Uneven grey matter loss serves as a powerful new biomarker for early neurodegeneration

	Rare Diseases
	The latest rare diseases news from News Medical

	Uneven grey matter loss serves as a powerful new biomarker for early neurodegeneration Universitat Oberta de Catalunya Alzheimer's disease begins to weave a web in the brain and remodel neuronal tissue 15 to 20 years before the first symptoms appear. From the time this happens, however, until the disease is diagnosed and, later, enters an advanced phase, it progresses along a continuum of changes to the brain.

	UCLA researchers identify potential drug target for treating Fragile X syndrome UCLA Health researchers have identified a potential drug target for treating Fragile X syndrome, the most common genetic cause of intellectual disability and autism that affects roughly 1 in 2,000 boys.

			Scientists link schizophrenia risk gene to early cortical neuron changes Researchers at King's College London have identified the biological nature and timing of changes in human cortical neurons caused by altering activity of a schizophrenia-associated gene in developing human neurons.

			Targeting tumor-specific inflammatory process may prevent drug resistance in colon cancer Chemotherapy drugs that target a common mutation in colorectal cancer rapidly lose efficacy in patients, leading to relapse.

			Tumor microenvironment markers forecast immunotherapy response in rare cancers A new study in Cell Reports Medicine from researchers at The University of Texas MD Anderson Cancer Center identified key features that may help predict which types of rare cancers are likely to respond to immunotherapy.

	New computational tool uses plain language for genetic diagnosis A new computational tool called MARRVEL-MCP helps researchers move toward genetic diagnoses more efficiently by analyzing and interpreting vast amounts of genetic and biological information using everyday language.

	New discovery maps how mutant colorectal tumors adapt to KRAS inhibitors A new preclinical study led by researchers at The University of Texas MD Anderson Cancer Center and Weill Cornell Medicine has uncovered genetic and cell-state adaptive mechanisms that drive resistance to KRAS inhibitors in patients with KRAS-mutant colorectal cancer.

	Specific gene fusion patterns tied to solitary fibrous tumor outcomes Specific genetic fusion patterns in solitary fibrous tumors may help identify which patients face a higher risk of metastasis, recurrence and more aggressive disease behavior, according to new research that could improve how physicians assess and eventually treat this rare cancer.

	New TriPcide antibiotics kill dormant MRSA without resistance The study on TriPcides reveals their ability to combat MRSA and dormant bacteria, offering a new strategy to address antimicrobial resistance in public health.

	Boost iPSC culture efficiency with automated differentiated cell detection Improve iPSC culture efficiency and reproducibility with machine learning-enabled passaging control and automated differentiated cell detection.

	Brazilian study links TP53 mutations to poor lung cancer prognosis Lung cancer is the most common and deadly form of cancer worldwide. It is increasingly understood to be a complex genetic disease with different mutations that vary according to factors such as smoking and ethnicity.

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