Study links ancient evolutionary pressures to severe COVID-19 risk
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 Advances in X chromosome inactivation open therapeutic opportunities for X-linked genetic disordersAdvances in X chromosome inactivation open therapeutic opportunities for X-linked genetic disorders
 
A new review explores how advances in understanding X chromosome inactivation (XCI) are creating potential therapeutic opportunities for a range of X-linked genetic disorders, including Rett syndrome, Fabry disease, Duchenne muscular dystrophy, hemophilia, and others.
 
   Study links ancient evolutionary pressures to severe COVID-19 riskStudy links ancient evolutionary pressures to severe COVID-19 risk
 
Every time a virus invades a person, it collides with thousands of years of human history. A study led by researchers at the USC Dornsife College of Letters, Arts and Sciences and Howard University suggests that some of the genes involved in the body's immune response today bear the marks of ancient battles with infectious diseases.
 
   Scientists uncover cellular mechanism behind congenital heart defectsScientists uncover cellular mechanism behind congenital heart defects
 
Congenital heart disease affects approximately two in every 100 newborns globally. But why do they occur?
 
   Early vitamin B3 treatment may benefit children with rare genetic conditionEarly vitamin B3 treatment may benefit children with rare genetic condition
 
Children with a rare and often fatal genetic condition may benefit from early treatment with vitamin B3, halting their significant deterioration, according to a new study.
 
 Can Alzheimer's genes predict who becomes a SuperAger?
 
Can Alzheimer's genes predict who becomes a SuperAger?A study on SuperAgers shows exceptional memory isn't solely due to lower Alzheimer's genetic risk, highlighting the role of biological and lifestyle factors.
 
 
 Accumulation of somatic mutations drives vascular damage in people with progeria
 
Accumulation of somatic mutations drives vascular damage in people with progeriaHutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder that causes remarkable premature aging.
 
 
 Rare BTK mutation drives resistance to targeted therapies for blood cancer
 
Rare BTK mutation drives resistance to targeted therapies for blood cancerScientists at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, and collaborators have uncovered a rare genetic mutation that enables some blood cancers to evade both approved Bruton tyrosine kinase (BTK) inhibitors and newer BTK degraders, a finding that could help shape the next generation of therapies for patients with chronic lymphocytic leukemia (CLL) and related malignancies.
 
 
 Advances in DNA technology are reshaping preventive healthcare
 
Advances in DNA technology are reshaping preventive healthcareA new review highlights how advances in DNA technology are reshaping the future of healthcare by shifting the focus from treatment to prevention.
 
 
 Insilico Medicine highlights AI-powered biological target discovery for rare sinonasal cancer
 
Insilico Medicine highlights AI-powered biological target discovery for rare sinonasal cancerInsilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced the publication of a collaborative study in the journal npj Precision Oncology.
 
 
 FDA grants fast track designation to Insilico's AI-designed mesothelioma drug candidate
 
FDA grants fast track designation to Insilico's AI-designed mesothelioma drug candidateInsilico Medicine ("Insilico"; HKEX: 3696), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, today announced that ISM6331, a novel, potential best-in-class pan-TEAD inhibitor driven by Insilico's proprietary AI, has received Fast Track Designation (FTD) from the U.S.
 
 
 Multi-omics research uncovers new therapeutic targets for Fabry disease
 
Multi-omics research uncovers new therapeutic targets for Fabry diseaseA comprehensive review is shedding new light on Fabry disease, a rare inherited disorder that can progressively damage multiple organs and significantly affect quality of life.
 
 
 Scientists uncover how muscle actin filaments grow and renew themselves
 
Scientists uncover how muscle actin filaments grow and renew themselvesBiophysicists unraveled a mystery of how muscles form at the molecular level and how they maintain their function.
 
 
 New protein blueprint opens door for targeted Parkinson's disease therapies
 
New protein blueprint opens door for targeted Parkinson's disease therapiesResearchers at Weill Cornell Medicine have uncovered how a key Parkinson's protein called LRRK2 shifts between inactive and active forms, revealing the structural changes that enable certain mutations to push the protein into an overactive state.
 
 
 Ion channel TPC1 identified as key regulator of iron homeostasis
 
Ion channel TPC1 identified as key regulator of iron homeostasisResearchers have deciphered the role of an ion channel in iron homeostasis, opening up new possibilities for treating iron metabolism disorders.
 
 
 New study uncovers metabolic vulnerability in high-risk myelodysplastic syndromes
 
New study uncovers metabolic vulnerability in high-risk myelodysplastic syndromesResearchers at the University of Colorado Anschutz Cancer Center have identified a previously unknown metabolic weakness in the stem cells that drive high-risk myelodysplastic syndromes (MDS), a discovery that could lead to more targeted treatments for this aggressive blood cancer.
 
 
 Patient-derived tumor models strengthen precision oncology research
 
Patient-derived tumor models strengthen precision oncology researchA research project funded by the National Institutes of Health (NIH), with collaborators around the country and the world, has generated one of the most extensive and diverse collections of patient-derived tumor models.
 
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