Aircraft emissions could double air pollution deaths by 2040
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 Men's fertility-friendly underwear may be briefs without benefitsMen's fertility-friendly underwear may be briefs without benefits
 
A narrative review found that tight-fitting underwear may modestly raise scrotal temperature and is inconsistently linked to lower sperm production measures. However, current evidence does not show that switching to looser underwear improves real-world fertility outcomes.
 
 
 Aircraft emissions could double air pollution deaths by 2040Aircraft emissions could double air pollution deaths by 2040
 
Scenario-based modeling projects that aviation-related air pollution could drive a major rise in premature deaths by 2040, mainly through PM2.5 and ozone exposure. The study estimates that aircraft emissions caused 33,900 PM2.5-related deaths and 24,600 ozone-related deaths in 2019, with baseline 2040 deaths projected to more than double.
 
   New biological age tools could reveal health risks before symptoms appearNew biological age tools could reveal health risks before symptoms appear
 
A JCI review traces biological age measurement from functional tests and blood biomarkers to epigenetic, proteomic, imaging, wearable, and AI-based clocks. It finds that these tools can improve risk prediction beyond chronological age, but standardization, interpretability, and prospective validation are needed before routine clinical use.
 
   NHS dental costs will hit £5.3 billion as older adults carry the burdenNHS dental costs will hit £5.3 billion as older adults carry the burden
 
A UK cost-of-illness projection estimates that direct NHS dental treatment costs for adult caries and periodontal disease will rise by 20%, from £4.42 billion in 2020 to £5.30 billion by 2050. The burden shifts strongly toward older adults and severe disease, supporting prevention and earlier intervention as NHS dental planning priorities.
 
   US adults are taking more supplements as multivitamins lose groundUS adults are taking more supplements as multivitamins lose ground
 
A 25-year NHANES analysis of 63,442 US adults found that reported dietary supplement use rose from 51% to 60%, with the largest increases among adults aged 65 years and older. Use shifted away from multivitamin-multimineral products and toward vitamins, minerals, botanicals, and nonvitamin nonmineral supplements marketed for immune, anti-inflammatory, gut, skin, and joint health.
 
 Gut bacteria may help explain why fatigue appears before illness
 
Gut bacteria may help explain why fatigue appears before illnessA small study of healthy Japanese adults found that fatigue was associated with distinct gut microbiome, microbial gene, and fecal metabolite patterns. The findings suggest fatigue may track with altered microbial energy metabolism and oxidative stress-related functional potential, but larger longitudinal studies are needed to test causality and clinical value.
 
 
 Migraine affects driving more often than clinicians may realize
 
Migraine affects driving more often than clinicians may realizeA multicenter study of 1,333 active drivers with migraine found that 70.6% had experienced headache while driving, with headaches occurring during about 13% of driving sessions. The findings suggest that migraine-related symptoms may impair attention, increase sensitivity to road conditions, and contribute indirectly to driving cessation and accident risk.
 
 
 Persistent anxiety and depression may delay emotional maturity into midlife
 
Persistent anxiety and depression may delay emotional maturity into midlifeA long-running Australian cohort study found that personality traits generally matured from early to middle adulthood, with agreeableness and conscientiousness rising and extraversion, openness, and neuroticism declining. People with persistent common mental disorders showed the clearest decline in neuroticism by midlife, but they still had higher emotional instability than peers without persistent mental health difficulties.
 
 
 Purdue develops next-generation platform to accelerate cancer drug discovery
 
Researchers at the Purdue Institute for Cancer Research (PICR) have developed a next-generation technology platform designed to dramatically accelerate one of the slowest and most challenging stages of cancer drug discovery: identifying promising compounds that could eventually become new therapies.
 
 
 GLP-1s may improve testosterone levels and sperm quality in men with obesity
 
GLP-1s may improve testosterone levels and sperm quality in men with obesityGLP‑1s do not harm male hormones or fertility after long-term use, according to a study being presented Monday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill.
 
 
 Higher BMI raises risk for 19 cancers as global review expands the obesity-cancer link
 
Higher BMI raises risk for 19 cancers as global review expands the obesity-cancer linkA major systematic review and meta-analysis links higher BMI to increased risk of 19 cancer types, including leukemia, non-Hodgkin lymphoma, bladder cancer, and glioma, which were not previously recognized in major consensus reports. The study also reveals regional and sex-based variation in cancer risk, with genetic evidence generally supporting many observational links while highlighting the need for more diverse global cohorts.
 
 
 Gut microbes may help explain why obesity and type 2 diabetes become harder to reverse
 
Gut microbes may help explain why obesity and type 2 diabetes become harder to reverseThis review describes how gut microbial messengers, including SCFAs, microbiota-modified bile acids, neuroactive metabolites, and extracellular vesicles, may shape obesity and type 2 diabetes through the microbiota-gut-brain axis.
 
 
 Blood proteins reveal which aging cells may raise disease risk
 
Blood proteins reveal which aging cells may raise disease riskA large plasma proteomics study shows that aging patterns in specific cell types may help identify who is more vulnerable to disease and who is more resilient. Study: Plasma proteomic signatures of cellular aging predict human disease.
 
 
 Synthetic gut communities reveal how diet rewires the microbiome
 
Synthetic gut communities reveal how diet rewires the microbiomeSynthetic microbial communities give researchers controlled models for testing how diet reshapes gut microbial ecology, metabolism, and host-relevant responses. The review highlights how SynComs can strengthen causal inference, improve intervention testing, and support future precision nutrition, while noting major challenges in stability, standardization, and ecological realism.
 
 
 Study reveals gender-based diet inequality in ancient European societies
 
Study reveals gender-based diet inequality in ancient European societiesA new Simon Fraser University study has found men in ancient Europe likely had better access to protein-rich foods than women did.
 
 
 New study uncovers how prostate cancer cells evade treatment
 
New study uncovers how prostate cancer cells evade treatmentCancer cells are remarkably good at adapting to stress. When treatments damage them, they often find new ways to survive, fueling drug resistance and disease progression.
 
 
 Semaglutide, omega-3s and diet shift epigenetic aging clocks in human studies
 
Semaglutide, omega-3s and diet shift epigenetic aging clocks in human studiesA systematic review identified 41 human studies evaluating interventions targeting next-generation DNA methylation-based aging clocks. Pharmaceutical, lifestyle, supplement, clinical, and psychosocial interventions shifted some clock outputs, but these biomarkers remain investigational rather than proven clinical surrogates.
 
 
 Nearby wind turbines show no broad health hit, but clusters raise questions
 
Nearby wind turbines show no broad health hit, but clusters raise questionsA German longitudinal study found no robust evidence that nearby construction of wind turbines broadly reduced physical or mental health-related quality of life among residentially stable adults. However, living within 3 km of a higher turbine density was associated with lower mental HRQoL, suggesting cumulative exposure may matter more than distance alone.
 
 
 Paid paternity leave supports new fathers' mental health, study finds
 
Paid paternity leave supports new fathers' mental health, study findsA new study from Northwestern University and Ann & Robert H. Lurie Children's Hospital of Chicago highlights the critical role paid paternal leave plays in supporting new dads' mental health following the birth of their baby.
 
 
 Engineered silica nanoparticles destroy prostate tumors in preclinical study
 
Engineered silica nanoparticles destroy prostate tumors in preclinical studyProstate-targeted, engineered nanoparticles made of amorphous silica are effective in killing prostate tumors directly while enhancing anti-tumor immunity, according to a preclinical study led by investigators at Weill Cornell Medicine and the Cornell College of Engineering.
 
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