| |  Integrating proteomics with systems biology reveals complex cellular networks, improving disease mechanisms understanding and precision medicine applications. | |
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| |  Intrahepatic cholangiocarcinoma (iCCA), the second most common primary liver cancer after hepatocellular carcinoma, remains one of the most challenging malignancies to treat due to its highly concealed and heterogeneous nature. | |
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| |  For decades, multiple sclerosis research has focused on myelin, the insulation around the brain's wiring. Scientists paid less attention to another loss that was happening in parallel: neurons in the cortex, the seat of higher thinking and cognition, were quietly dying. | |
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| |  A collaboration between Karolinska Institutet, Karolinska University Hospital, and SciLifeLab has integrated whole genome sequencing into routine diagnostic investigations for rare diseases at Karolinska University Hospital. | |
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| |  Erica Periandri and Gabor Egervari, from Washington University in St. Louis, led a study to explore how alcohol exposure in male mice influences gene expression and mechanisms that regulate gene function-or epigenetics. | |
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| |  MethylScan is a new low-cost cell-free DNA methylome test that removes much of the healthy blood DNA background, helping rare disease signals stand out more clearly. In more than 1,000 people, it showed strong performance for detecting four cancers, classifying liver diseases, and identifying organ-specific damage. | |
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| |  Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer picture of how the genome is regulated and disrupted in diseases like cancer. | |
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| |  Human papillomavirus (HPV) is a double-stranded circular DNA virus with a genome of approximately 7–8 kb. This study aimed to establish an overlapping extension polymerase chain reaction method for the amplification of the entire genome of HPV16. | |
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| |  Scientists at the Buck Institute for Research on Aging, along with collaborators at UC San Francisco, have discovered that APOE4, the most common genetic risk factor for Alzheimer's disease, causes bone quality deficits specifically in female mice, through a mechanism that is invisible to standard imaging and can emerge as early as midlife. | |
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| |  What if some of the risk of anxiety and depression in children is not only about the genes they inherit, but also about their parents' genetic dispositions and how these influence the home environment? | |
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| |  Cancer cells excel at evading detection, but subtle chemical differences set them apart from healthy cells. | |
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| |  Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare diseases. | |
