the American Society of Human Genetics 2019 Annual Meeting in Houston.