Immunology - Unveiling the role of auto-antibodies in COVID-19 severity
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Autoimmune diseases: Targeting the cGAS-STING pathwayAutoimmune diseases: Targeting the cGAS-STING pathway

Cyclic GMP-AMP synthase (cGAS) functions as a foreign DNA sensor, triggering an immune response to pathogens by activating the STING (stimulator of interferon genes) receptor. Shortly after its discovery in 2013, abnormal activation of cGAS by self-DNA was found to cause debilitating and often deadly autoimmune disorders, such as systemic lupus erythematosus (SLE) and Aicardi–Goutieres Syndrome (AGS).

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   Unveiling the role of auto-antibodies in COVID-19 severityUnveiling the role of auto-antibodies in COVID-19 severity
 
Even though COVID-19 manifests as a mild and short-lived disease in most people, some suffer extremely severe symptoms; in the worst cases, these patients die due to complications such as respiratory failure or thromboembolism.
 
   Designing hybrid antibodies with enhanced mobility and signaling capacityDesigning hybrid antibodies with enhanced mobility and signaling capacity
 
Antibodies are the body's superheroes, recognizing and eliminating disease-causing substances. By combining parts from antibodies, researchers at Lund University have designed a hybrid antibody that better stimulates the immune system against both the SARS-CoV-2 virus and streptococcal bacteria.
 
 New armored CAR T cell therapy boosts response in Relapsed non-Hodgkin lymphoma patients
 
New armored CAR T cell therapy boosts response in Relapsed non-Hodgkin lymphoma patientsWhile CAR T cell therapy has revolutionized treatment for many blood cancers, including non-Hodgkin lymphoma (NHL), many patients who receive CAR T cell therapy do not experience a long-term remission.
 
 
 Advanced imaging reveals hidden differences in T cell activation
 
Advanced imaging reveals hidden differences in T cell activationFrom the outside, most T cells look the same: small and spherical. Now, a team of researchers led by Berend Snijder from the Institute of Molecular Systems Biology at ETH Zurich has taken a closer look inside these cells using advanced techniques.
 
 
 Cellular Architecture Dictates T Cell Fate in Immune Response
 
Cellular Architecture Dictates T Cell Fate in Immune ResponseFrom the outside, most T cells look the same: small and spherical. Now, a team of researchers led by Berend Snijder from the Institute of Molecular Systems Biology at ETH Zurich has taken a closer look inside these cells using advanced techniques.
 
 
 Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue
 
Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissueResearchers investigated populations of regulatory T cells, a type of white blood cell, in various tissues.
 
 
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