Wholegrain rye changes gut bacteria and lowers inflammation in obesity trial
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 Moderate coffee intake may lower heart failure riskModerate coffee intake may lower heart failure risk
 
A systematic review and dose-response meta-analysis of seven prospective cohorts found that drinking 2 to 4 cups of coffee a day was associated with a modestly lower risk of incident heart failure. The lowest estimated risk appeared at 1 to 2 cups daily, although the evidence for a true non-linear J-shaped pattern was suggestive rather than definitive.
 
 
 Wholegrain rye changes gut bacteria and lowers inflammation in obesity trialWholegrain rye changes gut bacteria and lowers inflammation in obesity trial
 
In a 12-week randomized trial, replacing refined wheat with wholegrain rye in a calorie-restricted diet did not produce greater weight loss in adults with overweight or obesity. Wholegrain rye did, however, lower C-reactive protein and alter gut microbiota and short-chain fatty acids in ways that may have positive cardiometabolic implications.
 
   Nepal and Afghanistan show how abrupt aid cuts can unravel essential careNepal and Afghanistan show how abrupt aid cuts can unravel essential care
 
Abrupt cuts to external health aid can destabilize multiple essential services simultaneously in fragile, donor-dependent settings, as illustrated by Nepal and Afghanistan. The paper argues that donor withdrawal is not just a resilience test, but also an ethical and governance issue that should be managed through “transition discipline.”
 
   UPFs before conception may shape fertility and embryo growthUPFs before conception may shape fertility and embryo growth
 
Findings show ultraprocessed food consumption before conception influences fertility and embryonic development, urging further research in this area.
 
   Heavily processed foods may raise heart disease risk beyond poor nutrition aloneHeavily processed foods may raise heart disease risk beyond poor nutrition alone
 
A 2026 review in Cardiology in Review reports that higher intake of ultra-processed foods is consistently associated with greater risks of cardiovascular disease, stroke, and cardiovascular mortality across cohort studies and meta-analyses.
 
 New fathers face delayed mental health risks after childbirth
 
New fathers face delayed mental health risks after childbirthPaternal mental health risks increase after childbirth, with delayed detection of psychiatric disorders underscoring the need for targeted support for fathers.
 
 
 50 years of data reveal higher death risks in London transport workers
 
50 years of data reveal higher death risks in London transport workersA 50-year retrospective cohort study of 117,166 Transport for London workers found that bus and London Underground job categories had higher all-cause, respiratory, cardiovascular, and lung cancer mortality than office workers. The authors caution that broad job categories, missing cause-of-death data, and unmeasured confounding mean the findings show association, not proof of specific occupational causes.
 
 
 Men show major gaps in male fertility knowledge, study finds
 
Men show major gaps in male fertility knowledge, study findsA study of 156 adult men found that knowledge about male fertility was generally low across both medical and lifestyle-related topics, with only 5 of 25 questions answered correctly by most respondents. Older men, those with a medical background, and those with suspected or treated infertility tended to score higher, while supplement use was common despite limited fertility literacy.
 
 
 Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth
 
Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growthResearchers showed that chronic colitis leaves a long-lasting epigenetic memory in colonic stem cells, persisting for more than 100 days after recovery in mice. This memory is marked by durable AP-1-linked chromatin changes and later amplifies tumour outgrowth after oncogenic mutation.
 
 
 Do GLP-1 Drugs Reduce Cancer Risk or Increase It?
 
Do GLP-1 Drugs Reduce Cancer Risk or Increase It?Emerging evidence links popular weight-loss drugs to lower cancer rates, but are these effects real, or simply a reflection of better metabolic health?
 
 
 Estradiol patches as effective as injections for locally advanced prostate cancer
 
Estradiol patches as effective as injections for locally advanced prostate cancerHormone patches are as good at controlling locally advanced prostate cancer as the injections typically used to deliver hormone therapy, according to the results of a large clinical trial led by UCL (University College London) researchers.
 
 
 Blood pressure drug boosts effectiveness of cancer therapy
 
Blood pressure drug boosts effectiveness of cancer therapyIn a new Dartmouth Cancer Center (DCC) study led by clinical researcher Tyler J. Curiel, MD, MPH, FACP, investigators found that the FDA-approved blood pressure drug telmisartan can significantly enhance the cancer-killing activity of the targeted therapy olaparib, potentially expanding its use to many more patients.
 
 
 Systematic review identifies stress-induced biological triggers in oncology
 
Systematic review identifies stress-induced biological triggers in oncologyStress is a constant companion in the oncologist's office. It appears at the time of diagnosis, increases with each stage of treatment, and often does not resolve even after therapy formally ends. It accompanies therapeutic decisions, waiting for test results, fear of recurrence, and changes in daily functioning. Studies show that chronic stress can trigger biological processes that promote disease progression and weaken the body's defenses.
 
 
 CREB5 drives stem cell-like transcriptional programs in aggressive prostate cancer
 
CREB5 drives stem cell-like transcriptional programs in aggressive prostate cancerA new research paper was published in Volume 17 of Oncotarget on March 17, 2026, titled "CREB5 regulates stem cell-like transcriptional programs to enhance tumor progression in prostate cancer."
 
 
 Research reveals potential new strategy for targeting deadly small cell neuroendocrine cancers
 
Research reveals potential new strategy for targeting deadly small cell neuroendocrine cancersUCLA researchers have uncovered a hidden weakness in some of the deadliest cancers, revealing a potential new strategy for targeting tumors that have long resisted treatment.
 
 
 Detailed cell atlas reveals earliest changes in prostate cancer
 
Prostate cancer affects one in five Australian men, making it the most common cancer in the country.
 
 
 Early testosterone surge triggers rare muscle disease
 
Early testosterone surge triggers rare muscle diseaseSpinal and Bulbar Muscular Atrophy (SBMA) is a rare inherited disease that causes progressive muscle weakness and wasting in men.
 
 
 ATLAS platform enables realistic study of metastatic cancer clusters
 
ATLAS platform enables realistic study of metastatic cancer clustersMetastasis, the spread of cancer from a primary tumor to other parts of the body, is difficult to study in the lab, in part because researchers lack reliable ways to recreate the conditions cancer cells encounter as they travel through the bloodstream.
 
 
 Leaving home may worsen diet quality in young adults, Australian study finds
 
Leaving home may worsen diet quality in young adults, Australian study findsAustralian longitudinal data suggest that leaving the parental home is associated with a small decline in overall diet quality and a short-term rise in discretionary food intake during the transition from adolescence to adulthood. The study also found that diet quality tended to worsen most among those moving in with a partner, while the discretionary-food gap narrowed over time.
 
 
 APOE4 alters brain immunity and cognition differently in females and males
 
APOE4 alters brain immunity and cognition differently in females and malesAPOE4 drove sex-specific changes in meningeal immunity, lymphatic drainage, brain lipids, neuroinflammation, and cognition in mouse models, with females showing greater inflammatory and cognitive vulnerability. Suppressing innate immunity improved some cognitive outcomes in female E4/E4 mice but worsened them in male E4/E4 mice, underscoring the need for sex-tailored approaches.
 
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