People exposed to Agent Orange face higher risk of developing myelodysplastic syndrome

	Rare Diseases
	The latest rare diseases news from News Medical

	People exposed to Agent Orange face higher risk of developing myelodysplastic syndrome A new national study shows for the first time that people exposed to Agent Orange face a higher risk of developing myelodysplastic syndrome (MDS), tend to develop it earlier, and often have more aggressive disease that is more likely to progress to acute myeloid leukemia.

	A multi-gene mouse model reveals new mechanisms of Hirschsprung disease During development of the digestive system, a complex network of nerves forms around it, creating a "second brain" - the enteric nervous system (ENS) - which controls the movement of food and waste through the gut.

	Scientists unravel how citrin deficiency can trigger fat buildup in the liver even in lean individuals Scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. and a leading research center for diabetes and other life-threatening illnesses, have unraveled how citrin deficiency (CD), a rare genetic disorder that prevents the liver from converting food into energy efficiently, can trigger fat buildup in the liver - even in lean individuals.

	Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells This study shows that vacancy-engineered MoS₂ nanoflowers drive mitochondrial biogenesis in human mesenchymal stem cells by activating SIRT1–PGC-1α signaling and reducing oxidative stress. These treated cells transfer more functional mitochondria to injured recipient cells, restoring energy metabolism and redox balance in multiple in vitro models.

			Genetic variant linked to higher heart failure risk in children with myocarditis A genetic variant is likely putting some children suffering with myocarditis - inflammation of the heart muscle - at higher risk of developing heart failure, which can be fatal, according to a study published today in Circulation Heart Failure.

			Novel AI tool not only identifies genetic mutations but also predicts the type of disease Scientists at the Icahn School of Medicine at Mount Sinai have developed a novel artificial intelligence tool that not only identifies disease-causing genetic mutations but also predicts the type of disease those mutations may trigger.

			Timing of genetic mutation dictates childhood leukemia aggressiveness A team of researchers at the Icahn School of Medicine at Mount Sinai has uncovered why children with the same leukemia-causing gene mutation can have dramatically different outcomes: it depends on when in development the mutation first occurs.

			SARS-CoV-2 evolves after jumping from humans to zoo animals Research on SARS-CoV-2 in zoo tigers, lions, and hyenas shows rapid viral evolution and adaptation, offering insights into cross-species transmission dynamics.

	Autoimmune attack on CASPR2 drives nerve hyperexcitability and involuntary muscle activity A scientific review on autoimmune neurological diseases reveals what occurs in our body when the immune system, by mistake, produces antibodies that target a protein essential for the normal functioning of nerves.

	AI-driven method uncovers genetic interactions that fuel cancer progression University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel cancer progression, paving the way for earlier and more precise treatments.

	Broken DNA loops trigger lymphoma development Cancer involves more than just genetic mutations; it also involves structural failures. Consider a city where roads disappear, isolating communities from vital resources.

	Comprehensive gene maps reveal hidden networks behind disease traits Today's biomedical researchers are relentlessly searching for genes that drive disease, with the goal of creating therapies that target those genes to restore health.

	Researchers decipher anti-MOG antibody construction, paving way for therapies MOG Antibody-associated Disease (MOGAD) is a rare autoimmune disease of the central nervous system. The blood of patients contains antibodies against myelin oligodendrocyte glycoprotein (MOG), a protein in the myelin layer that surrounds the neurons in the brain. It is believed that these antibodies contribute to the destruction of this protective layer in the brain.

	Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows quickly, spreads early and lacks the hormone receptors that make other breast cancers treatable with targeted therapies.

	Cleveland Clinic reports promising results for breast cancer vaccine from final Phase 1 data Cleveland Clinic researchers are presenting final Phase 1 data from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

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