The right seafood choices can help diets meet health and climate goals
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 How do everyday spices help protect the heart?How do everyday spices help protect the heart?
 
A Nutrition Reviews supplement article reviewed controlled studies showing that culinary spice and herb blends may improve selected cardiometabolic risk markers, including post-meal triglycerides, insulin responses, inflammation, endothelial function, and 24-hour blood pressure.
 
 
 The right seafood choices can help diets meet health and climate goalsThe right seafood choices can help diets meet health and climate goals
 
Fish can support healthy and sustainable diets, especially when it replaces red and processed meat rather than adding to overall animal-food intake. However, its environmental value depends on species, production system, supply chain, local dietary patterns, and the scale of greenhouse gas reductions required.
 
   Indian adapted Mediterranean diet targets inflammation in heart disease trialIndian adapted Mediterranean diet targets inflammation in heart disease trial
 
The paper describes a single-center randomized controlled trial testing whether an Indian Adapted Mediterranean Diet can reduce dietary inflammation in adults with stable coronary artery disease or moderate-to-high cardiovascular risk. The protocol will assess changes in the Dietary Inflammatory Index, inflammatory biomarkers, cardiometabolic risk factors, body measurements, and metabolic hormones over six months.
 
   Why blood pressure rises faster in women after midlifeWhy blood pressure rises faster in women after midlife
 
This review examines how sex-specific blood pressure trajectories are shaped by genetics, hormones, metabolic risk factors, lifestyle exposures, environmental stressors, and medical treatments. It highlights that women generally have lower blood pressure earlier in life but may experience steeper increases with aging, especially around and after menopause, with exogenous stressors appearing to have a greater impact in women than in men.
 
   Why Kenya, Ethiopia, Japan, and the US stand out in global distance runningWhy Kenya, Ethiopia, Japan, and the US stand out in global distance running
 
This global analysis of 152,943 endurance runners found that nationality, gender, age, and race distance were significantly associated with running performance from 1999 to 2024. Men were faster across all distances, women were generally older in longer races, and runners from Kenya, Ethiopia, Japan, and the United States showed distinct participation and performance patterns.
 
 Gut microbes may reveal who is at risk of type 2 diabetes years before diagnosis
 
Gut microbes may reveal who is at risk of type 2 diabetes years before diagnosisA large Swedish prospective cohort study found that specific gut microbial species and metabolic pathways measured years before diagnosis were associated with future type 2 diabetes risk. The findings suggest that gut microbiome composition and functional potential may help explain T2D development, but replication is needed before clinical use.
 
 
 How heat-smart cities can protect outdoor recreation in a warming world
 
How heat-smart cities can protect outdoor recreation in a warming worldThis review shows how rising humid heat threatens the health benefits of nature-based recreation in tropical cities. The authors call for heat-smart urban planning, targeted advisories, and inclusive strategies that keep outdoor activity safe, accessible, and beneficial.
 
 
 Mesenchymal drift may explain how aging cells lose their identity
 
Mesenchymal drift may explain how aging cells lose their identityMesenchymal drift may help explain how cells lose stable identity and acquire pro-fibrotic, inflammatory mesenchymal traits during aging. The review proposes MD as a unifying framework that links multiple hallmarks of aging and highlights partial reprogramming as a potential, but still preclinical, way to counteract this process.
 
 
 Ghrelin rises in depression despite obesity’s usual appetite-hormone suppression
 
Ghrelin rises in depression despite obesity’s usual appetite-hormone suppressionResearchers found that both acylated and deacylated ghrelin were elevated in unmedicated adults with major depressive disorder and obesity compared with non-depressed adults with obesity. The cross-sectional findings suggest ghrelin-system dysregulation may be linked to depression in obesity, but larger longitudinal studies are needed to test whether ghrelin is a reliable biomarker.
 
 
 How the right diet could support the gut bacteria that matter most
 
How the right diet could support the gut bacteria that matter mostThis review examines how gut keystone bacteria shape microbiome stability, disease risk, and responses to diet. It highlights why better identification methods, experimental validation, and precision diet-probiotic strategies are needed to restore gut homeostasis.
 
 
 Study links ceramide levels to prostate cancer drug response differences
 
Study links ceramide levels to prostate cancer drug response differencesCeramides-lipid molecules in cells that affect many physiological functions including cell differentiation, migration, and death-and their metabolites have been implicated in the development of cancer and other conditions.
 
 
 Why new Alzheimer’s drugs are dividing regulators worldwide
 
Why new Alzheimer’s drugs are dividing regulators worldwideThe Lancet World Report examines why regulators in the US, UK, and Europe have reached different decisions on new amyloid-targeting Alzheimer’s drugs despite evidence that they can modestly slow clinical decline. It highlights the unresolved balance among benefits, safety risks, costs, access, and the need for broader, earlier, and more patient-centered treatment strategies.
 
 
 Tomato-soy juice curbs inflammation in obese adults
 
Tomato-soy juice curbs inflammation in obese adultsDrinking tomato-soy juice loaded with compounds shown in animal studies to promote health lowered pro-inflammatory proteins in healthy adults with obesity after four weeks, a new study found.
 
 
 Scientists uncover shared gene signatures that reveal how mammals age
 
Scientists uncover shared gene signatures that reveal how mammals ageResearchers mapped more than 11,000 transcriptomes across mice, rats, macaques, and humans, revealing conserved molecular signatures of aging and mortality across tissues, species, and cell types. The study developed interpretable transcriptomic clocks that track age, mortality-related molecular change, chronic disease signals and responses to lifespan-altering interventions.
 
 
 Scientists identify new therapeutic target for deadly prostate cancer
 
Scientists identify new therapeutic target for deadly prostate cancerResearchers at Columbia University Irving Medical Center have identified a gene that drives the development of neuroendocrine prostate cancer (NEPC), an aggressive form of the disease.
 
 
 Research challenges long standing beliefs about cannabis and male hormones
 
Research challenges long standing beliefs about cannabis and male hormonesThe effects of cannabis on the hormonal system and male fertility remain controversial within the scientific community. A study conducted by the University of Geneva (UNIGE), in collaboration with the Swiss Center for Applied Human Toxicology (SCAHT), provides a new answer by showing that cannabis use does not reduce testosterone levels in young men and may even increase its testicular synthesis.
 
 
 PSMA PET detects high-risk prostate cancer bone metastases
 
PSMA PET detects high-risk prostate cancer bone metastasesCompared to conventional imaging techniques, prostate specific membrane antigen (PSMA) PET imaging provides superior detection of bone metastases in prostate cancer patients a critical indicator of a patient's long-term survival.
 
 
 High-risk prostate cancer patients benefit from perioperative apalutamide therapy
 
High-risk prostate cancer patients benefit from perioperative apalutamide therapyHigh-risk localized and locally advanced prostate cancer patients treated with apalutamide - a next generation neoadjuvant androgen-receptor pathway inhibitor (ARPI) - plus hormone therapy before and after prostate cancer surgery resulted in more major pathologic responses and reduced the risk of metastasis or death, meeting both primary endpoints, in an international phase 3 clinical trial led by principal investigator Mary-Ellen Taplin, MD,...
 
 
 Predictive model helps tailor PSMA therapy for prostate cancer patients
 
Predictive model helps tailor PSMA therapy for prostate cancer patientsA new machine-learning approach for prostate-specific membrane antigen (PSMA) treatment of metastatic castration-resistant prostate cancer (mCRPC) could estimate radiation dose to tumors and healthy organs before therapy begins.
 
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