Immunology - Regulatory Requirements of Cell and Gene Therapy
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TNF-α: A Master Pro-inflammatory Cytokine TNF-α: A Master Pro-inflammatory Cytokine

Tumor Necrosis Factor-alpha (TNF-α) is a cytokine important in nearly all acute inflammatory reactions by acting as an amplifier of inflammation. Sino Biological has developed a panel of high-quality recombinant TNF-α & receptor proteins to support its study.

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    Regulatory Requirements of Cell and Gene TherapyRegulatory Requirements of Cell and Gene Therapy
 
Cell and gene therapy (CGT) has developed rapidly since 2017 when two CAR-T cell therapy drugs were approved by FDA. However, quality research and quality control are more complicated due to the large heterogeneity in the cell source, type, and in vitro operation of cell and gene therapy products. FDA and EMA issued a series of guidelines to standardize the research and development of CGT products and improve their safety, effectiveness, and quality control ability.
 
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   How do Cancer Cells Interact with Our Immune System?How do Cancer Cells Interact with Our Immune System?
 
Generally, the immune system works to identify foreign “non-self” antigens present on pathogenic, infected, or malignant cells.
 
 Manipulating immune cells to suppress the growth of some solid tumors
 
Manipulating immune cells to suppress the growth of some solid tumorsCancer researchers at the Case Western Reserve University School of Medicine say they have successfully suppressed the growth of some solid tumors in research models by manipulating immune cells known as a macrophages.
 
 
 Study reveals key characteristics of immune cells in ovarian cancer
 
Study reveals key characteristics of immune cells in ovarian cancerOvarian cancer is a difficult to diagnose malignancy that is often caught at a more advanced stage. Treatments for this cancer have changed little over the past few decades, with surgery and chemotherapy being the most common therapeutic approaches.
 
 
 Researchers analyze the body’s immune cells with blood cancer cells
 
Researchers analyze the body’s immune cells with blood cancer cellsOne in every two people will acquire cancer at some point in their lives, according to the most recent international estimate.
 
 
 Researchers identify a way to accelerate "handbrake" immune cells to remove disease faster
 
Researchers identify a way to accelerate "handbrake" immune cells to remove disease fasterResearchers at WEHI have discovered a mechanism to boost immune cells, allowing them to remove disease and infections more quickly.