Sperm RNA aging shift that may explain paternal age effects
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 Exercise variety, not just volume, is tied to longer lifeExercise variety, not just volume, is tied to longer life
 
Researchers analysed nearly three decades of data from more than 111,000 adults to examine whether the variety of physical activities people perform is linked to long-term survival. They found that engaging in a broader range of activity types was associated with lower all-cause mortality, independent of total exercise volume.
 
 
 Sperm RNA aging shift that may explain paternal age effectsSperm RNA aging shift that may explain paternal age effects
 
Study reveals an 'aging cliff' in sperm RNA, linking age-related changes to early development and highlighting risks associated with advanced paternal age.
 
   GLP-1 weight-loss drugs show early promise for treating addictionGLP-1 weight-loss drugs show early promise for treating addiction
 
This systematic review evaluates preclinical and clinical evidence on glucagon-like peptide-1 receptor agonists as potential treatments for substance use disorders. Findings show consistent reductions in drug- and alcohol-seeking behaviors in animal models, while human evidence remains limited, heterogeneous, and preliminary.
 
   Adding lean pork to a plant-forward diet supports healthy aging biomarkersAdding lean pork to a plant-forward diet supports healthy aging biomarkers
 
A randomized crossover feeding trial in adults aged 65 years or older found that plant-forward diets incorporating either minimally processed lean pork or lentils produced similar short-term improvements in cardiometabolic and neuroactive biomarkers.
 
 Regular aerobic exercise slows a key marker of brain aging in midlife
 
Regular aerobic exercise slows a key marker of brain aging in midlifeRegular aerobic activity significantly reduces brain-PAD, indicating that exercise is crucial for maintaining brain health and reducing dementia risk.
 
 
 Shingles vaccination is linked to slower biological aging in older adults
 
Shingles vaccination is linked to slower biological aging in older adultsThis population-based study of U.S. adults aged 70 and older found that shingles vaccination was associated with slower epigenetic and transcriptomic aging, as well as lower systemic inflammation. No significant associations were observed for neurodegeneration or cardiovascular biomarkers, highlighting domain-specific molecular effects rather than broad clinical changes.
 
 
 Ashwagandha aids recovery without blunting training stress in athletes
 
Ashwagandha aids recovery without blunting training stress in athletesSix weeks of Ashwagandha root extract supplementation in semi-professional team-sport athletes was associated with sex-specific effects during pre-season training. Females showed improved perceived recovery with stable cortisol, while males demonstrated gains in lower-body power with stable cortisone levels.
 
 
 When you eat matters: early time-restricted eating improves metabolic health
 
When you eat matters: early time-restricted eating improves metabolic healthTime-restricted eating improves several metabolic outcomes compared with usual diets, with benefits observed for body weight, adiposity, blood pressure, insulin, glucose, and triglycerides. Early eating windows consistently outperform late eating, while the optimal duration of food intake remains uncertain.
 
 
 Long-term air pollution exposure raises motor neuron disease risk
 
Long-term air pollution exposure raises motor neuron disease riskLong-term exposure to ambient air pollution was associated with a higher risk of developing motor neuron disease and poorer prognosis after diagnosis in a large nationwide Swedish study. Higher particulate matter and nitrogen dioxide exposure were also linked to faster functional decline and increased likelihood of invasive ventilation.
 
 
 Research suggests bamboo-based foods could support metabolic health
 
Research suggests bamboo-based foods could support metabolic healthThis systematic review synthesizes human, in vitro, and food-processing studies on bamboo consumption, finding limited but suggestive evidence for metabolic, digestive, and antioxidant benefits when products are properly prepared. It also highlights safety considerations, including potential goitrogenic effects from inadequately processed shoots, and calls for higher-quality human trials.
 
 
 Pre-surgical medication use grows for pancreatic, gynecologic, and abdominal lining cancers
 
The second annual report from the National Cancer Database (NCDB) of the American College of Surgeons (ACS) documents a substantial rise in medication treatments, such as chemotherapy, immunotherapy, and hormone therapy, used before surgery to treat many cancers, often allowing less invasive surgery and helping clinicians assess how a patient's cancer responds to medication to guide the most effective treatment options.
 
 
 High-dose flu shots lower hospitalization risk in older adults
 
High-dose flu shots lower hospitalization risk in older adultsHigh-dose influenza vaccines may lower serious hospitalization rates in older adults, particularly those with diabetes, according to a recent Danish trial.
 
 
 Nearly half of adults now live with heart disease as obesity and diabetes surge
 
Nearly half of adults now live with heart disease as obesity and diabetes surgeThe 2026 American Heart Association Heart Disease and Stroke Statistics report shows that nearly half of adults are living with cardiovascular disease, with cardiometabolic risk factors projected to rise substantially by 2050. Despite progress in smoking reduction and cholesterol control, worsening obesity, diabetes, hypertension, sleep health, and persistent inequities threaten future cardiovascular health.
 
 
 PFAS exposure increases gestational diabetes risk
 
PFAS exposure increases gestational diabetes riskA review of 130 studies links PFAS exposure to gestational diabetes, highlighting the need for further research on diabetes outcomes and environmental factors.
 
 
 Genetic study links vitamin B1 metabolism to gut motility and IBS risk
 
Genetic study links vitamin B1 metabolism to gut motility and IBS riskResearch links thiamine metabolism to gut motility, identifying genetic markers that could lead to new therapies for IBS and related digestive disorders.
 
 
 Wearable AI device turns silent throat signals into fluent speech for stroke patients
 
Wearable AI device turns silent throat signals into fluent speech for stroke patientsAI technology in a wearable choker helps stroke survivors overcome communication barriers by transforming throat vibrations into clear, context-aware speech.
 
 
 Alcohol-free drinks may reduce harm, if marketing loopholes stop
 
Alcohol-free drinks may reduce harm, if marketing loopholes stopThe BMJ review warns that unregulated alcohol-free drinks may widen inequalities and undermine effective alcohol control, emphasizing the need for caution.
 
 
 Ageing slows brain protein clearance and shifts synaptic waste to microglia
 
Ageing slows brain protein clearance and shifts synaptic waste to microgliaAgeing slows neuronal protein degradation in mice, leading to widespread accumulation and aggregation of long-lived proteins, particularly at synapses. As neuronal clearance declines, microglia selectively accumulate synaptic proteins, suggesting a compensatory but potentially strained proteostasis pathway in the ageing brain.
 
 
 Blood lipid–hormone ratios predict future asthma attacks years in advance
 
Blood lipid–hormone ratios predict future asthma attacks years in advanceThis study shows that specific ratios of circulating sphingolipids to steroids can predict the risk of future asthma exacerbations over five years with high discriminatory performance. By integrating metabolomics with longitudinal medical records, the research highlights lipid–hormone pathway imbalance as a key driver of asthma instability.
 
 
 A routine blood test may reveal who is most at risk of osteoporosis
 
A routine blood test may reveal who is most at risk of osteoporosisA routine creatinine blood test may identify individuals at higher risk for osteoporosis and fractures, highlighting its potential as a risk assessment tool.
 
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