Why pulses could play a bigger role in healthy and sustainable diets
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 The healthiest super-agers may have one thing in common: stable cognitionThe healthiest super-agers may have one thing in common: stable cognition
 
A 10-year study of 1,003 older adults linked cognitive super-aging to fewer emergency visits, unplanned hospital admissions, delirium episodes, dementia diagnoses, and residential aged care placements. Maintaining cognitive performance over time showed the strongest overall association with favorable health outcomes and was linked to a 46% lower mortality risk.
 
 
 Why pulses could play a bigger role in healthy and sustainable dietsWhy pulses could play a bigger role in healthy and sustainable diets
 
A narrative review finds that pulses may support gut and metabolic health through their fiber, protein, phytochemicals, and interactions with the gut microbiota, while offering a lower environmental footprint than many animal protein sources. Human evidence is strongest for selected cardiometabolic outcomes, while many microbiome and fermentation-related benefits remain supported mainly by animal and laboratory studies.
 
   Simple biological age score flags higher cognitive decline risk in older adultsSimple biological age score flags higher cognitive decline risk in older adults
 
A study of 4,818 middle-aged and older Chinese adults found that higher light BioAge was associated with greater risks of cognitive impairment, episodic memory decline, and reduced mental intactness. The simple measure, based on age, creatinine, glucose, and CRP, added modest predictive information but requires further validation before clinical use.
 
   Restricting select amino acids may mimic protein restriction’s healthy aging benefitsRestricting select amino acids may mimic protein restriction’s healthy aging benefits
 
A review finds that restricting protein, particularly methionine, isoleucine, and valine, may improve metabolism and influence key aging pathways, largely in experimental models. Short human studies suggest metabolic benefits, but effects on lifespan remain unknown and restriction may harm people with unmet or increased protein needs.
 
   Older men’s sexual priorities extend well beyond erectile functionOlder men’s sexual priorities extend well beyond erectile function
 
A web-based survey of 6,000 Japanese men aged 50 or older found that sexual arousal was the function they most wanted to preserve, while erection became more highly valued as erectile function worsened. Erection showed the earliest age-related decline pattern, whereas ejaculation was the function most often reported as lost in older age.
 
 Nighttime light linked to conflicting signs of biological aging
 
Nighttime light linked to conflicting signs of biological agingHigher residential nighttime light exposure was associated with contrasting biological aging patterns in nearly 300,000 UK Biobank participants, depending on the aging algorithm used. PhenoAge and homeostatic dysregulation suggested a potentially adverse aging pattern, while KDM-BA showed the opposite association, underscoring uncertainty about how nighttime light relates to biological aging.
 
 
 Study maps how birth order tracks disease risk across 10 million siblings
 
Study maps how birth order tracks disease risk across 10 million siblingsResearchers analyzing claims from more than 10 million siblings linked first-born status to higher odds of several neurodevelopmental and allergic diagnoses, while second-born status tracked with substance abuse and gastrointestinal conditions. The observational study identified 150 significant birth-order associations across the phenome, but claims data and residual confounding prevent causal conclusions.
 
 
 Study links better midlife vascular health to nearly 13 more dementia-free years
 
Study links better midlife vascular health to nearly 13 more dementia-free yearsA long-term study of 12,409 adults found that a greater burden of diabetes, hypertension, and current smoking in midlife was associated with substantially fewer years lived free of dementia. Adults with none of these risk factors had about 30.1 dementia-free years from age 55, compared with 17.5 years among those with all three, a difference of nearly 13 years.
 
 
 Cortisol may distort the body signals that guide risky choices in men
 
Cortisol may distort the body signals that guide risky choices in menIn a randomized study of 109 young adults, researchers measured cortisol responses, skin conductance signals, and risk-taking during the Iowa Gambling Task after an acute psychosocial stressor. Cortisol reactivity altered how anticipatory bodily signals related to risky choices in men, although the stress condition did not increase overall risk-taking.
 
