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The latest life science microscopy news from AZoNetwork |
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 Tailored Cryo-EM and Correlative Workflows for Challenging Biological Samples
Finding a structure only hundreds of nanometres across within a complex biological sample is just the beginning. This interview explores how fluorescence-guided navigation, cryo-FIB-SEM, cryo lift-out and correlative imaging enable researchers to target specific regions while preserving sensitive specimens for high-resolution analysis. Read how these workflows are advancing challenging biological research.
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| | | | |  Researchers combined microfluidic enrichment, AI-assisted holography, and fluorescence profiling to identify circulating tumor cell candidates in 13 men with metastatic castration-resistant prostate cancer and 8 healthy donors. The platform found higher median candidate counts in patients, while nearly two-thirds of PSMA-positive candidates lacked EpCAM, suggesting EpCAM-dependent assays could miss some cells. | | | | |  Neural activity is three-dimensional and fast. Signals propagate through brain circuits on millisecond-to-microsecond timescales, while animals move, sense, and act. | | | | |  Researchers show that ultrathin aluminum adhesion layers can help preserve optical performance and mechanical stability in gold-based zero-reflection metasurfaces. | | | | |  Deep learning applied to more than 25,000 histopathology slides revealed tissue-specific structural signatures of biological aging that tracked telomere attrition, pathology, comorbidity, and molecular changes more closely than chronological age alone. | |
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