Discover how fluorescence-guided cryo-FIB milling enables reliable localization of intracellular protein crystals within vitrified cells, eliminates purification steps, and supports precise, site-specific lamella preparation for subsequent TEM electron diffraction analysis.
Advancements in multiplex imaging are reshaping cancer diagnostics, leveraging spatial biology and AI for improved biomarker discovery and treatment strategies.
Researchers introduced TFM-IR, an ambient-condition infrared microscopy method that uses torsional cantilever dynamics and nonlinear frequency mixing to map in-plane and out-of-plane photothermal responses at the nanoscale. The technique resolved anisotropic strain in mica nanobubbles and achieved near-nanometer optical imaging in twisted bilayer graphene, enabling site-resolved spectroscopy within individual moiré cells.
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