How DNA Leakage into the Cytoplasm Drives Ruijs-Aalfs Syndrome
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 Polygenic analysis provides new insight into hypermobile Ehlers–Danlos syndromePolygenic analysis provides new insight into hypermobile Ehlers–Danlos syndrome
 
Hypermobile Ehlers–Danlos syndrome (hEDS) is one of the most common heritable connective tissue disorders.
 
 
 How DNA leakage into the cytoplasm drives Ruijs-Aalfs syndromeHow DNA leakage into the cytoplasm drives Ruijs-Aalfs syndrome
 
Although DNA is tightly packed and safeguarded within the cell nucleus, it remains continually at risk of damage from normal metabolic activity and external stressors such as radiation and chemical agents.
 
   Study elucidates key steps in the ubiquitin tagging of mutated huntingtin proteinStudy elucidates key steps in the ubiquitin tagging of mutated huntingtin protein
 
Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future therapies.
 
   Ancient DNA reveals rare growth disorder in upper paleolithic individualsAncient DNA reveals rare growth disorder in upper paleolithic individuals
 
Researchers led by the University of Vienna and Liège University Hospital Centre have identified genetic variants associated with a rare inherited growth disorder in two prehistoric individuals who lived more than 12,000 years ago.
 
 Beta arrestin 1 emerges as key driver of pulmonary hypertension
 
Beta arrestin 1 emerges as key driver of pulmonary hypertensionResearchers have uncovered the pivotal role of a previously overlooked protein in the development of the serious illness.
 
 
 Study identifies link between gut bacteria and deterioration of the brain in ALS, dementia
 
Study identifies link between gut bacteria and deterioration of the brain in ALS, dementiaA significant discovery by Case Western Reserve University researchers could change how doctors treat two of the most devastating neurodegenerative diseases.
 
 
 Autism-linked mutations converge on shared early brain pathways
 
Autism-linked mutations converge on shared early brain pathwaysUCLA Health researchers have created a comprehensive map showing how eight different genetic mutations associated with autism spectrum disorder affect early brain development, providing new insights into the ways diverse genetic causes may lead to shared features and symptoms of the disorder.
 
 
 CRISPR screen reveals genes driving human muscle development
 
CRISPR screen reveals genes driving human muscle developmentMuscles make up nearly 40% of the human body and power every move we make, from a child’s first steps to recovery after injury. For some, however, muscle development goes awry, leading to weakness, delayed motor milestones or lifelong disabilities.
 
 
 Engineered CAR-T cells reduce Alzheimer’s plaques in mice
 
Chimeric antigen receptor (CAR) T cell therapy, a type of immunotherapy that leverages the immune system to combat diseases, is a powerful treatment option for certain cancers.
 
 
 Genetic variants associated with rare inherited growth disorder identified in two prehistoric individuals
 
Researchers led by the University of Vienna and Liège University Hospital Centre have identified genetic variants associated with a rare inherited growth disorder in two prehistoric individuals who lived more than 12,000 years ago.
 
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