What decades of wine research can, and cannot, tell us about health
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 A childhood shaped by sugar rationing was linked to mental health more than 50 years laterA childhood shaped by sugar rationing was linked to mental health more than 50 years later
 
UK Biobank researchers examined whether sugar rationing during pregnancy and the first two years of life was associated with adult sweet-food preferences, sugar intake, brain structure, anxiety, and depression.
 
 
 What decades of wine research can, and cannot, tell us about healthWhat decades of wine research can, and cannot, tell us about health
 
A narrative review found that moderate wine intake has repeatedly been associated with lower all-cause and cardiovascular mortality, with proposed mechanisms involving ethanol and grape-derived polyphenols, but the evidence remains largely observational and cannot establish causation.
 
   A decades-long study raises questions about sugary drinks and stomach cancerA decades-long study raises questions about sugary drinks and stomach cancer
 
A large prospective U.S. study followed more than 111,000 adults to examine whether sugar-sweetened and artificially sweetened beverage intake was associated with gastric cancer incidence. Researchers identified 278 gastric cancer cases over 3.2 million person-years and found that associations differed according to beverage type and level of consumption.
 
   A two-year diet trial challenges the idea that weight loss is the only result that mattersA two-year diet trial challenges the idea that weight loss is the only result that matters
 
In the two-year DELISH randomized trial, adults with obesity achieved modest, sustained weight loss with either an adapted Mediterranean-style program or a commercial weight loss program. The Mediterranean-style intervention produced greater improvements in self-reported diet quality, while 24-month weight loss did not materially differ between groups.
 
   From caffeine to trigonelline, coffee has surprising links to muscle biologyFrom caffeine to trigonelline, coffee has surprising links to muscle biology
 
A scoping review of 54 studies found that coffee and several coffee-derived bioactive compounds influence pathways linked to skeletal muscle metabolism, including insulin signaling, mitochondrial function, oxidative stress, inflammation, glucose uptake, and protein turnover.
 
 More coffee, higher testosterone? This study found a more complicated picture
 
More coffee, higher testosterone? This study found a more complicated pictureHigher habitual coffee intake was associated with a leaner body composition, lower circulating branched-chain amino acids, and distinct cardiometabolic patterns in 2,264 middle-aged Finnish adults. Hormonal associations differed by sex, with broader testosterone- and SHBG-related patterns in men and more limited SHBG-related changes in women.
 
 
 Why living to 100 may depend on far more than diet and exercise
 
Why living to 100 may depend on far more than diet and exerciseA critical narrative review found that healthy diets, regular physical activity, strong social ties, and psychological well-being can support healthier aging and reduce premature mortality, but none has been shown to reliably determine who reaches 100.
 
 
 Pomegranate-derived compound shows promise against preserved ejection fraction heart failure
 
Pomegranate-derived compound shows promise against preserved ejection fraction heart failureA compound produced in the body after eating pomegranates improves heart function by up to 80% in a type of heart failure with limited treatment options.
 
 
 Study shows how prostate tumors rewire metabolism to resist therapy
 
Prostate tumors can rewire amino acid metabolism to override the normal brakes on cholesterol production, a process that may fuel hormone therapy resistance, according to a study by Weill Cornell Medicine investigators.
 
 
 FDA clears innovative blood test for earlier Alzheimer's diagnosis
 
The U.S. Food and Drug Administration (FDA) has cleared for marketing an innovative blood test with underlying technology invented at Washington University School of Medicine in St. Louis for the early diagnosis of Alzheimer's disease.
 
 
 Historic redlining continues limiting healthy food access, study finds
 
Bad housing, high crime and poor schools are more important than transportation or income when it comes to accessing healthy food in neighborhoods historically subjected to "redlining" - the now-illegal practice once used to refuse loans, insurance or mortgages to people in certain neighborhoods that were disproportionately inhabited by racial and ethnicity minorities.
 
 
 Pet food may be a contributor to long-chain PFAS exposure in dogs and cats
 
Pet food may be a contributor to long-chain PFAS exposure in dogs and catsResearchers at the Center for Marine Environmental Studies (CMES), Ehime University, have published two linked studies on PFAS exposure in companion animals.
 
 
 Higher BPA exposure tracked with higher estrogen and progesterone in women
 
Higher BPA exposure tracked with higher estrogen and progesterone in womenResearchers found that higher urinary concentrations of BPA and several phthalate metabolites were associated with higher serum estrogen and progesterone levels in 90 premenopausal women from Iran. The cross-sectional study also identified positive associations for combined chemical exposures, although the authors cautioned that the mixture findings are exploratory and cannot establish causality.
 
 
 Scientists compared 51 longevity studies to see which aging biomarkers respond most reliably
 
Scientists compared 51 longevity studies to see which aging biomarkers respond most reliablyResearchers analyzing 51 longitudinal intervention studies found that reliable generation 2+ DNA methylation biomarkers, particularly those predicting mortality or pace of aging, were the most responsive to interventions aimed at longevity or healthspan.
 
 
 UC Berkeley researchers find new potential treatment for obesity and diabetes
 
UC Berkeley researchers find new potential treatment for obesity and diabetesOver the past five years, medications called GLP-1s have revolutionized the treatment of metabolic disorders like obesity, diabetes and fatty liver diseases.
 
 
 Only three of 1,357 FDA-cleared AI devices tested patient outcomes
 
Only three of 1,357 FDA-cleared AI devices tested patient outcomesResearchers found that among 1,357 FDA-cleared or approved AI/ML-enabled medical devices, only 34 were linked to registered clinical trials and just three had been evaluated for patient-centered outcomes. The study highlights major gaps in prospective testing, demographic representation, transparency, and evidence showing whether medical AI meaningfully improves patients’ health.
 
 
 FDA-cleared medical AI rarely tested for real-world benefits
 
FDA-cleared medical AI rarely tested for real-world benefitsA new analysis shows that, of 1,357 artificial intelligence (AI)-based medical devices authorized by the U.S. Food and Drug Administration (FDA) for use in patient care, only three had been tested on whether they actually improve patients' health.
 
 
 Food waste used to produce vital omega-3 fatty acids
 
Food waste used to produce vital omega-3 fatty acidsIn a global first, Hiroshima University researchers demonstrate that food processing liquid waste can be used and reused to produce two omega-3 fatty acids by the cultivation of Aurantiochytrium sp., a marine microorganism.
 
 
 Only 15% of eligible American adults discuss lung cancer screening with their doctors
 
Only 15% of eligible American adults discuss lung cancer screening with their doctorsLung cancer screenings can save lives by detecting cancer in its early stages, but only 15% of eligible American adults have discussed the screening with their doctors, according to data analysis performed by University of Cincinnati Cancer Center researchers.
 
 
 AI-powered DANDELION identifies overlooked genes linked to asthma
 
One of the most important goals of studying genetics is to find genes that are involved with diseases. The problem is that most diseases aren't caused by a single gene or mutation.
 
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