 
 Global surveys reveal little progress in tobacco risk awareness over two decades
 
Global surveys reveal little progress in tobacco risk awareness over two decadesAcross 46 countries, adults who smoked showed high awareness that tobacco causes lung cancer but substantially lower knowledge of cardiovascular and secondhand smoke harms. Knowledge changed little overall across two decades, supporting stronger health warnings, mass media campaigns and enforced smoke-free policies.
 
 
 AI sleep model reveals health risks missed by standard apnea scores
 
AI sleep model reveals health risks missed by standard apnea scoresAn AI foundation model extracted hidden physiological patterns from routine polysomnography and identified five patient groups with distinct long-term risks of mortality, cardiovascular disease, and neurological disorders. The approach outperformed apnea–hypopnea index severity categories for risk stratification and remained informative in an independent sleep cohort.
 
 
 Fine particle pollution raises rheumatoid arthritis flare risk and disease activity
 
Fine particle pollution raises rheumatoid arthritis flare risk and disease activityHigher ambient PM2.5 exposure was associated with increased rheumatoid arthritis disease activity and a greater likelihood of flares in a four-year South Korean cohort of 1,070 patients. The association appeared stronger with sustained exposure over approximately two weeks or longer, while women and nonsmokers showed more pronounced links between PM2.5 and DAS28-CRP.
 
 
 AI tool helps customize radiopharmaceutical therapy dosing
 
AI tool helps customize radiopharmaceutical therapy dosingRadiopharmaceutical therapy (RPT) has made great strides over the last 50 years, having only recently received FDA approval to treat prostate cancer. But despite the progress-and billions of dollars of industry investments-one area that has lagged behind is dosing, which is still one-size-fits-all.
 
 
 Optimal prostate-specific antigen cutoff linked to improved prostate cancer survival
 
Optimal prostate-specific antigen cutoff linked to improved prostate cancer survivalAfter treatment for metastatic prostate cancer, a drop in prostate-specific antigen (PSA) levels in the blood is an indicator that the treatment is working.
 
 
 Ferroptosis-based therapy shows promise for advanced prostate cancer treatment
 
Ferroptosis-based therapy shows promise for advanced prostate cancer treatmentA recent review explores the rapidly expanding field of ferroptosis-based therapy for prostate cancer, presenting ferroptosis as a promising strategy to overcome resistance in advanced and castration-resistant prostate cancer (CRPC).
 
 
 Living near a dry cleaner may come with an unexpected Parkinson’s disease link
 
Living near a dry cleaner may come with an unexpected Parkinson’s disease linkA nationwide case-control study of older U.S. Medicare beneficiaries found that living closer to a dry-cleaning establishment was associated with higher odds of incident Parkinson’s disease, with the strongest association among people living within 0.1 mile.
 
 
 Long-acting HIV prevention tools could help close the gap before a vaccine arrives
 
Long-acting HIV prevention tools could help close the gap before a vaccine arrivesA review of non-vaccine HIV interventions highlights the strong preventive effects of long-acting PrEP, sustained ART, U=U, vertical transmission programs, and voluntary medical male circumcision. Gene editing and multispecific antibodies may expand future options, but safety, cost, access, adherence, and implementation barriers remain.
 
 
 Tadalafil may increase glaucoma risk in men with enlarged prostates
 
Tadalafil may increase glaucoma risk in men with enlarged prostatesAn erectile dysfunction drug that is also used to treat symptoms like sudden urgency and frequency, which are associated with an enlarged prostate in men, may heighten the risk of the serious eye condition, glaucoma, finds a large comparative study published online in the British Journal of Ophthalmology.
 
 
 Study identifies a novel direct drug target for head and neck squamous cell carcinoma
 
Study identifies a novel direct drug target for head and neck squamous cell carcinomaChemotherapy remains a cornerstone of treatment for head and neck cancers, the seventh-most common cancer type worldwide.
 
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