Open the Door to Metabolomics Discovery with LECO

	Metabolomics
	The latest metabolomics news from AZoNetwork

Whatever challenges your analyses bring, LECO instruments can deliver the sensitivity and accuracy needed to go beyond the surface of metabolomics and produce confident annotations. Explore LECO's solutions for metabolomics analyses today.

Go Beyond the Surface

			Depleting TM6SF2 in the Gut Worsens Liver Fat Buildup, Study Finds A new study finds that gut-specific TM6SF2 depletion exacerbates liver fat accumulation and dysbiosis in mice on high-fat diets, highlighting its importance in gut-liver metabolic regulation.

			Metabolite profiles in spinal fluid predict mortality in tuberculous meningitis Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi Minh City (Vietnam).

	Ultra-processed foods increase risk of anxiety and depression, study shows A large UK Biobank study linked ultra-processed food (UPF) consumption to increased risks of anxiety, depression, substance use disorder, and other mental health outcomes. A metabolomic signature associated with UPF intake partially mediated these relationships, especially in adults under 60.

	Maternal exposure to metals rewires infants’ gut and resistance genes Prenatal exposure to trace elements like selenium, copper, and arsenic can significantly alter the infant gut microbiome, metabolism, and antibiotic resistance gene patterns. These changes appear as early as three months and evolve during the first year of life.

	Understanding the interconnected roles of microbial, metabolic, and immune biomarkers in IBD Inflammatory Bowel Disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is a chronic inflammatory condition of the gastrointestinal tract with a rising global burden.

	COVID-19 triggers metabolic signatures in kids that mirror adult heart risk Children with acute COVID-19 and MIS-C show significant disruptions in lipid metabolism, including patterns resembling adult severe COVID-19. These findings highlight potential long-term cardiovascular risks in pediatric SARS-CoV-2 cases and underscore the need for follow-up care.

	How Do Genetics and Diet Shape the Human Microbiome? Discover how genetics and diet shape the human gut microbiome, influencing health, metabolism, and disease risk. Explore implications for precision nutrition.

	Blood and urine tests reveal how much ultra-processed food you really eat, study finds Researchers developed and validated blood and urine metabolite scores that objectively measure ultra-processed food (UPF) intake in adults. These biomarker profiles accurately distinguished between high- and low-UPF diets and may transform nutrition research and public health monitoring.

	Small weight loss leads to big gains in heart health Even without weight loss, healthy lifestyle changes enhance heart health. This study highlights the importance of habits for cardiometabolic improvement.

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